scholarly journals Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates of Penicillium bilaiae MA-267 and Penicillium chermesinum EN-480

Marine Drugs ◽  
2020 ◽  
Vol 18 (7) ◽  
pp. 339
Author(s):  
Ling-Hong Meng ◽  
Xiao-Ming Li ◽  
Hong-Lei Li ◽  
Bin-Gui Wang
Keyword(s):  
Spectroscopic Analysis ◽  
Experimental Approach ◽  
Octadecadienoic Acid ◽  
Edwardsiella Tarda ◽  
Culture Vessel ◽  
Fungal Isolates ◽  
Microbial Strains ◽  
Inhibitory Activities ◽  
Modified Mosher’S Method ◽  
Penicillium Bilaiae

The co-cultivation of two or more different microbial strains in one culture vessel was supposed to be a viable experimental approach for enhancing the diversity of the compounds produced. Two new meroterpenoid derivatives, chermebilaenes A (1) and B (2), together with three known sesquiterpenoids, sesquicaranoic acid B (3), cyclonerodiol (4) and bisabol-l-on-13-säuremethylester (5), were characterized from a co-culture of the marine-derived fungal isolates of Penicillium bilaiae MA-267 and Penicillium chermesinum EN-480. Neither fungus produced these compounds when cultured alone under the same conditions. Compound 1 represents an unprecedented acorane-type sesquiterpene hybridized with an octadecadienoic acid skeleton. The structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations were assumed on the basis of acidic hydrolysis combined with modified Mosher’s method and electronic circular dichroism (ECD) calculations. Compound 1 showed potent inhibitory activities against Ceratobasidium cornigerum and Edwardsiella tarda.

scholarly journals Sacraoxides A–G, Bioactive Cembranoids from Gum Resin of Boswellia sacra

2021 ◽  
Vol 9 ◽  
Author(s):  
Bingyang Zhang ◽  
Di Liu ◽  
Wenyue Ji ◽  
Kouharu Otsuki ◽  
Koji Higai ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Spectroscopic Analysis ◽  
Raw264.7 Cells ◽  
No Production ◽  
X Ray Diffraction ◽  
X Ray ◽  
Inhibitory Activities ◽  
Modified Mosher’S Method ◽  
Boswellia Sacra

Seven undescribed cembranoids, sacraoxides A–G (1, 3–8) were isolated from the gum resin of Boswellia sacra. Their structures were elucidated by extensive physicochemical and spectroscopic analysis, as well as ECD calculation, modified Mosher’s method and X-ray diffraction crystallography. Compounds 6 and 7 exhibited inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in RAW264.7 cells with IC50 values of 24.9 ± 1.7 and 36.4 ± 2.9 μM.

Isolation of New Glycosides from Anemarrhena Asphodeloides Rhizome and Screening of their Anticancer Activity

2019 ◽  
Vol 16 (6) ◽  
pp. 474-477 ◽  
Author(s):  
Pham Van Khang ◽  
Nguyen Thi Hien Lan ◽  
Le Quang Truong ◽  
Mai Thi Minh Chau ◽  
Mai Xuan Truong ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Spectral Data ◽  
Cell Lines ◽  
Cancer Cell ◽  
Spectroscopic Analysis ◽  
2D Nmr ◽  
Ic50 Values ◽  
Nmr Techniques ◽  
Inhibitory Activities ◽  
Anemarrhena Asphodeloides

In this report, two new steroidal glycosides were isolated and determined from n-butanol fraction of A.asphodeloides. The structures were confirmed in comparison with the spectral data of known compounds by using different spectroscopic analysis approaches including 1D & 2D-NMR techniques and HRMS. The anti-proliferation screening against cancer cell lines A549 and HeLa indicated that compound 1 exhibited good inhibitory activities with IC50 values of 0.79 and 0.55 µg/mL, respectively.

scholarly journals α-Amylase and α-Glucosidase Inhibitory Activities of Chemical Constituents from Wedelia chinensis (Osbeck.) Merr. Leaves

