New Insights on the Interaction of Phenanthroline Based Ligands and Metal Complexes and Polyoxometalates with Duplex DNA and G-Quadruplexes

This work provides new insights from our team regarding advances in targeting canonical and non-canonical nucleic acid structures. This modality of medical treatment is used as a form of molecular medicine specifically against the growth of cancer cells. Nevertheless, because of increasing concerns about bacterial antibiotic resistance, this medical strategy is also being explored in this field. Up to three strategies for the use of DNA as target have been studied in our research lines during the last few years: (1) the intercalation of phenanthroline derivatives with duplex DNA; (2) the interaction of metal complexes containing phenanthroline with G-quadruplexes; and (3) the activity of Mo polyoxometalates and other Mo-oxo species as artificial phosphoesterases to catalyze the hydrolysis of phosphoester bonds in DNA. We demonstrate some promising computational results concerning the favorable interaction of these small molecules with DNA that could correspond to cytotoxic effects against tumoral cells and microorganisms. Therefore, our results open the door for the pharmaceutical and medical applications of the compounds we propose.

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Structural Insights into the Recognition of DNA Defects by Small Molecules

Dalton Transactions ◽

10.1039/d0dt04289g ◽

2021 ◽

Author(s):

David Dayanidhi Paul Elisa Sundar ◽

Vaidyanathan Ganesan

Keyword(s):

Nucleic Acids ◽

Metal Complexes ◽

Small Molecules ◽

Chemical Properties ◽

Biological Applications ◽

Binding Interaction ◽

Structural Insights

Studies on the binding interaction of small molecules and nucleic acids have been explored for their biological applications. With excellent photophysical/chemical properties, numerous metal complexes have been studied as structural...

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Photoaddition of Ru(tap)2(bpy)2+to DNA: A New Mode of Covalent Attachment of Metal Complexes to Duplex DNA

Journal of the American Chemical Society ◽

10.1021/ja971163z ◽

1997 ◽

Vol 119 (49) ◽

pp. 11763-11768 ◽

Cited By ~ 69

Author(s):

Luc Jacquet ◽

R. Jeremy H. Davies ◽

Andrée Kirsch-De Mesmaeker ◽

John M. Kelly

Keyword(s):

Metal Complexes ◽

Covalent Attachment ◽

Duplex Dna

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Ru(II)-Dppz Derivatives and Their Interactions with DNA: Thirty Years and Counting

Applied Sciences ◽

10.3390/app11073038 ◽

2021 ◽

Vol 11 (7) ◽

pp. 3038

Author(s):

Maria Letizia Di Pietro ◽

Giuseppina La Ganga ◽

Francesco Nastasi ◽

Fausto Puntoriero

Keyword(s):

Transition Metal ◽

Metal Complexes ◽

Small Molecules ◽

Transition Metal Complexes ◽

Mechanism Of Action ◽

Spectroscopic Techniques ◽

Biological Applications ◽

Ancillary Ligands ◽

Structural Modifications ◽

Over Time

Transition metal complexes with dppz-type ligands (dppz = dipyrido[3,2-a:2′,3′-c]phenazine) are extensively studied and attract a considerable amount of attention, becoming, from the very beginning and increasingly over time, a powerful tool for investigating the structure of the DNA helix. In particular, [Ru(bpy)2(dppz)]2+ and [Ru(phen)2(dppz)]2+ and their derivatives were extensively investigated as DNA light-switches. The purpose of this mini-review, which is not and could not be exhaustive, was to first introduce DNA and its importance at a biological level and research in the field of small molecules that are capable of interacting with it, in all its forms. A brief overview is given of the results obtained on the Ru-dppz complexes that bind to DNA. The mechanism of the light-switch active in this type of species is also briefly introduced along with its effects on structural modifications on both the dppz ligand and the ancillary ligands. Finally, a brief mention is made of biological applications and the developments obtained due to new spectroscopic techniques, both for understanding the mechanism of action and for cellular imaging applications.

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Catalytic Hydrolysis of Phosphate Diester with Metal Complexes of Macrocyclic Tetraamine in Comicellar Solution

Chinese Journal of Chemistry ◽

10.1002/cjoc.20010190208 ◽

2010 ◽

Vol 19 (2) ◽

pp. 158-163 ◽

Cited By ~ 5

Author(s):

Qing-Xiang Xiang ◽

Xiao-Qi Yu ◽

Jing-Song You ◽

Qian-Shun Yan ◽

Rn-Gang Xie

Keyword(s):

Metal Complexes ◽

Catalytic Hydrolysis ◽

Phosphate Diester ◽

Hydrolysis Of

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Ultrafast Photochemistry of a Molybdenum Carbonyl-Nitrosyl Complex with a Triazacyclononane Coligand

Physical Chemistry Chemical Physics ◽

10.1039/d1cp03514b ◽

2021 ◽

Author(s):

Niklas Gessner ◽

Anna Karina Bäck ◽

Johannes Knorr ◽

Christoph Nagel ◽

Philipp Marquetand ◽

...

Keyword(s):

Nitric Oxide ◽

Carbon Monoxide ◽

Transition Metal ◽

Metal Complexes ◽

Small Molecules ◽

Transition Metal Complexes ◽

Nitrosyl Complex ◽

Molybdenum Carbonyl

Transition metal complexes capable of releasing small molecules such as carbon monoxide and nitric oxide upon photoactivation are versatile tools in various fields of chemistry and biology. In this work,...

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