scholarly journals Exposure to Different Amounts of Dietary Gluten in Patients with Non-Celiac Gluten Sensitivity (NCGS): An Exploratory Study

Nutrients ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 136 ◽  
Author(s):  
Leda Roncoroni ◽  
Karla Bascuñán ◽  
Maurizio Vecchi ◽  
Luisa Doneda ◽  
Maria Bardella ◽  
...  

It is unclear whether patients with non-celiac gluten sensitivity (NCGS) can tolerate gluten. We have evaluated the changes of both gastrointestinal symptoms and quality of life for NCGS patients after the re-introduction of dietary gluten. Twenty-two NCGS patients reporting functional gastroenterological symptoms and on gluten-free diet (GFD) for the previous three weeks were exposed to incremental gluten-containing diets. Three groups were compared at baseline (immediately after 3-weeks on GFD) and immediately after the return of symptomatology: (i) a group tolerating a low-gluten diet (3.5 g gluten/day, week 1, n = 8), (ii) a group tolerating a mid-gluten diet (8 g gluten/day, week 2, n = 6), and (iii) a group tolerating a high-gluten diet (13 g gluten/day, week 3, n = 8). Their gastrointestinal symptoms and quality of life were assessed at baseline and post-intervention. The most common symptoms were: constipation (46%), abdominal pain (50%) and dyspepsia (38%). A decrease in several short form health survey (SF-36) sub-scores (all p < 0.03) after gluten re-introduction was only observed in the group tolerating the low-gluten diet; the same group showed a lower post-intervention role-emotional SF-36 score (p = 0.01). Most gastrointestinal symptoms remained similar after gluten re-introduction. However, a decrease in the general perception of well-being was only found after gluten re-introduction in the group tolerating a low-gluten diet (p = 0.01); the same was true when comparing the post-intervention general well-being perception among the three groups (p = 0.050). In conclusion, dissimilar responses from patients with NCGS were observed after the re-introduction of gluten, with gluten at a low dosage affecting the quality of life and general well-being of a group of patients, whereas others tolerate even higher doses of dietary gluten.

2020 ◽  
pp. 33-38
Author(s):  
E. Yu. Gan ◽  
L. P. Evstigneeva

Purpose of the study. Assessing the association between the life quality of patients with Sjogren’s Disease and ongoing therapy with various disease-modifying antirheumatic drugs.Material and methods. The study was conducted on the basis of the regional rheumatology center of the consultative diagnostic clinic of the Sverdlovsk Regional Clinical Hospital No. 1. This work is based on the results of a simultaneous study of 74 patients with primary Sjogren’s Disease (SD), distributed in three comparison groups receiving various disease-modifying antirheumatic drugs chlorambucil, methotrexate and hydroxychloroquine. The diagnosis of SD was carried out according to European-American criteria AECGC (2002) [18]. In order to analyze the quality of life of patients with SD, the 36-Item Short Form Health Survey (SF‑36) was used. Statistical data processing was carried out using Statistica 7.0 program.Results. Assessment of the quality of life of patients with SD, which is an integrative criterion of human health and well-being, revealed the absence of statistically significant differences (p > 0.05) on eight scales and two health components of the SF‑36 questionnaire in the analyzed groups that differ in the treatment of disease-modifying antirheumatic drugs chlorambucil, methotrexate and hydroxychloroquine.Conclusions. The obtained data indicate an equivalent quality of life in SD patients treated with different disease-modifying antirheumatic drugs methotrexate, chlorambucil and hydroxychloroquine, and therefore hydroxychloroquine can be considered as an alternative basic therapy in patients with SD with certain limitations and contraindications methotrexate and chlorambucil.


