scholarly journals Human Fecal Metabolome Reflects Differences in Body Mass Index, Physical Fitness, and Blood Lipoproteins in Healthy Older Adults

Metabolites ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 717
Author(s):  
Mengni Cui ◽  
Alessia Trimigno ◽  
Josue L. Castro-Mejía ◽  
Søren Reitelseder ◽  
Jacob Bülow ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Physical Fitness ◽  
Glutamic Acid ◽  
Human Health ◽  
Body Mass ◽  
Gut Microbiome ◽  
Density Lipoprotein ◽  
Healthy Older Adults ◽  
Lipoprotein Particles

This study investigated how body mass index (BMI), physical fitness, and blood plasma lipoprotein levels are related to the fecal metabolome in older adults. The fecal metabolome data were acquired using proton nuclear magnetic resonance spectroscopy and gas chromatography–mass spectrometry on 163 healthy older adults (65–80 years old, 80 females and 83 males). Overweight and obese subjects (BMI ≥ 27) showed higher levels of fecal amino acids (AAs) (valine, alanine, and phenylalanine) compared to normal-weight subjects (BMI ≤ 23.5). Adults classified in the high-fitness group displayed slightly lower concentrations of fecal short-chain fatty acids, propionic acid, and AAs (methionine, leucine, glutamic acid, and threonine) compared to the low-fitness group. Subjects with lower levels of cholesterol in low-density lipoprotein particles (LDLchol, ≤2.6 mmol/L) displayed higher fecal levels of valine, glutamic acid, phenylalanine, and lactic acid, while subjects with a higher level of cholesterol in high-density lipoprotein particles (HDLchol, ≥2.1 mmol/L) showed lower fecal concentration of isovaleric acid. The results from this study suggest that the human fecal metabolome, which primarily represents undigested food waste and metabolites produced by the gut microbiome, carries important information about human health and should be closely integrated to other omics data for a better understanding of the role of the gut microbiome and diet on human health and metabolism.

scholarly journals Five-Year Change in Body Mass Index Predicts Conversion to Mild Cognitive Impairment or Dementia Only in APOE ɛ4 Allele Carriers

2021 ◽  
pp. 1-11
Author(s):  
Kylie R. Kadey ◽  
John L. Woodard ◽  
Allison C. Moll ◽  
Kristy A. Nielson ◽  
J. Carson Smith ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Body Mass ◽  
Carrier Status ◽  
Healthy Older Adults ◽  
E4 Allele ◽  
Lifestyle Risk

Background: Body mass index (BMI) has been identified as an important modifiable lifestyle risk factor for dementia, but less is known about how BMI might interact with Apolipoprotein E ɛ4 (APOE ɛ4) carrier status to predict conversion to mild cognitive impairment (MCI) and dementia. Objective: The aim of this study was to investigate the interaction between APOE ɛ4 status and baseline (bBMI) and five-year BMI change (ΔBMI) on conversion to MCI or dementia in initially cognitively healthy older adults. Methods: The associations between bBMI, ΔBMI, APOE ɛ4 status, and conversion to MCI or dementia were investigated among 1,289 cognitively healthy elders from the National Alzheimer’s Coordinating Center (NACC) database. Results: After five years, significantly more carriers (30.6%) converted to MCI or dementia than noncarriers (17.6%), p <  0.001, OR = 2.06. Neither bBMI (OR = 0.99, 95%CI = 0.96–1.02) nor the bBMI by APOE interaction (OR = 1.02, 95%CI = 0.96–1.08) predicted conversion. Although ΔBMI also did not significantly predict conversion (OR = 0.90, 95%CI = 0.78–1.04), the interaction between ΔBMI and carrier status was significant (OR = 0.72, 95%CI = 0.53–0.98). For carriers only, each one-unit decline in BMI over five years was associated with a 27%increase in the odds of conversion (OR = 0.73, 95%CI = 0.57–0.94). Conclusion: A decline in BMI over five years, but not bBMI, was strongly associated with conversion to MCI or dementia only for APOE ɛ4 carriers. Interventions and behaviors aimed at maintaining body mass may be important for long term cognitive health in older adults at genetic risk for AD.

Body mass index and its relation to neuropsychological functioning and brain volume in healthy older adults

2018 ◽  
Vol 348 ◽  
pp. 235-240 ◽  
Author(s):  
Marissa Ann Gogniat ◽  
Talia Loren Robinson ◽  
Catherine Mattocks Mewborn ◽  
Kharine Renee Jean ◽  
L. Stephen Miller
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Body Mass ◽  
Brain Volume ◽  
Neuropsychological Functioning ◽  
Healthy Older Adults

scholarly journals Enhanced task-related brain activation and resting perfusion in healthy older adults after chronic blueberry supplementation

2017 ◽  
Vol 42 (7) ◽  
pp. 773-779 ◽  
Author(s):  
Joanna L. Bowtell ◽  
Zainie Aboo-Bakkar ◽  
Myra E. Conway ◽  
Anna-Lynne R. Adlam ◽  
Jonathan Fulford
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Cognitive Function ◽  
Magnetic Resonance ◽  
Body Mass ◽  
Brain Perfusion ◽  
Magnetic Resonance Images ◽  
Healthy Older Adults ◽  
Male Age ◽  
Blueberry Supplementation

