Cloudy Apple Juice Fermented by Lactobacillus Prevents Obesity Via Modulating Gut Microbiota and Protecting Intestinal Tract Health

Obesity and hyperglycemia are two serious chronic diseases that are increasing in incidence worldwide. This research aimed to develop a fermented cloudy apple juice with good hyperglycemia intervention activities. Here, cloudy apple juice (CAJ), cloudy apple juice rich in polyphenols (CAJP) and fermented cloudy apple juice rich in polyphenols (FCAJP) were prepared sequentially, and then the effects of the three apple juices on weight, lipid level, gut microbiota composition and intestinal tract health were evaluated for obese mice induced by a high-fat diet. The research findings revealed that the FCAJP showed potential to inhibit the weight gain of mice, reduce fat accumulation, and regulate the blood lipid levels of obese mice by decreasing the ratio of the Firmicutes/Bacteroidotas, improving the Sobs, Ace, and Chao indexes of the gut microbiota and protecting intestinal tract health. In addition, the FCAJP augmented the abundance of Akkermansia and Bacteroides, which were positively related to SCFAs in cecal contents. This study inferred that FCAJP could be developed as a healthy food for preventing obesity and hyperglycemia.

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Standardized hot water extract from the leaves of Hydrangea serrata (Thunb.) Ser. alleviates obesity via the AMPK pathway and modulation of the gut microbiota composition in high fat diet-induced obese mice

Food & Function ◽

10.1039/d0fo02185g ◽

2021 ◽

Author(s):

Hee-Soo Han ◽

Hwi-Ho Lee ◽

Hyo-Sun Gil ◽

Kyung-Sook Chung ◽

Jeon-Kyung Kim ◽

...

Keyword(s):

Gut Microbiota ◽

High Fat Diet ◽

Water Extract ◽

Hot Water ◽

Microbiota Composition ◽

Obese Mice ◽

Mtor Signaling Pathway ◽

High Fat ◽

Hot Water Extract ◽

Gut Microbiota Composition

WHS prevented the HFD-induced obesity via regulating AMPK and AKT/mTOR signaling pathway. WHS might be a potential dietary supplement for alleviating obesity.

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Uridine attenuates obesity, ameliorates hepatic lipid accumulation and modifies the gut microbiota composition in mice fed with a high-fat diet

Food & Function ◽

10.1039/d0fo02533j ◽

2021 ◽

Author(s):

Yilin Liu ◽

Chunyan Xie ◽

Zhenya Zhai ◽

Ze-yuan Deng ◽

Hugo R. De Jonge ◽

...

Keyword(s):

Gut Microbiota ◽

Lipid Accumulation ◽

High Fat Diet ◽

Microbiota Composition ◽

High Fat ◽

Fat Accumulation ◽

Hepatic Lipid ◽

Hepatic Lipid Accumulation ◽

Gut Microbiota Composition

This study aimed to investigate the effect of uridine on obesity, fat accumulation in liver, and gut microbiota composition in high-fat diet-fed mice.

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Yeast β-glucan reduces obesity-associated Bilophila abundance and modulates bile acid metabolism in healthy and high-fat diet mouse models

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.00226.2021 ◽

2021 ◽

Author(s):

Sik Yu So ◽

Qinglong Wu ◽

Kin Sum Leung ◽

Zuzanna Maria Kundi ◽

Tor C Savidge ◽

...

Keyword(s):

