scholarly journals Dietary Acrylamide Intake and the Risk of Liver Cancer: The Japan Public Health Center-Based Prospective Study

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2503 ◽  
Author(s):  
Ling Zha ◽  
Tomotaka Sobue ◽  
Tetsuhisa Kitamura ◽  
Yuri Kitamura ◽  
Junko Ishihara ◽  
...  
Keyword(s):  
Public Health ◽  
Liver Cancer ◽  
Prospective Study ◽  
Health Center ◽  
Japanese Population ◽  
Smoking Status ◽  
Coffee Consumption ◽  
Multivariable Model ◽  
Public Health Center ◽  
Dietary Acrylamide

Acrylamide has been studied for its carcinogenicity in experimental animals, causing tumors at several organ sites, and has been considered probably carcinogenic to humans as well. Given the small number of epidemiological studies that have been conducted, it is still uncertain whether the consumption of acrylamide is associated with liver cancer. Therefore, we investigated a study to determine the possible relationship between acrylamide intake and the risk of developing liver cancer in the Japanese population. A total of 85,305 participants, from the Japan Public Health Center-based Prospective Study, who provided a validated food-frequency questionnaire were enrolled between 1995 and 1998. During a median of 16.0 years follow-up, 744 new liver cancer cases were identified. Compared to the lowest tertile of acrylamide consumption (<4.8 µg/day), the multivariate hazard ratio (HR) for the highest tertile (≥7.6 µg/day) was 0.79 (95% confidence interval [CI] = 0.65–0.95) for liver cancer using multivariable model 1, adjusted for smoking status, body mass index (BMI), physical activity, medical history, and alcohol consumption; whereas the inverse relationship disappeared after additionally adjusting for coffee consumption in multivariable model 2 with HR of 1.08 (95% CI = 0.87–1.34) for the highest tertile. The effect of dietary acrylamide intake on the risk of liver cancer was not observed in the Japanese population.

scholarly journals Dietary Acrylamide Intake and the Risk of Pancreatic Cancer: The Japan Public Health Center-Based Prospective Study

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3584
Author(s):  
Kumiko Kito ◽  
Junko Ishihara ◽  
Ayaka Kotemori ◽  
Ling Zha ◽  
Rong Liu ◽  
...  
Keyword(s):  
Public Health ◽  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Prospective Study ◽  
Health Center ◽  
Smoking Status ◽  
Cox Proportional Hazards ◽  
Public Health Center ◽  
Pancreatic Cancer Risk ◽  
Dietary Acrylamide

Acrylamide is a probable carcinogen in humans. Few studies have assessed dietary acrylamide intake and the risk of pancreatic cancer; however, these studies are based on Western populations. Our purpose was to investigate the association of dietary acrylamide intake with the risk of pancreatic cancer utilizing data from the Japan Public Health Center-based Prospective Study. We evaluated the data of 89,729 participants aged 45–74 years, who replied to a questionnaire on past medical history and lifestyle habits from 1995–1998. Dietary acrylamide intake was estimated utilizing a validated food frequency questionnaire. We calculated the hazard ratios and 95% confidence intervals by using Cox proportional-hazards regression models. The average follow-up was 15.2 years, and 576 cases of pancreatic cancer were diagnosed. In the multivariate-adjusted model, an association between dietary acrylamide intake and pancreatic cancer risk was not demonstrated (hazard ratio for the highest vs. lowest quartile = 0.83, 95% confidence interval: 0.65–1.05, p for trend = 0.07). Furthermore, in the analyses stratified by sex, smoking status, coffee consumption, green tea consumption, alcohol consumption, and body mass index, no significant association was detected. Dietary acrylamide intake was not associated with the pancreatic cancer risk in Japanese individuals.

scholarly journals Perceived stress level and risk of cancer incidence in a Japanese population: the Japan Public Health Center (JPHC)-based Prospective Study

