scholarly journals Reusable Embedded Microcoils for Magnetic Nano-Beads Trapping in Microfluidics: Magnetic Simulation and Experiments

Micromachines ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 257 ◽  
Author(s):  
Olivier Lefebvre ◽  
Hong Ha Cao ◽  
Meritxell Cortés Francisco ◽  
Marion Woytasik ◽  
Elisabeth Dufour-Gergam ◽  
...  
Keyword(s):  
Power Consumption ◽  
Microfluidic Chip ◽  
Coating Layer ◽  
Adhesion Layer ◽  
Fe Method ◽  
New Approach ◽  
Lab On Chip ◽  
Highly Sensitive ◽  
On Chip ◽  
The Magnetic Field

In this study, a microfluidic chip with integrated coil was designed and fabricated for the aim of effectively trapping magnetic nanobeads (Adembeads®, 300 nm) and measuring the chip’s temperature during the working time. In addition, a reversible technique of bonding Polydimethylsiloxane (PDMS) channels was presented. This bonding process used a coating layer of CYTOP®product as a protection, insulation and low-adhesion layer. The reversible packaging technique allows the bottom substrate to be reused, possibly equipped with sensors, and to use a disposable microchannels network. The FE method was employed to calculate the magnetic field and power consumption by the ANSYS® version 12.1 software. Merit factors were defined in order to synthetically represent the ability of the simulated coil to trap beads for a unit power consumption, i.e. a given heat generation. The simulation results propose a new approach to optimize the design criteria in fabricating planar microcoils. The optimal microcoils were fabricated and then used to realize a magnetic immunoassay in a microfluidic chip. The aim was to integrate these microcoils into a lab-on-chip and obtain a fast and highly sensitive biological element detection.

scholarly journals The Rise of the OM-LoC: Opto-Microfluidic Enabled Lab-on-Chip

Micromachines ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1467
Author(s):  
Harry Dawson ◽  
Jinane Elias ◽  
Pascal Etienne ◽  
Sylvie Calas-Etienne
Keyword(s):  
Low Cost ◽  
Optical Components ◽  
New Era ◽  
Lab On Chip ◽  
Highly Sensitive ◽  
Multiple Challenges ◽  
On Chip ◽  
Optical Circuits ◽  
Made In

The integration of optical circuits with microfluidic lab-on-chip (LoC) devices has resulted in a new era of potential in terms of both sample manipulation and detection at the micro-scale. On-chip optical components increase both control and analytical capabilities while reducing reliance on expensive laboratory photonic equipment that has limited microfluidic development. Notably, in-situ LoC devices for bio-chemical applications such as diagnostics and environmental monitoring could provide great value as low-cost, portable and highly sensitive systems. Multiple challenges remain however due to the complexity involved with combining photonics with micro-fabricated systems. Here, we aim to highlight the progress that optical on-chip systems have made in recent years regarding the main LoC applications: (1) sample manipulation and (2) detection. At the same time, we aim to address the constraints that limit industrial scaling of this technology. Through evaluating various fabrication methods, material choices and novel approaches of optic and fluidic integration, we aim to illustrate how optic-enabled LoC approaches are providing new possibilities for both sample analysis and manipulation.

scholarly journals Subwavelength Grating Double Slot Waveguide Racetrack Ring Resonator for Refractive Index Sensing Application

Sensors ◽  
2020 ◽  
Vol 20 (12) ◽  
pp. 3416 ◽  
Author(s):  
Nikolay Lvovich Kazanskiy ◽  
Svetlana Nikolaevna Khonina ◽  
Muhammad Ali Butt
Keyword(s):  
Ring Resonator ◽  
Numerical Study ◽  
Slot Waveguide ◽  
Lab On Chip ◽  
Subwavelength Grating ◽  
Resonator Design ◽  
Highly Sensitive ◽  
Light Matter Interaction ◽  
On Chip ◽  
The One

In this paper, a racetrack ring resonator design based on a subwavelength grating double slot waveguide is presented. The proposed waveguide scheme is capable of confining the transverse electric field in the slots and the gaps between the grating segments. This configuration facilitates a large light–matter interaction which elevates the sensitivity of the device approximately 2.5 times higher than the one that can be obtained via a standard slot waveguide resonator. The best sensitivity of the design is obtained at 1000 nm/RIU by utilizing a subwavelength grating double slot waveguide of period 300 nm. The numerical study is conducted via 2D and 3D finite element methods. We believe that the proposed sensor design can play an important role in the realization of highly sensitive lab-on-chip sensors.