Blueberries are rich in flavonoids, which possess antioxidant and anti-inflammatory properties. High flavonoid intakes attenuate age-related cognitive decline, but data from human intervention studies are sparse. We investigated whether 12 weeks of blueberry concentrate supplementation improved brain perfusion, task-related activation, and cognitive function in healthy older adults. Participants were randomised to consume either 30 mL blueberry concentrate providing 387 mg anthocyanidins (5 female, 7 male; age 67.5 ± 3.0 y; body mass index, 25.9 ± 3.3 kg·m−2) or isoenergetic placebo (8 female, 6 male; age 69.0 ± 3.3 y; body mass index, 27.1 ± 4.0 kg·m−2). Pre- and postsupplementation, participants undertook a battery of cognitive function tests and a numerical Stroop test within a 1.5T magnetic resonance imaging scanner while functional magnetic resonance images were continuously acquired. Quantitative resting brain perfusion was determined using an arterial spin labelling technique, and blood biomarkers of inflammation and oxidative stress were measured. Significant increases in brain activity were observed in response to blueberry supplementation relative to the placebo group within Brodmann areas 4/6/10/21/40/44/45, precuneus, anterior cingulate, and insula/thalamus (p < 0.001) as well as significant improvements in grey matter perfusion in the parietal (5.0 ± 1.8 vs –2.9 ± 2.4%, p = 0.013) and occipital (8.0 ± 2.6 vs –0.7 ± 3.2%, p = 0.031) lobes. There was also evidence suggesting improvement in working memory (2-back test) after blueberry versus placebo supplementation (p = 0.05). Supplementation with an anthocyanin-rich blueberry concentrate improved brain perfusion and activation in brain areas associated with cognitive function in healthy older adults.

scholarly journals Impact of body mass index on neuronal fiber bundle lengths among healthy older adults

2013 ◽  
Vol 7 (3) ◽  
pp. 300-306 ◽  
Author(s):  
Jacob D. Bolzenius ◽  
David H. Laidlaw ◽  
Ryan P. Cabeen ◽  
Thomas E. Conturo ◽  
Amanda R. McMichael ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Body Mass ◽  
Fiber Bundle ◽  
Healthy Older Adults

scholarly journals Variation in the Association of Body Types to Decreased High-Density Lipoprotein in Older Adults (NHANES 2005-2014)

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 213-213
Author(s):  
Queendaleen Chukwurah
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Waist Circumference ◽  
High Density Lipoprotein ◽  
Body Mass ◽  
Disease Risk ◽  
Density Lipoprotein ◽  
Normal Weight ◽  
High Density ◽  
Sample Population

Abstract General obesity and central obesity represent cardiovascular disease risk factors and are known to be related to dyslipidemia. I examine the variation in the association of combined body mass index/waist circumference classification to decreased high-density lipoprotein cholesterol (HDL-C). Body mass index /waist circumference (WC) cut off values were used to create six body types: normal weight with normal WC (NWT-NWC), overweight with normal WC (OWT-NWC), obese with normal WC (O-NWC), normal weight with high WC (NWT-HWC), overweight with high WC (OWT-HWC), and obese with high WC (O-HWC). HDL-C was defined as decreased if &lt; 40 mg/dl for men or &lt; 50 mg/dl for women and normal if ≥ 40 mg/dL for men or ≥ 50 mg/dL for women. Sample population included 5,772 participants of the National Health and Nutrition Examination Survey (NHANES 2005-2014) aged 50 years and older. The mean (SD) age was 61.8 (0.2), and 50.5% were females, while 10% were minority. The prevalence of decreased HDL-C was 29.1%. Analysis involved weighted multivariable logistic regression adjusted for age, race-ethnicity, gender, education, poverty-income-ratio, smoking, and alcohol intake. Regression reveals a higher likelihood of decreased HDL-C for OWT-NWC (aOR 2.12 95% CI 1.43,3.15 ), NWT-HWC (aOR 2.57 95% CI 1.59,4.16 ), OWT-HWC(aOR 3.09 95% CI 2.29,4.15 ), and O-HWC (aOR 5.30 95% CI 4.01,6.86 ) when compared to NWT-NWC. These associations are important to public health practice and policies as it demonstrates the implications of the parallel use of anthropometric measures for all body weights in health-risk assessments of older adults.

scholarly journals Brain structure and cognitive correlates of body mass index in healthy older adults

2015 ◽  
Vol 278 ◽  
pp. 342-347 ◽  
Author(s):  
Jacob D. Bolzenius ◽  
David H. Laidlaw ◽  
Ryan P. Cabeen ◽  
Thomas E. Conturo ◽  
Amanda R. McMichael ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Body Mass ◽  
Brain Structure ◽  
Healthy Older Adults ◽  
Cognitive Correlates
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