2006 ◽  
Vol 10 (01) ◽  
pp. 47-55 ◽  
Author(s):  
Boonsin Tangtrakulwanich ◽  
Virasakdi Chongsuvivatwong ◽  
Alan F. Geater

Objective: To identify what extent different patterns and severities of involvement affect quality of life of people suffering knee osteoarthritis. Methods: This population-based survey involved 288 women and 288 men aged 40 years or older from Songkhla province, southern Thailand. Quality of life was measured using the Medical Outcome Study Short Form Health sutvery (SF-36) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Radiographic investigation included antero-posterior and skyline view of both knees. Osteoarthritis was categorized into 3 patterns; isolated patellofemoral, isolated tibiofemoral and combined with diagnosis based on Kellgren & Lawrence grade 2 or higher. Results: Quality of life as measured by SF-36 and WOMAC showed poorer score in moderate or severe grade than in mild grade of severity. Isolated patellofemoral and combined patterns demonstrated showed poorer scores on both WOMAC and SF-36 than isolated tibiofemoral pattern. Body mass index, income level and pattern of involvement could independently predict total scores of WOMAC, while age, marital status and pattern of involvement affected total score of SF-36. Conclusion: Pattern of involvement is a better predictor of quality of life than disease severity in patients with knee osteoarthritis.


2019 ◽  
Vol 11 (1) ◽  
pp. 186-191
Author(s):  
Camila Zanesco ◽  
Erica De Brito Pitilin ◽  
Maíra Rossetto ◽  
Débora Tavares de Resende e Silva

Objetivo: Caracterizar os pacientes com DRC em tratamento de hemodiálise (HD) de uma clínica do oeste catarinense, suas relações e variáveis sociodemográficas, e, a sua QV. Metodologia: Estudo transversal descritivo, com 116 pacientes com DRC em HD. Para coleta dos dados usou-se questionário sociodemográfico e o intrumento Medical Outcomes Study 36 – Item Short – Form Health Survey (SF-36). Resultados: Houve prevalência da população com idade igual ou > 60 anos, caucasianos (74,77%), do sexo masculino (54,31%), destaca-se a presença de profissões relacionadas a classe média ebaixa e quantidade de anos de estudo reduzidos. Em relação a comorbidades, prevaleceu a Hipertensão Arterial Sistêmica(38,79%). Quanto a QV as limitações por aspectos físicos tiveram menores médias (29,09) e limitações em atividades sociais maior média (73,71). Conclusão: A QV negativa têm repercussões pessoais, familiares e sociais devido ao impacto da doença na rotina de atividades de vida diária dos doentes renais.


2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Elvira Estorninos ◽  
Rachel Lawenko ◽  
Katherine Buluran ◽  
Yipu Chen ◽  
Jowena Lebumfacil ◽  
...  

Abstract Objectives Health-related quality of life (QoL) is an important component of overall wellbeing. The study aimed to describe the parent-perceived infant quality of life of exclusively breastfed infants along with their mother's physical and mental health in a Filipino cohort. Methods Healthy term infants, who were exclusively breastfed since birth and whose mothers had decided to exclusively breastfeed until 6 months (m) of age, were enrolled at 21–26 days of age from a single center in the Philippines. Parents completed the Infant Toddler Quality of Life Questionnaire (ITQoL) and the Short Form Health Survey (SF-36v2) (assessing maternal QoL) at enrollment and when infants were 2.5 m, 4 m, and 6 m of age. Infants’ anthropometrics were measured and parents completed gastrointestinal (GI) diaries and Infant Gastrointestinal Symptoms Questionnaire (IGSQ) throughout the study. Results Among 75 enrolled infants, 70 completed the study at age 6 m. Infant QoL mean scores were high throughout the study (range 0–100 for each concept; Table 1). Nonetheless, noticeable improvements were observed between enrollment and 2.5 m, especially in the infant-focused concept of Temperament and Moods as well as in all three parent-focused concepts (Emotional, Time, and Family Cohesion) which measure impact of child's health on parents. Between 2.5 and 6 m, the scores remained relatively stable. For maternal QoL mean scores (scores standardized to Mean = 50, SD = 10 for each scale; Table 1), noticeable improvements were observed between enrollment and 2.5 m, with Physical Health showing more pronounced improvements. The Role-Emotional scale, which measures role limitations due to emotional problems, showed the lowest scores. From enrollment to age 6 m, mean z-scores for weight-for-age, length-for-age and head circumference-for-age stably tracked WHO Growth Standards. Additionally, infant stool consistency became more formed, and incidences of spitting up/vomiting and flatulence decreased. The overall GI burden also decreased (IGSQ index score: range 13–65; 15.8 ± 3.2 at enrollment and 14.0 ± 1.2 at 6 m). Conclusions In a cohort of exclusively breastfed Filipino mother-infant dyads, parent-perceived infant health-related quality of life was high and comparable to that reported in literature1. Maternal quality of life, particularly their perceived state of emotional well-being, warrants further investigation. Funding Sources Nestec Ltd. Supporting Tables, Images and/or Graphs


