scholarly journals Effects of Puerarin on the Ovariectomy-Induced Depressive-Like Behavior in ICR Mice and Its Possible Mechanism of Action

Molecules ◽  
2019 ◽  
Vol 24 (24) ◽  
pp. 4569 ◽  
Author(s):  
Ariyawan Tantipongpiradet ◽  
Orawan Monthakantirat ◽  
Onchuma Vipatpakpaiboon ◽  
Charinya Khampukdee ◽  
Kaoru Umehara ◽  
...  
Keyword(s):  
Forced Swimming Test ◽  
Tail Suspension Test ◽  
Root Bark ◽  
Tail Suspension ◽  
Icr Mice ◽  
17Β Estradiol ◽  
Swimming Test ◽  
Immunosuppressive Cells ◽  
The Brain ◽  
Suspension Test

Daily treatment of ovariectomized (OVX) ICR mice with puerarin, a glycosyl isoflavone isolated from the root bark of Pueraria candollei var. mirifica, and 17β-estradiol attenuated ovariectomy-induced depression-like behavior, as indicated by a decrease in immobility times in the tail suspension test (TST) and the forced swimming test (FST), an increase in the uterine weight and volume, a decrease in serum corticosterone levels, and dose-dependently normalized the downregulated transcription of the brain-derived neurotrophic factor (BDNF) and estrogen receptor (Erβ and Erα) mRNAs. Like 17β-estradiol, puerarin also inhibited ovariectomy-induced suppression of neurogenesis in the dentate gyrus of the hippocampus (increased the number of doublecortin (DCX)-immunosuppressive cells). These results suggest that puerarin exerts antidepressant-like effects in OVX animals, possibly by attenuating the OVX-induced hyperactivation of the HPA axis and/or normalizing the downregulated transcription of BDNF and ER mRNA in the brain.

scholarly journals Antidepressant-like Effect and Mechanisms of Essential Oils From Citrus Reticulata in Reserpine-induced Depression Model Mice

2021 ◽  
Author(s):  
Minghui Tang ◽  
Yong Ai ◽  
Siyang Zhu ◽  
Ni Song ◽  
Xian Xu ◽  
...  
Keyword(s):  
Essential Oil ◽  
Forced Swimming Test ◽  
Tail Suspension Test ◽  
Control Group ◽  
Citrus Reticulata ◽  
Tail Suspension ◽  
Immobility Time ◽  
Swimming Test ◽  
The Brain ◽  
Suspension Test

Abstract Citrus reticulata, has been used for various diseases such as cough. According to previous studies, the essential oil of C. reticulata (CREOs) have been shown to be effectively alleviate depression-like behaviors in mice. This study is aimed to investigate the antidepressant-like effect of CREOs in the rapid reserpine-induced depression model mice as well as its possible mechanisms. The experiment was conducted in six groups, each with four mice. The essential oil group and the control group were administered by sniffing (1h/d), while the reserpine group and fluoxetine group by intraperitoneal injection. Body weight, forced swimming test (FST) and tail suspension test (TST) were used to assess depressive behavior. The compositions and contents of CREOs were analyzed by GC-MS. The results indicated that reserpine could reduce the weight of mice and prolong the immobility time of FST and TST. Moreover, the level of 5HT-1A, GR and Nissl bodies in the brain tissue were significantly reduced, while the level of BDNF was increased in reserpine-treated mice. The administration of CREOs could effectively inhibit the weight loss and the prolongation of immobility time caused by reserpine. In addition, the treatment of CREOs has also been shown to reverse the changes in Nissl body, 5-HT, GR and BDNF levels. Limonene was the main active component of CREOs and might be related to the reduction of BDNF. By up-regulating the level of BDNF, CREOs could regulate the hyperexcitability of the HPA axis, thereby increasing the level of neurotransmitters and restoring neurons.

scholarly journals ANTI-DEPRESSANT EFFECT OF CEFTRIAXONE IN FORCED SWIMMING TEST AND IN TAIL SUSPENSION TEST IN MICE

2016 ◽  
Vol 8 (11) ◽  
pp. 191 ◽  
Author(s):  
Ajoy Borah ◽  
Binita Singha ◽  
Swopna Phukan
Keyword(s):  
Forced Swimming Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Forced Swimming ◽  
Antidepressant Effect ◽  
Tail Suspension ◽  
Neuroprotective Effects ◽  
The Central Nervous System ◽  
Swimming Test ◽  
Suspension Test

