scholarly journals Electrospun Asymmetric Membranes as Promising Wound Dressings: A Review

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 183
Author(s):  
Mariana F. P. Graça ◽  
Duarte de Melo-Diogo ◽  
Ilídio J. Correia ◽  
André F. Moreira
Keyword(s):  
Wound Healing ◽  
Phase Inversion ◽  
Antimicrobial Agents ◽  
Skin Layer ◽  
Wound Dressings ◽  
Electrospinning Technique ◽  
Asymmetric Membranes ◽  
Structural And Functional Properties ◽  
Wet Phase Inversion ◽  
Native Skin

Despite all the efforts that have been done up to now, the currently available wound dressings are still unable to fully re-establish all the structural and functional properties of the native skin. To overcome this situation, researchers from the tissue engineering area have been developing new wound dressings (hydrogels, films, sponges, membranes) aiming to mimic all the features of native skin. Among them, asymmetric membranes emerged as a promising solution since they reproduce both epidermal and dermal skin layers. Wet or dry/wet phase inversion, scCO2-assisted phase inversion, and electrospinning have been the most used techniques to produce such a type of membranes. Among them, the electrospinning technique, due to its versatility, allows the development of multifunctional dressings, using natural and/or synthetic polymers, which resemble the extracellular matrix of native skin as well as address the specific requirements of each skin layer. Moreover, various therapeutic or antimicrobial agents have been loaded within nanofibers to further improve the wound healing performance of these membranes. This review article provides an overview of the application of asymmetric electrospun membranes as wound dressings displaying antibacterial activity and as delivery systems of biomolecules that act as wound healing enhancers.

Thickness Dependence of Macrovoid Evolution in Wet Phase-Inversion Asymmetric Membranes

2004 ◽  
Vol 43 (6) ◽  
pp. 1553-1556 ◽  
Author(s):  
Dongfei Li ◽  
Tai-Shung Chung ◽  
Jizhong Ren ◽  
Rong Wang
Keyword(s):  
Phase Inversion ◽  
Thickness Dependence ◽  
Asymmetric Membranes ◽  
Wet Phase Inversion

Rheology Assessment of PSf/ NMP Solution and its Influence on Membrane Structure

2012 ◽  
Vol 326-328 ◽  
pp. 422-427 ◽  
Author(s):  
Priscila Anadão ◽  
Rafael Rezende Montes ◽  
Henrique Souza de Santis ◽  
Hélio Wiebeck
Keyword(s):  
Membrane Structure ◽  
Phase Inversion ◽  
Molar Mass ◽  
Polymer Concentration ◽  
Inversion Method ◽  
Asymmetric Membranes ◽  
Wet Phase Inversion ◽  
Microfiltration Membranes ◽  
Skin Formation ◽  
Phase Inversion Method

Asymmetric polysulfone membranes were prepared by wet-phase inversion method from casting solutions consisting of PSf/NMP and water as non-solvent. The effects of polymer concentration and molar mass were investigated by rheological studies. Moreover, membranes were characterized by scanning electron microscope (SEM). It was found that polymer solutions containing between 22 and 25 wt% PSf/NMP originated microfiltration membranes. The use of a higher mass molar polysulfone has been shown to reduce diameter pore and to maintain morphology. All the results were interrelated into a discussion of the skin formation of asymmetric membranes.

scholarly journals Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

Polymers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 2959 ◽  
Author(s):  
Sindi P. Ndlovu ◽  
Kwanele Ngece ◽  
Sibusiso Alven ◽  
Blessing A. Aderibigbe
Keyword(s):  
Mechanical Properties ◽  
Antimicrobial Activity ◽  
Wound Healing ◽  
Antimicrobial Agents ◽  
Healing Process ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Delayed Wound Healing

