scholarly journals Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Sarah Al-Maawi ◽  
Kathrin Becker ◽  
Frank Schwarz ◽  
Robert Sader ◽  
Shahram Ghanaati
Keyword(s):  
Wound Healing ◽  
Soft Tissue ◽  
Tooth Extraction ◽  
Meta Analysis ◽  
Platelet Rich Fibrin ◽  
Hand Search ◽  
Healing Period ◽  
Thomson Reuters ◽  
Tissue Healing ◽  
Pubmed Database

Abstract Purpose To address the focused question: in patients with freshly extracted teeth, what is the efficacy of platelet-rich fibrin (PRF) in the prevention of pain and the regeneration of soft tissue and bone compared to the respective control without PRF treatment? Methods After an electronic data search in PubMed database, the Web of Knowledge of Thomson Reuters and hand search in the relevant journals, a total of 20 randomized and/or controlled studies were included. Results 66.6% of the studies showed that PRF significantly reduced the postoperative pain, especially in the first 1–3 days after tooth extraction. Soft tissue healing was significantly improved in the group of PRF compared to the spontaneous wound healing after 1 week (75% of the evaluated studies). Dimensional bone loss was significantly lower in the PRF group compared to the spontaneous wound healing after 8–15 weeks but not after 6 months. Socket fill was in 85% of the studies significantly higher in the PRF group compared to the spontaneous wound healing. Conclusions Based on the analyzed studies, PRF is most effective in the early healing period of 2–3 months after tooth extraction. A longer healing period may not provide any benefits. The currently available data do not allow any statement regarding the long-term implant success in sockets treated with PRF or its combination with biomaterials. Due to the heterogeneity of the evaluated data no meta-analysis was performed.

scholarly journals The Effectiveness of Advanced Platelet-Rich Fibrin in comparison with Leukocyte-Platelet-Rich Fibrin on Outcome after Dentoalveolar Surgery

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Alaa Z. Makki ◽  
Anoud M. Alsulami ◽  
Arwa S. Almatrafi ◽  
Moroj Z. Sindi ◽  
Shahinaz N. Sembawa
Keyword(s):  
Soft Tissue ◽  
Tooth Extraction ◽  
Control Group ◽  
Soft Tissue Healing ◽  
Control Groups ◽  
Platelet Rich Fibrin ◽  
Healing Index ◽  
Tissue Healing ◽  
Surgical Extraction ◽  
And Control

Background and Purpose. Some physiological changes may occur following tooth extraction, and symptoms during the postextraction period may affect the patient’s quality of life. Many techniques have been developed to improve postextraction pain and soft tissue healing. Accordingly, this study will compare the postextraction pain and early soft tissue healing characteristics of extraction sites treated with leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF). The aim is to evaluate the effect of advanced PRF in comparison with L-PRF on soft tissue healing and pain after teeth extraction and to advice dental practitioner to use the advanced PRF in clinic to enhance soft tissue healing and decrease pain. Methods. The study included 60 patients according to sample size calculation, recruited from patients seeking tooth extraction at oral and maxillofacial surgery clinic at Umm Al-Qura University, Faculty of Dentistry. Patients were divided into three groups. Group Ӏ included 20 patients managed by advanced platelet-rich fibrin after extraction. Group ӀӀ included 20 patients managed by leukocyte-platelet-rich fibrin after tooth extraction. Group ӀII included 20 patients left without any addition. Each group was further subdivided into surgical and nonsurgical extraction. Afterwards, patients in each group were assessed for postextraction pain by VAS, number of analgesics, and early soft tissue healing by LWHI. Results. The study outcomes demonstrate that the use of A-PRF significantly reduces postoperative pain in the 1st and 2nd day. VAS pain scores on the first day were significantly higher in the control surgical extraction group and L-PRF nonsurgical extraction group. In early soft tissue healing. The Landry Wound Healing Index (LWHI) was used after 1 and 2 weeks of extraction to evaluate the extraction site. In first week, the A-PRF group and L-PRF group (nonsurgical extraction) had a better healing index when compared to control group, and A-PRF group (surgical extraction) had a best healing index when compared to L-PRF and control groups. In the second week, individuals in the A-PRF group (surgical and nonsurgical extraction) had a better healing index when compared to L-PRF and control groups.