Bile Acid ◽

Gut Microbiota ◽

High Fat Diet ◽

Metabolic Health ◽

Metabolic Phenotype ◽

Bile Acid Metabolism ◽

Microbiota Composition ◽

High Fat ◽

Mrna Accumulation ◽

Gut Microbiota Composition

Emerging evidence links dietary fiber with altered gut microbiota composition and bile acid signaling in maintaining metabolic health. Yeast β-glucan (Y-BG) is a dietary supplement known for its immunomodulatory effect, yet its impact on the gut microbiota and bile acid composition remains unclear. This study investigated whether dietary forms of Y-BG modulate these gut-derived signals. We performed 4-week dietary supplementation in healthy mice to evaluate effects of different fiber composition (soluble vs particulate Y-BG) and dose (0.1 vs. 2%). We found that 2% particulate Y-BG induced robust gut microbiota community shifts with elevated liver Cyp7a1 mRNA abundance and bile acid synthesis. These diet-induced responses were notably different when compared to the prebiotic inulin, and included a marked reduction in fecal Bilophila abundance which we demonstrated as translatable to obesity in population-scale American Gut and TwinsUK clinical cohorts. This prompted us to test whether 2% Y-BG maintained metabolic health in mice fed 60% HFD over 13 weeks. Y-BG consistently altered the gut microbiota composition and reduced Bilophila abundance, with trends observed in improvement of metabolic phenotype. Notably, Y-BG improved insulin sensitization and this was associated with enhanced ileal Glpr1r mRNA accumulation and reduced Bilophila abundance. Collectively, our results demonstrate that Y-BG modulates gut microbiota community composition and bile acid signaling, but the dietary regime needs to be optimized to facilitate clinical improvement in metabolic phenotype in an aggressive high-fat diet animal model.

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Black rice anthocyanins alleviate hyperlipidemia, liver steatosis and insulin resistance by regulating lipid metabolism and gut microbiota in obese mice

Food & Function ◽

10.1039/d1fo01394g ◽

2021 ◽

Author(s):

Haizhao Song ◽

Xinchun Shen ◽

Yang Zhou ◽

Xiaodong Zheng

Keyword(s):

Insulin Resistance ◽

Lipid Metabolism ◽

Gut Microbiota ◽

Hepatic Steatosis ◽

High Fat Diet ◽

Liver Steatosis ◽

Obese Mice ◽

Black Rice ◽

High Fat ◽

Diet Induced Obesity

Supplementation of black rice anthocyanins (BRAN) alleviated high fat diet-induced obesity, insulin resistance and hepatic steatosis by improvement of lipid metabolism and modification of the gut microbiota.

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Lactobacillus rhamnosus strain LRH05 intervention ameliorated body weight gain and adipose inflammation via modulating the gut microbiota in high‐fat diet‐induced obese mice

Molecular Nutrition & Food Research ◽

10.1002/mnfr.202100348 ◽

2021 ◽

pp. 2100348

Author(s):

Yung‐Tsung Chen ◽

Shiou‐Yun Chiou ◽

Ai‐Hua Hsu ◽

Yu‐Chun Lin ◽

Jin‐Seng Lin

Keyword(s):

Body Weight ◽

Weight Gain ◽

Gut Microbiota ◽

High Fat Diet ◽

Body Weight Gain ◽

Lactobacillus Rhamnosus ◽

Obese Mice ◽

High Fat ◽

Adipose Inflammation

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Dietary wood pulp-derived sterols modulation of cholesterol metabolism and gut microbiota in high-fat-diet-fed hamsters

Food & Function ◽

10.1039/c8fo02271b ◽

2019 ◽

Vol 10 (2) ◽

pp. 775-785 ◽

Cited By ~ 13

Author(s):

Xiang Li ◽

Huali Wang ◽

Tianxin Wang ◽

Fuping Zheng ◽

Hao Wang ◽

...

Keyword(s):

Gut Microbiota ◽

High Fat Diet ◽

Metabolic Disorder ◽

Cholesterol Metabolism ◽

Wood Pulp ◽

Microbiota Composition ◽

High Fat ◽

Fecal Sterols ◽

Gut Microbiota Composition

Wood pulp-derived sterols (WS) supplementation ameliorated HFD-associated metabolic disorder; WS supplementation increased the amounts of fecal sterols excretion and SCFAs content; WS supplementation modulated gut microbiota composition.