Wound care is a major biomedical field that is challenging due to the delayed wound healing process. Some factors are responsible for delayed wound healing such as malnutrition, poor oxygen flow, smoking, diseases (such as diabetes and cancer), microbial infections, etc. The currently used wound dressings suffer from various limitations, including poor antimicrobial activity, etc. Wound dressings that are formulated from biopolymers (e.g., cellulose, chitin, gelatin, chitosan, etc.) demonstrate interesting properties, such as good biocompatibility, non-toxicity, biodegradability, and attractive antimicrobial activity. Although biopolymer-based wound dressings display the aforementioned excellent features, they possess poor mechanical properties. Gelatin, a biopolymer has excellent biocompatibility, hemostatic property, reduced cytotoxicity, low antigenicity, and promotes cellular attachment and growth. However, it suffers from poor mechanical properties and antimicrobial activity. It is crosslinked with other polymers to enhance its mechanical properties. Furthermore, the incorporation of antimicrobial agents into gelatin-based wound dressings enhance their antimicrobial activity in vitro and in vivo. This review is focused on the development of hybrid wound dressings from a combination of gelatin and other polymers with good biological, mechanical, and physicochemical features which are appropriate for ideal wound dressings. Gelatin-based wound dressings are promising scaffolds for the treatment of infected, exuding, and bleeding wounds. This review article reports gelatin-based wound dressings which were developed between 2016 and 2021.

scholarly journals Imination of Microporous Chitosan Fibers—A Route to Biomaterials with “On Demand” Antimicrobial Activity and Biodegradation for Wound Dressings

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 117
Author(s):  
Alexandru Anisiei ◽  
Irina Rosca ◽  
Andreea-Isabela Sandu ◽  
Adrian Bele ◽  
Xinjian Cheng ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Antimicrobial Agents ◽  
Dermal Fibroblast ◽  
Intermolecular Forces ◽  
Wound Dressings ◽  
Conversion Degree ◽  
Fiber Morphology ◽  
On Demand ◽  
Vis Spectroscopy

Microporous chitosan nanofibers functionalized with different amounts of an antimicrobial agent via imine linkage were prepared by a three-step procedure including the electrospinning of a chitosan/PEO blend, PEO removal and acid condensation reaction in a heterogeneous system with 2-formylphenylboronic acid. The fibers’ characterization was undertaken keeping in mind their application to wound healing. Thus, by FTIR and 1H-NMR spectroscopy, it was confirmed the successful imination of the fibers and the conversion degree of the amine groups of chitosan into imine units. The fiber morphology in terms of fiber diameter, crystallinity, inter- and intra-fiber porosity and strength of intermolecular forces was investigated using scanning electron microscopy, polarized light microscopy, water vapor sorption and thermogravimetric analysis. The swelling ability was estimated in water and phosphate buffer by calculating the mass equilibrium swelling. The fiber biodegradation was explored in five media of different pH, corresponding to different stages of wound healing and the antimicrobial activity against the opportunistic pathogens inflicting wound infection was investigated according to standard tests. The biocompatibility and bioadhesivity were studied on normal human dermal fibroblast cells by direct contact procedure. The dynamic character of the imine linkage of the functionalized fibers was monitored by UV-vis spectroscopy. The results showed that the functionalization of the chitosan microporous nanofibers with antimicrobial agents via imine linkage is a great route towards bio-absorbable wound dressings with “on demand” antimicrobial properties and biodegradation rate matching the healing stages.

scholarly journals Electrospun antibacterial nanofibers for wound dressings and tissue medicinal fields: A Review

2020 ◽  
Vol 13 (05) ◽  
pp. 2030012 ◽  
Author(s):  
Zhimei Wei ◽  
Liqun Wang ◽  
Shouyu Zhang ◽  
Tonghai Chen ◽  
Jie Yang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Biomedical Applications ◽  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Antimicrobial Agents ◽  
Electrospinning Process ◽  
Wound Dressings ◽  
Electrospun Fibers ◽  
Chronic Infections ◽  
Antibacterial Material

