scholarly journals Production of Hydroxycarboxylic Acid Receptor 3 (HCA3) Ligands by Bifidobacterium

2021 ◽  
Vol 9 (11) ◽  
pp. 2397
Author(s):  
Takuma Sakurai ◽  
Ayako Horigome ◽  
Toshitaka Odamaki ◽  
Takashi Shimizu ◽  
Jin-zhong Xiao
Keyword(s):  
Lactic Acid ◽  
Phenyllactic Acid ◽  
Acid Receptor ◽  
Hydroxycarboxylic Acid ◽  
The Absolute

Hydroxycarboxylic acid receptor 3 (HCA3) was recently identified in the genomes of humans and other hominids but not in other mammals. We examined the production of HCA3 ligands by Bifidobacterium spp. In addition to 4-hydroxyphenyllactic acid, phenyllactic acid (PLA), and indole-3-lactic acid (ILA), we found that LeuA was produced by Bifidobacterium as an HCA3 ligand. The four ligands produced were the mixtures of enantiomers, and D-ILA, D-PLA, and D-LeuA showed stronger activity of the HCA3 ligand than their respective L-isomers. However, there was no difference in AhR activity between the two ILA enantiomers. These results provide new insights into the HCA3 ligands produced by Bifidobacterium and suggest the importance of investigating the absolute stereo structures of these metabolites.

scholarly journals Correction: Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3

PLoS Genetics ◽  
2019 ◽  
Vol 15 (7) ◽  
pp. e1008283 ◽  
Author(s):  
Anna Peters ◽  
Petra Krumbholz ◽  
Elisabeth Jäger ◽  
Anna Heintz-Buschart ◽  
Mehmet Volkan Çakir ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Fermented Foods ◽  
Acid Receptor ◽  
Hydroxycarboxylic Acid

scholarly journals Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3

PLoS Genetics ◽  
2019 ◽  
Vol 15 (5) ◽  
pp. e1008145 ◽  
Author(s):  
Anna Peters ◽  
Petra Krumbholz ◽  
Elisabeth Jäger ◽  
Anna Heintz-Buschart ◽  
Mehmet Volkan Çakir ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Fermented Foods ◽  
Acid Receptor ◽  
Hydroxycarboxylic Acid

scholarly journals UPLC-QTOF-MS/MS and GC-MS Characterization of Phytochemicals in Vegetable Juice Fermented Using Lactic Acid Bacteria from Kimchi and Their Antioxidant Potential

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1761
Author(s):  
Moeun Lee ◽  
Jung Hee Song ◽  
Eun Ji Choi ◽  
Ye-Rang Yun ◽  
Ki Won Lee ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Total Phenolic ◽  
Phenyllactic Acid ◽  
Antioxidant Power ◽  
Vegetable Juice ◽  
Daucus Carota L ◽  
Ferric Reducing Antioxidant Power

This study aims to investigate fermentative metabolites in probiotic vegetable juice from four crop varieties (Brassica oleracea var. capitata, B. oleracea var. italica, Daucus carota L., and Beta vulgaris) and their antioxidant properties. Vegetable juice was inoculated with two lactic acid bacteria (LAB) (Companilactobacillus allii WiKim39 and Lactococcus lactis WiKim0124) isolated from kimchi and their properties were evaluated using untargeted UPLC-QTOF-MS/MS and GC-MS. The samples were also evaluated for radical (DPPH• and OH•) scavenging activities, lipid peroxidation, and ferric-reducing antioxidant power. The fermented vegetable juices exhibited high antioxidant activities and increased amounts of total phenolic compounds. Fifteen compounds and thirty-two volatiles were identified using UPLC-QTOF-MS/MS and GC-MS, respectively. LAB fermentation significantly increased the contents of d-leucic acid, indole-3-lactic acid, 3-phenyllactic acid, pyroglutamic acid, γ-aminobutyric acid, and gluconic acid. These six metabolites showed a positive correlation with antioxidant properties. Thus, vegetable juices fermented with WiKim39 and WiKim0124 can be considered as novel bioactive health-promoting sources.

scholarly journals Production of phenyllactic acid by lactic acid bacteria: an approach to the selection of strains contributing to food quality and preservation

2004 ◽  
Vol 233 (2) ◽  
pp. 289-295 ◽  
Author(s):  
Francesca Valerio ◽  
Paola Lavermicocca ◽  
Michelangelo Pascale ◽  
Angelo Visconti
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Food Quality ◽  
Phenyllactic Acid ◽  
Selection Of

scholarly journals Müller Cell–Localized G-Protein–Coupled Receptor 81 (Hydroxycarboxylic Acid Receptor 1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways

2019 ◽  
Vol 189 (9) ◽  
pp. 1878-1896 ◽  
Author(s):  
Ankush Madaan ◽  
Prabhas Chaudhari ◽  
Mathieu Nadeau-Vallée ◽  
David Hamel ◽  
Tang Zhu ◽  
...  
Keyword(s):  
G Protein ◽  
Müller Cell ◽  
Retinal Vasculature ◽  
G Protein Coupled Receptor ◽  
Acid Receptor ◽  
Hydroxycarboxylic Acid ◽  
Wnt Pathways ◽  
Muller Cell ◽  
G Protein Coupled

scholarly journals The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation

2018 ◽  
Vol 9 ◽  
Author(s):  
Melanie Wannick ◽  
Julian C. Assmann ◽  
Jakob F. Vielhauer ◽  
Stefan Offermanns ◽  
Detlef Zillikens ◽  
...  
Keyword(s):  
Skin Inflammation ◽  
Dimethyl Fumarate ◽  
Therapeutic Effects ◽  
Acid Receptor ◽  
Hydroxycarboxylic Acid

scholarly journals Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Anna Peters ◽  
Philipp Rabe ◽  
Petra Krumbholz ◽  
Hermann Kalwa ◽  
Robert Kraft ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptor ◽  
Acid Receptor ◽  
Hydroxycarboxylic Acid ◽  
Biased Signaling ◽  
G Protein Coupled
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