scholarly journals Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2588 ◽  
Author(s):  
Noriyuki Miyoshi ◽  
Hiroki Tanabe ◽  
Takuji Suzuki ◽  
Koichi Saeki ◽  
Yukihiko Hara
Keyword(s):  
Green Tea ◽  
Case Reports ◽  
Animal Experiments ◽  
Health Benefits ◽  
Epigallocatechin Gallate ◽  
Clinical Intervention ◽  
Clinical Effectiveness ◽  
Epidemiological Studies ◽  
Anogenital Warts ◽  
Green Tea Catechin

Most cell-based and animal experiments have shown that green tea catechins (GTC) exhibit various health benefits. In human experimental and epidemiological studies, there are conflicting results, and more precise investigations are required. One of the most effective ways to prove beneficial health effects in humans might be clinical intervention studies. Polyphenon®E was developed as a standardized GTC preparation, which was approved by Food and Drug Administration of US in 2006 as a medication to treat genital warts (Veregen® or sinecatechins). Positive efficacy of Polyphenon®E/sinecatechins/Veregen® (PSV) on anogenital warts has been demonstrated in several epidemiological studies and there have been several case reports to show the clinical effectiveness of PSV. In addition, several studies have provided evidence to suggest that PSV is effective in other human papillomavirus (HPV)-related diseases, although some studies failed to show such effects. Since (−)-epigallocatechin gallate (EGCG) is the major component of PSV, the mechanism of the action of PSV might be deduced from that of EGCG. The microarray analysis of the biopsy samples from the patients suggested that apoptosis induction and the downregulation of inflammation are involved in the mechanism of the action of PSV in the clearance of anogenital warts. Cell-based and animal experiments using PSV also demonstrated effects similar to those elicited by EGCG, explaining how PSV works to induce apoptosis and exert anti-inflammatory actions in HPV-related diseases. Future studies would clarify what kinds of diseases respond effectively to PSV, showing health benefits of GTC and EGCG in humans.

Versatile Health Benefits of Catechin from Green Tea (Camellia sinensis)

2019 ◽  
Vol 15 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Satheesh Babu Natarajan ◽  
Suriyakala Perumal Chandran ◽  
Sahar Husain Khan ◽  
Packiyaraj Natarajan ◽  
Karthiyaraj Rengarajan
Keyword(s):  
Green Tea ◽  
Camellia Sinensis ◽  
Health Benefits ◽  
Epigallocatechin Gallate ◽  
Extraction Methods ◽  
Major Constituent ◽  
Epicatechin Gallate ◽  
Wide Range ◽  
Green Tea Catechin ◽  
Anti Inflammatory

Background: Tea (Camellia sinensis, Theaceae) is the second most consumed beverage in the world. Green tea is the least processed and thus contain rich antioxidant level, and believed to have most of the health benefits. </p><p> Methods: We commenced to search bibliographic collection of peer reviewed research articles and review articles to meet the objective of this study. </p><p> Results: From this study, we found that the tea beverage contains catechins are believed to have a wide range of health benefits which includes neuroprotective, anti-inflammatory, antiulcer, antiviral, antibacterial, and anti-parasitic effects. The four major catechin compounds of green tea are epigallocatechin (EGC), epicatechin (EC), epigallocatechin gallate (EGCG), and epicatechin gallate (ECG), of which EGCG is the major constituent and representing 50-80% of the total catechin content. And also contain xanthine derivatives such as caffeine, theophylline, and theobromine, and the glutamide derivative theanine. It also contains many nutritional components, such as vitamin E, vitamin C, fluoride, and potassium. We sum up the various green tea phytoconstituents, extraction methods, and its medicinal applications. </p><p> Conclusion: In this review article, we have summarized the pharmacological importance of green tea catechin which includes antioxidant potential, anti-inflammatory, antimicrobial, anticancer, antidiabetic and cosmetic application.

scholarly journals The Immunological Benefits of Green Tea (Camellia sinensis)

2016 ◽  
Vol 9 (1) ◽  
pp. 10 ◽  
Author(s):  
Ngoc B. Huynh
Keyword(s):  
Green Tea ◽  
Camellia Sinensis ◽  
Health Benefits ◽  
Good Health ◽  
Epidemiological Studies ◽  
Health Impacts ◽  
Chinese Traditional Medicine ◽  
Negative Impacts ◽  
Tea Extract ◽  
Primary Impact

This paper explores the health benefits of green tea (Camellia sinensis). Green tea is known for its health benefits. Its primary impact is through the immune system. The paper begins with an overview of tea’s properties according to Chinese traditional medicine, and outlines the main impacts of green tea on T-cells. By reviewing more contemporary studies using green tea extract, the health impacts are quantifiable and epidemiological studies also indicate the link to improved health outcomes in terms of chronic ailments such as diabetes. This paper examines some of the ways in which tea is currently consumed, with an emphasis on how green tea is processed in order to maximize its health benefits. Focusing on EGCG found in green tea, this paper discsses some of the dosages and their impacts, as well as some of the negative impacts of other caffeinated beverages. While further research in this area would reveal more in terms of the limitations on safe consumption associated with these benefits, and exploring the mechanisms through which they take place. This paper concludes that drinking green tea regularly is a safe and inexpensive way for most people to maintain good health.

