scholarly journals Using Micropropagation to Develop Medicinal Plants into Crops

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1752
Author(s):  
Rita M. Moraes ◽  
Antonio Luiz Cerdeira ◽  
Miriam V. Lourenço
Keyword(s):  
Medicinal Plants ◽  
Functional Foods ◽  
Quality And Safety ◽  
High Demand ◽  
Herbal Products ◽  
Natural Substances ◽  
Crop Development ◽  
Therapeutic Molecules ◽  
Threaten Species

Medicinal plants are still the major source of therapies for several illnesses and only part of the herbal products originates from cultivated biomass. Wild harvests represent the major supply for therapies, and such practices threaten species diversity as well as the quality and safety of the final products. This work intends to show the relevance of developing medicinal plants into crops and the use of micropropagation as technique to mass produce high-demand biomass, thus solving the supply issues of therapeutic natural substances. Herein, the review includes examples of in vitro procedures and their role in the crop development of pharmaceuticals, phytomedicinals, and functional foods. Additionally, it describes the production of high-yielding genotypes, uniform clones from highly heterozygous plants, and the identification of elite phenotypes using bioassays as a selection tool. Finally, we explore the significance of micropropagation techniques for the following: a) pharmaceutical crops for production of small therapeutic molecules (STM), b) phytomedicinal crops for production of standardized therapeutic natural products, and c) the micropropagation of plants for the production of large therapeutic molecules (LTM) including fructooligosaccharides classified as prebiotic and functional food crops.

scholarly journals Medicinal Plants – Derived Natural Products and Phytochemical Extract as Potential Therapies for Coronavirus : Future Perspective

2021 ◽  
Vol 14 (02) ◽  
pp. 771-791
Author(s):  
S Rehan Ahmad
Keyword(s):  
Natural Products ◽  
Life Cycle ◽  
Medicinal Plants ◽  
Virus Infection ◽  
Future Perspective ◽  
Special Treatment ◽  
The Novel ◽  
Herbal Products ◽  
Global Pandemic ◽  
Therapeutic Molecules

On 11th March 2020 , the WHO has declared that the Coronavirus 2 ( SARS-CoV-2) or noval coronavirus ( COVID-19) as Global Pandemic in the whole world . Yet there is no vaccine or any kind of special treatment developed even though all the nations are testing several therapeutic molecules. Different herbs that are traditional are also being used with conventional drugs since the COVID-19 outbreak and are showing promising results in for the treatment of the patients. In this paper, we will review on the use of the natural products and its findings on how it is being used for treating and preventing the infection of COVID-19.. Only those reports were included that WHO edited in the situation. The extracts of the various herbal products and the molecules that are purified exert an anti-SARS-CoV-2 action and they inhibit the virus directly since the entry of the virus by replicating them. It is even interesting to find that some of the herb related products are able to block the C-2 receptors that are protease serine TMPRRS2. These are the proteins COVID-19 virus requires to infect the human cells. Additionally it was also seen that the that he natural products we able to inhibit proteins such as papain-like or chymotrypsin-like proteases that were required in the life cycle of the SARS-CoV-2. Hence, it is concluded that the natural products can be used in combination or alone as an alternative for preventing or treating of the novel corona virus infection.

Stilbenes and Xanthones from Medicinal Plants as Potential Antitumor Agents

2020 ◽  
Vol 16 ◽  
Author(s):  
Eugenia Dumitra Teodor ◽  
Oana Ungureanu ◽  
Veronica Moroeanu ◽  
Gabriel Lucian Radu
Keyword(s):  
Medicinal Plants ◽  
Anticancer Agents ◽  
Antitumor Agents ◽  
Plant Polyphenols ◽  
Natural Substances ◽  
Abnormal Cells ◽  
Digestive Disorders ◽  
Potential Antitumor

