scholarly journals Fatty Acid Metabolism in Carriers of Apolipoprotein E Epsilon 4 Allele: Is It Contributing to Higher Risk of Cognitive Decline and Coronary Heart Disease?

Nutrients ◽  
2014 ◽  
Vol 6 (10) ◽  
pp. 4452-4471 ◽  
Author(s):  
Raphaël Chouinard-Watkins ◽  
Mélanie Plourde
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Fatty Acid ◽  
Cognitive Decline ◽  
Apolipoprotein E ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism

scholarly journals Assessment of Myocardial Perfusion and Fatty Acid Metabolism in a Patient With Churg-Strauss Syndrome Associated With Eosinophilic Heart Disease

2004 ◽  
Vol 68 (6) ◽  
pp. 595-598 ◽  
Author(s):  
Nobuaki Shikama ◽  
Tomoo Nakagawa ◽  
Yasuo Takiguchi ◽  
Nobuyuki Aotsuka ◽  
Yoichi Kuwabara ◽  
...  
Keyword(s):  
Heart Disease ◽  
Fatty Acid ◽  
Myocardial Perfusion ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Churg Strauss Syndrome ◽  
Strauss Syndrome ◽  
Churg Strauss

Myocardial Fatty Acid Metabolism in Health and Disease

2010 ◽  
Vol 90 (1) ◽  
pp. 207-258 ◽  
Author(s):  
Gary D. Lopaschuk ◽  
John R. Ussher ◽  
Clifford D. L. Folmes ◽  
Jagdip S. Jaswal ◽  
William C. Stanley
Keyword(s):  
Fatty Acids ◽  
Heart Disease ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Contractile Activity ◽  
Myocardial Fatty Acid ◽  
Cardiac Pathology ◽  
Energy Demands ◽  
Obesity And Diabetes

There is a constant high demand for energy to sustain the continuous contractile activity of the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of fatty acid β-oxidation is complex and is aimed at ensuring that the supply and oxidation of the fatty acids is sufficient to meet the energy demands of the heart. The metabolism of fatty acids via β-oxidation is not regulated in isolation; rather, it occurs in response to alterations in contractile work, the presence of competing substrates (i.e., glucose, lactate, ketones, amino acids), changes in hormonal milieu, and limitations in oxygen supply. Alterations in fatty acid metabolism can contribute to cardiac pathology. For instance, the excessive uptake and β-oxidation of fatty acids in obesity and diabetes can compromise cardiac function. Furthermore, alterations in fatty acid β-oxidation both during and after ischemia and in the failing heart can also contribute to cardiac pathology. This paper reviews the regulation of myocardial fatty acid β-oxidation and how alterations in fatty acid β-oxidation can contribute to heart disease. The implications of inhibiting fatty acid β-oxidation as a potential novel therapeutic approach for the treatment of various forms of heart disease are also discussed.

scholarly journals ZiBuPiYin Recipe Prevented and Treated Cognitive Decline in ZDF Rats With Diabetes-Associated Cognitive Decline via Microbiota–Gut–Brain Axis Dialogue

2021 ◽  
Vol 9 ◽  
Author(s):  
Tingting Bi ◽  
Ruiqi Feng ◽  
Libin Zhan ◽  
Weiming Ren ◽  
Xiaoguang Lu
Keyword(s):  
Fatty Acid ◽  
Gut Microbiota ◽  
Cognitive Decline ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Neurological Diseases ◽  
Metabolic Changes ◽  
Protective Mechanisms ◽  
Prevention And Treatment ◽  
Zdf Rats

Gut microbiota is becoming one of the key determinants in human health and disease. Shifts in gut microbiota composition affect cognitive function and provide new insights for the prevention and treatment of neurological diseases. Diabetes-associated cognitive decline (DACD) is one of the central nervous system complications of type 2 diabetes mellitus (T2DM). ZiBuPiYin recipe (ZBPYR), a traditional Chinese medicine (TCM) formula, has long been used for the treatment of T2DM and prevention of DACD. However, the contribution of ZBPYR treatment to the interaction between the gut microbiota and metabolism for preventing and treating DACD remains to be clarified. Here, we investigate whether the gut microbiota plays a key role in ZBPYR-mediated prevention of DACD and treatment of T2DM via incorporating microbiomics and metabolomics, and investigate the links between the microbiota–gut–brain axis interaction and the efficacy of ZBPYR in ZDF rats. In the current study, we found that ZBPYR treatment produced lasting changes in gut microbiota community and metabolites and remotely affected hippocampus metabolic changes, thereby improving memory deficits and reversing β-amyloid deposition and insulin resistance in the brain of ZDF rats from T2DM to DACD. This may be related to a series of metabolic changes affected by gut microbiota, including alanine, aspartic acid, and glutamic acid metabolism; branched-chain amino acid metabolism; short-chain fatty acid metabolism; and linoleic acid/unsaturated fatty acid metabolism. In summary, this study demonstrates that prevention and treatment of DACD by ZBPYR partly depends on the gut microbiota, and the regulatory effects of bacteria-derived metabolites and microbiota–gut–brain axis are important protective mechanisms of ZBPYR.

The Influence of Lactate and Dipyridamole on Myocardial Fatty Acid Metabolism in Man, Traced with 123l-17-lodo-heptadecanoic Acid

1990 ◽  
Vol 29 (01) ◽  
pp. 28-34 ◽  
Author(s):  
F. C. Visser ◽  
M. J. van Eenige ◽  
G. Westera ◽  
J. P. Roos ◽  
C. M. B. Duwel
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Time Activity ◽  
Time Value ◽  
Myocardial Fatty Acid Metabolism ◽  
Coronary Vasodilatation ◽  
Activity Curve ◽  
Normal Human ◽  
Plasma Lactate Level

Changes in myocardial metabolism can be detected externally by registration of time-activity curves after administration of radioiodinated fatty acids. In this scintigraphic study the influence of lactate on fatty acid metabolism was investigated in the normal human myocardium, traced with 123l-17-iodoheptadecanoic acid (123l-17-HDA). In patients (paired, n = 7) lactate loading decreased the uptake of 123l-17-HDA significantly from 27 (control: 22-36) to 20 counts/min/pixel (16-31; p <0.05 Wilcoxon). The half-time value increased to more than 60 rriin (n = 5), oxidation decreased from 61 to 42%. Coronary vasodilatation, a well-known side effect of lactate loading, was studied separately in a dipyridamole study (paired, n = 6). Coronary vasodilatation did not influence the parameters of the time-activity curve. These results suggest that changes in plasma lactate level as occurring, among other effects, during exercise will influence the parameters of dynamic 123l-17-HDA scintigraphy of the heart.

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