scholarly journals GREEN TEA CATECHIN LOADED NANODELIVERY SYSTEMS FOR THE TREATMENT OF PANDEMIC DISEASES

2019 ◽  
pp. 1-7
Author(s):  
SATHEESH BABU NATARAJAN ◽  
SURIYAKALA PERUMAL CHANDRAN ◽  
ANJANEYULU VINUKONDA ◽  
SENTHIL RAJAN D
Keyword(s):  
Green Tea ◽  
Value Of Information ◽  
Scientific Evidence ◽  
Health Benefits ◽  
Food Product ◽  
Target Delivery ◽  
Site Specific ◽  
Minimal Dose ◽  
Wide Range ◽  
Green Tea Catechin

Tea (Camellia sinensis, Family: Theaceae) is one of the extremely consumed beverages around the world, behind to water. The brew tea is the merely food product contains abundant quantity of the catechins. Green tea is the least processed and thus contains rich antioxidant, polyphenols, especially catechin called epigallocatechin-3-gallate (EGCG), which is whispered to be responsible for a wide range of the health benefits. The key to the amazing health benefits that are derived from green tea is that the leaves are steamed which preserves the EGCG compound from being oxidized. However, the other varieties of teas are under go fermentation process, which breaks down the potential EGCG and destroy from its healing properties. In reality, green tea has very extensive history dating back thousands and thousands of years ago. However, the pharmacological efficacy and stability of green tea catchiness are primarily depended on the formulation and way to drink to alleviate the deadly diseases with scientific evidence. Nanotechnology is a vibrantly emerging field especially in the pharmaceutical industry to explore a lot of application. The promising nano-delivery system used to enhance the therapeutic efficacy with a minimal dose, minimize the dose-related toxicity, target delivery, site-specific delivery, and controlled/sustain the delivery application. In recent decades, the application of nanotechnology has been utilized for phytopharmaceutical industry including green tea catechins to maximize the health benefits. In this review, we tried our level best retrieve the value of information on nanodelivery application of green tea catchiness for various devastating diseases.

Mucosal Immunity Against HIV-1 Infection by the Green Tea Catechin, Epigallocatechin Gallate

2009 ◽  
Vol 123 (2) ◽  
pp. S208-S208
Author(s):  
C.L. Nance ◽  
E. Siwak ◽  
M. D'Souza ◽  
A. McMullen ◽  
S. Sanga ◽  
...  
Keyword(s):  
Green Tea ◽  
Mucosal Immunity ◽  
Epigallocatechin Gallate ◽  
Green Tea Catechin ◽  
Hiv 1

scholarly journals Stress-Reducing Function of Matcha Green Tea in Animal Experiments and Clinical Trials

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1468 ◽  
Author(s):  
Keiko Unno ◽  
Daisuke Furushima ◽  
Shingo Hamamoto ◽  
Kazuaki Iguchi ◽  
Hiroshi Yamada ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Green Tea ◽  
Animal Experiment ◽  
Animal Experiments ◽  
High Stress ◽  
Epigallocatechin Gallate ◽  
Antagonistic Effect ◽  
Molar Ratio ◽  
Mental Function ◽  
Major Amino Acid

Theanine, a major amino acid in green tea, exhibits a stress-reducing effect in mice and humans. Matcha, which is essentially theanine-rich powdered green tea, is abundant in caffeine. Caffeine has a strong antagonistic effect against theanine. The stress-reducing effect of matcha was examined with an animal experiment and a clinical trial. The stress-reducing effect of matcha marketed in Japan and abroad was assessed based on its composition. The stress-reducing effect of matcha in mice was evaluated as suppressed adrenal hypertrophy using territorially-based loaded stress. High contents of theanine and arginine in matcha exhibited a high stress-reducing effect. However, an effective stress-reducing outcome was only possible when the molar ratio of caffeine and epigallocatechin gallate (EGCG) to theanine and arginine was less than two. Participants (n = 39) consumed test-matcha, which was expected to have a stress-reducing effect, or placebo-matcha, where no effect was expected. Anxiety, a reaction to stress, was significantly lower in the test-matcha group than in the placebo group. To predict mental function of each matcha, both the quantity of theanine and the ratios of caffeine, EGCG, and arginine against theanine need to be verified.

T.75. Inhibition of Dendritic Cell HIV-1 Infection by the Green Tea Catechin, Epigallocatechin Gallate

2009 ◽  
Vol 131 ◽  
pp. S72
Author(s):  
Christina Nance ◽  
Edward Siwak ◽  
Andrew Victores ◽  
Melinda D'Souza ◽  
Ashley McMullen ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Green Tea ◽  
Epigallocatechin Gallate ◽  
Green Tea Catechin ◽  
Hiv 1

HIV-1 Infectivity Inhibited by Binding of the Green Tea Catechin, Epigallocatechin Gallate, to CD4

2007 ◽  
Vol 123 ◽  
pp. S13
Author(s):  
Christina Nance ◽  
Edward Siwak ◽  
Aarthi Ram ◽  
Van Willis ◽  
Susan Westerfield ◽  
...  
Keyword(s):  
Green Tea ◽  
Epigallocatechin Gallate ◽  
Green Tea Catechin ◽  
Hiv 1
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