scholarly journals Common Variations in Prothrombotic Genes and Susceptibility to Ischemic Stroke in Young Patients: A Case-Control Study in Southeast Iran

Medicina ◽  
2019 ◽  
Vol 55 (2) ◽  
pp. 47
Author(s):  
Seyed Hashemi ◽  
Nourollah Ramroodi ◽  
Hamed Amiri Fard ◽  
Sahar Talebian ◽  
Maryam Haghighi Rohani ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Case Control Study ◽  
Young Patients ◽  
Mthfr C677t ◽  
Case Control ◽  
Prothrombin G20210a ◽  
Increased Risk ◽  
Objective Evidence ◽  
Control Study ◽  
Stroke In Young

Background and Objective: Evidence indicates that genetic factors may be involved in the risk of ischemic stroke (IS). The aim of this study was to assess the effect of genetic polymorphisms located in exons or untranslated regions of MTHFR as well as FV genes on ischemic stroke. Materials and Methods: In this case-control study, 106 patients with IS and 157 healthy volunteers (age <50 years) were genotyped for MTHFR C677T, A1298C, C2572A and C4869G, FVL, and prothrombin G20210A polymorphisms. Results: The MTHFR 677CT genotype was more frequent in patients and increased risk of IS with Odds Ratio = 1.9. The MTHFR A1298C and C2572A polymorphisms were not associated with IS in dominant and recessive models. Our findings showed a significant decrease in the MTHFR 4869CG genotype in IS patients, and this variant was associated with a decreased risk of IS in the dominant model. The CAAT haplotype was associated with increased risk, and the GAAC haplotype was associated with decreased risk of IS compared to other haplotypes. There was no relation between FVL G1691A polymorphism and IS risk. Conclusions: The present study showed that the MTHFR 677CT genotype was more frequent and the MTHFR 4869CG genotype was less frequent in young IS patients.

scholarly journals The Relationship between Risk Factors and Microalbumiuria for Ischaemic Stroke : A Case Control Study

2013 ◽  
Vol 12 (3) ◽  
pp. 37-43
Author(s):  
Md Shaheen Wadud ◽  
Aminur Rahman ◽  
Mohammad Selim Shahi ◽  
Uttam Kumar Saha ◽  
AK Takib Uddin Ahmed ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Case Control Study ◽  
Positive Family History ◽  
Case Control ◽  
Epidemiologic Studies ◽  
Case Group ◽  
Medical College ◽  
Increased Risk ◽  
Control Study

Background: Epidemiologic studies have reported that microalbuminuria is a risk factor for stroke in men and a limited case control study found that the highest quintile of microalbuminuria values was associated with 13 fold increased risk for stroke. The goal of this study is designed to determine its relationship to risk factors for ischemic stroke. Materials and Methods: It was a prospective observational study conducted in the Department of Neurology, Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh. Fifty consecutive patients with ischemic stroke with at least two risk factors who fulfilled the inclusion criteria of case were confirmed by CT or MRI. Equal number of controls same ages without stroke who had at least two risk factors were compared with the case group. The patients were assessed clinically with structured questionnaire including blood pressure, height and weight, and monitoring blood glucose and microalbuminuria. Results: Microalbuminuria was found 58.0% in patients with ischemic stroke. Patients who had diabetes mellitus will have 13.86 times the risk for developing microalbuminuria (p<0.05). Patients who had HTN will have 4.19 times the risk for developing microalbuminuria (p<0.05) and BMI (?23 kg/m2) will have 4.24 times the risk for developing microalbuminuria with (p<0.05). Whereas TIA, IHD, dyslipidemia, smoking and positive family history were not significantly (P>0.05) associated with microalbuminuria in patients with ischemic stroke. Conclusion: The findings of this study show that diabetes is the factor most closely associated with microalbuminuria followed by HTN and BMI?23 kg/m2 with statistically significance in patients with ischemic stroke. Chattagram Maa-O-Shishu Hospital Medical College Journal Volume 12, Issue 3, September 2013: 37-43

Migraine as a risk factor for young patients with ischemic stroke: a case–control study

2017 ◽  
Vol 38 (4) ◽  
pp. 611-617 ◽  
Author(s):  
Yasin Abanoz ◽  
Yeşim Gülen Abanoz ◽  
Ayşegül Gündüz ◽  
Derya Uludüz ◽  
Birsen İnce ◽  
...  
Keyword(s):  
Risk Factor ◽  
Ischemic Stroke ◽  
Case Control Study ◽  
Young Patients ◽  
Case Control ◽  
Control Study

scholarly journals The Relationship between Risk Factors and Microalbumiuria for Ischemic Stroke- A Case Control Study

2013 ◽  
Vol 29 (1) ◽  
pp. 43-53
Author(s):  
Md Shaheen Wadud ◽  
Aminur Rahman ◽  
Mohammad Selim Shahi ◽  
A K Takib Uddin Ahmed ◽  
Uttam Kumar Saha ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Case Control Study ◽  
Positive Family History ◽  
Case Control ◽  
Epidemiologic Studies ◽  
Case Group ◽  
Medical College ◽  
Increased Risk ◽  
Control Study

Background: Epidemiologic studies have reported that microalbuminuria is a risk factor for stroke in men and a limited case control study found that the highest quintile of microalbuminuria values was associated with 13 fold increased risk for stroke. The goal of this study was designed to determine its relationship to risk factors for ischemic stroke. Materials and Methods: It was a prospective observational study conducted in the Department of Neurology, Sir Salimullah Medical College & Mitford Hospital, Dhaka, Bangladesh. Fifty consecutive patients with ischemic stroke were enrolled in this study, with at least two risk factors that fulfilled the inclusion criteria and were confirmed by CT or MRI of brain. Equal number of controls of same age group without stroke who had at least two risk factors was compared with the case group. The patients were assessed clinically with structured questionnaire including blood pressure, height and weight, and monitoring blood glucose and microalbuminuria. Results: Microalbuminuria was found 58.0% in patients with ischemic stroke. Patients who had diabetes mellitus will have 13.86 times the risk for developing of microalbuminuria (p<0.05). Patients who had hypertension will have 4.19 times the risk of developing microalbuminuria (p<0.05) and BMI (e”23 kg/m2) will have 4.24 times the risk of developing microalbuminuria (p<0.05). Whereas TIA, IHD, dyslipidemia, smoking and positive family history were not significantly (P>0.05) associated with microalbuminuria in patients with ischemic stroke. Conclusion: The findings of this study show that diabetes is the factor most closely associated with microalbuminuria followed by HTN and BMI >23 kg/ m2 with statistically significance in patients with ischemic stroke. Bangladesh Journal of Neuroscience 2013; Vol. 29 (1) : 43-53

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