scholarly journals First Trimester Serum Copper or Zinc Levels, and Risk of Pregnancy-Induced Hypertension

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2479 ◽  
Author(s):  
Małgorzata Lewandowska ◽  
Stefan Sajdak ◽  
Wojciech Marciniak ◽  
Jan Lubiński
Keyword(s):  
Early Pregnancy ◽  
Odds Ratio ◽  
Inductively Coupled Plasma ◽  
Adjusted Odds Ratio ◽  
First Trimester ◽  
Pregnancy Induced Hypertension ◽  
Odds Ratios ◽  
Oxidative Balance ◽  
Induced Hypertension ◽  
Zinc Levels

Early identification of women at risk of developing pregnancy-induced hypertension (PIH) is very important. The involvement of copper (Cu) and zinc (Zn) in the oxidative balance suggests the possibility of their association with this disease, in which oxidative stress plays a key role. However, it has not been established so far whether the microelement levels in early pregnancy may be risk markers of the disease, as prospective studies are limited in number. In our innovative single-center study, we identified from a prospective cohort of healthy women in the 10–14th week of a single pregnancy: women subsequently developing pregnancy-induced hypertension (n = 121) and matched women remaining normotensive (n = 363). We measured the concentrations of microelements in the serum from 10–14 week, using the inductively coupled plasma mass spectrometry (ICP-MS). The odds ratios of the disease (and 95% confidence intervals) were assessed in logistic regression. In the whole cohort, the odds ratio (OR) of PIH was 1.52 (p = 0.174) for women in the lowest (Q1) quartile of Cu (≤1540.58 µg/L) compared with women in the highest (Q4) quartile (>1937.46 µg/L), but adjusted odds ratio (AOR) was 2.17 (p = 0.019) after adjusted for pre-pregnancy body mass index (BMI) and gestational age at recruitment. The higher levels of Cu in the subgroup of BMI ≥ 25 kg/m2 compared to normal BMI were found (1847.64 vs. 1673.36 µg/L; p < 0.0001). In the subgroup of women with the normal pre-pregnancy BMI, the adjusted odds ratio of PIH was AOR = 2.95 (p = 0.040) for Q1 vs. Q4 quartile. Our results suggest that lower Cu levels in early pregnancy may be connected with higher risk of PIH, but BMI affected estimated odds ratios. Zinc levels had no effect on the risk.

scholarly journals The Role of Early Pregnancy Maternal Selenium Levels on the Risk for Small-for-Gestational Age Newborns

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2298 ◽  
Author(s):  
Małgorzata Lewandowska ◽  
Stefan Sajdak ◽  
Jan Lubiński
Keyword(s):  
Birth Weight ◽  
Early Pregnancy ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Inductively Coupled Plasma ◽  
Maternal Serum ◽  
Risk Marker ◽  
Serum Selenium ◽  
Odds Ratios ◽  
Oxidative Balance

It has not yet been established, whether or not the maternal serum selenium (Se) in early pregnancy may be a risk marker of small-for-gestational age (SGA) birth weight. Selenium is important for human health and is involved in oxidative balance, a key element in the development of the placenta and fetus. This innovative study was nested in a prospective cohort of 750 women recruited in the 10–14th week of a single pregnancy, all of whom were healthy during recruitment. We examined mothers delivering SGA infants (with birth weight <10th percentile) (n = 48) and matched mothers delivering appropriate-for-gestational age (AGA) infants (between 10–90th percentile) (n = 192). We measured the maternal microelement concentrations in the serum from the 10–14th gestational week, using the inductively coupled plasma mass spectrometry (ICP-MS). The odds ratios of SGA (and 95% confidence intervals) were assessed in logistic regression. The mean maternal Se concentrations were lower in mothers in the SGA group compared to the AGA group (59.60 vs. 62.54 µg/L; p = 0.020). Women in the lowest Q1 quartile of Se (≤56.60 µg/L) have about three times higher risk of SGA compared to women in the higher quartiles (Q2 or Q4); the odds ratio of SGA was OR = 3.02 (p = 0.019) for Q1 vs. Q2 quartile. The risk profile graph confirms the results. We found that excessive pre-pregnancy BMI (body mass index) affected the estimated SGA odds ratios. Early pregnancy maternal serum selenium status can be a risk marker of SGA newborns and more research is needed in larger groups.

scholarly journals First trimester employment, working conditions and preterm birth: a prospective population-based cohort study

2021 ◽  
pp. oemed-2020-107072
Author(s):  
Tanja Vrijkotte ◽  
Teus Brand ◽  
Gouke Bonsel
Keyword(s):  
Preterm Birth ◽  
Working Conditions ◽  
Work Load ◽  
First Trimester ◽  
Physical Work ◽  
Pregnancy Induced Hypertension ◽  
Prolonged Standing ◽  
Physical Work Load ◽  
Increased Risk ◽  
Induced Hypertension

