Controlling methacryloyl substitution of chondroitin sulfate: injectable hydrogels with tunable long-term drug release profiles

2019 ◽  
Vol 7 (13) ◽  
pp. 2151-2161 ◽  
Author(s):  
Kimberly J. Ornell ◽  
Danilo Lozada ◽  
Nhi V. Phan ◽  
Jeannine M. Coburn
Keyword(s):  
Drug Release ◽  
Chondroitin Sulfate ◽  
Release Kinetics ◽  
Injectable Hydrogels ◽  
Drug Release Kinetics ◽  
Release Profiles

Controlling the degree of methacryloyl substitution on chondroitin sulfate allows for tunable drug release kinetics.

Drug release kinetics from biodegradable UV-transparent hollow calcium-phosphate glass fibers

2017 ◽  
Vol 191 ◽  
pp. 116-118 ◽  
Author(s):  
Edoardo Ceci-Ginistrelli ◽  
Carlotta Pontremoli ◽  
Diego Pugliese ◽  
Nadia Barbero ◽  
Nadia G. Boetti ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Drug Release ◽  
Phosphate Glass ◽  
Release Kinetics ◽  
Glass Fibers ◽  
Drug Release Kinetics

scholarly journals Influence of Elongation of Paclitaxel-Eluting Electrospun-Produced Stent Coating on Paclitaxel Release and Transport Through the Arterial Wall after Stenting

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1165
Author(s):  
Zhanna K. Nazarkina ◽  
Boris P. Chelobanov ◽  
Konstantin A. Kuznetsov ◽  
Alexey V. Shutov ◽  
Irina V. Romanova ◽  
...  
Keyword(s):  
Drug Release ◽  
Arterial Wall ◽  
Release Kinetics ◽  
Artery Wall ◽  
Vascular Stents ◽  
Drug Eluting ◽  
Fiber Breaks ◽  
Stent Diameter ◽  
Stent Coating

It was previously shown that polycaprolactone (PCL)-based electrospun-produced paclitaxel (PTX)-enriched matrices exhibit long-term drug release kinetics and can be used as coatings for drug-eluting stents (DES). The installation of vascular stents involves a twofold increase in stent diameter and, therefore, an elongation of the matrices covering the stents, as well as the arterial wall in a stented area. We studied the influence of matrix elongation on its structure and PTX release using three different electrospun-produced matrices. The data obtained demonstrate that matrix elongation during stent installation does not lead to fiber breaks and does not interfere with the kinetics of PTX release. To study PTX diffusion through the expanded artery wall, stents coated with 5%PCL/10%HSA/3%DMSO/PTX and containing tritium-labeled PTX were installed into the freshly obtained iliac artery of a rabbit. The PTX passing through the artery wall was quantified using a scintillator β-counter. The artery retained the PTX and decreased its release from the coating. The retention of PTX by the arterial wall was more efficient when incubated in blood plasma in comparison with PBS. The retention/accumulation of PTX by the arterial wall provides a prolonged drug release and allows for the reduction in the dose of the drugs in electrospun-produced stent coatings.

scholarly journals Modeling of Anti-Cancer Drug Release Kinetics From Liposomes and Micelles: A Review

2021 ◽  
Vol 20 (4) ◽  
pp. 565-576
Author(s):  
Nour Al Sawaftah ◽  
Vinod Paul ◽  
Nahid Awad ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Cancer Drug ◽  
Drug Release Kinetics ◽  
Anti Cancer

scholarly journals Tuneable spheroidal hydrogel particles for cell and drug encapsulation

Soft Matter ◽  
2018 ◽  
Vol 14 (27) ◽  
pp. 5622-5627 ◽  
Author(s):  
Isabel M. Bjørge ◽  
Ana M. S. Costa ◽  
A. Sofia Silva ◽  
João P. O. Vidal ◽  
J. Miguel Nóbrega ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Cell Encapsulation ◽  
Drug Encapsulation ◽  
Drug Release Kinetics ◽  
Hydrogel Particles ◽  
The Impact

Straight-forward production of spheroidal particles allows the assessment of the impact of geometry on cell encapsulation viability and drug release kinetics.

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