scholarly journals Effectiveness of Platelet-Rich Fibrin as an Adjunctive Material to Bone Graft in Maxillary Sinus Augmentation: A Meta-Analysis of Randomized Controlled Trails

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Ruimin Liu ◽  
Mingdong Yan ◽  
Sulin Chen ◽  
Wenxiu Huang ◽  
Dong Wu ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Bone Formation ◽  
Bone Graft ◽  
Bone Substitute ◽  
Meta Analysis ◽  
New Bone Formation ◽  
Sinus Augmentation ◽  
Platelet Rich Fibrin ◽  
Randomized Controlled ◽  
Tissue Area

Purpose. To date, it remains unknown whether the addition of platelet-rich fibrin (PRF) to bone grafts actually improves the effectiveness of maxillary sinus augmentation. This study aimed to perform a meta-analysis to evaluate the efficacy of PRF in sinus lift.Materials and Methods. PubMed, Embase, and the Cochrane Library were searched. Randomized controlled studies were identified. The risk of bias was evaluated using the Cochrane Collaboration tool.Results. Five RCTs were included in our meta-analysis. Clinical, radiographic, and histomorphometric outcomes were considered. No implant failure or graft failure was detected in all included studies within the follow-up period. The percentage of contact length between newly formed bone substitute and bone in the PRF group was lower but lacked statistical significance (3.90%, 95% CI, -2.91% to 10.71%). The percentages of new bone formation (-1.59%, 95% CI, -5.36% to 2.18%) and soft-tissue area (-3.73%, 95% CI, -10.11% to 2.66%) were higher in the PRF group but were not significantly different. The percentage of residual bone graft was not significant in either group (4.57%, 95% CI, 0% to 9.14%).Conclusions. Within the limitations of this review, it was concluded that there were no statistical differences in survival rate, new bone formation, contact between newly formed bone and bone substitute, percentage of residual bone graft (BSV/TV), and soft-tissue area between the non-PRF and PRF groups. Current evidence supporting the necessity of adding PRF to bone graft in sinus augmentation is limited.

scholarly journals Platelet-Rich Fibrin in third molar surgery. Systematic review and meta-analysis protocol

2020 ◽  
Author(s):  
Gaston Salas ◽  
Shuheng Lai ◽  
Francisca Verdugo-Paiva ◽  
Roberto Requena
Keyword(s):  
Systematic Review ◽  
Wound Healing ◽  
Meta Analysis ◽  
Grey Literature ◽  
Third Molar ◽  
Risk Of Bias ◽  
Third Molar Surgery ◽  
Cochrane Central Register ◽  
Eligibility Criteria ◽  
Platelet Rich Fibrin

Objective: The objective of this systematic review is to assess the effectiveness and safety of platelet rich fibrin (PRF) in third molar surgery. Data sources: A comprehensive search strategy is meant to be used in an attempt to identify all relevant RCTs, ongoing investigation reported in specialty congresses and trials regardless of language or publication status (published, unpublished, in press, and in progress). Search will be conducted in The Cochrane Central Register of Controlled Trials (CENTRAL); PUBMED; Embase; Lilacs, and also conduct a search through trial registries of the International Clinical Trials Registry Platform (ICTRP), Word Health Organization (WHO) and the ClinicalTrials.gov, US National Institutes of Health (NIH), grey literature search and specialty congress will be reviewed. Eligibility criteria: We will include randomised trials evaluating the effect of PRF on wound healing after third molar surgery. Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias using Cochrane 'risk of bias' tool. We will pool the results using meta-analysis and will apply the GRADE system to assess the certainty of the evidence for each outcome. Ethics and dissemination: As researchers will not access information that could lead to the identification of an individual participant, obtaining ethical approval was waived. Keywords: platelet-rich fibrin; third molars; wound healing; systematic review

