scholarly journals Independent Tailoring of Dose and Drug Release via a Modularized Product Design Concept for Mass Customization

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 771
Author(s):  
Rydvikha Govender ◽  
Susanna Abrahmsén-Alami ◽  
Anette Larsson ◽  
Anders Borde ◽  
Alexander Liljeblad ◽  
...  
Keyword(s):  
Drug Release ◽  
Product Design ◽  
Mass Customization ◽  
Dosage Form ◽  
Modular Design ◽  
Release Kinetics ◽  
Product Variety ◽  
Design Concept ◽  
Modular Product ◽  
Release Profiles

Independent individualization of multiple product attributes, such as dose and drug release, is a crucial overarching requirement of pharmaceutical products for individualized therapy as is the unified integration of individualized product design with the processes and production that drive patient access to such therapy. Individualization intrinsically demands a marked increase in the number of product variants to suit smaller, more stratified patient populations. One established design strategy to provide enhanced product variety is product modularization. Despite existing customized and/or modular product design concepts, multifunctional individualization in an integrated manner is still strikingly absent in pharma. Consequently, this study aims to demonstrate multifunctional individualization through a modular product design capable of providing an increased variety of release profiles independent of dose and dosage form size. To further exhibit that increased product variety is attainable even with a low degree of product modularity, the modular design was based upon a fixed target dosage form size of approximately 200 mm3 comprising two modules, approximately 100 mm3 each. Each module contained a melt-extruded and molded formulation of 40% w/w metoprolol succinate in a PEG1500 and Kollidon® VA64 erodible hydrophilic matrix surrounded by polylactic acid and/or polyvinyl acetate as additional release rate-controlling polymers. Drug release testing confirmed the generation of predictable, combined drug release kinetics for dosage forms, independent of dose, based on a product’s constituent modules and enhanced product variety through a minimum of six dosage form release profiles from only three module variants. Based on these initial results, the potential of the reconfigurable modular product design concept is discussed for unified integration into a pharmaceutical mass customization/mass personalization context.

Modular Design of Small Marine Aquatic Cutting Machine

2013 ◽  
Vol 401-403 ◽  
pp. 207-209
Author(s):  
Shu Lei Wu ◽  
Li Zhen Zhang ◽  
Yang Zhao
Keyword(s):  
Product Design ◽  
Mass Customization ◽  
Product Innovation ◽  
Modular Design ◽  
Design Concept ◽  
Cutting Machine ◽  
Design Cycle

With the rise of mass customization production, the advantages of modular design are highlighted. Through the selection and combination of modules, different products can be made. It can help to meet the various market demands for the product design. The modular design concept in the small aquatic cutting machine, can enhance product innovation, shorten the design cycle and improve the degree of customization.

Preparation and Characterization of Mucoadhesive Microcapsules of Gliclazide with Natural Gums

1970 ◽  
Vol 4 (1) ◽  
pp. 38-48 ◽  
Author(s):  
Santhosh Kumar Mankala ◽  
Nishanth Kumar Nagamalli ◽  
Ramakrishna Raprla ◽  
Rajyalaxmi Kommula
Keyword(s):  
Drug Release ◽  
Dosage Form ◽  
Guar Gum ◽  
Release Kinetics ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Release Mechanism ◽  
Ionic Gelation ◽  
Release Formulation