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Nguyen Phuong Thao ◽  
Pham Thanh Binh ◽  
Nguyen Thi Luyen ◽  
Ta Manh Hung ◽  
Nguyen Hai Dang ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Inhibitory Effects ◽  
Meoh Extract ◽  
Inhibitory Activities ◽  
Isolated Compound ◽  
New Compounds ◽  
Modified Mosher’S Method

As part of an ongoing search for new natural products from medicinal plants to treat type 2 diabetes, two new compounds, a megastigmane sesquiterpenoid sulfonic acid (1) and a new cyclohexylethanoid derivative (2), and seven related known compounds (3–9) were isolated from the leaves of Wedelia chinensis (Osbeck.) Merr. The structures of the compounds were conducted via interpretation of their spectroscopic data (1D and 2D NMR, IR, and MS), and the absolute configurations of compound 1 were determined by the modified Mosher’s method. The MeOH extract of W. chinensis was found to inhibit α-amylase and α-glucosidase inhibitory activities as well as by the compounds isolated from this extract. Furthermore, compound 7 showed the strongest effect with IC50 values of 112.8 ± 15.1 μg/mL (against α-amylase) and 785.9 ± 12.7 μg/mL (against α-glucosidase). Compounds 1, 8, and 9 showed moderate α-amylase and α-glucosidase inhibitory effects. Other compounds showed weak or did not show any effect on both enzymes. The results suggested that the antidiabetic properties from the leaves of W. chinensis are not simply a result of each isolated compound but are due to other components such as the accessibility of polyphenolic groups to α-amylase and α-glucosidase activities.

scholarly journals Phialemonium Fungemia: Two Documented Nosocomial Cases

1999 ◽  
Vol 37 (8) ◽  
pp. 2493-2497 ◽  
Author(s):  
Josep Guarro ◽  
Marcio Nucci ◽  
Tiyomi Akiti ◽  
Josepa Gené ◽  
Josep Cano ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Internal Transcribed Spacer ◽  
Antifungal Agents ◽  
The Other ◽  
Source Of Infection ◽  
Fungal Isolates ◽  
Immunosuppressed Patients ◽  
Internal Transcribed Spacer Sequences ◽  
Inhibitory Activities

Two fungal isolates recovered from the blood of two immunosuppressed patients are described as Phialemonium curvatum. One patient died, while the other, who was infected with Exophiala jeanselmei at the same time, survived after successful treatment with itraconazole. Analysis of internal transcribed spacer sequences demonstrated that the isolates belonged to the same strain and that the source of infection was probably a catheter. The taxonomic position of P. curvatum is discussed, and Phialemonium dimorphosporum is considered a synonym. The in vitro inhibitory activities of six antifungal agents (amphotericin B, itraconazole, ketaconazole, miconazole, flucytosine, and fluconazole) were determined against seven isolates ofPhialemonium. Except for flucytosine, all of them were remarkably effective. Phialemonium should be added to the list of potential causes of nosocomial fungemia in cancer patients.

scholarly journals α-Glucosidase and 15-Lipoxygenase Inhibitory Activities of Phytochemicals from Calophyllum symingtonianum

2015 ◽  
Vol 10 (9) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Nurul Iman Aminudin ◽  
Farediah Ahmad ◽  
Muhammad Taher ◽  
Razauden Mohamed Zulkifli
Keyword(s):  
Positive Result ◽  
Inhibitory Activity ◽  
Spectroscopic Analysis ◽  
Chemical Structures ◽  
Crude Extracts ◽  
Phytochemical Investigation ◽  
Lipoxygenase Inhibition ◽  
Inhibitory Activities

A phytochemical investigation of the crude extracts of the bark and leaves of Calophyllum symingtonianum has resulted in the isolation of inophyllum D, inophyllum H, calanone, isocordato-oblongic acid, amentoflavone, carpachromene and lupenone. Their chemical structures were elucidated and confirmed by spectroscopic analysis. All flavonoids and coumarins showed significant α-glucosidase inhibitory activity, while amentoflavone gave a positive result against 15-lipoxygenase inhibition.