Abstract:: There is an emerging interest for plant polyphenols as dietary ingredients, particularly in digestive disorders and/or as antitumor agents. The plant compounds or extracts continue to be an alternative to drug use, many studies being aimed to find natural substances with selective cytotoxicity on abnormal cells. Phenolic compounds as important secondary metabolites from plants are intensively studied as substitute of drugs. In this review, the recent literature data from past five years about potential anticancer/antitumor effect of some categories of phenolics such as stilbenes and xanthones extracted from medicinal plants are surveyed. The most important results concerning the effectiveness as antitumor/anticancer agents of these active compounds, as isolated compounds or as plant extracts, some bioavailability aspects and their mechanism of action in vitro and in vivo were considered.

scholarly journals Mycotoxin Contamination Concerns of Herbs and Medicinal Plants

Toxins ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 182 ◽  
Author(s):  
Iwona Ałtyn ◽  
Magdalena Twarużek
Keyword(s):  
European Union ◽  
Medicinal Plants ◽  
Ochratoxin A ◽  
Medicinal Herbs ◽  
Quality And Safety ◽  
The European Union ◽  
New Materials ◽  
Herbal Products ◽  
Safety Standards ◽  
Mycotoxin Contamination

Plants and medicinal herbs that are available on the market do not always meet quality and safety standards. One particular concern is the risk of contamination with mycotoxins. Aflatoxins and ochratoxin A are the most frequently described mycotoxins in herbal products and have repeatedly been reported to occur at concentrations which exceed regulatory levels set by the European Union (EU). Possible solutions include enforcing existing limits, and for the new materials, establishing tighter limits and mandate the growth of medicinal plants in EU member countries under more strict conditions.

Effects of herbal products in vitro and in vivo

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
MJ Groot ◽  
MG Pikkemaat ◽  
WD Driessen van Lankveld
Keyword(s):  
Herbal Products

In Vitro Anti-Infective Screening Of Selected West African Medicinal Plants

Planta Medica ◽  
2016 ◽  
Vol 82 (05) ◽  
Author(s):  
VO Imieje ◽  
PS Fasinu ◽  
KO Ogbeide ◽  
NO Egiebor ◽  
A Falodun
Keyword(s):  
Medicinal Plants ◽  
West African

Preparation and In-vitro Evaluation of Fe3O4 Encapsulated by Chitosan Loaded Capecitabine Nanoparticles for the Treatment of Breast Cancer

2016 ◽  
Vol 6 (3) ◽  
Author(s):  
Shanmuganathan S. ◽  
Nigma S. ◽  
Anbarasan B. ◽  
Harika B.
Keyword(s):  
Fe3o4 Nanoparticles ◽  
Polymer Concentration ◽  
In Vitro Release ◽  
Entrapment Efficiency ◽  
In Vitro Evaluation ◽  
Sem Image ◽  
Therapeutic Molecules ◽  
Dialysis Method ◽  
Vitro Release

Nanoparticulate Carriers which is biodegradable, biocompatible and bio adhesive have significant feasible applications for administration of therapeutic molecules. The present study was aimed to formulate and optimise Capecitabine loaded Chitosan-Fe3O4 Nanoparticles and to study the in-vitro evaluation by sigma dialysis method. Capecitabine loaded chitosan – Fe3O4 nanoparticles batches with different ratios of drug: polymer (1:1, 1:2, 1:3, 1:4, 1:5, 1:6) were prepared by ionic gelation method. Increase in polymer concentration increases the nanoparticle drug content. Entrapment efficiency was 60.12% with drug to polymer ratio F3 (1:3). In-vitro release was found to be 65.20% for 12 hrs. Capecitabine from chitosanFe3O4 nanoparticles SEM image reveals discrete spherical structure and particles with size range of 100-500nm. FTIR studies represent the functional groups present with no characteristics change in formulations. Samples stored at refrigerator conditions showed better stability compared with samples kept at other conditions during 8 weeks of storage.

