scholarly journals Stimuli-Responsive Polymers for Transdermal, Transmucosal and Ocular Drug Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2050
Author(s):  
Dmitriy Berillo ◽  
Zharylkasyn Zharkinbekov ◽  
Yevgeniy Kim ◽  
Kamila Raziyeva ◽  
Kamila Temirkhanova ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Release Kinetics ◽  
Primary Metabolism ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Diffusion Parameters ◽  
Routes Of Drug Administration ◽  
Alternative Routes ◽  
Multiple Drugs

Despite their conventional and widespread use, oral and intravenous routes of drug administration face several limitations. In particular, orally administered drugs undergo enzymatic degradation in the gastrointestinal tract and first-pass metabolism in the liver, which tend to decrease their bioavailability. Intravenous infusions of medications are invasive, painful and stressful for patients and carry the risk of infections, tissue damage and other adverse reactions. In order to account for these disadvantages, alternative routes of drug delivery, such as transdermal, nasal, oromucosal, ocular and others, have been considered. Moreover, drug formulations have been modified in order to improve their storage stability, solubility, absorption and safety. Recently, stimuli-responsive polymers have been shown to achieve controlled release and enhance the bioavailability of multiple drugs. In this review, we discuss the most up-to-date use of stimuli-responsive materials in order to optimize the delivery of medications that are unstable to pH or undergo primary metabolism via transdermal, nasal, oromucosal and ocular routes. Release kinetics, diffusion parameters and permeation rate of the drug via the mucosa or skin are discussed as well.

scholarly journals Stimuli-responsive polymers and their applications

2017 ◽  
Vol 8 (1) ◽  
pp. 127-143 ◽  
Author(s):  
Menglian Wei ◽  
Yongfeng Gao ◽  
Xue Li ◽  
Michael J. Serpe
Keyword(s):  
Drug Delivery ◽  
Physical Properties ◽  
Artificial Muscles ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Responsive Polymer ◽  
External Stimuli

Responsive polymer-based materials are capable of altering their chemical and/or physical properties upon exposure to external stimuli. This review highlights their use for sensing and biosensing, drug delivery, and artificial muscles/actuators.

Poly(ε-caprolactone) with pH and UCST responsiveness as a 5-fluorouracil carrier

2020 ◽  
Vol 11 (32) ◽  
pp. 5173-5180
Author(s):  
Shuang Zhu ◽  
Lianlei Wen ◽  
Yan Xiao ◽  
Meidong Lang
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

Stimuli-responsive polymers with excellent biocompatibility and biodegradability are highly demanded as carriers for controlled drug delivery.

Stimuli-responsive polymers and their applications in drug delivery

2009 ◽  
Vol 4 (2) ◽  
pp. 022001 ◽  
Author(s):  
Priya Bawa ◽  
Viness Pillay ◽  
Yahya E Choonara ◽  
Lisa C du Toit
Keyword(s):  
Drug Delivery ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

scholarly journals Stimuli-Responsive Polymeric Nanosystem for Colon Specific Drug Delivery

2019 ◽  
Vol 10 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Sharon Kunnath Joseph ◽  
Mangalath Sabitha ◽  
Sreeja Chandrasekharan Nair
Keyword(s):  
Drug Delivery ◽  
Chemical Change ◽  
Specific Drug ◽  
Stimuli Responsive ◽  
Diagnostic Systems ◽  
Nanodrug Delivery ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Environment Temperature ◽  
Colon Specific Drug Delivery

An ideal colon specific drug delivery system needs to perform multiple functions like greater bio availability, less toxicity and higher therapeutic efficacy, all of which require high degree of smartness. This article focuses on the overview of the stimuli-responsive polymers and various nanodrug delivery systems which have found applications in colon specific delivery of drugs as this system provide a link between therapeutic need and drug delivery. These polymers exhibit a non-linear response to a small stimulus leading to a macroscopic alteration in their structure/properties. Stimuli responsive polymers display a significant physio chemical change in response to small changes in their environment (temperature, pH, light etc.). Colonic drug delivery has gained increased importance in treating diseases like Crohn’s disease, ulcerative colitis, colon cancer etc. The expansion in the development of polymers based system with greater flexibility, versatility and unexplored potential enables new opportunities for them in uplifting bio medicine. Applying the concepts of smartness in the context of clinically relevant therapeutic and diagnostic systems, it can prelude in a new era of ‘smart’ therapeutics that can improve the health care fields. In particular, due to its high sensitivity to the stimuli, this system has been identified as a sensible platform for releasing drug at suitable site and at appropriate time.

scholarly journals Mucoadhesive Hydrogel Nanoparticles as Smart Biomedical Drug Delivery System

2019 ◽  
Vol 9 (5) ◽  
pp. 825 ◽  
Author(s):  
Nemany Hanafy ◽  
Stefano Leporatti ◽  
Maged El-Kemary
Keyword(s):  
Drug Delivery ◽  
Biological Activity ◽  
Mammalian Cells ◽  
Biomedical Applications ◽  
Biological Fluids ◽  
Medical Applications ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Hydrogel Formulation

Hydrogels are widely used materials which have many medical applications. Their ability to absorb aqueous solutions and biological fluids gives them innovative characterizations resulting in increased compatibility with biological activity. In this sense, they are used extensively for encapsulation of several targets such as biomolecules, viruses, bacteria, and mammalian cells. Indeed, many methods have been published which are used in hydrogel formulation and biomedical encapsulations involving several cross-linkers. This system is still rich with the potential of undiscovered features. The physicochemical properties of polymers, distinguished by their interactions with biological systems into mucoadhesive, gastro-adhesive, and stimuli responsive polymers. Hydrogel systems may be assembled as tablets, patches, gels, ointments, and films. Their potential to be co-formulated as nanoparticles extends the limits of their assembly and application. In this review, mucoadhesive nanoparticles and their importance for biomedical applications are highlighted with a focus on mechanisms of overcoming mucosal resistance.

scholarly journals Advancing the stimuli response of polymer-based drug delivery systems for ocular disease treatment

2020 ◽  
Vol 11 (44) ◽  
pp. 6988-7008 ◽  
Author(s):  
Duc Dung Nguyen ◽  
Jui-Yang Lai
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Disease Treatment ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Stimuli Response

Recent exploitations of stimuli-responsive polymers as ophthalmic drug delivery systems for the treatment of eye diseases are summarized and discussed.

scholarly journals Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

2020 ◽  
Vol 21 (13) ◽  
pp. 4724 ◽  
Author(s):  
Sofia Municoy ◽  
María I. Álvarez Echazú ◽  
Pablo E. Antezana ◽  
Juan M. Galdopórpora ◽  
Christian Olivetti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Smart Materials ◽  
Controlled Drug Release ◽  
Stimuli Responsive ◽  
Responsive Materials ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Stimuli Response ◽  
Materials Used

Smart or stimuli-responsive materials are an emerging class of materials used for tissue engineering and drug delivery. A variety of stimuli (including temperature, pH, redox-state, light, and magnet fields) are being investigated for their potential to change a material’s properties, interactions, structure, and/or dimensions. The specificity of stimuli response, and ability to respond to endogenous cues inherently present in living systems provide possibilities to develop novel tissue engineering and drug delivery strategies (for example materials composed of stimuli responsive polymers that self-assemble or undergo phase transitions or morphology transformations). Herein, smart materials as controlled drug release vehicles for tissue engineering are described, highlighting their potential for the delivery of precise quantities of drugs at specific locations and times promoting the controlled repair or remodeling of tissues.

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