From CAD to microfluidic chip within one day: rapid prototyping of lab-on-chip cartridges using generic polymer parts

2020 ◽  
Vol 30 (11) ◽  
pp. 115012 ◽  
Author(s):  
Daniel Podbiel ◽  
Lorenz Boecking ◽  
Hannah Bott ◽  
Julian Kassel ◽  
Daniel Czurratis ◽  
...  
Keyword(s):  
Rapid Prototyping ◽  
Microfluidic Chip ◽  
Lab On Chip ◽  
On Chip

Capture of Magnetic Microspheres in Electrokinetic Flow for Application in Lab-on-Chip Devices

2012 ◽  
Author(s):  
Debarun Das ◽  
Marwan Al-Rjoub ◽  
Jagjit S. Yadav ◽  
Rupak K. Banerjee
Keyword(s):  
Magnetic Field ◽  
Electric Fields ◽  
Magnetic Beads ◽  
Magnetic Microspheres ◽  
Electrokinetic Flow ◽  
Lab On Chip ◽  
Micro Total Analysis Systems ◽  
Total Analysis ◽  
On Chip ◽  
The Magnetic Field

Isolation of bio-molecules, cells and pathogens for immunoassays is a critical component in micro total analysis systems (μTAS). Magnetophoretic technique is often used for separation of such target species, where magnetic beads tagged with specific antibodies against cell surface epitopes, are captured in the microfluidic device. In this study, a numerical model is developed for capture of beads under an external magnetic field in electrokinetically driven flow. The results indicate an increase in the number of beads captured when the magnetic field is higher and the flow is driven by lower electric fields.

Development of highly sensitive polysilicon nanogap with APTES/GOx based lab-on-chip biosensor to determine low levels of salivary glucose

2014 ◽  
Vol 220 ◽  
pp. 101-111 ◽  
Author(s):  
Sharma Rao Balakrishnan ◽  
U. Hashim ◽  
G.R. Letchumanan ◽  
M. Kashif ◽  
A.R. Ruslinda ◽  
...  
Keyword(s):  
Lab On Chip ◽  
Highly Sensitive ◽  
Low Levels ◽  
On Chip

scholarly journals Epitaxial Graphene Sensors Combined with 3D Printed Microfluidic Chip for Heavy Metals Detection

Proceedings ◽  
2018 ◽  
Vol 2 (13) ◽  
pp. 982 ◽  
Author(s):  
Maria Francesca Santangelo ◽  
Ivan Shtepliuk ◽  
Donatella Puglisi ◽  
Daniel Filippini ◽  
Rositsa Yakimova ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Microfluidic Chip ◽  
Chemical Interaction ◽  
High Sensitivity ◽  
Epitaxial Graphene ◽  
Phase Detection ◽  
Lab On Chip ◽  
Sensing Platform ◽  
3D Printed ◽  
On Chip

Two-dimensional materials may constitute key elements in the development of a sensing platform where extremely high sensitivity is required, since even minimal chemical interaction can generate appreciable changes in the electronic state of the material. In this work, we investigate the sensing performance of epitaxial graphene on Si-face 4H-SiC (EG/SiC) for liquid-phase detection of heavy metals (e.g., Pb). The integration of preparatory steps needed for sample conditioning is included in the sensing platform, exploiting fast prototyping using a 3D printer, which allows direct fabrication of a microfluidic chip incorporating all the features required to connect and execute the Lab-on-chip (LOC) functions. It is demonstrated that interaction of Pb2+ ions in water-based solutions with the EG enhances its conductivity exhibiting a Langmuir correlation between signal and Pb2+ concentration. Several concentrations of Pb2+ solutions ranging from 125 nM to 500 µM were analyzed showing good stability and reproducibility over time.

Design and Modelling of Highly Sensitive Glucose Biosensor for Lab-on-chip Applications

Silicon ◽  
2022 ◽  
Author(s):  
M. Durga Prakash ◽  
Shaik Lathifa Nihal ◽  
Shaik Ahmadsaidulu ◽  
Raghunandan Swain ◽  
Asisa Kumar Panigrahy
Keyword(s):  
Glucose Biosensor ◽  
Lab On Chip ◽  
Highly Sensitive ◽  
On Chip

Highly sensitive lab-on-chip with deep learning AI for detection of bacteria in water

2019 ◽  
Vol 12 (2) ◽  
pp. 495-501 ◽  
Author(s):  
Shaikh Afzal Nehal ◽  
Debpriyo Roy ◽  
Manju Devi ◽  
T. Srinivas
Keyword(s):  
Deep Learning ◽  
Lab On Chip ◽  
Highly Sensitive ◽  
On Chip

scholarly journals Fast Track DNA Analysis Suite for human identification

2013 ◽  
Author(s):  
Peter T Docker ◽  
Joanna Baker ◽  
Steve Haswell
Keyword(s):  
Microfluidic Chip ◽  
Fast Track ◽  
Dna Analysis ◽  
Human Identification ◽  
Rapid Analysis ◽  
Human Interaction ◽  
Lab On Chip ◽  
Human Dna ◽  
On Chip ◽  
Proof Of Principle

This paper details the development of a portable ‘Lab on chip’ DNA analyser that was developed to facilitate rapid analysis of DNA samples for ‘at scene of crime’ and in custody suite situations where human identification is required rapidly. This system was proven to work with human DNA for 3 loci, namely VWA, D21 and D18 taken from raw sample through PCR separation to detection within 90miniutes. Once the sample was loaded onto the microfluidic chip which in turn was loaded into the instrument no further human interaction took place. This paper details the approach to the biochemistry, hardware before going on to give results proving the proof of principle and then the authors’ conclusions.

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