scholarly journals Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2509
Author(s):  
Velia Cassano ◽  
Daniele Crescibene ◽  
Marta Letizia Hribal ◽  
Corrado Pelaia ◽  
Giuseppe Armentaro ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Uric Acid ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Vascular Damage ◽  
Newly Diagnosed ◽  
Hypertensive Patients

Increased levels of uric acid (UA) have been shown to be correlated with many clinical conditions. Uric acid may adversely affect the insulin signalling pathway inducing insulin resistance (IR). Several studies report the association between arterial stiffness (AS), an early indicator of atherosclerosis, and UA. The purpose of the present study was to evaluate the association between UA and AS, considering the potential role of IR. We enrolled 1114 newly diagnosed, never-treated hypertensive patients. Insulin resistance was assessed by the homeostatic model assessment (HOMA) index. Arterial stiffness was evaluated as the measurement of the carotid–femoral pulse wave velocity (PWV). The study cohort was divided into subgroups, according to increasing tertiles of UA. The mean values of UA were 5.2 ± 1.6 mg/dL in the overall population. Pulse wave velocity was linearly correlated with UA (p < 0.0001), HOMA (p < 0.0001), high sensitivity C-reactive protein (p < 0.0001), systolic blood pressure (p < 0.0001) and LDL cholesterol (p = 0.005). Uric acid was the strongest predictor of PWV and was associated with the highest risk for increased AS. The interaction analysis showed that the joint effect of increased UA and HOMA was significantly higher than that expected in the absence of interaction under the additive model, indicating that the two biomarkers synergically interacted for promoting vascular damage. Our data showed that UA interacted with IR to increase AS in a large cohort of newly diagnosed, never-treated hypertensive patients.

scholarly journals COMPARATIVE ANALYSIS OF THE RESULTS IN ARTERIAL STIFFNESS BETWEEN TWO ASSESSMENT METHODS – SPHYGMOCOR AGAINST MOBIL-PULSE WAVE VELOCITY – IN HYPERTENSIVE PATIENTS

2021 ◽  
Vol 39 (Supplement 1) ◽  
pp. e114-e115
Author(s):  
João Marcos De M Zanatta ◽  
Fábio Dos S Ricardi ◽  
Tatiana De A Rubio ◽  
Elizabeth E S Cestário ◽  
Luciana N Cosenso-Martin ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Assessment Methods ◽  
Hypertensive Patients

scholarly journals Increased Arterial Stiffness in Adolescents With Obesity

2019 ◽  
Vol 6 ◽  
pp. 2333794X1983129
Author(s):  
Yvette E. Lentferink ◽  
Lisa A. J. Kromwijk ◽  
Marloes P. van der Aa ◽  
Catherijne A. J. Knibbe ◽  
Marja M. J. van der Vorst
Keyword(s):  
Insulin Resistance ◽  
Cardiovascular Disease ◽  
Risk Assessment ◽  
Cardiovascular Risk ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Cardiovascular Risk Assessment

Increased arterial stiffness (AS) is an early sign of cardiovascular disease. Influence of weight, puberty, and insulin resistance (IR) on AS in adolescents is unclear. Therefore, this study compared AS, assessed with pulse wave velocity (PWV) and augmentation index (AIx), of adolescents with and without obesity and evaluated the influence of puberty and IR on AS. Sixty-two lean and 61 adolescents with obesity were included. Significantly higher PWV was observed in adolescents with obesity (4.1 ms−1 [2.4 to 5.6 ms−1] vs 3.6 ms−1 [0.4 to 6.1 ms−1]; P = .01), while AIx was not significant different. However, significantly higher AIx was observed in adolescents with obesity and IR (3.0 [−17.5% to 28.5%] vs −3.0 [−19.0% to 13.0%]; P = .01). For Tanner stages, no differences were observed. The higher PWV in adolescents with obesity and higher AIx in adolescents with obesity and IR both indicate an increased AS. Consequently, measurement of AS should be considered in adolescents with obesity and IR as part of cardiovascular risk assessment.

scholarly journals ASSOCIATION BETWEEN URIC ACID AND PULSE WAVE VELOCITY IN HYPERTENSIVE PATIENTS AND GENERAL POPULATION: A SYSTEMATIC REVIEW AND META-ANALYSIS

2021 ◽  
Vol 39 (Supplement 1) ◽  
pp. e310
Author(s):  
Alessandro Maloberti ◽  
Paola Rebora ◽  
Anita Andreano ◽  
Nicola Triglione ◽  
Enrico Piccinelli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Uric Acid ◽  
General Population ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Meta Analysis ◽  
Hypertensive Patients