scholarly journals Coumarins from Seseli hartvigii

2010 ◽  
Vol 5 (7) ◽  
pp. 1934578X1000500
Author(s):  
Lin Zhang ◽  
Alev Tosun ◽  
Masaki Baba ◽  
Yoshihito Okada ◽  
Lijun Wu ◽  
...  
Keyword(s):  
Natural Product ◽  
Spectroscopic Analysis ◽  
Chemical Conversion ◽  
Linear Type ◽  
Whole Plants ◽  
Modified Mosher’S Method

Linear-type furocoumarins, 5-[(2″ E,6″R)-6″-hydroxy-3″,7″-dimethylocta-2″,7″-dienyloxy]psoralen and 5-[(2″ E,6″ S)-6″-hydroxy-3″,7″-dimethylocta-2″,7″-dienyloxy]psoralen (1) were first isolated from whole plants of Seseli hartvigii together with one new natural product 6-(3’-methyl-2’-oxo-3’-butenyl)-7-methoxycoumarin (2), and four known compounds (tamarin, bergaptol, notoptol, and a mixture of β-sitosterol and stigmasterol). The structure of 1 was elucidated by extensive spectroscopic analysis and chemical conversion. The modified Mosher's method and HPLC were applied to determine its stereochemistry. Both R- and S-configurations exist in 1; after modification by Mosher's reagent, they were effectively separated, and their ratio was deduced to be 59% and 41%, respectively.

scholarly journals Four New Isocoumarins and a New Natural Tryptamine with Antifungal Activities from a Mangrove Endophytic Fungus Botryosphaeria ramosa L29

Marine Drugs ◽  
2019 ◽  
Vol 17 (2) ◽  
pp. 88 ◽  
Author(s):  
Zhihui Wu ◽  
Jiaqing Chen ◽  
Xiaolin Zhang ◽  
Zelin Chen ◽  
Tong Li ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Culture Medium ◽  
Spectroscopic Analysis ◽  
Calculated Data ◽  
Cd Spectra ◽  
Mangrove Endophytic Fungus ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Weak Growth ◽  
Inhibitory Activities

Four new isocoumarin derivatives, botryospyrones A (1), B (2), C (3), and D (4), and a new natural tryptamine, (3aS, 8aS)-1-acetyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo [2,3b] indol-3a-ol (5), were isolated from a marine mangrove endophytic fungus Botryosphaeria ramosa L29, obtained from the leaf of Myoporum bontioides. Their structures were elucidated using spectroscopic analysis. The absolute configurations of compounds 3, 4, and 5 were determined by comparison of their circular dichroism (CD) spectra with the calculated data. The inhibitory activities of compound 1 on Fusarium oxysporum, of compounds 2 and 3 on F. oxysporum and Fusarium graminearum, and of compound 5 on F. oxysporum, Penicillium italicum, and F. graminearum were higher than those of triadimefon, widely used as an agricultural fungicide. Compound 5 was produced after using the strategy we called “using inhibitory stress from components of the host” (UISCH), wherein (2R, 3R)-3, 5, 7-trihydroxyflavanone 3-acetate, a component of M. bontioides with weak growth inhibitory activity towards B. ramosa L29, was introduced into the culture medium.

scholarly journals Synthesis of Some Phenylisoindoline-1,3-Diones and their Acetylcholinesterase and Butyryl Cholinesterase Inhibitory Activities

2021 ◽  
pp. 194-201
Author(s):  
F. O. Taiwo ◽  
C. A. Obafemi ◽  
E. M. Obuotor ◽  
I. J. Olawuni
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Cholinesterase Inhibitors ◽  
Spectroscopic Analysis ◽  
Choline Chloride ◽  
Biological Properties ◽  
Active Inhibitor ◽  
Magnetic Resonance Spectroscopic Analysis ◽  
Butyryl Cholinesterase ◽  
Inhibitory Activities