2012 ◽  
Vol 101 (1-2) ◽  
pp. 157-165 ◽  
Author(s):  
Ji Wang ◽  
Yi Wang ◽  
Li Bo Wang ◽  
Hui Xu ◽  
Xiao-lei Zhang

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Prachita P. Walankar ◽  
Vrushali P. Panhale ◽  
Manali M. Patil

Chronic shoulder pain is a complex and multidimensional phenomenon with multiple causative factors involved in its perpetuation. Alteration of central nervous system processing along with the central sensitization is a predominant feature in chronic pain. Reduction in physical function has an impact on the psychological well-being of an individual. The aim of the study was to compare pain, kinesiophobia, catastrophizing, disability and quality of life in chronic shoulder pain patients with and without central sensitization. Eighty chronic unilateral shoulder pain patients in the age group of 40 to 60 years were recruited. Of them, 38 were chronic shoulder pain with central sensitization and 42 without central sensitization, classified on the basis of central sensitization inventory. Pain catastrophizing was measured using the pain catastrophizing scale, kinesiophobia using Tampa scale of kinesiophobia, disability using Shoulder pain and disability index and quality of life using 36-Item Short Form Health Survey questionnaire was evaluated in both the groups. Increased pain catastrophizing (p=0.000), kinesiophobia (p=0.000) and disability (p=0.000) was observed in centrally sensitized chronic shoulder pain patients. Also, physical component summary (p=0.000) and mental component summary (p=0.000) of SF-36 quality of life were reduced in chronic shoulder pain with central sensitization as compared to without central sensitization. Hence, these components should be included during assessment which will provide a holistic and multimodal approach towards the understanding, planning and management of chronic shoulder pain patients.


2000 ◽  
Vol 80 (10) ◽  
pp. 986-995 ◽  
Author(s):  
Pat G Camp ◽  
Jessica Appleton ◽  
W Darlene Reid

Abstract Background and Purpose. The purpose of this study was to use quantitative and qualitative research methods to evaluate quality-of-life (QOL) changes in patients with chronic obstructive pulmonary disease (COPD) after pulmonary rehabilitation. Subjects. Twenty-nine individuals with COPD (18 women and 11 men), with a mean age of 69 years (SD=8.6, range=53–92), participated. Methods. Subjects were assessed before and after a 5-week control phase and after a 5-week rehabilitation phase using the Chronic Respiratory Questionnaire (CRQ), the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), and spirometry. Our qualitative research was based on a subsample of 7 subjects who were interviewed after pulmonary rehabilitation. Results. Pulmonary rehabilitation improved QOL, as demonstrated by increases of 22% and 14% in the physical function categories of the CRQ and the SF-36, respectively, and by an increase of 10% in the CRQ's emotional function category. The qualitative data indicated how pulmonary rehabilitation influenced QOL. Conclusion and Discussion. The use of both quantitative and qualitative methods illustrated the nature of improvement in QOL after pulmonary rehabilitation. Improved physical function, less dyspnea, and a heightened sense of control over the subjects' COPD resulted in increased confidence and improved emotional well-being.