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Huan Song ◽  
Eiko Saito ◽  
Norie Sawada ◽  
Sarah K. Abe ◽  
Akihisa Hidaka ◽  
...  
Keyword(s):  
Public Health ◽  
Prospective Study ◽  
Health Center ◽  
Perceived Stress ◽  
Stress Level ◽  
Cancer Incidence ◽  
Japanese Population ◽  
Public Health Center ◽  
Risk Of Cancer

scholarly journals Intake of Vegetables and Fruits and the Risk of Cataract Incidence in a Japanese Population: The Japan Public Health Center-Based Prospective Study

2021 ◽  
Vol 31 (1) ◽  
pp. 21-29
Author(s):  
Sayaka Adachi ◽  
Norie Sawada ◽  
Kenya Yuki ◽  
Miki Uchino ◽  
Motoki Iwasaki ◽  
...  
Keyword(s):  
Public Health ◽  
Prospective Study ◽  
Health Center ◽  
Japanese Population ◽  
Public Health Center ◽  
Vegetables And Fruits

scholarly journals Diet quality and depression risk in a Japanese population: the Japan Public Health Center (JPHC)-based Prospective Study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ryo Okubo ◽  
Yutaka J. Matsuoka ◽  
Norie Sawada ◽  
Masaru Mimura ◽  
Kayo Kurotani ◽  
...  
Keyword(s):  
Public Health ◽  
Prospective Study ◽  
Health Center ◽  
Diet Quality ◽  
Japanese Population ◽  
Public Health Center ◽  
Depression Risk

scholarly journals Dietary Acrylamide Intake and Risk of Lung Cancer: The Japan Public Health Center Based Prospective Study

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2417
Author(s):  
Rong Liu ◽  
Ling Zha ◽  
Tomotaka Sobue ◽  
Tetsuhisa Kitamura ◽  
Junko Ishihara ◽  
...  
Keyword(s):  
Public Health ◽  
Lung Cancer ◽  
Prospective Study ◽  
Health Center ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Public Health Center ◽  
Hazard Ratios ◽  
Dietary Acrylamide ◽  
Using Data

Acrylamide, which forms in heat-treated foods with high carbohydrate content, is a probable human carcinogen. This study aimed to evaluate the association between dietary acrylamide intake and lung cancer using data from the Japan Public Health Center based Prospective Study. Our study included 85,303 participants who completed a food frequency questionnaire. Cox proportional hazards regression models were used to assess hazard ratios and 95% confidence intervals (CIs) after adjusting for confounders. After 14.3 years and 15.4 years of mean follow-up period, 1187 and 485 lung cancer cases were identified in men and women, respectively. The multivariable-adjusted hazard ratios of 10-µg/day increment in acrylamide intake were 1.01 (95% CI, 0.99–1.02) in men and 0.98 (95% CI, 0.95–1.02) in women. Compared with the lowest quartile of acrylamide intake, the hazard ratios for the highest quartile were 1.13 (95% CI, 0.95–1.33; p for trend = 0.12) in men and 1.03 (95% CI, 0.78–1.36; p for trend = 0.86) in women in the multivariable-adjusted model. Moreover, there was also no significant association observed in the stratified analysis for histological subtypes of lung cancer. This study demonstrated that dietary acrylamide intake was not associated with increased lung cancer risk in the Japanese population.

scholarly journals Dietary Acrylamide Intake and Risk of Esophageal, Gastric, and Colorectal Cancer: The Japan Public Health Center-based Prospective Study

2019 ◽  
pp. cebp.1259.2018 ◽  
Author(s):  
Rong Liu ◽  
Tomotaka Sobue ◽  
Tetsuhisa Kitamura ◽  
Yuri Kitamura ◽  
Junko Ishihara ◽  
...  
Keyword(s):  
Public Health ◽  
Colorectal Cancer ◽  
Prospective Study ◽  
Health Center ◽  
Public Health Center ◽  
Dietary Acrylamide

scholarly journals Dietary acrylamide intake and risk of breast cancer: The Japan Public Health Center-based Prospective Study