ObjectivesTo explore the association between working conditions during first trimester and total preterm birth (PTB), and subtypes: spontaneous PTB and iatrogenic PTB, additionally to explore the role of hypertension.MethodsPregnant women from the Amsterdam Born Children and their Development study, filled out a questionnaire between January 2003 and March 2004, two weeks after first prenatal screening (singleton liveborn, n=7561). Working conditions were working hours/week, standing/walking hours/week, physical work load and job strain.ResultsProlonged standing/walking during first trimester was associated with an increased risk for total PTB (OR=1.5; 95% CI 1.0–2.3, after adjustments). Other working conditions were not related to total PTB. The separation into spontaneous and iatrogenic PTB revealed that standing/walking was associated with iatrogenic PTB only (OR=2.09; 95% CI 1.00–4.97). The highest risk was found for the combination of a long workweek with high physical work load (OR=3.42; 95% CI 1.04–8.21). Hypertension did not mediate these associations; however, stratified analysis revealed that high physical work load was only related to iatrogenic PTB when pregnancy-induced hypertension was present (OR=6.44; 95% CI 1.21–29.76).ConclusionThis study provides evidence that high physically demanding work is associated with an increased risk for iatrogenic PTB and not with spontaneous PTB. Pregnancy-induced hypertension may play a role: when present, high physical work load leads to a more severe outcome.

First Trimester Biological Markers for the Prediction of Pregnancy-Induced Hypertension

1996 ◽  
Vol 13 (02) ◽  
pp. 89-93 ◽  
Author(s):  
Shoji Tomoda ◽  
Toshitsugu Tamura ◽  
Takashi Kitanaka ◽  
Sachio Ogita
Keyword(s):  
Biological Markers ◽  
First Trimester ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension

scholarly journals Association Between First-Trimester Intrauterine Hematoma and Twin Pregnancy Outcomes: A Retrospective Cohort Study

2020 ◽  
Author(s):  
Wanqing Ji ◽  
Jie Zheng ◽  
Weidong Li ◽  
Fang Guo ◽  
Bo Hou ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Odds Ratio ◽  
Vaginal Bleeding ◽  
Pregnancy Loss ◽  
Twin Pregnancy ◽  
Adjusted Odds Ratio ◽  
First Trimester ◽  
Multivariable Logistic Regression Analysis ◽  
Vanishing Twin Syndrome ◽  
Twin Pregnancies

Abstract Background: In recent years, we have found that first-trimester intrauterine hematoma in twin pregnancy has become increasingly common. The majority of studies on intrauterine hematoma have excluded twin pregnancies, while others did not differentiate between singleton and twin pregnancies. The associations in twin pregnancy are not clear. Therefore, the primary objective of our study was to examine the associations between first-trimester intrauterine hematoma and pregnancy outcomes in twin pregnancy. Material and methods: 1020 twin pregnancies in women who underwent a routine examination from January 2014 to December 2018 were enrolled. According to the presence or absence of intrauterine hematoma, we compared the baseline data and pregnancy outcomes between two groups. Multivariable logistic regression analysis was used to adjust for possible confounding factors. Results: A total of 209 patients (21.3%) developed intrauterine hematoma in the first trimester. First-trimester intrauterine hematoma was significantly associated with increased odds of miscarriage (adjusted odds ratio 14.27, 95% CI 8.25-24.70) and the vanishing twin syndrome (adjusted odds ratio 3.26, 95% CI 1.11-4.61). However, It did not have increased odds of adverse pregnancy outcomes after 20 Weeks of Gestation .In the final regression model analysis, the associations of hematoma with previous miscarriage history, accepted assisted conception, accompanying vaginal bleeding and miscarriage and vanishing twin syndrome were no longer significant. No association was found between hematoma size or the presence of vaginal bleeding and the risk of pregnancy loss or the vanishing twin syndrome before 20 weeks of gestation (P>0.05). Conclusion: In women with twin pregnancies, the presence of intrauterine hematoma in the first trimester was associated with one or both fetal losses before 20 weeks of gestation. However, chorionicity in twins, the conception method, the intrauterine hematoma size and the presence of vaginal bleeding were not independently associated with pregnancy loss.

scholarly journals Serum Selenium Level in Early Healthy Pregnancy as a Risk Marker of Pregnancy Induced Hypertension