Aims: To synthesize some phthalimides derivatives and evaluate the compounds for their possible biological properties. Methods: The substituted phenylisoindoline-1,3-dione were synthesized from the reactions of N-phenyl phthalimide with different substituted aromatic aldehyde. The synthesized compounds were characterized using nuclear magnetic resonance spectroscopic analysis. The acetylcholinesterase and butyryl cholinesterase inhibitions were determined by Spectro photochemical analysis of acetylthiocholine and butyryl choline chloride. Results: Compounds 6 (IC50 = 30±3 µg/mL) and 4 (IC50 = 141±60 µg/mL) were found to be the most active inhibitors against acetylcholinesterase, while compounds 4 (IC50 = 102±10 µg/mL), 5 (IC50 = 105 ± 20 µg/mL) and 2 (IC50 = 190 ± 10 µg/mL), were found to be most active inhibitor against butyryl cholinesterase. Conclusion: The considerable acetylcholinesterase and butyryl cholinesterase inhibitory activities of the synthesized compounds makes them good candidates for the development of selective acetylcholinesterase and butyryl cholinesterase inhibitors.

scholarly journals New sesquiterpenoids from the South China Sea soft corals Clavularia viridis and Lemnalia flava

2019 ◽  
Vol 15 ◽  
pp. 695-702
Author(s):  
Qihao Wu ◽  
Yuan Gao ◽  
Meng-Meng Zhang ◽  
Li Sheng ◽  
Jia Li ◽  
...  
Keyword(s):  
South China Sea ◽  
South China ◽  
Spectroscopic Analysis ◽  
The South China Sea ◽  
Soft Corals ◽  
The South ◽  
China Sea ◽  
Inhibitory Activities ◽  
Detailed Chemical

A detailed chemical investigation of the South China Sea soft corals Clavularia viridis and Lemnalia flava yielded four new halogenated laurane-type sesquiterpenoids, namely, isobromolaurenisol (1), clalaurenol A (2), ent-laurenisol (3), clalaurenol B (4), and the new aromadendrane-type sesquiterpenoid claaromadendrene (6), together with three known sesquiterpenoids (5, 7, and 8). Their structures were determined by extensive spectroscopic analysis and by comparison with the previously reported analogues. In a bioassay, compounds 1, 2 and 4 exhibited interesting inhibitory activities in vitro against PTP1B and NF-κB.

scholarly journals Clerodane-type Diterpene Glycosides from Dicranopteris pedata

2021 ◽  
Author(s):  
Bei-Bei Gao ◽  
Yu-Fei Ou ◽  
Qin-Feng Zhu ◽  
Zhi-Ping Zhou ◽  
Zhen-Tao Deng ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Spectroscopic Analysis ◽  
Addition Compound ◽  
Inhibitory Activities ◽  
The Absolute ◽  
Mcf 7

AbstractThree new clerodane-type diterpene glycosides, (5R,6S,8R,9S,10R)-6-O-[β-d-glucopyranosyl-(1 → 4)-α-l-rhamnopyranosyl]cleroda-3,13(16),14-diene (1), (5R,6S,8R,9S,10R,13S)-6-O-[β-d-glucopyranosyl-(1 → 4)-α-l-rhamnopyranosyl]-2-ox-oneocleroda-3,13-dien-15-ol (2), (5R,6S,8R,9S,10R)-6-O-[β-d-glucopyranosyl-(1 → 4)-α-l-rhamnopyranosyl]-(13E)-2-oxoneocleroda-3,14-dien-13-ol (3), together with two known compounds 4 and 5 were isolated from Dicranopteris pedata. The structures of these compounds were elucidated by detailed spectroscopic analysis, and the absolute configuration of compound 2 was determined by ECD calculations. In addition, compound 1 exhibited weak inhibitory activities against SMMC-7721, MCF-7 and SW480. Graphic Abstract

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