Objective: Depression is a major psychiatric disorder affecting nearly 350 million people worldwide and imposes a substantial health burden on the society. Ceftriaxone has demonstrated neuroprotective effects in animals. It has also undergone trials as a treatment option for amyotrophic lateral sclerosis. This study was therefore undertaken to evaluate the antidepressant-like effect of ceftriaxone in mice.Methods: Ceftriaxone was administered at three different doses (0.130, 0.195 and 0.260g/kg) to Swiss albino mice of either sex by intra peritoneal (i. p.) route. The period of immobility in control and drug-treated mice were recorded in forced swimming test (FST) and tail suspension test (TST). The antidepressant effect of ceftriaxone indicated by the decrease in duration of immobility was compared to that of fluoxetine (0.020 g/kg, i. p.).Results: Ceftriaxone decreased the duration of immobility in mice. It showed a significant dose-dependent antidepressant effect. The antidepressant effect of 0.260g/kg of ceftriaxone was comparable to that of fluoxetine in the TST but not in the FST.Conclusion: The results of the present study indicate antidepressant activity of Ceftriaxone. The study shows that ceftriaxone has additional action on the central nervous system other than neuroprotection. Ceftriaxone therapy in cases of encephalomeningitis and in various cases of hemorrhages in the brain can, therefore, prevent the development of depression in future

scholarly journals Antidepressant-Like Activity of the Ethanolic Extract fromUncaria lanosaWallich var.appendiculataRidsd in the Forced Swimming Test and in the Tail Suspension Test in Mice

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Lieh-Ching Hsu ◽  
Yu-Jen Ko ◽  
Hao-Yuan Cheng ◽  
Ching-Wen Chang ◽  
Yu-Chin Lin ◽  
...  
Keyword(s):  
Forced Swimming Test ◽  
Antidepressant Drugs ◽  
Ethanolic Extract ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Probable Mechanism ◽  
Tail Suspension ◽  
Swimming Test ◽  
Mice Brain ◽  
Suspension Test

This study investigated the antidepressant activity of ethanolic extract ofU. lanosaWallich var.appendiculataRidsd (ULEtOH) for two-weeks administrations by using FST and TST on mice. In order to understand the probable mechanism of antidepressant-like activity of ULEtOHin FST and TST, the researchers measured the levels of monoamines and monoamine oxidase activities in mice brain, and combined the antidepressant drugs (fluoxetine, imipramine, maprotiline, clorgyline, bupropion and ketanserin). Lastly, the researchers analyzed the content of RHY in the ULEtOH. The results showed that ULEtOHexhibited antidepressant-like activity in FST and TST in mice. ULEtOHincreased the levels of 5-HT and 5-HIAA in cortex, striatum, hippocampus, and hypothalamus, the levels of NE and MHPG in cortex and hippocampus, the level of NE in striatum, and the level of DOPAC in striatum. Two-week injection of IMI, CLO, FLU and KET enhanced the antidepressant-like activity of ULEtOH. ULEtOHinhibited the activity of MAO-A. The amount of RHY in ULEtOHwas 17.12 mg/g extract. Our findings support the view that ULEtOHexerts antidepressant-like activity. The antidepressant-like mechanism of ULEtOHmay be related to the increase in monoamines levels in the hippocampus, cortex, striatum, and hypothalamus of mice.

Evaluation of Antidepressant Activity of Ethanolic Extract of Cissus quadrangularis on Swiss Albino Mice

2021 ◽  
pp. 4197-4202
Author(s):  
Salman Kapadia ◽  
Vanita Kanase
Keyword(s):  
Forced Swimming Test ◽  
Ethanolic Extract ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Behavioral Models ◽  
Tail Suspension ◽  
Stress Control ◽  
Cissus Quadrangularis ◽  
Swimming Test ◽  
Suspension Test

Background: Cissus quadrangularis has been used for cure of various ailments that includes bone cracks, frail bones (osteoporosis), scurvy, malignant growth, annoyed stomach, hemorrhoids, peptic ulcer sickness, excruciating menstrual periods, asthma, jungle fever (malaria), and mental distress. Specially it is used for bone healing properties. According to this background, the aim of the study was to evaluate the antidepressant-like effect of the ethanolic extract of Cissus quadrangularis (EECQ) in different behavioral models such as forced swimming test (FST) and tail suspension test (TST) on mice after two weeks treatment. Methods: Mice were divided into six groups (n=6/group): control group (normal saline), stress control (normal saline), standard group where Imipramine (15mg/kg) was used as standard drug and three test groups where three doses of ethanolic extract of C. quadrangularis (EECQ) (100, 250, and 350mg/kg) was used for two weeks treatment. All the medication and test samples were managed by means of gavage through oral course. To evaluate the antidepressant like impact of EECQ forced swim test (FST) and tail suspension test (TST) have been done in mice. Results: The outcomes demonstrated that a solid and dose-dependent antidepressant effects in various mice models. The main findings of the EECQ significantly decreased the duration of immobility times in the forced swimming test (p<0.5). Likewise, the extract significantly decreased the immobility time in the tail suspension test (p<0.5) when compared against stress control as well as against imipramine which was used as a standard. Conclusion: The present results clearly demonstrate that the ethanolic extract of C. quadrangularis possesses antidepressant-like activity in the animal behavioral models. Cissus quadrangularis plant can be used for the treatment of neurological disorders and may be recommended as a supplement for the antidepressant activity.