COMPARISON OF POST EXTRACTION SOCKET HEALING WITH AND WITHOUT USING PLATELET RICH FIBRIN (PRF) – A CLINICAL AND RADIOGRAPHIC STUDY

2021 ◽  
pp. 62-65
Author(s):  
S.P. Indra Kumar ◽  
Kavin T ◽  
Narendar R ◽  
E. Gayathri Priyadharshini ◽  
Akshaya murugan ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Maxillofacial Surgery ◽  
Test Group ◽  
Control Group ◽  
Oral And Maxillofacial Surgery ◽  
Soft Tissue Healing ◽  
Extraction Socket ◽  
Platelet Rich Fibrin ◽  
Tissue Healing ◽  
Socket Healing

AIM: The aim of this study is to comparatively evaluate the post extraction socket healing clinically and radiographically with and without using Platelet Rich Fibrin (PRF). MATERIALS AND METHODS: Fifty, otherwise healthy individuals undergoing dental treatment in the department of Oral and Maxillofacial surgery, Vivekananda Dental College for women, Thiruchengode, were randomly selected and the participants were divided into two groups – test group(PRF, n=25) and control group (Blood clot, n=25). Blood was freshly obtained from the participants of the test group and PRF was prepared. PRF was placed in the sockets of the test group and followed by the pressure application and suturing. Control group were allowed to heal naturally. Clinically, soft tissue healing and socket closure were assessed. Radiographic analysis of socket healing done by comparison of pre- and post-operative radiographs. The clinical follow-up assessments were done at an interval of 3 days, 1 week and 4 weeks and the data obtained were assessed. The patients were aged above 18 years, i RESULT: ncluding 33 females and 17 males. The soft tissue and socket healing were higher in the test group when compared with the control group clinically and the mean proportion of radiographic bone ll was signicantly higher in the test group in all the time intervals of 3 days, 1 week and 4 weeks, respectively. Outcome of the study CONCLUSION: demonstrate that the PRF placement in the extraction socket accelerates soft tissue healing and socket healing and increases the bone ll and reduces the bone resorption using clinical and radiographic methods.

Laser-assisted uncovering of dental implants

2020 ◽  
Author(s):  
Farnoosh Razmara ◽  
Rezvaneh Ghazanfari ◽  
Ghazal Shabankare
Keyword(s):  
Soft Tissue ◽  
Dental Implants ◽  
Temperature Rise ◽  
Keyword Search ◽  
Ex Vivo ◽  
Soft Tissue Healing ◽  
Medical Subject Headings ◽  
Healing Period ◽  
Tissue Healing ◽  
Lower Temperature

Introduction: Laser assisted uncovering of dental implants is one of the most interesting aspects of lasers utilization. Compared to conventional scalpel technique, this method provides less bleeding and pain and shorter healing period, leading to a better patient compliance. The objective of this study is to contribute a comprehensive review on laser assisted second-stage of implant surgery. Materials and Methods: We searched Pubmed and Google Scholar databases using combined keyword search or medical subject headings. Eight articles from 2009 to 2019 were identified and assessed. Results: Selected studies were categorized according to variables including amount of pain, need for anesthesia, soft tissue healing, temperature rise and quality of impressions. All the reviewed articles, measuring the amount of required anesthesia, agreed that laser-aided uncovering of implants needs significantly less anesthesia compared to conventional scalpel technique. Laser-assisted uncovering of their implants led to less pain. Ex-vivo studies measuring temperature rise, suggested that application of a non-contact 445nm diode laser reduces the temperature rise significantly. However, Er:YAG lasers proved to generate lower temperature rise. Diode lasers showed no significant amelioration of soft tissue healing whilst Er:YAG and Er,Cr:YSGG lasers revealed superior esthetic results and shorter healing period. Impressions can be taken 4-7 days after the laser-assisted surgery with a satisfactory quality. Conclusion: Laser-assisted uncovering of implants can be selected as an alternative over the conventional scalpel technique. But, further studies are advisable

scholarly journals Early Implant Placement with Delayed Loading in Anterior Aesthetic Zone - A Case Report

