scholarly journals Fused Deposition Modeling as a Possible Approach for the Preparation of Orodispersible Tablets

2022 ◽  
Vol 15 (1) ◽  
pp. 69
Author(s):  
Thao Tranová ◽  
Jolanta Pyteraf ◽  
Mateusz Kurek ◽  
Witold Jamróz ◽  
Witold Brniak ◽  
...  
Keyword(s):  
Fused Deposition Modeling ◽  
High Surface ◽  
Immediate Release ◽  
Storage Conditions ◽  
Mass Ratio ◽  
Disintegration Time ◽  
Surface Mass ◽  
Fused Deposition ◽  
Orodispersible Tablets ◽  
Deposition Modeling

Additive manufacturing technologies are considered as a potential way to support individualized pharmacotherapy due to the possibility of the production of small batches of customized tablets characterized by complex structures. We designed five different shapes and analyzed the effect of the surface/mass ratio, the influence of excipients, and storage conditions on the disintegration time of tablets printed using the fused deposition modeling method. As model pharmaceutical active ingredients (APIs), we used paracetamol and domperidone, characterized by different thermal properties, classified into the various Biopharmaceutical Classification System groups. We found that the high surface/mass ratio of the designed tablet shapes together with the addition of mannitol and controlled humidity storage conditions turned out to be crucial for fast tablet’s disintegration. As a result, mean disintegration time was reduced from 5 min 46 s to 2 min 22 s, and from 11 min 43 s to 2 min 25 s for paracetamol- and domperidone-loaded tablets, respectively, fulfilling the European Pharmacopeia requirement for orodispersible tablets (ODTs). The tablet’s immediate release characteristics were confirmed during the dissolution study: over 80% of APIs were released from printlets within 15 min. Thus, this study proved the possibility of using fused deposition modeling for the preparation of ODTs.

scholarly journals Glycerol gelatin for 3D-printing of implants using a paste extrusion technique

2017 ◽  
Vol 3 (2) ◽  
pp. 389-392
Author(s):  
Wiebke Kempin ◽  
Anna Baden ◽  
Werner Weitschies ◽  
Anne Seidlitz
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Storage Conditions ◽  
Pharmaceutical Dosage Forms ◽  
Fused Deposition ◽  
Crosslinking Process ◽  
Paste Extrusion ◽  
Deposition Modeling ◽  
Model Drug ◽  
Great Dependency

AbstractFused deposition modeling as an additive manufacturing technique has gained great popularity for the fabrication of medical devices as well as pharmaceutical dosage forms over the last years. Particularly the variety of geometries that can be printed determines the attractiveness of this technique enabling a shape adaption of e.g. implants. In the presented work the soft hydrogel material glycerol gelatin was investigated towards its applicability in 3D-printing as an alternative to the commonly applied and mostly rigid polyesters. Model implants loaded with the model drug quinine and with the shape of a hollow cylinder were printed via an extrusion based technique utilizing the piston feed in a hydrogel filled heatable syringe. Glycerol gelatin hydrogels need to be crosslinked to avoid gel-sol-transition at body temperature. For this purpose three different crosslinking methods (insertion, dipping, spraying) with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) were evaluated regarding their crosslinking efficiency and drug losses during the crosslinking process. Dipping of the implant into an aqueous solution with at least 50 mM EDC and 10 mM NHS was found to be the most efficient crosslinking technique in conjunction with a smaller drug loss during processing compared to inserting. However, the use of hydrogels also causes problems as an intense and highly variable swelling of the printed structures during crosslinking (120.7 % ± 11.9 % for 10 times dipping in 50mM EDC/10 mM NHS) and a great dependency of the volume on storage conditions complicate the preparation of tailor-made implants. The release of the model drug quinine from printed and crosslinked implants was fast and nearly completed within 6 hours.

scholarly journals Systematic Experimental Evaluation of Function Based Cellular Lattice Structure Manufactured by 3D Printing

2021 ◽  
Vol 11 (21) ◽  
pp. 10489
Author(s):  
Shaheen Perween ◽  
Muhammad Fahad ◽  
Maqsood A. Khan
Keyword(s):  
Experimental Evaluation ◽  
Fused Deposition Modeling ◽  
Lattice Structure ◽  
Cylindrical Specimen ◽  
Compressive Load ◽  
Lattice Structures ◽  
Mass Ratio ◽  
Compressive Properties ◽  
Fused Deposition ◽  
Deposition Modeling

Additive manufacturing (AM) has a greater potential to construct lighter parts, having complex geometries with no additional cost, by embedding cellular lattice structures within an object. The geometry of lattice structure can be engineered to achieve improved strength and extra level of performance with the advantage of consuming less material and energy. This paper provides a systematic experimental evaluation of a series of cellular lattice structures, embedded within a cylindrical specimen and constructed according to terms and requirements of ASTMD1621-16, which is standard for the compressive properties of rigid cellular plastics. The modeling of test specimens is based on function representation (FRep) and constructed by fused deposition modeling (FDM) technology. Two different test series, each having eleven test specimens of different parameters, are printed along with their replicates of 70% and 100% infill density. Test specimens are subjected to uniaxial compressive load to produce 13% deformation to the height of the specimen. Comparison of results reveals that specimens, having cellular lattice structure and printed with 70% infill density, exhibit greater strength and improvement in strength to mass ratio, as compared to the solid printed specimen without structure.

Immediate Release 3D-Printed Tablets Produced Via Fused Deposition Modeling of a Thermo-Sensitive Drug

2018 ◽  
Vol 35 (6) ◽  
Author(s):  
Wiebke Kempin ◽  
Vanessa Domsta ◽  
Georg Grathoff ◽  
Iris Brecht ◽  
Beatrice Semmling ◽  
...  
Keyword(s):  
Fused Deposition Modeling ◽  
Immediate Release ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed

scholarly journals Improve Surfaces properties of ABS Products fabricated by fused deposition modeling (FDM) 3D Printing: تحسين خواص الأسطح المصنعة عن طريق الطباعة ثلاثية الأبعاد بتقنية نمذجة ترسيب المنصهر FDM لمنتجات ABS

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Suleiman Ibrahim Yousef, Mahmoud Al-Assad, Maher Al-Ibrahim
Keyword(s):  
Surface Roughness ◽  
3D Printing ◽  
Surface Treatment ◽  
Fused Deposition Modeling ◽  
Metal Layer ◽  
High Surface ◽  
Fused Deposition ◽  
Deposited Metal ◽  
Deposition Modeling ◽  
Effect Of Surface

  FDM (fused deposition modeling) 3D printing products often suffer from high surface roughness and low durability compared to conventional methods. In this paper, the effect of surface treatment after printing and coating with a layer of metal on its properties has been studied, The mechanical surface treatment methods (sandpaper) and chemical (solvent treatment) were compared and their effect on the adhesion strength of the deposited metal layer on the surface. The surface of the ABS product was coated with a layer of metal, the effect of both treatment and coating on the mechanical properties of printing products was studied. The results showed a clear decrease in surface roughness after surface treatment, where surface roughness decreased by 92%, and the best result was when grinding with sandpaper (2000 Grit) was Ra 0.35 μm. The tensile strength after acetone surface treatment was improved by 50% and after coating the product with a layer of metal by 56.25%. The adhesion test of the surface-deposited metal (CROSS-CUT) was conducted, and the result showed that the best adhesion durability was when the surface was treated with acetone vapor before coating.

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

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