Assessing the Influence of Dyes Physico-Chemical Properties on Incorporation and Release Kinetics in Silk Fibroin Matrices

Silk fibroin (SF) is a promising and versatile biodegradable protein for biomedical applications. This study aimed to develop a prolonged release device by incorporating SF microparticles containing dyes into SF hydrogels. The influence of dyes on incorporation and release kinetics in SF based devices were evaluated regarding their hydrophilicity, molar mass, and cationic/anionic character. Hydrophobic and cationic dyes presented high encapsulation efficiency, probably related to electrostatic and hydrophobic interactions with SF. The addition of SF microparticles in SF hydrogels was an effective method to prolong the release, increasing the release time by 10-fold.

Download Full-text

How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

Materials ◽

10.3390/ma14061510 ◽

2021 ◽

Vol 14 (6) ◽

pp. 1510

Author(s):

Sylwia Grabska-Zielińska ◽

Alina Sionkowska

Keyword(s):

Silk Fibroin ◽

Biomedical Applications ◽

Magnetic Particles ◽

Chemical Properties ◽

Ternary Mixtures ◽

Cross Linking ◽

Advantages And Disadvantages ◽

Physico Chemical ◽

Binary And Ternary Mixtures ◽

To Receive

This review supplies a report on fresh advances in the field of silk fibroin (SF) biopolymer and its blends with biopolymers as new biomaterials. The review also includes a subsection about silk fibroin mixtures with synthetic polymers. Silk fibroin is commonly used to receive biomaterials. However, the materials based on pure polymer present low mechanical parameters, and high enzymatic degradation rate. These properties can be problematic for tissue engineering applications. An increased interest in two- and three-component mixtures and chemically cross-linked materials has been observed due to their improved physico-chemical properties. These materials can be attractive and desirable for both academic, and, industrial attention because they expose improvements in properties required in the biomedical field. The structure, forms, methods of preparation, and some physico-chemical properties of silk fibroin are discussed in this review. Detailed examples are also given from scientific reports and practical experiments. The most common biopolymers: collagen (Coll), chitosan (CTS), alginate (AL), and hyaluronic acid (HA) are discussed as components of silk fibroin-based mixtures. Examples of binary and ternary mixtures, composites with the addition of magnetic particles, hydroxyapatite or titanium dioxide are also included and given. Additionally, the advantages and disadvantages of chemical, physical, and enzymatic cross-linking were demonstrated.

Download Full-text

Thermodynamics and acoustic effects of quercetin on micellization and interaction behaviour of CTAB in different hydroethanol solvent systems

Zeitschrift für Physikalische Chemie ◽

10.1515/zpch-2020-1603 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Vikrant Abbot ◽

Poonam Sharma

Keyword(s):

Pharmaceutical Industry ◽

Hydrophobic Interactions ◽

Chemical Properties ◽

Formulation Development ◽

Surfactant Interactions ◽

Physico Chemical ◽

Ultrasonic Sound ◽

Apparent Molar Compressibility ◽

Solvent Systems ◽

Thermoacoustic Properties

AbstractFlavonoids amongst the class of secondary metabolites possess numerous health benefits, are known for its use in pharmaceutical industry. Quercetin, a flavonoid has more prominent medical advantages however its utilization is constrained because of various instability and insolubility issues and therefore, taken into consideration for studying its physico-chemical properties. In view of that, the thermodynamic and thermoacoustic properties of quercetin were examined in presence of cationic surfactant cetyltrimethylammonium bromide (CTAB) at different hydroethanolic concentrations and temperatures. The conductivity studies were used to calculate change in enthalpy (∆Hom), change in entropy (∆Som) and change in Gibbs free Energy (∆Gom) of micellization. The interactions between quercetin and CTAB were found to be endothermic, entropically controlled and spontaneous. Further, ultrasonic sound velocity and density studies were carried out and utilized for the calculation of thermoacoustic parameters i.e. apparent molar volume and apparent molar compressibility. Thermoacoustic properties revealed that at higher surfactant concentration, hydrophobic interactions are dominant. The results suggested that the flavonoid-surfactant interactions in hydroethanolic solutions is more favourable as compared with aqueous solution. Overall, the data is favourable for the framework to be used for detailing advancement, drug development, drug industry, pharmaceutical industry, medical administration and formulation development studies.

