scholarly journals Effect of Solution Composition Variables on Electrospun Alginate Nanofibers: Response Surface Analysis

Polymers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 692 ◽  
Author(s):  
Janja Mirtič ◽  
Helena Balažic ◽  
Špela Zupančič ◽  
Julijana Kristl
Keyword(s):  
Molecular Weight ◽  
Response Surface ◽  
Polymer Blend ◽  
Polymer Concentration ◽  
Electrospun Nanofibers ◽  
Complex Viscosity ◽  
Fine Tuning ◽  
Major Influence ◽  
Solution Composition ◽  
Poly Ethylene

Alginate is a promising biocompatible and biodegradable polymer for production of nanofibers for drug delivery and tissue engineering. However, alginate is difficult to electrospin due to its polyelectrolyte nature. The aim was to improve the ‘electrospinability’ of alginate with addition of exceptionally high molecular weight poly(ethylene oxide) (PEO) as a co-polymer. The compositions of the polymer-blend solutions for electrospinning were varied for PEO molecular weight, total (alginate plus PEO) polymer concentration, and PEO proportion in the dry alginate–PEO polymer mix used. These were tested for rheology (viscosity, complex viscosity, storage and loss moduli) and conductivity, and the electrospun nanofibers were characterized by scanning electron microscopy. One-parameter-at-a-time approach and response surface methodology (RSM) were used to optimize the polymer-blend solution composition to obtain defined nanofibers. Both approaches revealed that the major influence on nanofiber formation and diameter were total polymer concentration and PEO proportion. These polymer-blend solutions of appropriate conductivity and viscosity enabled fine-tuning of nanofiber diameter. PEO molecular weight of 2–4 million Da greatly improved the electrospinnability of alginate, producing nanofibers with >85% alginate. This study shows that RSM can be used to design nanofibers with optimal alginate and co-polymer contents to provide efficient scaffold material for regenerative medicine.

scholarly journals Optimization of the Electrospun Niobium–Tungsten Oxide Nanofibers Diameter Using Response Surface Methodology

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1644
Author(s):  
Babajide Oluwagbenga Fatile ◽  
Martin Pugh ◽  
Mamoun Medraj
Keyword(s):  
Response Surface Methodology ◽  
Tungsten Oxide ◽  
Response Surface ◽  
Flow Rate ◽  
Desirability Function ◽  
Polymer Concentration ◽  
Electrospun Nanofibers ◽  
Second Order ◽  
Working Parameters ◽  
Factor Interactions

The present research aimed to investigate the effect of working parameters on the electrospinning of niobium–tungsten oxide nanofibers and optimize the process using central composite design (CCD) based on the response surface methodology (RSM). An experiment was designed to assess the effects of five variables including the applied voltage (V), spinning distance (D), polymer concentration (P), flow rate (F), and addition of NaCl (N) on the resulting diameter of the nanofibers. Meanwhile, a second-order prediction model of nanofibers diameter was fitted and verified using analysis of variance (ANOVA). The results show that the diameter of the nanofibers was significantly influenced by all the variables except the flow rate. Some second-order and cross factor interactions such as VD, DP, PF, PN, and P2 also have significant effects on the diameter of the nanofibers. The results of the ANOVA yielded R2 and adjusted R2 values of 0.96 and 0.93 respectively, this affirmed that the predictive model fitted well with the experimental data. Furthermore, the process parameters were optimized using the CCD method and a maximum desirability function of 226 nm was achieved for the diameter of the nanofibers. This is very close to the 233 nm diameter obtained from a confirmatory experiment using the optimum conditions. Therefore, the model is representative of the process, and it could be used for future studies for the reduction of the diameter of electrospun nanofibers.

scholarly journals Electrospraying poloxamer/(bio-)polymer blends using a needleless electrospinning machine

2018 ◽  
Vol 1 ◽  
pp. 251522111774307 ◽  
Author(s):  
Robin Böttjer ◽  
Timo Grothe ◽  
Daria Wehlage ◽  
Andrea Ehrmann
Keyword(s):  
Molecular Weight ◽  
Polymer Concentration ◽  
Low Molecular Weight ◽  
Poly Ethylene Glycol ◽  
Poloxamer 188 ◽  
Chemical Structures ◽  
Inner Surface ◽  
Poly Ethylene ◽  
Material Solution ◽  
Nanofiber Mats