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1028 ◽  
Author(s):  
Małgorzata Lewandowska ◽  
Stefan Sajdak ◽  
Jan Lubiński
Keyword(s):  
Logistic Regression ◽  
Adverse Outcomes ◽  
Case Group ◽  
Risk Marker ◽  
Serum Selenium ◽  
Pregnancy Induced Hypertension ◽  
Odds Ratios ◽  
Healthy Pregnancy ◽  
Icp Ms ◽  
Induced Hypertension

Selenium (Se) is an antioxidant nutrient whose deficiency can influence adverse outcomes of pregnancy. The aim of this study is to determine whether serum Se level in early healthy pregnancy may be a risk marker for pregnancy induced hypertension. We obtained data from our prospective study in which we recruited healthy women in weeks 10–14 of a single pregnancy. In this analysis, we examined 121 women who subsequently developed pregnancy-induced hypertension and matched 363 women who remained normotensive. We measured Se levels (using the ICP-MS technique) in the serum in weeks 10–14 of the pregnancy. The odds ratios of pregnancy-induced hypertension (95% confidence intervals) were calculated using multivariate logistic regression. We found that the mean Se level was lower in the case group compared to the control (57.51 vs. 62.89 μg/L; p = 2.6 × 10−10). Excessive body mass index (BMI) and smoking influenced the estimated odds ratios. In the subgroup of women who had never smoked with normal pre-pregnancy BMI, the adjusted odds ratio (AOR) of pregnancy-induced hypertension was 15.34 (95% CI: 2.73–86.31, p = 0.002) for Se levels in the lowest quartile (≤57.68 µg/L), as compared to the highest quartile (>66.60 µg/L), after adjusting for all the accepted confounders. In the whole cohort, the prognostic value of Se by logistic regression showed that the area under curve (AUC) = 0.814. In our study, one can consider the role of Se as a risk marker of pregnancy-induced hypertension.

scholarly journals Is the serum L-arginine level during early pregnancy a predictor of pregnancy-induced hypertension?

2015 ◽  
Vol 57 (1) ◽  
pp. 74-81 ◽  
Author(s):  
Jingwen Wang ◽  
Tomomi Kotani ◽  
Hiroyuki Tsuda ◽  
Yukio Mano ◽  
Seiji Sumigama ◽  
...  
Keyword(s):  
Early Pregnancy ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
Arginine Level

scholarly journals Maternal Early-Pregnancy Thyroid Function Is Associated With Subsequent Hypertensive Disorders of Pregnancy: The Generation R Study

2014 ◽  
Vol 99 (12) ◽  
pp. E2591-E2598 ◽  
Author(s):  
Marco Medici ◽  
Tim I. M. Korevaar ◽  
Sarah Schalekamp-Timmermans ◽  
Romy Gaillard ◽  
Yolanda B. de Rijke ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Early Pregnancy ◽  
Pregnancy Induced Hypertension ◽  
Hypertensive Disorders Of Pregnancy ◽  
Normal Range ◽  
Free T4 ◽  
Hypertensive Disorders ◽  
Increased Risk ◽  
Wide Range ◽  
Induced Hypertension

Context: Hypertensive disorders during pregnancy are associated with a wide range of maternal and fetal complications, and only a few risk factors are known for the development of these disorders during pregnancy. Conflicting and limited data are available on the relationship between thyroid (dys)function and the risk of hypertensive disorders of pregnancy. Objective: The objective of the investigation was to study the associations between early-pregnancy thyroid dysfunction, thyroid function within the normal range, and the risk of hypertensive disorders. Design, Setting, and Participants: In early pregnancy, serum TSH, free T4 (FT4), and thyroperoxidase antibody (TPOAb) levels were determined in 5153 pregnant women. No interventions were done. The associations of thyroid function with the risk of hypertensive disorders were studied. Main Outcome Measures: Mean blood pressures and hypertensive disorders, including pregnancy-induced hypertension (n = 209) and preeclampsia (n = 136), were measured. Results: Hyperthyroid mothers had a higher risk of hypertensive disorders [odds ratio (OR) 3.40 [95% confidence interval (CI) 1.46–7.91], P = .005], which was mainly due to an increased risk of pregnancy-induced hypertension [OR 4.18 (95% CI 1.57–11.1), P = .004]. Hypothyroidism and hypothyroxinemia were not associated with hypertensive disorders. Within the normal range, the high-normal FT4 levels were associated with an increased risk of hypertensive disorders [OR 1.62 (95% CI 1.06–2.47), P = .03], which was mainly due to an increased risk of preeclampsia [OR 2.06 (95% CI 1.04–4.08), P = .04]. The TPOAb status was not associated with hypertensive disorders. Conclusions: We show that biochemical hyperthyroidism and also high-normal FT4 levels during early pregnancy are associated with an increased risk of hypertensive disorders. These data demonstrate that these associations are even seen for a mild variation in thyroid function within the normal range.

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