scholarly journals Self-Assembly of Soluble Chitosan Derivatives Nanoparticles for Vaccine: Synthesis, Characterization and Evaluation

Polymers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 4097
Author(s):  
Jinbao Liu ◽  
Shuang Yu ◽  
Wanying Qu ◽  
Zheng Jin ◽  
Kai Zhao

Herein, a novel chitosan derivative nanoparticle was proposed to function as a delivery carrier. First of all, an improvement was made to the way N-2-hydroxypropyl trimcthyl ammonium chloride chitosan (N-2-HACC) was synthesized. Moreover, the solution to one-step synthesis of N-2-HACC from chitosan (CS) was developed. Different from the previous report, the synthesis process was simplified, and there was a reduction in the amount of 2,3-epoxypropyl trimethyl ammonium chloride (EPTAC) used. With its excellent water solubility maintained, the relatively low degree of substitution was controlled to facilitate the cross-linking reaction. The results obtained from 1H-NMR, FTIR spectroscopy, and XRD indicated a smooth EPTAC onto CS for the formation of N-2-HACC with 59.33% the degree of substitution (DS). According to our results, N-2-HACC could be dissolved in various organic solvents, deionized water, 1% acetic acid aqueous solution, and others at room temperature. Finally, a novel chitosan nanoparticle material was prepared using the self-assembly method with β-glycerophosphate sodium (β-GC), with excellent immune properties achieved, thus providing a new strategy for chitosan self-assembled nanoparticles.

2021 ◽  
Vol 11 (11) ◽  
pp. 1766-1773
Author(s):  
Lei Jin ◽  
Tong Yang

The modulatory effect of miR-21 on the proliferation of melanoma cells through stimulation of PTEN (Phosphatase and tensin homologue deleted on chromosome 10) expression was investigated in the current study. PTEN, as a tumor suppressor, is expressed in low levels in melanoma tissues and cell lines. Nevertheless, miR-21 can stimulate cancer development and suppress cell apoptosis. Overexpression of PTEN substantially impaired the proliferation of miR-21-treated melanoma cells. In addition, miR-21 and PTEN were observed to exhibit a combinatorial effect, whereas miR-21 could negatively regulate the expression of PTEN. In conclusion, these findings demonstrate that miR-21 affects melanoma development by targeting PTEN, establishing a new strategy for treating malignant melanoma. Furthermore, in this study, microparticles and nanoparticles were employed as carriers to construct, through the self-assembly method, nanocapsules carrying miR-21 in order to develop an efficient nanocapsule delivery system of miR-21 against melanoma cells.


Nanoscale ◽  
2019 ◽  
Vol 11 (27) ◽  
pp. 12829-12836 ◽  
Author(s):  
Peng Wu ◽  
Lu-Bin Zhong ◽  
Qing Liu ◽  
Xi Zhou ◽  
Yu-Ming Zheng

A polymer induced one-step interfacial self-assembly method was developed to fabricate flexible, robust and free-standing SERS substrates for rapid pesticide residue detection.


CrystEngComm ◽  
2012 ◽  
Vol 14 (6) ◽  
pp. 2186 ◽  
Author(s):  
Chunli Guo ◽  
Aidong Lan ◽  
Fengxia Li ◽  
Yitai Qian ◽  
Lifeng Hou

2020 ◽  
Vol 44 (27) ◽  
pp. 11895-11900
Author(s):  
Shuang Li ◽  
Wen Xia ◽  
Yunqian Zhang ◽  
Zhu Tao

A novel class of cucurbit[n]urils–polyoxometalate (Q[n]–POM) hybrids and tetramethyl cucurbit[6]uril–phosphomolybdic acid (TMeQ[6]–PMA) nanocubes (NCs), are synthesized via a one-step self-assembly method.


2019 ◽  
Vol 16 (8) ◽  
pp. 882-891
Author(s):  
Yongjia Liu ◽  
Leilei Shi ◽  
Bangshang Zhu ◽  
Yue Su ◽  
Hui Li ◽  
...  

Background: The drug-drug self-assembly was considered as a simple and efficient approach to prepare high drug loading nano-drug carriers and present new opportunities for cancer therapeutics. The strategy of PTX amphiphiles preparation would be a possible way to solve the poor water solubility of PTX. Methods: The PTX-YSL conjugate were synthesized and characterized. The PTX-YSL nanocarriers was prepared by a simple self-assembly method. In vitro cell studies and pharmacokinetic studies were evaluated for their in vitro anti-tumor activities and blood retention time. Results: The structures of PTX-YSL conjugate were confirmed by LC-MS, 1H NMR and FTIR. The size and morphology of the PTX-YSL self-assembled nanocarriers were observed with TEM and DLS. PTX-YSL nanocarriers could facilitate cellular uptake and had low cytotoxicity. PTX-YSL nanocarriers have longer blood retention for enhancing accumulation in the tumor tissues via EPR effect. Conclusion: This drug delivery system formed by PTX-YSL conjugates constitutes a promising and effective drug carrier in cancer therapy.


Nanomaterials ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 438 ◽  
Author(s):  
Bowei Zhao ◽  
Tai Sun ◽  
Xi Zhou ◽  
Xiangzhi Liu ◽  
Xiaoxia Li ◽  
...  

Combining functional nanomaterials composite with three-dimensional graphene (3DG) is a promising strategy for improving the properties of stress sensors. However, it is difficult to realize stress sensors with both a wide measurement range and a high sensitivity. In this paper, graphene-SiO2 balls (GSB) were composed into 3DG in order to solve this problem. In detail, the GSB were prepared by chemical vapor deposition (CVD) method, and then were dispersed with graphene oxide (GO) solution to synthesize GSB-combined 3DG composite foam (GSBF) through one-step hydrothermal reduction self-assembly method. The prepared GSBF owes excellent mechanical (95% recoverable strain) and electrical conductivity (0.458 S/cm). Furthermore, it exhibits a broad sensing range (0–10 kPa) and ultrahigh sensitivity (0.14 kPa−1). In addition, the water droplet experiment demonstrates that GSBF is a competitive candidate of high-performance materials for stress sensors.


2007 ◽  
Vol 9 (9) ◽  
pp. 2224-2228 ◽  
Author(s):  
Yuping Shan ◽  
Guocheng Yang ◽  
Yongtang Jia ◽  
Jian Gong ◽  
Zhongmin Su ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document