Blood ◽  
2002 ◽  
Vol 99 (6) ◽  
pp. 1995-2001 ◽  
Author(s):  
Mina Nishimori ◽  
Yoshitsugu Yamada ◽  
Keiko Hoshi ◽  
Yuichi Akiyama ◽  
Yasutaka Hoshi ◽  
...  

Abstract To promote bone marrow donation, both the safety and well-being of healthy unrelated volunteer donors must be protected. This prospective cohort study evaluated donors' health-related quality of life (HRQOL) and identified factors associated with it. Using the Medical Outcomes Study Short Form 36 Health Survey (SF-36) before bone marrow harvesting (BMH), and again 1 week and 3 months after the donors' discharge, we evaluated HRQOL of 565 donors (329 men, 236 women) registered with the Japan Marrow Donor Program (JMDP). We also examined the data routinely collected by the JMDP, such as BMH-related problems and other demographic and medical variables, to determine whether such data could be used to predict donors' HRQOL after discharge. Mean scores of all pre-BMH SF-36 subscales showed better functioning than the national norm. One week after discharge, mean scores on physical functioning (PF) and role-physical (RP) subscales, indicative of physical states, and bodily pain (BP) were approximately 1 SD lower than the national norm; however, mental health (MH) and general health perception (GH) remained above normal; the most frequent BMH-related problems were pain at the donation site and lower back pain, which were associated with lower PF, RP, and BP scores. Female gender and duration of procedure predicted lower PF, RP, and BP. Three months after discharge, mean scores of all SF-36 subscales had returned to baseline levels. These data show that the adverse effects of BMH on donors' HRQOL are transient and can be minimized by better management of pain.


2021 ◽  
Vol 13 ◽  
pp. 1453-1459
Author(s):  
Gracielle Pampolim ◽  
Alaércia De Melo Recla ◽  
Rafaela Guio Suzana ◽  
Isabelle Gadiolli Verzola ◽  
Luciana Carrupt Machado Sogame

Objetivo: verificar os fatores associados a percepção regular/negativa da qualidade de vida entre idosos. Métodos: estudo observacional transversal realizado com 171 idosos de uma Unidade de Saúde da Família. A variável desfecho foi a qualidade de vida, avaliada através do Short Form Health Survey – SF-36, as variáveis independentes foram características sociodemográficas, de moradia, hábitos de vida e condições de saúde. Os dados foram analisados através do teste Chi-Quadrado de Pearson. Resultados: dos idosos entrevistados, 98 (57,3%) perceberam sua qualidade de vida como regular/negativa. Ser do sexo feminino, restrito ao lar, não praticar atividade física, de lazer ou atividades ofertadas pela Unidade de Saúde; auto-avaliar negativamente sua saúde, apresentar multimorbidade, polifarmacia, sintomas depressivos, risco de quedas e funcionalidade comprometida, estiveram associadas com o desfecho. Conclusão: incentivar o idoso a participar de atividades que promovam sociabilização e manutenção da funcionalidade é fundamental para preservação ou recuperação de sua qualidade de vida.  


2019 ◽  
Vol 12 (22) ◽  
pp. 13-17
Author(s):  
Nada Arseni ◽  
Hans-Eric Reitmayer

AbstractAim: The purpose of this research is to identify and analyze the association of the Body Mass Index (BMI) and quality of life (QoL) components in students aged 19 to 22 that attended physical education classes once a week during a whole semester. The students come from different faculties of the West University of Timişoara.Methods: The research was conducted during the physical education classes to which they participated during one semester. The research has begun in October 2018 and ended in January 2019. A total of 400 students were asked to participate in this study, 200 female and 200 male students. As research methods, we used the RAND 36 Item Short Form Health Survey SF-36 questionnaire to assess the quality of life, as well as the statistical-mathematical method.Results: Our results showed that 66% of the students had a normal BMI, 12% are underweight, 17% are overweight and 12% are obese. It has been found that the quality of life score does not depend on the body mass index. No correlation has been found between the QOL total score and BMI in neither male students r=0.035, R²=0.0012, p=0.62, nor female students r=-0.01, R²<0.001, p=0.88.


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