Is 24 hour central aortic pressure superior to single measurement of central aortic pressure in well controlled hypertensive patients

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
N Georgieva ◽  
A Borizanova-Petkova ◽  
E Kinova ◽  
A Goudev
Keyword(s):  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Systolic Pressure ◽  
Aortic Pressure ◽  
Single Measurement ◽  
Hypertensive Patients ◽  
Non Invasive ◽  
Central Aortic Pressure

Abstract Background Non-invasive measurements of 24 h ambulatory central aortic systolic pressure (24hCASP) is now feasible method than single measurement of CASP. There is growing interest in CASP as cardiovascular risk marker beyond conventional brachial blood pressure (BP). Pulse wave velocity estimates arterial stiffness, whereas CASP is representative of the BP in major organs. Purpose To evaluate non- invasive parameters for arterial stiffness using oscillometric method and to compare 24hCASP with single measurement of CASP in well-controlled hypertensive patients to detect target organ damage (TOD). Methods A total 95 patients (57±14 years) with hypertension, were separated in two groups: 22 patients with normal EA/Ees ratio (Arterial elastance (EA) and ventricular elastance (Ees)) and 73 hypertensive patients with decrease EA/Ees ratio, marker for ventriculo-arterial coupling. EA and Ees were calculated as and – systolic pressure/stroke volume and end-systolic pressure/end-systolic volume. Parameters for arterial stiffness – 24hCASP, ambulatory central systolic pressure (CASP), 24-hour pulse wave velocity (PWV24h) and ambulatory PWV were measured non-invasively with oscillometric method by Mobil-O-graph PWA. Results Statistically significant differences in parameters of vascular stiffness were found in patients with normal ventriculo-arterial coupling in comparison with disturbed EA/Ees: 24hCASP (107.64±9.19 vs. 116.64±16.7 mm Hg, p=0.02), CAP (117.45±9.26 vs. 128.42±16.15 mm Hg, p&lt;0.0001). There were no statistically significant differences in PWV and PWV24h. Multiple regression analysis demonstrated that CAP (B=−0.264 p=0.003; 95% CI: −0.003–0.014) is independent predictor of TOD in hypertensive patients, than 24 hour central aortic pressure. Conclusion There is no superiority of 24hCASP than single measurment of CASP. CASP could predict preclinical damage and cardiovascular outcome. Funding Acknowledgement Type of funding source: None

scholarly journals Body mass index influence the association between triglyceride-glucose index and atherosclerosis in community population: the cardiometabolic risk in Chinese (CRC) study

2020 ◽  
Author(s):  
Yun Wang ◽  
Qinqin Qiu ◽  
Xiangyu Meng ◽  
Xiu Zang ◽  
Xuekui Liu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Normal Weight ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Tyg Index

Abstract Background: Cardiovascular disease (CVD) is an universal problem in modern society. Atherosclerosis is the leading cause of CVD resulting in high rate of mortality in the population. The study aimed to examine the association of triglyceride-glucose (TyG) index, a novel marker of insulin resistance, with atherosclerosis in Chinese adults, and the effects of different body mass index (BMI) levels on this relationship.Methods: The study samples were from a community-based health examination survey in central China. A total of 4729 apparently healthy Chinese men and women were included. TyG index was calculated as ln[fasting triglycerides (mg/dL)×fasting glucose (mg/dL)/2]. Parameters of vascular damage, including carotid-femoral pulse wave velocity (cfPWV), carotid-radial pulse wave velocity (crPWV), carotid-dorsalis pedis pulse wave velocity (cdPWV) were measured.Results: After adjustment for conventional risk factors, TyG index was significantly associated with peripheral arterial stiffness (cdPWV>10.57cm/s or crPWV>11.12cm/s), however, TyG index was not associated with central arterial stiffness, measured by cfPWV. Moreover, we found significant interactions between TyG index and BMI in relation to crPWV and cdPWV. Risk for crPWV and cdPWV elevation was significantly decreased across increasing quartiles of TyG index under different BMI levels (P<0.001). There was a dose-response relationship of TyG index with crPWV and cdPWV in the normal-weight and overweight groups, with the most obvious in the normal-weight individuals. However, the dose-response relationship was not existed among the obesity group where the increase of TyG index did not significantly rise the risk of high crPWV and cdPWV.Conclusions: TyG index, a simple measure reflecting insulin resistance, might be useful to early identify individuals at a high risk of developing atherosclerosis. Increased BMI weakened the effect of TyG index on crPWV and cdPWV, indicating that the value of TyG index in assessing the risk of atherosclerosis in obese people maybe easily ignored, however, TyG index can better reflect the risk of atherosclerosis in normal-weight adults.

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