Gliclazide is an oral hypoglycemic agent used in management of non-insulin dependent diabetes mellitus. Among people who are suffering from long term disorders, the major were categorized under diabetes so, a dosage form is needed to provide continuous therapy with high margin of safety & such dosage form can be achieved by microencapsulation. Gliclazide microspheres with sodium alginate (coat material, gum kondagogu, gum guar and xanthan gum (mucoadhesive agents) were prepared by orifice-ionic gelation and emulsification ionic gelation techniques varying concentrations (1:0.25, 1:0.5, 1:0.75 and 1:1). Formulations were then evaluated for surface morphology, particle shape, Carr’s index, microencapsulation efficiency, drug release, mucoadhesion studies. Compatibility studies were performed by FTIR, DSC, and XRD techniques and no interactions were found between drug and excepients used. The microspheres were found spherical and free flowing with emulsion ionic gelation technique with a size range 400-600μm. % drug content and encapsulation efficiency found in the range of 55%-68% and, 86.23%-94.46% respectively. All microspheres showed good mucoadhesive property in in-vitro wash of test. In vitro drug release studies showed that the guar gum has more potentiality to retard the drug release compared to other gums and concentrations. Drug release from the microspheres was found slow following zero order release kinetics with non-fickian release mechanism stating release depended on the coat: core ratio and the method employed. The concentration of 1:1 of SA: GG (EMG 4) found suitable for preparing the controlled release formulation of gliclazide stating emulsification gelation technique is the best among followed.   Key words: Gliclazide; Natural gums; orifice ionic gelation technique; emulsification ionic gelation technique DOI: http://dx.doi.org/10.3329/sjps.v4i1.8865 SJPS 2011; 4(1): 38-48

DSM-Based Product Representation for Retirement Process-Based Modularity

2009 ◽  
Author(s):  
Xiaoxia Lai ◽  
John K. Gershenson
Keyword(s):  
Product Design ◽  
Modular Design ◽  
Design Method ◽  
Value Added ◽  
Design Methods ◽  
Process Efficiency ◽  
Modular Architecture ◽  
Product Representation ◽  
Modular Product ◽  
Product Modularity

Researchers have expanded the definition of product modularity from function-based modularity to life-cycle process-based modularity. In parallel, measures of product modularity have been developed as well as corresponding modular product design methods. However, a correct modularity measure and modular design method are not enough to realize modular product design. To apply the measure and design method correctly, product representation becomes an important aspect of modular design and imperative for realizing the promised cost savings of modularity. In this paper, a representation for retirement process-based modular design has been developed. Built upon previous representations for assembly and manufacturing-based product design, the representation includes a process similarity matrix and a process dependency matrix. The retirement process-based similarity is based on the similarity in components’ post-life intents (recycling, reuse, disposal), and either the degree of their material compatibility if the components will be recycled, or their disassembly direction or disassembly tools if they need to be disassembled from each other for retirement. Process similarity within a module leads to increased process efficiency (the elimination of non-value added tasks) from the sharing of tooling/equipment. Retirement process-based dependency is developed based on disassembly difficulty, one aspect of the physical interactions between components. Retiring components together as a module to eliminate disassembly and differential processing and reducing the disassembly difficulty between the modules can increase the efficiency of the retirement process. We have first presented which process elements we should consider for defining retirement process similarity and dependency, and then constructed the respective similarity and dependency factors tables. These tables include similarity and dependency factors, which, along with their quantifications, are used to determine a product’s modular architecture to facilitate the retirement process. Finally, a fishing reel is used to illustrate how to apply these factors tables to generate the similarity and dependency matrices that represent a product for retirement-process based modular design. Using these representations as input to the DSM-based modular design methods, we can achieve a design with a modular architecture that improves the retirement process efficiency and reduces retirement costs.

Controlling methacryloyl substitution of chondroitin sulfate: injectable hydrogels with tunable long-term drug release profiles

2019 ◽  
Vol 7 (13) ◽  
pp. 2151-2161 ◽  
Author(s):  
Kimberly J. Ornell ◽  
Danilo Lozada ◽  
Nhi V. Phan ◽  
Jeannine M. Coburn
Keyword(s):  
Drug Release ◽  
Chondroitin Sulfate ◽  
Release Kinetics ◽  
Injectable Hydrogels ◽  
Drug Release Kinetics ◽  
Release Profiles

Controlling the degree of methacryloyl substitution on chondroitin sulfate allows for tunable drug release kinetics.

