scholarly journals Chemical Characterization and Biological Evaluation of New Cobalt(II) Complexes with Bioactive Ligands, 2-Picolinehydroxamic Acid and Reduced Schiff Base N-(2-Hydroxybenzyl)alanine, in Terms of DNA Binding and Antimicrobial Activity

2021 ◽  
Vol 14 (12) ◽  
pp. 1254
Author(s):  
Magdalena Woźniczka ◽  
Marta Lichawska ◽  
Manas Sutradhar ◽  
Magdalena Chmiela ◽  
Weronika Gonciarz ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Schiff Base ◽  
Dna Binding ◽  
Metal Ion ◽  
Binary Systems ◽  
Biological Evaluation ◽  
Cell Nuclei ◽  
Gram Negative ◽  
Heteroligand Complexes ◽  
Reduced Schiff Base

Five new heteroligand cobalt(II) complexes with 2-picolinehydroxamic acid and reduced Schiff base, N-(2-hydroxybenzyl)alanine, were formed in an aqueous solution over a wide pH range. The coordination properties of ligands towards the metal ion were determined using a pH-metric method, and then the speciation model was confirmed by UV–Vis studies. A stacking interaction between the Schiff base phenol ring and the 2-picolinehydroxamic acid pyridine ring was found to improve the stability of the heteroligand species, indicating more effective coordination in mixed-ligand complexes than in their respective binary systems. The antimicrobial properties of heteroligand complexes were determined against Gram-negative and Gram-positive bacteria, as well as fungal strains. The formulation demonstrated the highest bacteriostatic and bactericidal activity (3.65 mM) against two strains of Gram-negative Helicobacter pylori bacteria and towards Candida albicans and Candida glabrata; this is important due to the potential co-existence of these microorganisms in the gastric milieu and their role in the development of gastritis. The binary complexes in the cobalt(II)—2-picolinehydroxamic acid system and 2-picolinehydroxamic acid were not cytotoxic against L929 mouse fibroblasts, neither freshly prepared solutions or after two weeks’ storage. By comparison, the heteroligand complexes within the range 0.91–3.65 mM diminished the metabolic activity of L929 cells, which was correlated with increased damage to cell nuclei. The concentration of the heteroligand species increased over time; therefore, the complexes stored for two weeks exhibited stronger anticellular toxicity than the freshly prepared samples. The complexes formed in an aqueous solution under physiological pH effectively bound to calf thymus DNA in an intercalative manner. This DNA-binding ability may underpin the antimicrobial/antifungal activity of the heteroligand complexes and their ability to downregulate the growth of eukaryotic cells.

scholarly journals Ni(II) Dimers of NNO Donor Tridentate Reduced Schiff Base Ligands as Alkali Metal Ion Capturing Agents: Syntheses, Crystal Structures and Magnetic Properties

2018 ◽  
Vol 4 (4) ◽  
pp. 51 ◽  
Author(s):  
Monotosh Mondal ◽  
Maharudra Chakraborty ◽  
Michael G. B. Drew ◽  
Ashutosh Ghosh
Keyword(s):  
Schiff Base ◽  
Metal Ion ◽  
Magnetic Measurements ◽  
Dft Method ◽  
Distorted Octahedral Geometry ◽  
Schiff Base Ligands ◽  
Reduced Schiff Base ◽  
Ferromagnetic Interactions ◽  
Experimental Values ◽  
Reduced Schiff Base Ligands

Three trinuclear Ni(II)-Na(I) complexes,[Ni2(L1)2NaCl3(H2O)]·H2O (1), [Ni2(L2)2NaCl3(H2O)] (2), and [Ni2(L3)2NaCl3(OC4H10)] (3) have been synthesized using three different NNO donor tridentate reduced Schiff base ligands, HL1= 2-[(3-methylamino-propylamino)-methyl]-phenol, HL2= 2-[(3-methylamino-propylamino)-methyl]-4-chloro-phenol, and HL3= 2-[(3-methylamino-propylamino)-methyl]-6-methoxy-phenol that had been structurally characterized. Among these complexes, 1 and 2 are isostructural in which dinuclearNi(II) units act as metalloligands to bind Na(I) ions via phenoxido and chlorido bridges. The Na(I) atom is five-coordinated, and the Ni(II) atom possesses hexacordinated distorted octahedral geometry. In contrast, in complex 3, two -OMe groups from the dinuclear Ni(II) unit also coordinate to Na(I) to make its geometry heptacordinated pentagonal bipyramidal. The magnetic measurements of complexes 1–3 indicate ferromagnetic interactions between dimeric Ni(II) units with J = 3.97 cm−1, 4.66 cm−1, and 5.50 cm−1for 1–3, respectively, as is expected from their low phenoxido bridging angles (89.32°, 89.39°, and 87.32° for 1–3, respectively). The J values have been calculated by broken symmetry DFT method and found to be in good agreement with the experimental values.

scholarly journals Kinetics of the Adsorption of Copper and Lead Ions from Aqueous Solution on to WD-ekstra Activated Carbon

2002 ◽  
Vol 20 (5) ◽  
pp. 441-452 ◽  
Author(s):  
Joanna Kapica ◽  
Robert Pełech ◽  
Jacek Przepiórski ◽  
Antoni W. Morawski
Keyword(s):  
Aqueous Solution ◽  
Activated Carbon ◽  
Binary System ◽  
Metal Ion ◽  
Binary Systems ◽  
Considerable Influence ◽  
Equilibrium Isotherms ◽  
Adsorption Processes ◽  
Two Stages ◽  
Kinetics Of

The kinetics of the adsorption of Cu2+ and Pb2+ ions from aqueous solution on to WD-ekstra activated carbon was studied by batch methods. Such adsorption processes proceeded in two stages: an initial rapid stage followed by a slower one. The Bangham equation was used to describe the kinetics of both adsorption processes. Measurements were carried out for solutions containing only one type of metal ion and also for binary systems containing both Cu2+ and Pb2+ ions. A considerable influence of Pb2+ ions on the adsorption of Cu2+ ions was observed in the binary system. It was found that the equilibrium isotherms could be analyzed using the Langmuir, Freundlich–Langmuir and Freundlich methods.

