scholarly journals Hafnia alvei Pneumonia: A Rare Cause of Infection in a Patient with COVID-19

2021 ◽  
Vol 9 (11) ◽  
pp. 2369
Author(s):  
Lucía Méndez ◽  
Jorge Ferreira ◽  
Cátia Caneiras

Herein, we describe a case report of a critically ill patient, a 48-year-old man without comorbidities admitted to the hospital with a serious type 1 (hypoxemic) respiratory insufficiency and confirmed diagnosis of COVID-19. After 5 days with invasive mechanical ventilation, the patient developed a bacterial co-infection, namely a pneumonia by Hafnia alvei, requiring the last line of respiratory support: extracorporeal membrane oxygenation (ECMO). Subsequently, his clinical situation gradually stabilized, until he was discharged from the hospital on day 61, being accompanied in ambulatory consultation by the physical medicine and pulmonology department during the post-COVID-19 recovery. H. alvei is a Gram-negative bacterium that is rarely isolated from human specimens and is rarely considered to be pathogenic. However, COVID-19 disease can cause substantial organ dysfunction and can be associated with bacterial secondary infections which can favor the emergence of rare infectious diseases by uncommon microorganisms.

Author(s):  
Andri Frediansyah ◽  
Jan Straetener ◽  
Heike Brötz-Oesterhelt ◽  
Harald Gross

AbstractA cyclic tetrapeptide, designated massiliamide, was isolated from the liquid culture of the Gram-negative bacterium Massilia albidiflava DSM 17472T. The structure was elucidated through extensive spectroscopic analysis, including HR-MS and 1D and 2D NMR experiments. The absolute configuration was determined using the Marfey´s method. Massiliamide showed potent inhibitory activity towards tyrosinase with an IC50 value of 1.15 µM and no cytotoxicity.


2021 ◽  
Vol 64 ◽  
pp. 173-175
Author(s):  
Salvatore Lucio Cutuli ◽  
Flavio De Maio ◽  
Gennaro De Pascale ◽  
Domenico Luca Grieco ◽  
Francesca Romana Monzo ◽  
...  

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Thomas V. Heidler ◽  
Karin Ernits ◽  
Agnieszka Ziolkowska ◽  
Rolf Claesson ◽  
Karina Persson

AbstractThe Gram-negative bacterium Porphyromonas gingivalis is a secondary colonizer of the oral biofilm and is involved in the onset and progression of periodontitis. Its fimbriae, of type-V, are important for attachment to other microorganisms in the biofilm and for adhesion to host cells. The fimbriae are assembled from five proteins encoded by the mfa1 operon, of which Mfa5 is one of the ancillary tip proteins. Here we report the X-ray structure of the N-terminal half of Mfa5, which reveals a von Willebrand factor domain and two IgG-like domains. One of the IgG-like domains is stabilized by an intramolecular isopeptide bond, which is the first such bond observed in a Gram-negative bacterium. These features make Mfa5 structurally more related to streptococcal adhesins than to the other P. gingivalis Mfa proteins. The structure reported here indicates that horizontal gene transfer has occurred among the bacteria within the oral biofilm.


2021 ◽  
Vol 36 (1) ◽  
pp. 372-376
Author(s):  
Andrea Petreni ◽  
Viviana De Luca ◽  
Andrea Scaloni ◽  
Alessio Nocentini ◽  
Clemente Capasso ◽  
...  

2020 ◽  
Vol 497 ◽  
pp. 108135
Author(s):  
Agnieszka Kowalczyk ◽  
Nikola Szpakowska ◽  
Wojciech Sledz ◽  
Agata Motyka-Pomagruk ◽  
Karolina Ossowska ◽  
...  

2012 ◽  
Vol 194 (23) ◽  
pp. 6610-6610 ◽  
Author(s):  
Kar-Wai Hong ◽  
Han Ming Gan ◽  
Siew-Moon Low ◽  
Patrick Kok Yuen Lee ◽  
Yee-Meng Chong ◽  
...  

ABSTRACTPantoeasp. strain A4 is a Gram-negative bacterium isolated from theRafflesiaflower. We present here, for the first time, the genome sequence ofRafflesia-associatedPantoeasp. strain A4, which exhibited quorum-sensing activity.


2019 ◽  
Vol 21 ◽  
pp. 101328 ◽  
Author(s):  
S. Dhanasekaran ◽  
A. Rajesh ◽  
Thangavel Mathimani ◽  
S. Melvin Samuel ◽  
Rajasree Shanmuganathan ◽  
...  

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