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Anti-Obesity and Gut Microbiota Modulation Effect of Secoiridoid-Enriched Extract from Fraxinus mandshurica Seeds on High-Fat Diet-Fed Mice

Molecules ◽

10.3390/molecules25174001 ◽

2020 ◽

Vol 25 (17) ◽

pp. 4001

Author(s):

Sen Guo ◽

Haoan Zhao ◽

Zhongxiao Ma ◽

Shanshan Zhang ◽

Mingrou Li ◽

...

Keyword(s):

Gut Microbiota ◽

Pancreatic Lipase ◽

Inhibitory Activity ◽

High Fat Diet ◽

Obese Mice ◽

Modulation Effect ◽

Fraxinus Mandshurica ◽

High Fat ◽

Stress Injury ◽

Phytochemical Study

Previously we conducted a phytochemical study on the seeds of Fraxinus excelsior and isolated nine secoiridoid compounds with adipocyte differentiation inhibitory activity and peroxisome proliferator activated receptor alpha (PPARα) activation effects. However, the bioactive constituents and functions of Fraxinus mandshurica seeds have not been studied. In the present study, we investigated the secoiridoid compounds in F. mandshurica seed extract (FM) using column chromatography, 1H-NMR, 13C-NMR and HPLC-DAD methods. The pancreatic lipase inhibitory activities of isolated compounds were evaluated in vitro. Additionally, the anti-obesity and gut microbiota modulation effect of FM on high-fat diet-induced obesity in C57BL/6 mice were also studied in vivo. The results showed that 19 secoiridoids were isolated from FM and identified. The total content of secoiridoids in FM reached 181.35 mg/g and the highest content was nuzhenide (88.21 mg/g). All these secoiridoid compounds exhibited good pancreatic lipase inhibitory activity with inhibition rate ranged from 33.77% to 70.25% at the concentration of 100 μM. After obese mice were administrated with FM at 400 mg/kg.bw for 8 weeks, body weight was decreased by 15.81%. Moreover, FM could attenuate the lipid accumulation in serum and liver, relieve the damage in liver and kidney, and extenuate oxidative stress injury and inflammation caused by obesity in mice. FM could also modulate the structural alteration of gut microbiota in obese mice, increasing the proportion of anti-obesity gut microbiota (Bacteroidetes, Bacteroidia, S24-7 and Allobaculum), and reducing the proportion of obesogenic gut microbiota (Firmicutes and Dorea). This study suggests that F. mandshurica seeds or their secoiridoids may have potential for use as a dietary supplement for obesity management.

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Effect of A Polyphenol-Rich Canarium album Extract on the Composition of the Gut Microbiota of Mice Fed a High-Fat Diet

Molecules ◽

10.3390/molecules23092188 ◽

2018 ◽

Vol 23 (9) ◽

pp. 2188 ◽

Cited By ~ 5

Author(s):

Ning-Ning Zhang ◽

Wen-Hui Guo ◽

Han Hu ◽

A-Rong Zhou ◽

Qing-Pei Liu ◽

...

Keyword(s):

Gut Microbiota ◽

High Fat Diet ◽

High Throughput Sequencing ◽

Chow Diet ◽

Microbiota Composition ◽

High Fat ◽

Canarium Album ◽

Normal Chow ◽

Gut Microbiota Composition ◽

Medium Dose

This study investigated the influence of Canarium album extract (CAext) on intestinal microbiota composition of mice fed a high-fat diet (HFD). Kun Ming (KM) mice were fed either a normal chow diet or a HFD for six weeks. At the seventh week, HFD-fed mice were gavaged daily with saline, or a different dose of CAext for four weeks, respectively. Then, the composition of the gut microbiota was analyzed by high-throughput sequencing technology. Analysis of fecal microbial populations, grouped by phyla, showed significant increases of Firmicutes and Verrucomicrobia, but a decrease of Bacteroidetes in all CAext-fed mice. Particularly, CAext gavage in a low dose or a medium dose caused a significant increase in the proportion of Akkermansia. These findings suggested that CAext can alter the gut microbiota composition of HFD-fed mice, and had a potential prebiotic effects on Akkermansia.

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