2020 ◽  
Vol 4 (2) ◽  
pp. 89-92
Author(s):  
Manoj Humagain ◽  
Simant Lamichhane ◽  
Mahima Subba ◽  
Manisha Neupane ◽  
Asmita Dawadi
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Tooth Extraction ◽  
Tissue Loss ◽  
Bone Augmentation ◽  
Numbering System ◽  
Implant Placement ◽  
Tissue Healing ◽  
Natural Dentition ◽  
Soft Tissue Loss

To prevent the sequelae of hard and soft tissue loss after tooth extraction, future need of bone augmentation procedures and utilisation of benefits during early stages of tissue healing, early implant promises to be an armoury for dental implantologists to perfectly simulate the natural dentition in anterior aesthetic areas. Here, a case of 30 years old male with a missing #11 (according to two-digit numbering system) planned for early implant placement and immediate temporisation with delayed loading is presented.

The Benefits of Platelet-Rich Fibrin in Promoting Post-Extraction Healing

2018 ◽  
Vol 68 (12) ◽  
pp. 2974-2977
Author(s):  
Cherana Gioga ◽  
Edwin Sever Bechir ◽  
Farah Curt Mola ◽  
Carmen Liliana Defta ◽  
Anamaria Bechir ◽  
...  
Keyword(s):  
Wound Healing ◽  
Pain Intensity ◽  
Local Anesthesia ◽  
Control Group ◽  
Analog Scale ◽  
Post Intervention ◽  
Platelet Rich Fibrin ◽  
Healing Period

The aim of this study was to evaluate pain intensity and wound healing of the post-extraction sites after the use of Platelet-Rich Fibrin (PRF). 240 patients which needed difficult or multiple extractions were included in the study. The extractions were realized under local anesthesia, with piezotome and pliers. The patients were divided in two groups, the first group of 120 patients which benefited the application of PRF in the post-extraction alveoli, and the second group of 120 patients represented the control group (without application of PRF). A questionnaire was realized after a VAS analog scale and was used to quantify the post-intervention pain intensity in the postoperative four days. The assessment of the post-extraction sites healing period was performed clinically. According to the obtained results, the healing period of the post-extraction sites was shorter in the patients of first group (PRF), compared to the sites of control group patients. No postextractional healing complications occurred in the patients of first group/PRF. The study demonstrated the benefits of PRF insertion in post-intervention healing.

scholarly journals Does Platelet-Rich Fibrin Decrease Dimensional Changes and Improve Postoperative Comfort in Post-Extraction Sockets? An Overview of Systematic Reviews

2020 ◽  
Vol 10 (17) ◽  
pp. 5750 ◽  
Author(s):  
Vittorio Moraschini ◽  
Carlos Fernando de Almeida Barros Mourão ◽  
Rafael Coutinho de Mello Machado ◽  
Jhonathan Raphaell Barros Nascimento ◽  
Kayvon Javid ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Bone Regeneration ◽  
Systematic Reviews ◽  
Selection Process ◽  
Soft Tissue Healing ◽  
Socket Preservation ◽  
Platelet Rich Fibrin ◽  
Dimensional Changes ◽  
Tissue Healing ◽  
The Impact

This overview aimed to evaluate the methods, quality, and outcomes of systematic reviews (SRs) conducted to investigate the effects of platelet-rich fibrin (PRF) in dental sockets on promoting bone regeneration and soft tissue healing and diminishing the incidence of pain, swelling, trismus, and alveolar osteitis after tooth extraction. An electronic search without date or language restriction was done in PubMed/MEDLINE, Cochrane, and Web of Science until March 2020. Eligibility criteria included SRs that assessed the effect of PRF for human alveolar socket preservation. The quality assessment of the included studies was performed using AMSTAR 2 guidelines. The protocol of this overview was recorded in PROSPERO under the number CRD42018089617. The search and selection process yielded 13 studies published between 2011 and 2018. The analysis of the studies showed inconclusive data for the effect of the PRF and the dimensional changes. There is no definitive evidence for the impact of using PRF alone on bone regeneration in post-extraction sockets. The use of PRF improves soft tissue healing and reduces pain, bleeding, and osteitis in post-extraction sockets.

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