scholarly journals Antifouling Activity of Halogenated Compounds Derived from the Red Alga Sphaerococcus coronopifolius: Potential for the Development of Environmentally Friendly Solutions

Marine Drugs ◽  
2021 ◽  
Vol 20 (1) ◽  
pp. 32
Author(s):  
Maxence Quémener ◽  
Stefanos Kikionis ◽  
Marilyne Fauchon ◽  
Yannick Toueix ◽  
Fanny Aulanier ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Green Chemistry ◽  
Red Alga ◽  
Point Of View ◽  
Economic Losses ◽  
Research Strategies ◽  
Antifouling Paints ◽  
Antifouling Activity ◽  
Bioactive Secondary Metabolites ◽  
Adhesion Process

Nowadays, biofouling is responsible for enormous economic losses in the maritime sector, and its treatment with conventional antifouling paints is causing significant problems to the environment. Biomimetism and green chemistry approaches are very promising research strategies for the discovery of new antifouling compounds. This study focused on the red alga Sphaerococcus coronopifolius, which is known as a producer of bioactive secondary metabolites. Fifteen compounds, including bromosphaerol (1), were tested against key marine biofoulers (five marine bacteria and three microalgae) and two enzymes associated with the adhesion process in macroalgae and invertebrates. Each metabolite presented antifouling activity against at least one organism/enzyme. This investigation also revealed that two compounds, sphaerococcinol A (4) and 14R-hydroxy-13,14-dihydro-sphaerococcinol A (5), were the most potent compounds without toxicity towards oyster larvae used as non-target organisms. These compounds are of high potential as they are active towards key biofoulers and could be produced by a cultivable alga, a fact that is important from the green chemistry point of view.

New Bioactive Secondary Metabolites from Bornean Red Alga, Laurencia similis (Ceramiales)

2013 ◽  
Vol 8 (3) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Takashi Kamada ◽  
Charles Santhanaraju Vairappan
Keyword(s):  
Antibacterial Activity ◽  
Secondary Metabolites ◽  
Secondary Metabolite ◽  
Red Alga ◽  
Algal Population ◽  
Cytotoxic Effects ◽  
Antibiotic Resistant ◽  
Good Antibacterial Activity ◽  
Bioactive Secondary Metabolites ◽  
Red Algal

A Bornean red algal population of Laurencia simlis Nam et Saito was analyzed for its secondary metabolite composition. Seven compounds were identified: ent -1(10)-aristolen-9β-ol (1), (+)-aristolone (2), axinysone B (3), 9-aristolen-1α-ol (4), 2,3,5,6-tetrabromoindole (5), 1-methyl-2,3,5,6-tetrabromoindole (6), and 1-methyl-2,3,5-tribromoindole (7). Compound 1 was identified as a new optical isomer of 1(10)-aristolen-9β-ol. Compounds 1, 4 and 5 exhibited good antibacterial activity against antibiotic resistant clinical bacteria and cytotoxic effects against selected cancer cell lines.

Bioactive Secondary Metabolites from Geosmithia langdonii

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
LG Malak ◽  
DW Bishay ◽  
AM Abdel-baky ◽  
AM Moharram ◽  
SJ Cutler ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Bioactive Secondary Metabolites

Screening bioactive secondary metabolites from Costa Rican enviromental microbial communities

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
JJ Araya ◽  
M Chavarría ◽  
A Pinto-Tomás ◽  
C Murillo ◽  
L Uribe ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Microbial Communities ◽  
Costa Rican ◽  
Bioactive Secondary Metabolites

Bioactive Secondary Metabolites from Endophytic Fungi

2020 ◽  
Vol 27 (11) ◽  
pp. 1836-1854 ◽  
Author(s):  
Elena Ancheeva ◽  
Georgios Daletos ◽  
Peter Proksch
Keyword(s):  
Secondary Metabolites ◽  
Endophytic Fungi ◽  
Host Plants ◽  
Biological Activities ◽  
Cytotoxic Agents ◽  
Special Focus ◽  
Plant Metabolites ◽  
Direct Production ◽  
Bioactive Secondary Metabolites ◽  
Fungal Genes

Background: Endophytes represent a complex community of microorganisms colonizing asymptomatically internal tissues of higher plants. Several reports have shown that endophytes enhance the fitness of their host plants by direct production of bioactive secondary metabolites, which are involved in protecting the host against herbivores and pathogenic microbes. In addition, it is increasingly apparent that endophytes are able to biosynthesize medicinally important “phytochemicals”, originally believed to be produced only by their host plants. Objective: The present review provides an overview of secondary metabolites from endophytic fungi with pronounced biological activities covering the literature between 2010 and 2017. Special focus is given on studies aiming at exploration of the mode of action of these metabolites towards the discovery of leads from endophytic fungi. Moreover, this review critically evaluates the potential of endophytic fungi as alternative sources of bioactive “plant metabolites”. Results: Over the past few years, several promising lead structures from endophytic fungi have been described in the literature. In this review, 65 metabolites are outlined with pronounced biological activities, primarily as antimicrobial and cytotoxic agents. Some of these metabolites have shown to be highly selective or to possess novel mechanisms of action, which hold great promises as potential drug candidates. Conclusion: Endophytes represent an inexhaustible reservoir of pharmacologically important compounds. Moreover, endophytic fungi could be exploited for the sustainable production of bioactive “plant metabolites” in the future. Towards this aim, further insights into the dynamic endophyte - host plant interactions and origin of endophytic fungal genes would be of utmost importance.

Streptomyces: host for refactoring of diverse bioactive secondary metabolites

3 Biotech ◽  
2021 ◽  
Vol 11 (7) ◽  
Author(s):  
Vivek Sharma ◽  
Randhir Kaur ◽  
Richa Salwan
Keyword(s):  
Secondary Metabolites ◽  
Bioactive Secondary Metabolites

scholarly journals Species Diversity and Secondary Metabolites of Sarcophyton-Associated Marine Fungi

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3227
Author(s):  
Yuanwei Liu ◽  
Kishneth Palaniveloo ◽  
Siti Aisyah Alias ◽  
Jaya Seelan Sathiya Seelan
Keyword(s):  
Secondary Metabolites ◽  
Soft Coral ◽  
Marine Fungi ◽  
Indole Alkaloids ◽  
Structural Diversity ◽  
Future Research ◽  
Soft Corals ◽  
Diverse Range ◽  
Symbiotic Relationships ◽  
Bioactive Secondary Metabolites

Soft corals are widely distributed across the globe, especially in the Indo-Pacific region, with Sarcophyton being one of the most abundant genera. To date, there have been 50 species of identified Sarcophyton. These soft corals host a diverse range of marine fungi, which produce chemically diverse, bioactive secondary metabolites as part of their symbiotic nature with the soft coral hosts. The most prolific groups of compounds are terpenoids and indole alkaloids. Annually, there are more bio-active compounds being isolated and characterised. Thus, the importance of the metabolite compilation is very much important for future reference. This paper compiles the diversity of Sarcophyton species and metabolites produced by their associated marine fungi, as well as the bioactivity of these identified compounds. A total of 88 metabolites of structural diversity are highlighted, indicating the huge potential these symbiotic relationships hold for future research.

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