scholarly journals Rhinovirus Infection in Children with Acute Bronchiolitis and Its Impact on Recurrent Wheezing and Asthma Development

2020 ◽  
Vol 8 (10) ◽  
pp. 1620
Author(s):  
Carlotta Biagi ◽  
Alessandro Rocca ◽  
Giulia Poletti ◽  
Marianna Fabi ◽  
Marcello Lanari
Keyword(s):  
Clinical Presentation ◽  
Clinical Course ◽  
Pediatric Population ◽  
Acute Bronchiolitis ◽  
Virus Infections ◽  
Recurrent Wheezing ◽  
Multiple Virus ◽  
Syncytial Virus

Acute bronchiolitis represents the leading cause of hospitalization in infants. Together with a respiratory syncytial virus, rhinovirus (RV) is one of the most common pathogens associated with bronchiolitis, and its genetic diversity (>150 types) makes the recurrence of RV infections each year quite typical. The frequency of RV infection and co-infection with other viruses and its impact on the clinical course of bronchiolitis have been studied by several authors with controversial results. Some studies demonstrate that multiple virus infections result in more severe clinical presentation and a higher risk of complications, whereas other studies suggest no influence on clinical course. Moreover, RV bronchiolitis has been reported to potentially contribute to the development of long-term sequelae, such as recurrent wheezing and asthma, in the pediatric population. In the present review, we summarize the most recent findings of the role of RV infection in children with acute bronchiolitis, its impact on subsequent asthma development, and the implication in clinical practice.

scholarly journals COVID-19 and rhinovirus in pediatric: are there differences in clinical presentation and outcomes?

2021 ◽  
Author(s):  
Maria Fernanda Pereira ◽  
Priscila Suguita ◽  
Nadia Litvinov ◽  
Sylvia Farhat ◽  
Carolina Lazari ◽  
...  
Keyword(s):  
Prospective Study ◽  
Respiratory Virus ◽  
Pediatric Patients ◽  
Clinical Presentation ◽  
Clinical Course ◽  
Pediatric Population ◽  
Virus Infections ◽  
Single Center ◽  
Clinical Context ◽  
Respiratory Virus Infections

The dynamic of SARS-CoV-2 and other respiratory virus in children and adolescents is relevant in clinical context. There are few studies comparing clinical course in COVID-19 (coronavirus disease) and other respiratory virus in pediatric patients. The aim of this study was to compare demographics and clinical features, exams abnormalities, and outcomes in SARS-CoV-2 and other respiratory virus infections in a pediatric population. This was a single-center prospective study, between April 17 to September 30, 2020. We evaluated 76 pediatric COVID-19 and 157 other respiratory virus infections. Rhinovirus occurred in 132/157(84%). COVID-19 patients were significantly older, had more fever (69% versus 50%; p=0.01), pneumonia (22% versus 5%; p<0.01), myalgia (29% versus 8%; p=0.001), headache (31% versus 14%; p=0.01) and worse outcomes than those with other respiratory virus infections. Our data emphasizes differences in clinical presentation and outcomes between pediatric COVID-19 and rhinovirus infections.

scholarly journals Epidemiology and aetiology of acute bronchiolitis in Hong Kong infants

1992 ◽  
Vol 108 (1) ◽  
pp. 147-154 ◽  
Author(s):  
R. Y. T. Sung ◽  
R. C. K. Chan ◽  
J. S. Tam ◽  
A. F. B. Cheng ◽  
H. G. S. Murray
Keyword(s):  
Hong Kong ◽  
Clinical Course ◽  
Influenza Viruses ◽  
Direct Immunofluorescence ◽  
Acute Bronchiolitis ◽  
Average Hospital Stay ◽  
Recurrent Wheezing ◽  
Average Hospital ◽  
Virus Culture ◽  
Syncytial Virus

SUMMARYThe epidemiological, clinical and virological features of 1220 children with acute bronchiolitis admitted to the Prince of Wales Hospital, Hong Kong, from 1985 to 1988 are reported. They accounted for 6·6% of total paediatric admissions and provided a case incidence of bronchiolitis requiring admission to hospital of approximately 21 per 1000 children 0–24 months of age.The clinical course and outcome was in general benign. The average hospital stay was 5 days and there were no deaths. Ten per cent of patients were repeatedly admitted to hospital with recurrent wheezing after discharge. Two infants developed bronchiolitis obliterans.Respiratory syncytial virus (RSV) was shown by direct immunofluorescence, virus culture and serology to be the commonest cause of acute bronchiolitis in Hong Kong. Other aetiological agents included parainfluenza and influenza viruses, adenoviruses, and Mycoplasma pneumoniae.In contrast to western countries, a seasonal variation of bronchiolitis was found with a peak incidence in the summer months. The significance of these observations is discussed.