2018 ◽  
Vol 109 (3) ◽  
pp. 843-853 ◽  
Author(s):  
Ayaka Kotemori ◽  
Junko Ishihara ◽  
Ling Zha ◽  
Rong Liu ◽  
Norie Sawada ◽  
...  
Keyword(s):  
Public Health ◽  
Breast Cancer ◽  
Prospective Study ◽  
Health Center ◽  
Public Health Center ◽  
Dietary Acrylamide

scholarly journals Dietary Acrylamide Intake and the Risk of Hematological Malignancies: The Japan Public Health Center-Based Prospective Study

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 590
Author(s):  
Ling Zha ◽  
Rong Liu ◽  
Tomotaka Sobue ◽  
Tetsuhisa Kitamura ◽  
Junko Ishihara ◽  
...  
Keyword(s):  
Public Health ◽  
Prospective Study ◽  
Health Center ◽  
Hematological Malignancies ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Categorical Variables ◽  
Continuous Variables ◽  
Public Health Center ◽  
Dietary Acrylamide

Acrylamide, which is present in many daily foods, is a probable human carcinogen. In 2002, it was identified in several common foods. Subsequently, western epidemiologists began to explore the relationship between dietary acrylamide exposure and cancer risk; however, limited suggestive associations were found. This prospective study aimed to examine the association between dietary acrylamide intake and the risk of hematological malignancies, including malignant lymphoma (ML), multiple myeloma (MM), and leukemia. We enrolled 85,303 participants in the Japan Public Health Center-based Prospective study on diet and cancer as from 1995. A food frequency questionnaire that included data on acrylamide in all Japanese foods was used to assess dietary acrylamide intake. We applied multivariable adjusted Cox proportional hazards models to reckon hazard ratios (HRs) for acrylamide intake for both categorical variables (tertiles) and continuous variables. After 16.0 median years of follow-up, 326 confirmed cases of ML, 126 cases of MM, and 224 cases of leukemia were available for final multivariable-adjusted analysis. HRs were 0.87 (95% confidence interval [CI]: 0.64–1.18) for ML, 0.64 (95% CI: 0.38–1.05) for MM, and 1.01 (95% CI: 0.71–1.45) for leukemia. Our results implied that acrylamide may not be related to the risk of hematological malignancies.

scholarly journals Dietary Acrylamide Intake and the Risks of Renal Cell, Prostate, and Bladder Cancers: A Japan Public Health Center-Based Prospective Study

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 780
Author(s):  
Sayaka Ikeda ◽  
Tomotaka Sobue ◽  
Tetsuhisa Kitamura ◽  
Junko Ishihara ◽  
Ayaka Kotemori ◽  
...  
Keyword(s):  
Public Health ◽  
Prospective Study ◽  
Health Center ◽  
Food Frequency Questionnaire ◽  
Renal Cell ◽  
Food Frequency ◽  
Public Health Center ◽  
Hazard Ratios ◽  
Dietary Acrylamide

Acrylamide can be carcinogenic to humans. However, the association between the acrylamide and the risks of renal cell, prostate, and bladder cancers in Asians has not been assessed. We aimed to investigate this association in the Japan Public Health Center-based Prospective Study data in 88,818 Japanese people (41,534 men and 47,284 women) who completed a food frequency questionnaire in the five-year follow-up survey in 1995 and 1998. A validated food frequency questionnaire was used to assess the dietary acrylamide intake. Cox proportional hazard regression models were used to estimate hazard ratios and 95% confidence intervals (CIs). During a mean follow-up of 15.5 years (15.2 years of prostate cancer), 208 renal cell cancers, 1195 prostate cancers, and 392 bladder cancers were diagnosed. Compared to the lowest quintile of acrylamide intake, the multivariate hazard ratios for the highest quintile were 0.71 (95% CI: 0.38–1.34, p for trend = 0.294), 0.96 (95% CI: 0.75–1.22, p for trend = 0.726), and 0.87 (95% CI: 0.59–1.29, p for trend = 0.491) for renal cell, prostate, and bladder cancers, respectively, in the multivariate-adjusted model. No significant associations were observed in the stratified analyses based on smoking. Dietary acrylamide intake was not associated with the risk of renal cell, prostate, and bladder cancers.

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