Download Full-text

An overview of Natural Superdisintegrants

Research Journal of Topical and Cosmetic Sciences ◽

10.52711/2321-5844.2021.00016 ◽

2021 ◽

pp. 113-124

Author(s):

Shushank Sharma

Keyword(s):

Gastrointestinal Tract ◽

Aqueous Media ◽

Chemical Properties ◽

Cost Effective ◽

Oral Route ◽

Drug Formulation ◽

Release Time ◽

Disintegration Time ◽

Physico Chemical ◽

Set Up

The oral route is the most convenient route of administration for various drugs. It is viewed as the most convenient, most secure, and economical route for patients. Fast disintegrating tablets are popular these days as they disintegrate in the mouth within a few seconds without the use of water. The burdens of regularly used medications in pediatric and geriatric patients have been overwhelmed by quick-dissolving tablets. Natural superdisintegrants have been used for fast-dissolving tablets because they are biodegradable, chemically inert, non-harmful, more affordable, and generally accessible. Natural polymer improves the properties of the tablet as it is commonly used as diluents and binders. Natural super disintegrants decrease the release time and give healthful results to the patients. Most polymers are obtained from nature, they are cost-effective, non-toxic, and non-irritants. Disintegration is the most important step for releasing the drug from the tablet matrix to decrease the disintegration time. In this, drug and polymers come in contact with water, it swells, hydrate, and react chemically to release the drug in the mouth and gastrointestinal tract. Superdisintegrants are those substances that encourage the quick breaking down with a lesser amount contrasted with disintegrants. The quick disintegrants tablets are set up by utilizing suitable polymers which rely on the Physico-chemical properties of drugs and excipients, for example, drug and polymer compatibility, hardness and thickness of tablet, nature of drug and excipients, PH of drug and release parameters of drug formulation. Superdisintegrants are the vehicles added to tablet formulation to advance the breaking of tablets and capsules into small microparticles in aqueous media resulting in to increase in the surface area and promote quick drug release. The disintegrants have a significant capacity to oppose the efficacy of tablet binders and compression forces to form the tablet. Commonly there are three methods to incorporate disintegrants into the tablet: A. Inner addition, B. External expansion, C. Internal, and external addition. Most of the regularly based tablets are those expected to be swallow, disintegrate and release medicaments in the gastrointestinal tract but over a while tablets are manufactured to deliver medicaments in the mouth and gastrointestinal tract within few seconds of swallowing. It has been demonstrated that characteristic polymers are more effective than synthetic polymers. Some research is going to develop safe and effective medication with super disintegrating agents that can be dissolved rapidly to treat the disease.

Download Full-text

Physico-chemical properties of silk fibroin membrane as a biomaterial

Biomaterials ◽

10.1016/0142-9612(90)90100-5 ◽

1990 ◽

Vol 11 (6) ◽

pp. 430-434 ◽

Cited By ~ 220

Author(s):

Norihiko Minoura ◽

Masuhiro Tsukada ◽

Masanobu Nagura

Keyword(s):

Silk Fibroin ◽

Chemical Properties ◽

Physico Chemical

Download Full-text

Synthesis, physico-chemical properties and biomedical applications of poly(amidoamine)s

Polymer ◽

10.1016/0032-3861(85)90309-x ◽

1985 ◽

Vol 26 (9) ◽

pp. 1336-1348 ◽

Cited By ~ 77

Author(s):

Paolo Ferruti ◽

Maria Antonietta Marchisio ◽

Rolando Barbucci

Keyword(s):

Biomedical Applications ◽

Chemical Properties ◽

Physico Chemical

Download Full-text

Self-Assembling Peptides and Carbon Nanomaterials Join Forces for Innovative Biomedical Applications

Molecules ◽

10.3390/molecules26134084 ◽

2021 ◽

Vol 26 (13) ◽

pp. 4084

Author(s):

Petr Rozhin ◽

Costas Charitidis ◽

Silvia Marchesan

Keyword(s):

Carbon Nanostructures ◽

Biomedical Applications ◽

Carbon Nanomaterials ◽

Chemical Properties ◽

Building Blocks ◽

Research Areas ◽

Self Assembling ◽

Concise Review ◽

Physico Chemical ◽

Great Progress

Self-assembling peptides and carbon nanomaterials have attracted great interest for their respective potential to bring innovation in the biomedical field. Combination of these two types of building blocks is not trivial in light of their very different physico-chemical properties, yet great progress has been made over the years at the interface between these two research areas. This concise review will analyze the latest developments at the forefront of research that combines self-assembling peptides with carbon nanostructures for biological use. Applications span from tissue regeneration, to biosensing and imaging, and bioelectronics.