The role of respiratory syncytial virus in acute bronchiolitis in small children in northern Japan

1994 ◽  
Vol 36 (4) ◽  
pp. 371-374 ◽  
Author(s):  
MASAYUKI SAIJO ◽  
SATORU TAKAHASHI ◽  
MASAYO KOKUBO ◽  
TOMOYUKI SAINO ◽  
TAKUMA ISHII ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Acute Bronchiolitis ◽  
Small Children ◽  
Syncytial Virus ◽  
Northern Japan

Update on the Diagnosis and Management of Popliteal Aneurysm and Literature Review

Vascular ◽  
2006 ◽  
Vol 14 (2) ◽  
pp. 103-108 ◽  
Author(s):  
Albeir Y. Mousa ◽  
Robert B. Beauford ◽  
Peter Henderson ◽  
Prem Patel ◽  
Peter L. Faries ◽  
...  
Keyword(s):  
Gold Standard ◽  
Open Surgery ◽  
Clinical Presentation ◽  
Survival Outcomes ◽  
Significant Morbidity ◽  
Endovascular Stents ◽  
Popliteal Aneurysm ◽  
Indications For Use

Popliteal artery aneurysms (PAAs) are the most frequent peripheral aneurysm with a significant morbidity if left untreated. Open surgical technique is still considered the gold standard; however the revolution in endovascular repair has proven to be a valid alternative option in selected patients. The role of endovascular treatment in PAA is still considered in its infancy. In addition, the indications for use of endovascular stents as compared to standard open surgery have not yet been fully defined and more studies are warranted to characterize the durability of this technique. This article describes the general principles of the natural history, clinical presentation, and long-term limb salvage and survival outcomes for patients with such aneurysms. It also details the features and results for the devices in current use and highlights the current consensus in the management of PAA.

scholarly journals Recurrent Focal Segmental Glomerulosclerosis in Renal Allograft Recipients: Role of Human Leukocyte Antigen Mismatching and Other Clinical Variables

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Shimi Sharief ◽  
Shefali Mahesh ◽  
Marcela Del Rio ◽  
Vivian Telis ◽  
Robert P. Woroniecki
Keyword(s):  
Focal Segmental Glomerulosclerosis ◽  
Pediatric Population ◽  
Surrogate Marker ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Clinical Variables ◽  
Segmental Glomerulosclerosis ◽  
Hla Compatibility

Recurrence of focal segmental glomerulosclerosis (FSGS) after renal transplantation impacts long-term graft survival and limits access to transplantation. We hypothesized that HLA donor/recipient matching could be used as a surrogate marker of recurrence. In a retrospective study of 42 pediatric and 77 adult subjects with primary FSGS, transplanted from 1990 to 2007 at a single center, we analyzed the degree of donor/recipient HLA compatibility and other clinical variables associated with FSGS recurrence. There were total of 131 allografts for primary FSGS (11 subjects were transplanted twice, and 1 had a third allograft) with 20 cases of FSGS recurrence (17 children) in the primary allograft, and two children who had FSGS recurrence in the second allograft. Fifty-two subjects (40%) were African American, and 66 (50%) Caucasians. Recurrent FSGS and controls were not different for age at transplant, gender, donor source, acute/chronic rejection episodes, and HLA matches. Recurrent FSGS was not associated with HLA mismatches; power equals 83%. Immunosuppressive regimen had no effect on recurrence of FSGS, . Recurrent FSGS is not associated with HLA mismatching, acute cellular or vascular rejection, and occurs primarily in the pediatric population.

scholarly journals Pediatric Crohn's Disease

2018 ◽  
Vol 31 (02) ◽  
pp. 080-088 ◽  
Author(s):  
Daniel von Allmen
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Older Patients ◽  
Pediatric Patients ◽  
Clinical Presentation ◽  
Surgical Intervention ◽  
Clinical Course ◽  
Pediatric Population ◽  
Medical Treatments ◽  
Course Of Disease

AbstractThe incidence of Crohn's disease in the pediatric population is increasing. While pediatric patients with Crohn's disease exhibit many of the characteristics of older patients, there are important differences in the clinical presentation and course of disease that can impact the clinical decisions made during treatment. The majority of children are diagnosed in the early teen years, but subgroups of very early onset and infantile Crohn's present much earlier and have a unique clinical course. Treatment paradigms follow the traditional laddered approach, but growth and development represent special considerations that must be given to pediatric-specific complications of the treatment and disease. Surgical intervention is an important component of Crohn's management and is often employed to allow improved nutritional intake or decrease reliance on medical treatments that compromise growth.

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