scholarly journals Effects of Fish Oil and Grape Seed Extract Combination on Hepatic Endogenous Antioxidants and Bioactive Lipids in Diet-Induced Early Stages of Insulin Resistance in Rats

Marine Drugs ◽  
2020 ◽  
Vol 18 (6) ◽  
pp. 318 ◽  
Author(s):  
Núria Taltavull ◽  
Bernat Miralles-Pérez ◽  
Maria Rosa Nogués ◽  
Sara Ramos-Romero ◽  
Lucía Méndez ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acid ◽  
Fish Oil ◽  
Polyunsaturated Fatty Acid ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Standard Diet ◽  
Early Stages ◽  
Endogenous Antioxidants

Diacylglycerols (DAG) and ceramides have been suggested as early predictors of insulin resistance. This study was aimed to examine the combined effects of fish oil (FO) and grape seed extract (GSE) on hepatic endogenous antioxidants, DAG and ceramides in diet-induced early stages of insulin resistance. Thirty-five rats were fed one of the following diets: (1) a standard diet (STD group), (2) a high-fat high-sucrose diet (HFHS group), (3) an HFHS diet enriched with FO (FO group), (4) an HFHS diet enriched with GSE (GSE group) or (5) an HFHS diet enriched with FO and GSE (FO + GSE group). In the liver, endogenous antioxidants were measured using spectrophotometric and fluorometric techniques, and non-targeted lipidomics was conducted for the assessment of DAG and ceramides. After 24 weeks, the FO + GSE group showed increased glutathione peroxidase activity, as well as monounsaturated fatty acid and polyunsaturated fatty acid-containing DAG, and long-chain fatty acid-containing ceramides abundances compared to the STD group. The FO and GSE combination induced similar activation of the antioxidant system and bioactive lipid accumulation in the liver than the HFHS diet without supplementation. In addition, the FO and GSE combination increased the abundances of polyunsaturated fatty acid-containing DAG in the liver.

Low-Fat Beef Patties with Augmented Omega-3 Fatty Acid and CLA Levels and Influence of Grape Seed Extract

2014 ◽  
Vol 79 (11) ◽  
pp. S2368-S2376 ◽  
Author(s):  
Inmaculada Gómez ◽  
María J. Beriain ◽  
María V. Sarriés ◽  
Kizkitza Insausti ◽  
José A. Mendizabal
Keyword(s):  
Fatty Acid ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Omega 3 ◽  
Low Fat ◽  
Omega 3 Fatty Acid ◽  
Beef Patties

scholarly journals Amelioration of cisplatin-induced nephrotoxicity by grape seed extract and fish oil is mediated by lowering oxidative stress and DNA damage

2013 ◽  
Vol 66 (3) ◽  
pp. 419-429 ◽  
Author(s):  
Hanaa A. Hassan ◽  
Gamal M. Edrees ◽  
Ezz M. El-Gamel ◽  
Elsamra A. El-sayed
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Fish Oil ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract

Effect of Grape Seed Extract, Cistus ladanifer L., and Vegetable Oil Supplementation on Fatty Acid Composition of Abomasal Digesta and Intramuscular Fat of Lambs

2010 ◽  
Vol 58 (19) ◽  
pp. 10710-10721 ◽  
Author(s):  
Eliana Jerónimo ◽  
Susana P. Alves ◽  
Maria T. P. Dentinho ◽  
Susana V. Martins ◽  
José A. M. Prates ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Vegetable Oil ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Intramuscular Fat ◽  
Seed Extract ◽  
Cistus Ladanifer

scholarly journals Grape seed extract modifies insulin resistance induced by a high fat/carbohydrate meal in metabolic syndrome patients

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Indika Edirisinghe ◽  
Jody Randolph ◽  
Mandeep Cheema ◽  
Eunyoung Park ◽  
Britt Burton-Freeman ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
High Fat ◽  
Carbohydrate Meal

Effects of grape seed extract, lutein, and fish oil on responses of canine lens epithelial cells in vitro

2018 ◽  
Vol 79 (7) ◽  
pp. 770-778
Author(s):  
Eric J. Miller ◽  
Anne J. Gemensky-Metzler ◽  
David A. Wilkie ◽  
Rachel M. Wynne ◽  
Elizabeth M. Curto ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Fish Oil ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Lens Epithelial Cells

Abstract 310: Improvement in Vascular Reactivity by Institution of a "Green-Based" Diet with Supplemental Fish Oil and the Polyphenolic Compounds, Grape Seed Extract and Pycnogenol

2012 ◽  
Vol 32 (suppl_1) ◽  
Author(s):  
Steven R Gundry ◽  
Jean Epstein
Keyword(s):  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Fish Oil ◽  
Olive Oil ◽  
Dietary Habits ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Dietary Factors ◽  
Grain Legume

Objectives: Endothelial dysfunction (ED) is highly correlated with the development of coronary artery and vascular disease in general. While dietary factors have been previously implicated in the causation of endothelial dysfunction, a purposeful change in dietary habits, coupled with the addition of several polyphenol-containing supplements, has not been studied for their effects on endothelial function, as measured by Peripheral Arterial Tonometry (PAT). Methods: 125 consecutive pts, aged 65-86, M:F ratio 3/2, with known vascular risk factors of HTN, DM, Hypercholesterolemia, hx of MI, Stent, CABG, were enrolled in a dietary program, which emphasizes large amts of leafy green vegetables, olive oil, radical reduction of grain, legumes, and fruits; and generous amts of animal proteins (Diet Evolution). All pts were instructed to take 2-4,000 mg of high DHA fish oil, 200mg of Grape Seed Extract, and 50 mg of Pycnogenol per day. All pts had Endothelial Reactivity (ER) using PAT before and after a 5-minute arm occlusion using the EndoPAT 2000 (Itamar, Israel) at baseline and at 6 months. Results: Baseline Endothelial Reactivity was 1.88+/-0.7 (range 1.0-3.3), with 90/125 pts (72%)having endothelial dysfunction (less than 1.60). At 6 months, ER increased to 2.25+/-0.5 (range 1.2-3.6) (p<0.01). Only 20/125 (16%) remained with ED, but all had increased ER numbers. Two pts stopped the polyphenols after a normal PAT; both developed ED on repeat PAT. Conclusions: We conclude that a limited grain, legume, fruit diet with emphasis on greens, olive oil and animal proteins with supplemental fish oil and polyphenols dramatically improves endothelial function in a group of high risk patients.

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