scholarly journals Unveiling the Correlation between Inadequate Energy/Macronutrient Intake and Clinical Alterations in Volunteers at Risk of Metabolic Syndrome by a Predictive Model

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1377
Author(s):  
Francesca Danesi ◽  
Carlo Mengucci ◽  
Simona Vita ◽  
Achim Bub ◽  
Stephanie Seifert ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
At Risk ◽  
Predictive Model ◽  
Univariate Analysis ◽  
Macronutrient Intake ◽  
Dietary Recall ◽  
Reciprocal Influence ◽  
Complex Interactions ◽  
Dietary Reference Values

Although lifestyle-based interventions are the most effective to prevent metabolic syndrome (MetS), there is no definitive agreement on which nutritional approach is the best. The aim of the present retrospective analysis was to identify a multivariate model linking energy and macronutrient intake to the clinical features of MetS. Volunteers at risk of MetS (F = 77, M = 80) were recruited in four European centres and finally eligible for analysis. For each subject, the daily energy and nutrient intake was estimated using the EPIC questionnaire and a 24-h dietary recall, and it was compared with the dietary reference values. Then we built a predictive model for a set of clinical outcomes computing shifts from recommended intake thresholds. The use of the ridge regression, which optimises prediction performances while retaining information about the role of all the nutritional variables, allowed us to assess if a clinical outcome was manly dependent on a single nutritional variable, or if its prediction was characterised by more complex interactions between the variables. The model appeared suitable for shedding light on the complexity of nutritional variables, which effects could be not evident with univariate analysis and must be considered in the framework of the reciprocal influence of the other variables.

scholarly journals Role of peers and family with the occurrence of human immunodeficiency virus in the working area of Seberang Padang health center, Padang city

2019 ◽  
Vol 6 (4) ◽  
pp. 1393
Author(s):  
Oktariyani Dasril ◽  
Puteri Fannya
Keyword(s):  
At Risk ◽  
Human Immunodeficiency Virus ◽  
Health Center ◽  
Univariate Analysis ◽  
Chi Square ◽  
Poor Family ◽  
Immunodeficiency Virus ◽  
The Family ◽  
Control Study

Background: The occurrence of human immunodeficiency virus (HIV) in the Seberang Padang health center has increased every year. The role of coeval friends and family is one of the factors that influence HIV prevalence. This study aims to discover the role of peers and family with HIV occurrence in the area of the Seberang Padang health center.Methods: This type of research is observational analytic with case control study design. Time of study in October 2017. The population were all of HIV cases at Seberang Padang Health Center, 41 cases with a sample of 16 cases and 16 controls. Data collection uses a questionnaire. Univariate analysis using descriptive statistical method in the form of frequency distribution and percentage while bivariate with α 0.05 chi square test.Results: More than half (78.6%) of respondents have a poor peer role, more than half (71.4%) respondents have a poor family role. There was a relationship between the role of peers and the role of the family with HIV. People with poor family roles are 15 times at risk for HIV incidence and 9 times at risk if they have a poor peer roles.Conclusions: Peers and family have an important role in shaping a person's behavior, thus increasing the risk of suffering from HIV. Seberang Padang Puskesmas officers are advised to educate families to always act as the most active group to remind respondents to maintain health and keep away from anything that can damage their health and avoid HIV.

scholarly journals Pfetin as a Risk Factor of Recurrence in Gastrointestinal Stromal Tumors

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Hajime Orita ◽  
Tomoaki Ito ◽  
Tomoyuki Kushida ◽  
Mutsumi Sakurada ◽  
Hiroshi Maekawa ◽  
...  
Keyword(s):  
Predictive Model ◽  
Gastrointestinal Stromal Tumors ◽  
Abdominal Cavity ◽  
Univariate Analysis ◽  
Risk Of Recurrence ◽  
Stromal Tumors ◽  
Primary Gist ◽  
Grade Of Malignancy ◽  
Complete Tumor

Background. Despite complete resection of gastrointestinal stromal tumors (GIST), recurrent and/or metastatic disease occurs, often depending on the grade of malignancy. As such, markers are needed that accurately predict patients at high risk for recurrence. Previously our group reported Pfetin as a prognostic biomarker for GIST. In order to create an approach for predicting risk of recurrence, we incorporated Pfetin expression with clinicopathological data to produce a predictive model.Object. Forty-five patients with localized primary GIST were treated with complete gross surgical resection surgically at our institution between 1995 and 2010 were included. The majority of tumors originated in the stomach (38 cases), as well as small intestine (6 cases) and rectum (1 case).Method. (1) We performed retrospective analysis of the connection between Pfetin expression, clinicopathological data, and incidences of recurrence, using bivariate and multivariate analyses. (2) The reactivity of the monoclonal antibody against Pfetin was examined by immunohistochemistry.Pfetin. We have reported Pfetin, identified microarray technology, and compared between statistically different GISTs for good and poor prognoses and for prognostic marker.Results. There were 7 cases of recurrences. (1) By univariate analysis, tumor size, mitoses, exposure to abdominal cavity, and complete tumor removal predicted risk of recurrence. (2) Pfetin-negative cases were significantly related to recurrence (P= 0.002).Conclusions. This analysis demonstrates that lack of Pfetin expression is an additional predictor of recurrence in resected GIST. Further study may determine the role of this variable added to the current predictive model for selection of adjuvant therapy.

