Secretases Related to Amyloid Precursor Protein Processing
Keyword(s):
Alzheimer’s disease (AD) is a common neurodegenerative disease whose prevalence increases with age. An increasing number of findings suggest that abnormalities in the metabolism of amyloid precursor protein (APP), a single transmembrane aspartic protein that is cleaved by β- and γ-secretases to produce β-amyloid protein (Aβ), are a major pathological feature of AD. In recent years, a large number of studies have been conducted on the APP processing pathways and the role of secretion. This paper provides a summary of the involvement of secretases in the processing of APP and the potential drug targets that could provide new directions for AD therapy.
2021 ◽
2017 ◽
Vol 313
(5)
◽
pp. R585-R593
◽
2011 ◽
Vol 18
(22)
◽
pp. 3314-3321
◽
2012 ◽
Vol 287
(25)
◽
pp. 21279-21289
◽
Keyword(s):
2006 ◽
Vol 18
(2)
◽
pp. 149-152
◽