scholarly journals Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6639
Author(s):  
Joanna Izabela Lachowicz ◽  
Luigi Isaia Lecca ◽  
Federico Meloni ◽  
Marcello Campagna
Keyword(s):  
Metal Ions ◽  
Metal Nanoparticles ◽  
Genetic Disorders ◽  
Qualitative And Quantitative Analysis ◽  
Essential Metal ◽  
Qualitative And Quantitative ◽  
Surrounding Environment ◽  
Chelating Ability ◽  
Free Metal

An increasing number of pathologies correlates with both toxic and essential metal ions dyshomeostasis. Next to known genetic disorders (e.g., Wilson’s Disease and β-Thalassemia) other pathological states such as neurodegeneration and diabetes are characterized by an imbalance of essential metal ions. Metal ions can enter the human body from the surrounding environment in the form of free metal ions or metal-nanoparticles, and successively translocate to different tissues, where they are accumulated and develop distinct pathologies. There are no characteristic symptoms of metal intoxication, and the exact diagnosis is still difficult. In this review, we present metal-related pathologies with the most common onsets, biomarkers of metal intoxication, and proper techniques of metal qualitative and quantitative analysis. We discuss the possible role of drugs with metal-chelating ability in metal dyshomeostasis, and present recent advances in therapies of metal-related diseases.

De digitale schandpaal

2010 ◽  
Vol 38 (2) ◽  
Author(s):  
Peter L. M. Vasterman
Keyword(s):  
Quantitative Analysis ◽  
Mass Media ◽  
The Internet ◽  
Level Playing Field ◽  
Qualitative And Quantitative Analysis ◽  
Qualitative And Quantitative ◽  
Playing Field ◽  
Internet Users ◽  
The Impact

The Digital Pillory: The impact of the Internet on the development of scandals The Digital Pillory: The impact of the Internet on the development of scandals This article explores the consequences of the changing public arena for the way scandals develop. Scandals, defined as a process of public outrage over a (presumed) transgression of the dominant morality, used to be the domain of the professional mass media. The Internet seems to offer a more level playing field for actors who want to trigger a scandal by disclosing compromising information. But what exactly is the role of the Internet in the different stages of a scandal; which type of actors are dominant and how do media and these websites interact? A qualitative and quantitative analysis of four recent Dutch scandals shows that the Internet, more specifically semiprofessional weblogs can indeed play an important role in exposing, accusing and denouncing the culprit. But the professional media are still very important; when they refuse to adopt a disclosure by bloggers the scandal fails. The role of the Internet users is mainly reactive, but the scale of outrage on the Internet fuels the scandal process.

scholarly journals The New Sykes-Picot: Imperial Geographies, Economic Violence and the Occupation of Northern and Eastern Syria

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Charles A. Sills ◽  
Keyword(s):  
Public Discourse ◽  
Qualitative And Quantitative Analysis ◽  
Trade Restrictions ◽  
Qualitative And Quantitative ◽  
Geographic Space ◽  
Economic Violence ◽  
Socio Economic Impact ◽  
Moral Necessity ◽  
The Impact

This article quantifies the socio-economic impact of Syria’s territorial fragmentation, framing western efforts to partition Syria against the backdrop of a broader campaign designed to achieve regime change using economic violence. While some have attempted to quantify the impact of sanctions and trade restrictions on Syrian civilians, much of the extant literature fails to address the illegal occupation of Syrian territory north and east of the Euphrates River. Critically, the direct seizure of geographic space through the occupation of Syrian territory facilitates economic violence far more effectively than sanctions alone. In western capitals, the tacit embrace of such methods indicates a re-discovery of old-line traditional territorial imperialism and the rhetorical devices needed to promote it: advocating the illegal seizure of Syrian territory demands a reinvigorated orientalist public discourse designed to promote western saviorism and the moral necessity of western interventionism. Using a hybridized research methodology incorporating qualitative and quantitative analysis, this study appraises the tangible consequences of Syria’s territorial fragmentation as experienced by Syrians while simultaneously appraising the role of orientalist, liberal-interventionist discourse in the promotion of empire.

Features of fears expression among preschool children

2021 ◽  
pp. 94-100
Author(s):  
Inessa V. Smolyarchuk ◽  
Ekaterina D. Safonova ◽  
Angelina S. Ivkina
Keyword(s):  
Preschool Children ◽  
Quantitative Analysis ◽  
Diagnostic Tools ◽  
Confined Space ◽  
Qualitative And Quantitative Analysis ◽  
Qualitative And Quantitative ◽  
Normative Development ◽  
Role Of Parents ◽  
Medical Fears

The emotional sphere is significant for the mental and social development of preschool children. We consider the main causes of children’s fears; the role of parents in their appearance and consolidation. We analyze the features of actual fears in preschool children with mental retardation and normative development. The empirical study (the ascertaining stage) was performed on a sample of 31 subjects (6–7 years old) using diagnostic tools such as: technique of “Choosing the Most Terrible Picture” (T. V. Lavrentiev), test “Fears in Houses” (modified by M.A. Panfilova), projective method “My Family”. Qualitative and quantitative analysis of the results allowed to identify 6 groups of dominant fears among preschool children: medical fears (fear of doctors, injections, blood, getting sick, getting infected), night fears (fear of being alone, terrible dreams, darkness), fear of natural disasters (fear of storms, hurricanes, floods, earthquakes, war, fire), specific fears (fear of darkness, height, depth, confined space, pain), social fears (fear of being late, parents, punishment, large areas), fear for their own lives and the lives of parents.

scholarly journals Modelling the Process of Reflection with Pre-Service Student Teachers