Electrospinning can be used to create nanofiber mats with high material purity and a large inner surface, applicable for medical or biotechnological filters, cell growth, and so on. Not each polymer which can be dissolved, however, can be spun in this way. Depending on the material, solution, and spinning parameters, especially on the molecular weight and the polymer concentration in the solution, either fibers or droplets can be formed. Both fibers and droplets are of technological interest for different applications. This article examines the possibilities of electrospinning or electrospraying poloxamer 188 (formerly known as Lutrol F 68, BASF, Germany) in combination with different biopolymers (dextran, gelatin, and agarose) as well as polyacrylonitrile (PAN) which belongs to the polymers spinnable from nontoxic solvents. Due to the similarity of the chemical structures of poloxamer and poly(ethylene glycol), a well-known spinning agent, and the relatively low molecular weight of poloxamer 188, it can be expected to work as a spraying agent. Our results show that electrospraying poloxamer/biopolymer blends is indeed possible, with the unexpected effect that for higher polymer concentrations, combining poloxamer 188 with dextran, fibers are formed additionally on parts of the substrate. Co-spinning poloxamer 188 with PAN, on the other hand, results in creation of a nanofiber mat whose morphology is mainly defined by the PAN content. The study shows that poloxamer can indeed be used as a spraying/spinning agent in electrospraying/electrospinning diverse biopolymers.

scholarly journals Characterization of Poly(Ethylene Oxide) Nanofibers—Mutual Relations between Mean Diameter of Electrospun Nanofibers and Solution Characteristics

Processes ◽  
2019 ◽  
Vol 7 (12) ◽  
pp. 948 ◽  
Author(s):  
Petr Filip ◽  
Petra Peer
Keyword(s):  
Molecular Weight ◽  
Ethylene Oxide ◽  
Shear Viscosity ◽  
Electrospun Nanofibers ◽  
Electrospinning Process ◽  
Initial Stage ◽  
Nanofiber Diameter ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Mutual Relations

The quality of electrospun poly(ethylene oxide) (PEO) nanofibrous mats are subject to a variety of input parameters. In this study, three parameters were chosen: molecular weight of PEO (100, 300, 600, and 1000 kg/mol), PEO concentration (in distilled water), and shear viscosity of PEO solution. Two relations free of any adjustable parameters were derived. The first, describing the initial stage of an electrospinning process expressing shear viscosity using PEO molecular weight and concentration. The second, expressing mean nanofiber diameter using concentration and PEO molecular weight. Based on these simple mathematical relations, it is possible to control the mean nanofiber diameter during an electrospinning process.

scholarly journals An Estimate of the Onset of Beadless Character of Electrospun Nanofibers Using Rheological Characterization

Polymers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 265
Author(s):  
Petra Peer ◽  
Jana Zelenkova ◽  
Petr Filip ◽  
Lenka Lovecka
Keyword(s):  
Vinylidene Fluoride ◽  
Polymer Concentration ◽  
Experimental Parameter ◽  
Electrospun Nanofibers ◽  
Key Factors ◽  
Rheological Characterization ◽  
Poly Vinylidene Fluoride ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Sudden Decrease

Electrospinning represents the very effective process of producing nanofibrous mats. This process is influenced by a number of mutually and strongly interlaced entry parameters (characteristics of polymer, solvent, process parameters) and their participation in the resulting nanofiber quality. The appearance of nanofibers is a result of the necessary primary experimental parameter setting within an acceptable range. However, finer analysis of nanofiber quality depends on the proper choice of these individual factors. The aim of this contribution is to evaluate one of the key factors—polymer concentration—with respect to the presence or absence of bead formation. This passage can be approximated by rheological oscillatory measurements when a sudden decrease in phase angle indicates this change. It replaces otherwise time- and cost-consuming trial-and-error experiments. This approach was tested using three different materials: solutions of poly(vinylidene fluoride-co-hexafluoropropylene), poly(vinyl butyral), and poly(ethylene oxide).

Influence of Chitosan Molecular Weight and Poly(ethylene oxide): Chitosan Proportion on Fabrication of Chitosan Based Electrospun Nanofibers

2018 ◽  
Vol 60 (4) ◽  
pp. 471-482 ◽  
Author(s):  
Alireza Naderi Sohi ◽  
Hossein Naderi-Manesh ◽  
Masoud Soleimani ◽  
Samaneh Mirzaei ◽  
Mohammad Delbari ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Ethylene Oxide ◽  
Electrospun Nanofibers ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

The Structure of Radiation Cross-Linked Poly (ethylene oxide) Gels

1971 ◽  
Vol 29 ◽  
pp. 76-77
Author(s):  
C. E. Cluthe ◽  
G. G. Cocks
Keyword(s):  
Molecular Weight ◽  
Ethylene Oxide ◽  
Parallel Plate ◽  
Average Molecular Weight ◽  
Radical Reaction ◽  
Free Radical Reaction ◽  
Nitrogen Gas ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Initial Viscosity

Aqueous solutions of a 1 weight-per cent poly (ethylene oxide) (PEO) were degassed under vacuum, transferred to a parallel plate viscometer under a nitrogen gas blanket, and exposed to Co60 gamma radiation. The Co60 source was rated at 4000 curies, and the dose ratewas 3.8x105 rads/hr. The poly (ethylene oxide) employed in the irradiations had an initial viscosity average molecular weight of 2.1 x 106.The solutions were gelled by a free radical reaction with dosages ranging from 5x104 rads to 4.8x106 rads.

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