scholarly journals Chromo-Fluorogenic Detection of Soman and Its Simulant by Thiourea-Based Rhodamine Probe

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 827 ◽  
Author(s):  
Shengsong Li ◽  
Yongchao Zheng ◽  
Weiqiang Chen ◽  
Meiling Zheng ◽  
He Zheng ◽  
...  
Keyword(s):  
Detection Limit ◽  
Dft Calculations ◽  
Gas Phase ◽  
Rhodamine B ◽  
Organophosphorus Compounds ◽  
Nerve Agent ◽  
Color Changes ◽  
Highly Sensitive ◽  
Td Dft ◽  
Membered Heterocycle

Here, we introduced a novel thiourea-based rhodamine compound as a chromo-fluorogenic indicator of nerve agent Soman and its simulant diethyl chlorophosphate (DCP). The synthesized probe N-(rhodamine B)-lactam-2-(4-cyanophenyl) thiourea (RB-CT), which has a rhodamine core linked by a cyanophenyl thiosemicarbazide group, enabled a rapidly and highly sensitive response to DCP with clear fluorescence and color changes. The detection limit was as low as 2 × 10−6 M. The sensing mechanism showed that opening of the spirolactam ring following the phosphorylation of thiosemicarbazides group formed a seven-membered heterocycle adduct, according to MS analysis and TD-DFT calculations. RB-CT exhibited high detecting selectivity for DCP, among other organophosphorus compounds. Moreover, two test kits were employed and successfully used to detect real nerve agent Soman in liquid and gas phase.

An electrochemical sensor based on rhodamine B hydrazide-immobilized graphene oxide for highly sensitive and selective detection of Cu(ii)

2015 ◽  
Vol 39 (4) ◽  
pp. 3137-3144 ◽  
Author(s):  
Mengmeng Kang ◽  
Donglai Peng ◽  
Yuanchang Zhang ◽  
Yanqin Yang ◽  
Linghao He ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Detection Limit ◽  
Electrochemical Sensor ◽  
Rhodamine B ◽  
Selective Detection ◽  
Highly Sensitive ◽  
Rhodamine B Hydrazide

A novel Cu2+ sensor based on rhodamine B hydrazide (RBH)-immobilized graphene oxide (GO) was fabricated and estimated to be a detection limit of 0.061 nM for Cu2+ detection.

Phase and Morphology in Mixed CuO-WO3 Films for Chemical Sensing

2002 ◽  
Vol 751 ◽  
Author(s):  
A. El Madi ◽  
B. Meulendyk ◽  
R. S. Pilling ◽  
G. Bernhardt ◽  
R. J. Lad ◽  
...  
Keyword(s):  
Gas Phase ◽  
Surface Segregation ◽  
Organophosphorus Compounds ◽  
Chemical Warfare Agents ◽  
Phase Changes ◽  
Highly Sensitive ◽  
Warfare Agents ◽  
Phase Sensor ◽  
Semiconducting Metal Oxide

ABSTRACTSemiconducting metal oxide (SMO) chemiresistive sensors are highly sensitive toward a broad range of hydrocarbons. To develop a gas phase sensor with selectivity toward organophosphorus compounds, such as chemical warfare agents and pesticides, we have developed dosimeters based upon a poisoning mechanism. Here, we report the growth and characterization of WO3 thin films, modified with Cu2O. XPS data show that exposure to phosphonate compounds leads to accumulation of phosphate on the surface, together with dramatic changes in the surface segregation of copper. We present XRD and XPS results to characterize the phase changes following growth, annealing, and exposure to phosphonate compounds. The correlation between sensor response and phosphorous accumulation shows that the highest activity occurs at intermediate coverages of Cu2O, in the15–25 Å range, on 500 Å WO3 films.

A naphthalimide-based fluorescent probe for the highly sensitive and selective detection of nerve agent mimic DCP in solution and vapor phase

2020 ◽  
Vol 44 (25) ◽  
pp. 10713-10718
Author(s):  
Hui Xu ◽  
Han Zhang ◽  
Lei Zhao ◽  
Cheng Peng ◽  
Guohua Liu ◽  
...  
Keyword(s):  
Detection Limit ◽  
Fluorescent Probe ◽  
Vapor Phase ◽  
Nerve Agent ◽  
Selective Detection ◽  
Low Detection Limit ◽  
Highly Sensitive ◽  
Excellent Selectivity

The fluorescent probe for DCP displays excellent selectivity and sensitivity with a low detection limit of 5.5 nM in DMF.

scholarly journals A Rhodamine-Based Probe for Detection of Nerve Agents Simulants

2021 ◽  
Author(s):  
Liang Zong ◽  
Jingning Zhang ◽  
Dan Li ◽  
Shaohui Sui ◽  
Yanhua Xiao ◽  
...  
Keyword(s):  
Rhodamine B ◽  
Structural Changes ◽  
Color Change ◽  
Limit Of Detection ◽  
Fluorescence Emission ◽  
Nerve Agents ◽  
Nerve Agent ◽  
Fluorescent Detection ◽  
Dependent Manner ◽  
Color Changes

In this paper, a rhodamine-based fluorescent and chromogenic probe, N-(Rhodamine B)-lactam-2-aminobenzyl alcohol (RB-AB), was designed to detect nerve agent simulants. We firstly synthesized RB-AB probe by using rhodamine B and 2-aminobenzyl alcohol as main materials. Secondly, the RB-AB probe was applied to evaluate its ability to detect two nerve agent simulants, diethyl chloride phosphate (DCP) and methyl ethyl chloride phosphate (MECP). It was assumed that RB-AB could react with the nerve agent simulants through the benzyl alcohol group and then undergoes structural changes. As a result, the RB-AB detection solution shows fluorescent and color changes during detecting process. The maximum intensity of fluorescence emission increases with the addition of DCP or MECP in a dose-dependent manner. The LOD (limit of detection) of the probe is about 20 ppm for DCP. Moreover, a significant pink color change can be observed in the RB-AB system within a few seconds when detecting DCP or MECP. In conclusion, a rhodamine-based molecule as a fluorescent and chromogenic probe was developed for detecting nerve agent simulants. The RB-AB probe solutions can give rapid and off-on type optical changes including color and fluorescence when reacting with DCP or MECP. We anticipate that RB-AB probe can be used as a helpful tool for visual and fluorescent detection of nerve agents when meeting with terrorist attacks involving with these agents so that effective measures could be promptly taken to cope with the crises.