2021 ◽  
Vol 13 (3) ◽  
pp. 116-133
Author(s):  
Ganna Krapivnyk ◽  
Natalia Tuchyna ◽  
Olha Bashkir ◽  
Volodymyr Borysov ◽  
Olena Gonchar ◽  
...  
Keyword(s):  
Student Teachers ◽  
Personal Growth ◽  
Teaching And Learning ◽  
Gradual Transition ◽  
Qualitative And Quantitative Analysis ◽  
Qualitative And Quantitative ◽  
Reflective Practitioners ◽  
Reflective Skills ◽  
Pair Work

The article traces the role of reflection in teacher education and explores the issue of the necessity of creating a system of developing student teachers reflective skills in the process of their university studies. The importance of reflection in linking theoretical knowledge with teaching and learning practices is emphasized. The model of guided reflection employed at the Department of Foreign Philology at H.S. Skovoroda Kharkiv National Pedagogical University is described in detail and examined through different research methods, including qualitative and quantitative analysis of various documents (questionnaires, observation charts, reflective essays etc.) and interviews with participant focus groups. The article presents samples of activities used in pedagogy and methodology classes, and observations of student teachers’ behaviours while performing them. Some information about students’ perception of the model steps is also provided. The collected data prove that student teachers manage to get accustomed to continuous reflection and, thanks to gradual transition from communal reflective activities to pair work and individual assignments as well as constant and sufficient scaffolding, interaction with the ‘knowledgeable other’ feel more confident, are getting aware of the benefits of reflection, and are developing skills of reflective practitioners, which are crucial for their further professional and personal growth.

scholarly journals Product Innovations in the Bulgarian Hospitality: Linking Theory and Practice

2020 ◽  
Vol 8 (5) ◽  
pp. 4614-4618
Keyword(s):  
Quantitative Analysis ◽  
Product Innovation ◽  
Market Research ◽  
Theory And Practice ◽  
Professional Experience ◽  
Qualitative And Quantitative Analysis ◽  
Qualitative And Quantitative ◽  
Product Innovations ◽  
Linking Theory And Practice

The main objective of this paper is to identify trends in product innovation from the hotel business in Bulgaria and to assess the influence of the professional experience on the ability for creating innovations. Based of qualitative and quantitative analysis, some main problems related to the hotel business are presented. The findings include identification of the role of product innovation for the development of the hotel business. The study outlines issues related to their implementation, namely low share of innovative enterprises; low share of developed and implemented new or modified products in the last three years; lack of thorough market research in the overall product development, etc. The study can be used as a model for analysis of product innovation in hotel business.

scholarly journals The New Sykes-Picot: Imperial Geographies, Economic Violence and the Occupation of Northern and Eastern Syria

2021 ◽  
Author(s):  
Charles A. Sills
Keyword(s):  
Public Discourse ◽  
Qualitative And Quantitative Analysis ◽  
Trade Restrictions ◽  
Qualitative And Quantitative ◽  
Geographic Space ◽  
Economic Violence ◽  
Socio Economic Impact ◽  
Moral Necessity ◽  
The Impact

This article quantifies the socio-economic impact of Syria’s territorial fragmentation, framing western efforts to partition Syria against the backdrop of a broader campaign designed to achieve regime change using economic violence. While some have attempted to quantify the impact of sanctions and trade restrictions on Syrian civilians, much of the extant literature fails to address the illegal occupation of Syrian territory north and east of the Euphrates River. Critically, the direct seizure of geographic space through the occupation of Syrian territory facilitates economic violence far more effectively than sanctions alone. In western capitals, the tacit embrace of such methods indicates a re-discovery of old-line traditional territorial imperialism and the rhetorical devices needed to promote it: advocating the illegal seizure of Syrian territory demands a reinvigorated orientalist public discourse designed to promote western saviorism and the moral necessity of western interventionism. Using a hybridized research methodology incorporating qualitative and quantitative analysis, this study appraises the tangible consequences of Syria’s territorial fragmentation as experienced by Syrians while simultaneously appraising the role of orientalist, liberal-interventionist discourse in the promotion of empire.

Effect of exopolysaccharides on the adsorption of metal ions by Pseudomonas sp. CU-1

2005 ◽  
Vol 52 (7) ◽  
pp. 63-68 ◽  
Author(s):  
T.C. Lau ◽  
X.A. Wu ◽  
H. Chua ◽  
P.Y. Qian ◽  
P.K. Wong
Keyword(s):  
Metal Ions ◽  
Metal Ion ◽  
Broth Culture ◽  
Ion Adsorption ◽  
Bacterial Cells ◽  
Pseudomonas Sp ◽  
Adsorption Ability ◽  
Metal Ion Adsorption ◽  
Surrounding Environment

Pseudomonas sp. CU-1, which was isolated from an interfacial biofilm of a sludge sample collected from an electroplating company, had a relatively high ability to adsorb Cu2 +  in solution. The bacterium grown in broth culture produced a large amount of capsular exopolymers mainly consisting of polysaccharides. The exopolysaccharides (EPS) were partially purified. The adsorption isotherm experiments showed that cells and EPS of Pseudomonas sp. CU-1 had similar Q0 and b for the dye, Janus Green, and Cu2+. The adsorption of Cu2 +  by cells could be monitored by the amount of dye displaced, due to the binding of metal ions onto the cell surface. The order of adsorption ability of metal ions and dye displacement by metal ion of the bacterium was: Cu2 + > Cd2 + > Zn2 + > Ni2 + . The results of the dye displacement by metal ions binding onto the surfaces of cells, EPS-removed cells, and EPS suggest that EPS produced by Pseudomonas sp. CU-1 plays an important role in preventing metal ions in the surrounding environment from contact with the bacterial cells. The possible role of the metal ion adsorption by the EPS of this biofilm bacterium was discussed.

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