Home-Based Exercise May Not Decrease the Insulin Resistance in Individuals With Metabolic Syndrome

2015 ◽  
Vol 12 (1) ◽  
pp. 74-79 ◽  
Author(s):  
Chiao-Nan Chen ◽  
Lee-Ming Chuang ◽  
Mallikarjuna Korivi ◽  
Ying-Tai Wu
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
At Risk ◽  
Self Efficacy ◽  
Exercise Intervention ◽  
Univariate Analysis ◽  
Exercise Program ◽  
Supervised Exercise ◽  
Home Based ◽  
Before And After

Background:This study investigated the differences in exercise self-efficacy, compliance, and effectiveness of home-based exercise in individuals with and without metabolic syndrome (MetS).Methods:One hundred and ten individuals at risk for diabetes participated in this study. Subjects were categorized into individuals with MetS and individuals without MetS. Metabolic risk factors and exercise self-efficacy were evaluated for all subjects before and after 3 months of home-based exercise. Univariate analysis of variance was used to compare the effectiveness of a home-based exercise program between individuals with and without MetS.Results:The home-based exercise program improved body mass index and lipid profile in individuals at risk for diabetes, regardless of MetS status at baseline. Individuals without MetS had higher exercise self-efficacy at baseline and performed greater exercise volume compared with individuals with MetS during the intervention. The increased exercise volume in individuals without MetS may contribute to their better control of insulin resistance than individuals with MetS. Furthermore, baseline exercise self-efficacy was correlated with exercise volume executed by subjects at home.Conclusions:We conclude that home-based exercise programs are beneficial for individuals at risk for diabetes. However, more intensive and/or supervised exercise intervention may be needed for those with MetS.

Growth hormone and IGFBP-3 but not IGF-1 are independent predictors of insulin sensitivity in healthy subjects: on the role of hGH in the metabolic syndrome

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
MA Arafat ◽  
F Perschel ◽  
C Schöfl ◽  
M Weickert ◽  
J Purschwitz ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Growth Hormone ◽  
Insulin Sensitivity ◽  
Healthy Subjects ◽  
The Metabolic Syndrome ◽  
Igfbp 3

Glucocorticoid-induced metabolic syndrome: establishing the role of AgRP

2018 ◽  
Author(s):  
Charlotte Sefton ◽  
Erika Harno ◽  
Alison Davies ◽  
Tiffany-Jayne Allen ◽  
Jonathan R Wray ◽  
...  
Keyword(s):  
Metabolic Syndrome

Role of blood catecholamine in cases with dysmetablolic iron overload syndrome (DIOS) in patients of Metabolic Syndrome

2019 ◽  
Author(s):  
Hany William Z Hanna ◽  
F El-Mougy ◽  
Heba N Baz ◽  
Haddad Hemmat E El
Keyword(s):  
Metabolic Syndrome ◽  
Iron Overload

The role of omentin in inflammation and metabolic syndrome risk assessment in women with PCO-S

2019 ◽  
Author(s):  
Iwona Zieleń-Zynek ◽  
Joanna Kowalska ◽  
Nowak Justyna ◽  
Barbara Zubelewicz-Szkodzińska
Keyword(s):  
Risk Assessment ◽  
Metabolic Syndrome

Role of genetic factors in the development of hypertension in young patients with metabolic syndrome

2020 ◽  
pp. 23-32
Author(s):  
Elena Korneeva ◽  
Mikhail Voevoda ◽  
Sergey Semaev ◽  
Vladimir Maksimov
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Arterial Hypertension ◽  
Genetic Factors ◽  
Young Patients ◽  
Integrin Αiibβ3 ◽  
Ace Gene ◽  
The Metabolic Syndrome

Results of the study related to polymorphism of ACE gene (rs1799752)‎, integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).

The Potential Role of Antioxidants in Metabolic Syndrome

2016 ◽  
Vol 22 (7) ◽  
pp. 859-869 ◽  
Author(s):  
Bianca Martins Gregório ◽  
Diogo Benchimol De Souza ◽  
Fernanda Amorim de Morais Nascimento ◽  
Leonardo Matta ◽  
Caroline Fernandes-Santos
Keyword(s):  
Metabolic Syndrome ◽  
Potential Role

Dietary Carotenoids in Managing Metabolic Syndrome and Role of PPARs in the Process

2020 ◽  
Vol 16 (6) ◽  
pp. 846-853
Author(s):  
Raghunandan Purohith ◽  
Nagendra P.M. Nagalingaswamy ◽  
Nanjunda S. Shivananju
Keyword(s):  
Metabolic Syndrome ◽  
Dietary Intervention ◽  
Bioactive Constituents ◽  
Dietary Antioxidants ◽  
Predisposing Factor ◽  
Beneficial Effects ◽  
Pathological Conditions ◽  
Established Relationship ◽  
Comprehensive Study

Metabolic syndrome is a collective term that denotes disorder in metabolism, symptoms of which include hyperglycemia, hyperlipidemia, hypertension, and endothelial dysfunction. Diet is a major predisposing factor in the development of metabolic syndrome, and dietary intervention is necessary for both prevention and management. The bioactive constituents of food play a key role in this process. Micronutrients such as vitamins, carotenoids, amino acids, flavonoids, minerals, and aromatic pigment molecules found in fruits, vegetables, spices, and condiments are known to have beneficial effects in preventing and managing metabolic syndrome. There exists a well-established relationship between oxidative stress and major pathological conditions such as inflammation, metabolic syndrome, and cancer. Consequently, dietary antioxidants are implicated in the remediation of these complications. The mechanism of action and targets of dietary antioxidants as well as their effects on related pathways are being extensively studied and elucidated in recent times. This review attempts a comprehensive study of the role of dietary carotenoids in alleviating metabolic syndromewith an emphasis on molecular mechanism-in the light of recent advances.

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