Modular Product Design, Considering Functions and Properties

2012 ◽  
Author(s):  
Israel Aguilera Navarrete ◽  
Alejandro A. Lozano Guzmán
Keyword(s):  
Product Design ◽  
Data Clustering ◽  
Design Problem ◽  
Modular Design ◽  
Recursive Method ◽  
Clustering Method ◽  
Data Presentation ◽  
Modular Product ◽  
Technical Solutions ◽  
Minimum Vector

In traditional machine, equipment and devices design, technical solutions are practically independent, thus increasing designs cost and complexity. Overcoming this situation has been tackled just using designers experience. In this work, a data clustering method which allows this data presentation in a more systematic way using a matrix arrangement, is shown. From this matrix, data can be reorganized in clusters with a hierarchical structure, in such a way that modular design is now more tractable. Proposed method is based on a Euclidean algorithm which allows finding the shortest vectorial distance among technical solutions. Taking product properties as vector dimensions, a recursive method for moving matrix rows and columns is applied. As a result of this procedure, the minimum vector distances are found thus being possible to identify the best technical solutions for the design problem raised. The proposed modular procedure is shown with a 30 inches oven door design.

Mastering High Product Variety of an Underwater Vehicle Class in the Concept Design Stage

2018 ◽  
Author(s):  
Willem Hendrik Wehner ◽  
Nicolas Richter ◽  
Marc Schiemann ◽  
Pia-Maria Haselberger ◽  
Sebastian Ritz ◽  
...  
Keyword(s):  
Modular Design ◽  
Design Method ◽  
Product Variety ◽  
Underwater Vehicle ◽  
Design Stage ◽  
Concept Design ◽  
Vehicle Class ◽  
Diving Depth ◽  
Modular Product ◽  
Payload Capacity

The paper provides considerations for a novel unmanned underwater vehicle class that offers new options to the offshore industries and marine science in matters of endurance, payload capacity, development time and economic viability. Today, different mission scenarios require different underwater vehicles. By applying modularization approach to the development of modular product classes, another way to design such vehicles is shown. Radical modularization of the vehicle enables collaborative as well as independent development of payload modules by industry or science. The design idea allows the combination of proven basic modules with novel mission modules. This allows assigning development activities of mission modules to diverse 3rd-party developers or customers. Topics covered in this paper are related to potential missions and the requirements they make on the vehicle. An evaluation of application scenarios considering the technical challenges vs. their economical relevance is made. The requirements for the MUM system are identified by analyzing the mission procedures regarding specific scenarios. The modular design method and challenges to validate feasibility of an extreme number of possible vehicle variants follow. Examples of variant drivers like diving depth or vehicle range as well as possible solutions will be discussed. The topics covered are the basis for further work within the three year research project MUM – Large Modifiable Underwater Mothership.

Chlorhexidine digluconate uptake and release from alkane-crosslinked nanocellulose hydrogels and subsequent antimicrobial effect

BioResources ◽  
2020 ◽  
Vol 15 (2) ◽  
pp. 3458-3472
Author(s):  
Jaka Levanič ◽  
Ida Poljanšek ◽  
Viljem Vek ◽  
Mojca Narat ◽  
Primoz Oven
Keyword(s):  
Antimicrobial Activity ◽  
Drug Release ◽  
Release Kinetics ◽  
Antimicrobial Effect ◽  
Chlorhexidine Digluconate ◽  
The Common ◽  
Uptake And Release ◽  
Release Profiles

Drug release profiles of novel alkane-crosslinked nanocellulose hydrogels were investigated. The common antiseptic compound chlorhexidine digluconate (CHX-DG) was loaded into the nanocellulose hydrogels, and the release kinetics were studied under two different release regimes. The hydrogels were effective at absorbing more than their dry weights of the antiseptic and retaining it during diffusion testing, with more than 60% of the drug retained in the hydrogels. Antimicrobial tests showed sustained antimicrobial activity of the CHX-DG-loaded hydrogels even after the two diffusion tests, which was attributable to non-ionic retention of the CHX-DG within the hydrogel structure.

scholarly journals Pharmaceutical Product Modularization as a Mass Customization Strategy to Increase Patient Benefit Cost-Efficiently