Bacterial infections are a major cause of chronic infections. Thus, antibacterial material is an urgent need in clinics. Antibacterial nanofibers, with expansive surface area, enable efficient incorporation of antibacterial agents. Meanwhile, structure similar to the extracellular matrix can accelerate cell growth. Electrospinning, the most widely used technique to fabricate nanofiber, is often used in many biomedical applications including drug delivery, regenerative medicine, wound healing and so on. Thus, this review provides an overview of all recently published studies on the development of electrospun antibacterial nanofibers in wound dressings and tissue medicinal fields. This reviewer begins with a brief introduction of electrospinning process and then discusses electrospun fibers by incorporating various types of antimicrobial agents used as in wound dressings and tissue. Finally, we finish with conclusions and further perspectives on electrospun antibacterial nanofibers as 2D biomedicine materials.

Wound healing and antibacterial activities of water-soluble chitosan nanoparticles and excretion/secretion as a natural combination from medicinal maggots, Lucilia cuprina

2021 ◽  
pp. 088391152110539
Author(s):  
Mohammad RK Abdel-Samad ◽  
Fatma A Taher
Keyword(s):  
Wound Healing ◽  
Antimicrobial Agents ◽  
Chitosan Nanoparticles ◽  
Antibacterial Activities ◽  
Water Soluble ◽  
Wound Dressings ◽  
Lucilia Cuprina ◽  
Healing Agent ◽  
Natural Combination

Wounds management takes a high interest in the medical field and the addition of antimicrobial agents in an assortment of wound dressings leads to delay the wound healing. This study aimed at preparing natural combination between excretion/secretion (ES) and water-soluble chitosan nanoparticles (from Lucilia cuprina maggots) and investigating its antibacterial and wound healing activities. ES of maggots was collected, and the water-soluble chitosan nanoparticles (WSCNPs) were prepared and characterized. Antibacterial activities of combinations were evaluated against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Proteus vulgaris. ES-WSC-2 combination that contains 50% ES and 1% WSCNPs showed highest antibacterial activity against all tested bacteria compared to the other combinations. In vitro, the ES-WSC-2 combination was used to study the wound healing activity by scratch assay. The synergism between ES and WSCNPs (in ES-WSC-2 combination) accelerated the wound healing rate which suggests the use of this combination as an effective natural antibacterial and wound healing agent.

Asymmetric membranes by wet phase inversion of phenylated polyphenylene

2012 ◽  
Vol 128 (1) ◽  
pp. 750-753 ◽  
Author(s):  
Congran Guo ◽  
Stephen M. Budy ◽  
Douglas A. Loy
Keyword(s):  
Phase Inversion ◽  
Asymmetric Membranes ◽  
Wet Phase Inversion

scholarly journals Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing

Polymers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 653 ◽  
Author(s):  
Patrícia Alves ◽  
Marta Santos ◽  
Sabrina Mendes ◽  
Sónia P. Miguel ◽  
Kevin D. de Sá ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Healing Process ◽  
Protective Layer ◽  
Fibroblast Cell ◽  
Wound Dressings ◽  
In Vitro Assays ◽  
Asymmetric Membrane ◽  
Electrospinning Technique ◽  
Asymmetric Membranes

Recently, the biomedical scientists who are working in the skin regeneration area have proposed asymmetric membranes as ideal wound dressings, since they are able to reproduce both layers of skin and improve the healing process as well as make it less painful. Herein, an electrospinning technique was used to produce new asymmetric membranes. The protective layer was composed of a blending solution between polycaprolactone and polylactic acid, whereas the underlying layer was comprised of methacrylated gelatin and chitosan. The chemical/physical properties, the in vitro hemo- and biocompatibility of the nanofibrous membranes were evaluated. The results obtained reveal that the produced membranes exhibited a wettability able to provide a moist environment at wound site. Moreover, the membranes’ hemocompatibility and fibroblast cell adhesion, spreading and proliferation at the surface of the membranes were also noticed in the in vitro assays. Such results highlight the suitability of these asymmetric membranes for wound dressing applications.

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