Natural products from the traditional Moroccan pharmacopoeia: A potential lead for the prevention and treatment of COVID-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1278-1285
Author(s):  
Mohamed Yafout ◽  
Amine Ousaid ◽  
Ibrahim Sbai El Otmani ◽  
Youssef Khayati ◽  
Amal Ait Haj Said
Keyword(s):  
Medicinal Plants ◽  
Plant Extracts ◽  
Molecular Mechanisms ◽  
Scientific Literature ◽  
Treatment Protocol ◽  
World Health ◽  
The World ◽  
Health Organization ◽  
Promising Source

The new SARS-CoV-2 belonging to the coronaviruses family has caused a pandemic affecting millions of people around the world. This pandemic has been declared by the World Health Organization as an international public health emergency. Although several clinical trials involving a large number of drugs are currently underway, no treatment protocol for COVID-19 has been officially approved so far. Here we demonstrate through a search in the scientific literature that the traditional Moroccan pharmacopoeia, which includes more than 500 medicinal plants, is a fascinating and promising source for the research of natural molecules active against SARS-CoV-2. Multiple in-silico and in-vitro studies showed that some of the medicinal plants used by Moroccans for centuries possess inhibitory activity against SARS-CoV or SARS-CoV-2. These inhibitory activities are achieved through the different molecular mechanisms of virus penetration and replication, or indirectly through stimulation of immunity. Thus, the potential of plants, plant extracts and molecules derived from plants that are traditionally used in Morocco and have activity against SARS-CoV-2, could be explored in the search for a preventive or curative treatment against COVID-19. Furthermore, safe plants or plant extracts that are proven to stimulate immunity could be officially recommended by governments as nutritional supplements.

QUALITY CONTROL AND IN-VITRO STUDY RELEASE BEHAVIOUR OF EURYCOMANONE IN HERBAL PRODUCTS SUPPLEMENT IN CAPSULE FORM

2020 ◽  
Vol 24 (04) ◽  
pp. 640-649
Author(s):  
Noorazwani Zainol ◽  
Mohamad Shahrizad Pairon ◽  
Mohd Eeyad Arief Mohd Nor Asri ◽  
Khetiswari Ganesan
Keyword(s):  
Quality Control ◽  
In Vitro Study ◽  
Vitro Study ◽  
Herbal Products

Medicinal Plants and Bioactive Compounds for Diabetes Management: Important Advances for Drug Discovery

2020 ◽  
Vol 26 ◽  
Author(s):  
Kondeti Ramudu Shanmugam ◽  
Bhasha Shanmugam ◽  
Gangigunta Venkatasubbaiah ◽  
Sahukari Ravi ◽  
Kesireddy Sathyavelu Reddy
Keyword(s):  
Herbal Medicine ◽  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Diabetes Management ◽  
Therapeutic Potential ◽  
Public Health Problem ◽  
In Vivo Studies ◽  
Major Public Health Problem

Background : Diabetes is a major public health problem in the world. It affects each and every part of the human body and also leads to organ failure. Hence, great progress made in the field of herbal medicine and diabetic research. Objectives: Our review will focus on the effect of bioactive compounds of medicinal plants which are used to treat diabetes in India and other countries. Methods: Information regarding diabetes, oxidative stress, medicinal plants and bioactive compounds were collected from different search engines like Science direct, Springer, Wiley online library, Taylor and francis, Bentham Science, Pubmed and Google scholar. Data was analyzed and summarized in the review. Results and Conclusion: Anti-diabetic drugs that are in use have many side effects on vital organs like heart, liver, kidney and brain. There is an urgent need for alternative medicine to treat diabetes and their disorders. In India and other countries herbal medicine was used to treat diabetes. Many herbal plants have antidiabetic effects. The plants like ginger, phyllanthus, curcumin, aswagandha, aloe, hibiscus and curcuma showed significant anti-hyperglycemic activities in experimental models and humans. The bioactive compounds like Allicin, azadirachtin, cajanin, curcumin, querceitin, gingerol possesses anti-diabetic, antioxidant and other pharmacological properties. This review focuses on the role of bioactive compounds of medicinal plants in prevention and management of diabetes. Conclusion: Moreover, our review suggests that bioactive compounds have the potential therapeutic potential against diabetes. However, further in vitro and in vivo studies are needed to validate these findings.

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