A highly selective fluorescence turn-on chemosensor for Zn2+, and its application in live cell imaging, and as a colorimetric sensor for Co2+: experimental and TD-DFT calculations

2018 ◽  
Vol 42 (15) ◽  
pp. 12595-12606 ◽  
Author(s):  
Marzieh Sohrabi ◽  
Mehdi Amirnasr ◽  
Soraia Meghdadi ◽  
Martin Lutz ◽  
Maryam Bikhof Torbati ◽  
...  
Keyword(s):  
Dft Calculations ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Colorimetric Detection ◽  
Live Cell ◽  
Fluorometric Detection ◽  
Turn On ◽  
Highly Sensitive ◽  
Td Dft ◽  
Fluorescence Turn On

A highly sensitive quinoline based “dual” chemosensor used for fluorometric detection of Zn2+, live-cell imaging, and colorimetric detection of Co2+.

scholarly journals Recent Advancements in Enzyme-Based Lateral Flow Immunoassays

Sensors ◽  
2021 ◽  
Vol 21 (10) ◽  
pp. 3358
Author(s):  
Donato Calabria ◽  
Maria Maddalena Calabretta ◽  
Martina Zangheri ◽  
Elisa Marchegiani ◽  
Ilaria Trozzi ◽  
...  
Keyword(s):  
Lateral Flow ◽  
Qualitative Information ◽  
Eye Color ◽  
Commercial Success ◽  
Color Changes ◽  
Naked Eye ◽  
Future Developments ◽  
Highly Sensitive ◽  
Critical Overview ◽  
Detection Technologies

Paper-based lateral-flow immunoassays (LFIAs) have achieved considerable commercial success and their impact in diagnostics is continuously growing. LFIA results are often obtained by visualizing by the naked eye color changes in given areas, providing a qualitative information about the presence/absence of the target analyte in the sample. However, this platform has the potential to provide ultrasensitive quantitative analysis for several applications. Indeed, LFIA is based on well-established immunological techniques, which have known in the last year great advances due to the combination of highly sensitive tracers, innovative signal amplification strategies and last-generation instrumental detectors. All these available progresses can be applied also to the LFIA platform by adapting them to a portable and miniaturized format. This possibility opens countless strategies for definitively turning the LFIA technique into an ultrasensitive quantitative method. Among the different proposals for achieving this goal, the use of enzyme-based immunoassay is very well known and widespread for routine analysis and it can represent a valid approach for improving LFIA performances. Several examples have been recently reported in literature exploiting enzymes properties and features for obtaining significative advances in this field. In this review, we aim to provide a critical overview of the recent progresses in highly sensitive LFIA detection technologies, involving the exploitation of enzyme-based amplification strategies. The features and applications of the technologies, along with future developments and challenges, are also discussed.

An ultra-highly sensitive and selective self-enhanced AIECL sensor for public security early warning in a nuclear emergency via a co-reactive group poisoning mechanism

2021 ◽  
Author(s):  
Ziyu Wang ◽  
Meiyun Xu ◽  
Nan Zhang ◽  
Jian-Bin Pan ◽  
Xinqi Wu ◽  
...  
Keyword(s):  
Detection Limit ◽  
Early Warning ◽  
High Selectivity ◽  
Public Security ◽  
Reactive Group ◽  
Low Detection Limit ◽  
Highly Sensitive ◽  
Vapor Sensors ◽  
Nuclear Emergency

A mechanism of co-reactive group poisoning (CGP) was discovered for designing efficient I2 vapor sensors for early warning of a nuclear emergency, which give an ultra-low detection limit of 0.13 ppt as well as high selectivity.

Graph theory-based reaction pathway searches and DFT calculations for the mechanism studies of free radical-initiated peptide sequencing mass spectrometry (FRIPS MS): a model gas-phase reaction of GGR tri-peptide

2020 ◽  
Vol 22 (9) ◽  
pp. 5057-5069 ◽  
Author(s):  
Jae-ung Lee ◽  
Yeonjoon Kim ◽  
Woo Youn Kim ◽  
Han Bin Oh
Keyword(s):  
Graph Theory ◽  
Dft Calculations ◽  
Gas Phase ◽  
Density Functional ◽  
Reaction Pathway ◽  
Peptide Sequencing ◽  
Phase Reaction ◽  
Functional Theory ◽  
Fragmentation Mechanisms ◽  
Gas Phase Fragmentation

A new approach for elucidating gas-phase fragmentation mechanisms is proposed: graph theory-based reaction pathway searches (ACE-Reaction program) and density functional theory (DFT) calculations.

Gas phase infrared spectra and corresponding DFT calculations of , -diphenylpolyenes

2010 ◽  
Vol 259 (1) ◽  
pp. 11-15 ◽  
Author(s):  
Lars Biemann ◽  
Michaela Braun ◽  
Karl Kleinermanns
Keyword(s):  
Dft Calculations ◽  
Gas Phase ◽  
Infrared Spectra
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