scholarly journals Synthesis and anti-depressant evaluation of novel pyrazolone derivatives

2016 ◽  
Vol 11 (2) ◽  
pp. 558 ◽  
Author(s):  
Vijay Kumar Merugumolu ◽  
Revanasiddappa Bistuvalli Chandrashekara
Keyword(s):  
Forced Swimming Test ◽  
Tail Suspension Test ◽  
Forced Swimming ◽  
Physical Parameters ◽  
Tail Suspension ◽  
Substituted Anilines ◽  
Standard Drug ◽  
Pyrazolone Derivatives ◽  
Swimming Test ◽  
Suspension Test

<p class="Abstract">Diazotization of substituted anilines with NaNO<sub>2</sub> and concentrated hydro-chloric acid at 0ºC gave the diazonium chlorides. Coupling of substituted aryl diazonium chlorides with ethyl acetoacetate in methanol gave ethyl-2-aryl-hydrazono-3-oxobutyrates (2a-h). Reaction of (2a-h) with naphthoic carbohydrazide (3) gave the title compounds pyrazolone derivatives (4a-h). The newly synthesized compounds were screened for their in vivo anti-depressant activity by tail suspension test and forced swimming test. Some of the tested compounds 4f, 4g showed very good activity when compared to the standard drug imipramine. The newly synthesized compounds were characterized by physical parameters and the structures were elucidated by spectral data.</p><p><strong>Video Clips</strong></p><p><a href="https://www.youtube.com/v/TZtb2a5u4CU">Forced swimming test</a>: 12 min 19 sec</p><p><a href="https://www.youtube.com/v/92mFRfBJgBw">Tail suspension test</a>: 8 min 5 sec</p><p> </p>

scholarly journals Tail suspension test to evaluate the antidepressant activity of experimental drugs

2016 ◽  
Vol 11 (2) ◽  
pp. 292 ◽  
Author(s):  
Muhammad Aslam
Keyword(s):  
Forced Swimming Test ◽  
Antidepressant Drugs ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Tail Suspension ◽  
Video Clips ◽  
Experimental Drugs ◽  
Behavioral Paradigm ◽  
Swimming Test ◽  
Suspension Test

<p>Tail suspension test (TST) is a common behavioral paradigm used to evaluate the antidepressant activity of experimental drugs. Like the forced swimming test, in this test the animals are set in an inescapable yet modestly distressing circumstance. In the tail suspension test, the extent of immobility is thought to be associated with the depressive-like condition of the animal and is significantly diminished by antidepressant drugs.</p><p><strong>Video clips</strong></p><p><a href="https://youtube.com/v/OqWrALPAGhA">Pre-experiment</a>:         53 sec</p><p><a href="https://youtube.com/v/T7sRbrn3xbQ">Experiment</a>:      7 min 31 sec</p><p> </p>

Anti-Fatigue Effect of Zizania caudiflora (Turczaninow) Nakai

2012 ◽  
Vol 40 (01) ◽  
pp. 111-120 ◽  
Author(s):  
Na-Hyung Kim ◽  
Phil-Dong Moon ◽  
Sok Cheon Pak ◽  
Hyung-Min Kim ◽  
Hyun-Ja Jeong
Keyword(s):  
Lactate Dehydrogenase ◽  
Creatine Phosphokinase ◽  
Forced Swimming Test ◽  
Tail Suspension Test ◽  
Control Group ◽  
Tail Suspension ◽  
Fatigue Effect ◽  
Significant Difference ◽  
Swimming Test ◽  
Suspension Test

The purpose of the present study was to investigate the anti-fatigue effect of Zizania caudiflora (Turczaninow) Nakai (ZC) and hydrolyzed ZC by malted barley (HZC) through a forced swimming test (FST) in mice. After the first measurement of immobility times, the mice were divided into control, fluoxetine, ZC, and HZC groups to match the swimming times in each group. The immobility times in the FST of the control as well as the fluoxetine, ZC, and HZC-administered groups after administration for three days were 135.3 ± 3.3,66.8 ± 3.9,120.2 ± 2.7, and 123.2 ± 2.9 sec, respectively. The immobility times in the FST of the ZC and HZC-administered groups for 14 days were significantly decreased in comparison with the control group (p < 0.01). In addition, the immobility times of ZC and HZC-administered groups for 14 days in the tail-suspension test were also significantly decreased in comparison with the control group (p < 0.05). The plasma levels of albumin, glucose, and total protein were significantly increased and creatine phosphokinase was significantly decreased in the ZC and HZC-administered groups compared to the control group. However, the levels of lactate dehydrogenase and blood urea nitrogen in the ZC and HZC-administered groups did not represent a significant difference compared to the control group. In summary, these results suggest that ZC or HZC might be a candidate for an anti-fatigue agent.

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