Synthesis, DNA binding, cellular DNA lesion and cytotoxicity of a series of new benzimidazole-based Schiff base copper(ii) complexes

2015 ◽  
Vol 44 (46) ◽  
pp. 19983-19996 ◽  
Author(s):  
Anup Paul ◽  
Sellamuthu Anbu ◽  
Gunjan Sharma ◽  
Maxim L. Kuznetsov ◽  
Biplob Koch ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Biological Evaluation ◽  
Dna Lesion ◽  
Cellular Dna

The synthesis, characterization and biological evaluation of a series of new benzimidazole-based Schiff base copper(ii) complexes.

Synthesis and Biological Evaluation of a New Schiff Base and its Cu(II) Complex

2017 ◽  
Vol 68 (3) ◽  
pp. 586-588
Author(s):  
Gladiola Tantaru ◽  
Antonia Poiata ◽  
Nela Bibire ◽  
Alina Diana Panainte ◽  
Mihai Apostu ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Elemental Analysis ◽  
Schiff Base Ligand ◽  
Biological Evaluation ◽  
Gram Negative Bacteria ◽  
Bacterial Strains ◽  
Gram Negative ◽  
Ft Ir ◽  
Synthesis And Biological Evaluation

A new Schiff base ligand, N-hydroxy-N�-salicylidene-urea was synthesized through the condensation of salicylaldehyde with hydroxyurea. The copper(II) complex of the Schiff base has been also obtained. Their structure has been proven using spectral methods such as UV-Vis, FT-IR, 1H-NMR and elemental analysis. The antimicrobial activity of the copper(II) complex was evaluated through comparison to the activity of the Schiff base on various bacterial strains. All tested compounds were very active against both gram-positive and gram-negative bacteria.

scholarly journals Synthesis, Spectral, Electrochemical, Antimicrobial and DNA Binding/Cleavage Studies of Metal Complexes with Schiff Base of Fluoro Substituted Aniline

2020 ◽  
Vol 32 (11) ◽  
pp. 2911-2916
Author(s):  
G. SARASWATHY ◽  
M. SANKARGANESH ◽  
C. ANITHA ◽  
M. KALANITHI
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Metal Complexes ◽  
Metal Ion ◽  
Thiophene Ring ◽  
Bidentate Ligand ◽  
Schiff Base Complexes ◽  
Azomethine Nitrogen ◽  
Spectroscopic Techniques ◽  
Electron Absorption Spectroscopy

A new series of Schiff base complexes of transition (Fe3+, Co2+, Ni2+, Cu2+ and Zn2+) metal were synthesized from 4-fluoroaniline and 2-thiophene carboxaldehyde and structurally characterized by spectroscopic techniques. The Schiff base is found to be a bidentate ligand and coordinates to the metal ion through azomethine nitrogen and sulphur atom of the thiophene ring. In fluorescence studies, an interaction of Ca2+ and Mg2+ ions with the ligand was also studied. The Schiff base and its transition metal complexes showed inhibition activity against Gram-positive bacteria (Staphylococcus aureus, Escherichia coli), Gram-negative bacteria (Pseudomonas aeruginosa) and antifungal activity against Candida albicans.Electrochemical redox reactions of the metal complexes were analyzed by cyclic voltammetry. The DNA binding properties of the complexes with HS-DNA have been explored by electron absorption spectroscopy. The cleavage reaction of the synthesized ligand and its metal complexes was monitored by gel-electrophoresis method. The nuclease activity of the above metal(II) complexes shows that the Cu(II) complex can cleave DNA effectively than ligand and other metal complexes.

Cellulose bearing Schiff base and carboxylic acid chelating groups: a low cost and green adsorbent for heavy metal ion removal from aqueous solution

2016 ◽  
Vol 74 (8) ◽  
pp. 1780-1792 ◽  
Author(s):  
R. Saravanan ◽  
L. Ravikumar
Keyword(s):  
Aqueous Solution ◽  
Schiff Base ◽  
Carboxylic Acid ◽  
Metal Binding ◽  
Metal Ion ◽  
Low Cost ◽  
Metal Ion Removal ◽  
Chemically Modified ◽  
13C Nuclear Magnetic Resonance ◽  
Modified Cellulose

Chemically modified cellulose bearing metal binding sites like Schiff base and carboxylic acid groups was synthesized and characterized through Fourier transform infrared and solid state 13C–nuclear magnetic resonance (NMR) analysis. The chemically modified cellulose (Cell-PA) adsorbent was examined for its metal ion uptake ability for Cu(II) and Pb(II) ions from aqueous solution. Kinetic and isotherm studies were carried out under optimum conditions. Pseudo-second-order kinetics and Langmuir isotherm fit well with the experimental data. Thermodynamic studies were also performed along with adsorption regeneration performance studies. The adsorbent (Cell-PA) shows high potential for the removal of Cu(II) and Pb(II) metal ions, and it shows antibacterial activity towards selected microorganisms.

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