Download Full-text

Synthesis, Physico-Chemical Properties, and Biomedical Applications of Gold Nanorods—A Review

Journal of Biomedical Nanotechnology ◽

10.1166/jbn.2016.2218 ◽

2016 ◽

Vol 12 (6) ◽

pp. 1136-1158 ◽

Cited By ~ 27

Author(s):

ValeriaS. Marangoni ◽

Juliana Cancino-Bernardi ◽

Valtencir Zucolotto

Keyword(s):

Gold Nanorods ◽

Biomedical Applications ◽

Chemical Properties ◽

Physico Chemical

Download Full-text

Chemo-physical Properties and Biomedical Applications of Hyaluronic Acid in Medicine

Revista de Chimie ◽

10.37358/rc.17.2.5458 ◽

2017 ◽

Vol 68 (2) ◽

pp. 384-386 ◽

Cited By ~ 1

Author(s):

Danut Vasile ◽

Raluca Iancu ◽

Camelia Bogdanici ◽

Emil Ungureanu ◽

Dana Ciobotea ◽

...

Keyword(s):

Hyaluronic Acid ◽

Physical Properties ◽

Biomedical Applications ◽

Chemical Properties ◽

Elastic Behavior ◽

Current Evidence ◽

Hydroxyl Groups ◽

Carboxylate Group ◽

Medical Problems ◽

Physico Chemical

Hyaluronic acid is a mucopolysaccharide encountered in most body fluids and extracellular matrix. The aim of our review is to summarize current evidence about chemico-physical properties of hyaluronic acid, highlighting biomedical applications of hyaluronan derivatives. It is a glycosaminoglycan made of repeating disaccharide units containing a carboxylate group, four hydroxyl groups and one carboxylate group, with hydrophilic properties. Its particular structure with multiple coils forming an entangled network results in unique pseudoplastic and viscoelastic characteristics. Its viscous and elastic behavior, depending on the applied strain, makes hyaluronan widely applicable in biomedical field. The large amount of functions and applications is determined by the physico-chemical properties, which allows a polymorphism of the hyaluronic acid structures depending on the molecular weight variations, concentration and ionic status. It is currently used in ophthalmology, orthopedics and rheumatology, in plastic surgery, surgery and otolaryngology as well. Already widely used in clinical practice, hyaluronic acid proves to be often the best solution for difficult medical problems. Future developments in nanomedicine and drug delivery linked to hyaluronic acid are emerging.

Download Full-text

A review: An overview of Natural Superdisintegrants

Research Journal of Topical and Cosmetic Sciences ◽

10.52711/2321-5844.2021.00003 ◽

2021 ◽

pp. 13-24

Author(s):

Shushank Sharma ◽

Sikha Chauhan

Keyword(s):

Gastrointestinal Tract ◽

Aqueous Media ◽

Chemical Properties ◽

Cost Effective ◽

Oral Route ◽

Drug Formulation ◽

Release Time ◽

Disintegration Time ◽

Physico Chemical ◽

Set Up

The oral route is the most convenient route of administration for various drugs. It is viewed as the most convenient, most secure, and economical route for patients. Fast disintegrating tablets are popular these days as they disintegrate in the mouth within a few seconds without the use of water. The burdens of regularly used medications in pediatric and geriatric patients have been overwhelmed by quick-dissolving tablets. Natural superdisintegrants have been used for fast-dissolving tablets because they are biodegradable, chemically inert, non-harmful, more affordable, and generally accessible. Natural polymer improves the properties of the tablet as it is commonly used as diluents and binders. Natural super disintegrants decrease the release time and give healthful results to the patients. Most polymers are obtained from nature, they are cost-effective, non-toxic, and non-irritants. Disintegration is the most important step for releasing the drug from the tablet matrix to decrease the disintegration time. In this, drug and polymers come in contact with water, it swells, hydrate, and react chemically to release the drug in the mouth and gastrointestinal tract. Superdisintegrants are those substances that encourage the quick breaking down with a lesser amount contrasted with disintegrants. The quick disintegrants tablets are set up by utilizing suitable polymers which rely on the Physico-Chemical properties of drugs and excipients, for example, drug and polymer compatibility, hardness and thickness of tablet, nature of drug and excipients, PH of drug and release parameters of drug formulation. Superdisintegrants are the vehicles added to tablet formulation to advance the breaking of tablets and capsules into small microparticles in aqueous media resulting in to increase in the surface area and promote quick drug release. The disintegrants have a significant capacity to oppose the efficacy of tablet binders and compression forces to form the tablet. Commonly there are three methods to incorporate disintegrants into the tablet: A. Inner addition, B. External expansion, C. Internal, and external addition. Most of the regularly based tablets are those expected to be swallow, disintegrate and release medicaments in the gastrointestinal tract but over a while tablets are manufactured to deliver medicaments in the mouth and gastrointestinal tract within few seconds of swallowing. It has been demonstrated that characteristic polymers are more effective than synthetic polymers. Some research is going to develop safe and effective medication with super disintegrating agents that can be dissolved rapidly to treat the disease.

Download Full-text