Systems ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 59
Author(s):  
Maria Siiskonen ◽  
Johan Malmqvist ◽  
Staffan Folestad
Keyword(s):  
Treatment Outcome ◽  
Product Design ◽  
Mass Customization ◽  
Product Variety ◽  
Pharmaceutical Products ◽  
Pharmaceutical Product ◽  
Patient Needs ◽  
Treatment Optimization ◽  
Design Requirements ◽  
The Individual

Customized pharmaceutical products aim to comply with the individual needs of a patient to enhance the treatment outcome. The current pharmaceutical production paradigm is, however, dominated by mass production, where the pharmaceutical products embrace a one-size-fits-all design with a low possibility of treatment optimization to patient needs. This production paradigm is not designed or intended for customized pharmaceutical products and operating this production context for customized pharmaceutical products is argued to be cost-inefficient. To address this challenge of inefficient production of customized pharmaceutical products, this study proposes an approach to modular pharmaceutical product design. As a mass customization strategy, product modularization enables serving customers with customized products cost-efficiently. The proposed modular pharmaceutical products integrate three product design requirements originating from patient needs: a scalable dose strength, a flexible target release profile, and a scalable treatment size. An approach to assess the value of these product designs is presented, by means of proposing three benefit metrics complying with respective design requirements and a cost metric assessing the cost of producing these modular pharmaceutical product designs. Results suggest that pharmaceutical product modularization can, by keeping the number of produced components low, substantially increase the external product variety and, hence, enhance the treatment outcome of patients. Furthermore, results indicate that the achieved benefit for the patient through product modularization increases beyond additional costs arising during production. However, a careful modularization must be performed to optimize the tradeoff between the increased benefit and cost.

The impact of modular design and innovation on new product performance

2019 ◽  
Vol 31 (2) ◽  
pp. 370-391
Author(s):  
Hongyi Sun ◽  
Antonio Lau
Keyword(s):  
Product Development ◽  
Product Design ◽  
Product Innovation ◽  
Modular Design ◽  
New Product ◽  
Product Performance ◽  
Design System ◽  
Innovation Capability ◽  
Content Type ◽  
Modular Product

Purpose The purpose of this paper is to propose a modular product design system and a product development roadmap (PDR), which can help to improve modular design (MD) and product innovation capabilities, respectively. Their relationships with product newness (PN) and new product performance are also assessed. Design/methodology/approach The proposed model was tested through structural equation modelling using data from a survey of 153 manufacturers in the electronic and electrical appliance industries in China. Findings The findings reveal that the proposed modular product design system and PDR can improve MD and product innovation capabilities. The authors also explore the conflicting relationships of MD and product innovation capability with PN. Research limitations/implications The findings contribute to the literature by showing that MD can constrain PN while product innovation can improve it. The study provides new empirical evidence of these relationships and has strategic implications. In addition, this study identifies two product development techniques that can improve MD and innovation capability, respectively. Originality/value The authors provide new evidence of the relationship between MD and innovation capability at product level, and confirm a side effect of pursuing both in terms of new product development. Through empirical testing, the authors first verify two product development techniques for implementing modular product design and product innovation.

scholarly journals Modularity and Product Innovation in Digital Markets

2007 ◽  
Vol 6 (2) ◽  
Author(s):  
Marc Bourreau ◽  
Pinar Dogan ◽  
Matthieu Manant
Keyword(s):  
Product Design ◽  
Product Innovation ◽  
Modular Design ◽  
Building Blocks ◽  
Specific Function ◽  
Digital Goods ◽  
Modular Product ◽  
Innovation Strategies ◽  
Integrated Or ◽  
Innovation Competition

Most digital goods have a modular design; that is, they consist of complementary and distinct building blocks, called modules. Modular product design, in contrast to integrated (or integral) design, enables alteration of a specific module that is usually assigned for a specific function without necessarily requiring an entire redesign of the product. This feature facilitates product innovation. The possibility of having common modules embedded in a range of products is likely to affect firms' product innovation strategies and post-innovation competition both in traditional and digital markets. In this paper, we explore such effects with a focus on digital markets.

Sign in / Sign up

Export Citation Format

Share Document