scholarly journals Inflammatory Bowel Disease, Are Symptoms and Diet Linked?

Proceedings ◽  
2019 ◽  
Vol 37 (1) ◽  
pp. 20
Author(s):  
Morton ◽  
Pedley ◽  
Stewart ◽  
Coad
Keyword(s):  
Inflammatory Bowel Disease ◽  
New Zealand ◽  
Gastrointestinal Tract ◽  
Bowel Disease ◽  
Inflammatory Conditions ◽  
Inflammatory Bowel ◽  
Collective Term

New Zealand (NZ) has one of the highest rates of Inflammatory Bowel Disease (IBD), a collective term for three chronic inflammatory conditions that affect the gastrointestinal tract. [...]

scholarly journals Disease-Related Knowledge in New Zealand Children with Inflammatory Bowel Disease (IBD) and Their Parents

2021 ◽  
Vol 3 (1) ◽  
pp. 23-28
Author(s):  
Laura Appleton ◽  
Andrew S. Day
Keyword(s):  
Inflammatory Bowel Disease ◽  
New Zealand ◽  
Bowel Disease ◽  
Patient Adherence ◽  
Intervention Strategy ◽  
Specific Knowledge ◽  
Poor Knowledge ◽  
Clinical Consequences ◽  
Inflammatory Bowel ◽  
Disease Specific

Insufficient disease-related knowledge can be a barrier to the effective management of the unpredictable and lifelong course of inflammatory bowel disease (IBD). Patients with chronic illnesses have high non-adherence rates, with direct clinical consequences. While no single intervention strategy can improve the adherence of all patients, the success of attempts to improve patient adherence depends upon the realistic assessment of patients’ knowledge and their understanding of the regimen. The aim of this study was to assess the disease-specific knowledge of the parents and patients with IBD in the South Island of New Zealand, and identify areas of poor knowledge. Families of children diagnosed with IBD were asked to complete the IBD Knowledge Inventory Device (IBD-KID). Patients 10 years and older were asked to participate along with their parents. Of 110 families, 91 responded, with completed questionnaires received from 153 parents and 66 patients. Overall, parents scored significantly higher (13.64 ± 3.88) than their children (10.03 ± 4.07; p < 0.001). Areas of poor knowledge included aspects of treatment (both conventional and alternative), along with long-term disease outcomes. This study has shown clear areas of concern in this population’s disease-specific knowledge of their disease. This should be addressed through targeted education for both the patient and the parents to improve not only their knowledge, but also their adherence and disease self-management.

scholarly journals Interfering With Inflammation: Heterogeneous Effects of Interferons in Graft-Versus-Host Disease of the Gastrointestinal Tract and Inflammatory Bowel Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Eileen Haring ◽  
Robert Zeiser ◽  
Petya Apostolova
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gastrointestinal Tract ◽  
Graft Versus Host Disease ◽  
Bowel Disease ◽  
Intestinal Barrier Function ◽  
Type I ◽  
Hematopoietic Stem ◽  
Host Disease ◽  
Graft Versus Host ◽  
Inflammatory Bowel

The intestine can be the target of several immunologically mediated diseases, including graft-versus-host disease (GVHD) and inflammatory bowel disease (IBD). GVHD is a life-threatening complication that occurs after allogeneic hematopoietic stem cell transplantation. Involvement of the gastrointestinal tract is associated with a particularly high mortality. GVHD development starts with the recognition of allo-antigens in the recipient by the donor immune system, which elicits immune-mediated damage of otherwise healthy tissues. IBD describes a group of immunologically mediated chronic inflammatory diseases of the intestine. Several aspects, including genetic predisposition and immune dysregulation, are responsible for the development of IBD, with Crohn’s disease and ulcerative colitis being the two most common variants. GVHD and IBD share multiple key features of their onset and development, including intestinal tissue damage and loss of intestinal barrier function. A further common feature in the pathophysiology of both diseases is the involvement of cytokines such as type I and II interferons (IFNs), amongst others. IFNs are a family of protein mediators produced as a part of the inflammatory response, typically to pathogens or malignant cells. Diverse, and partially paradoxical, effects have been described for IFNs in GVHD and IBD. This review summarizes current knowledge on the role of type I, II and III IFNs, including basic concepts and controversies about their functions in the context of GVHD and IBD. In addition, therapeutic options, research developments and remaining open questions are addressed.

Effects of dietary tryptophan supplementation in the acetic acid-induced colitis mouse model

2018 ◽  
Vol 9 (8) ◽  
pp. 4143-4152 ◽  
Author(s):  
Shuai Chen ◽  
Meiwei Wang ◽  
Lanmei Yin ◽  
Wenkai Ren ◽  
Peng Bin ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Acetic Acid ◽  
Gastrointestinal Tract ◽  
Mouse Model ◽  
Chronic Inflammation ◽  
Bowel Disease ◽  
Intestinal Immunity ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract and is strongly associated with intestinal immunity and the microbiome.

scholarly journals Differentiation of alimentary lymphoma from inflammatory bowel disease and the influence of breed and age on the outbreak of pathological changes in the canine gastrointestinal tract

2020 ◽  
Vol 51 (3) ◽  
pp. 293-304
Author(s):  
Aneta Piplica ◽  
Marko Hohšteter ◽  
Lidija Medven Zagradišnik ◽  
Branka Artuković ◽  
Andrea Gudan Kurilj ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gastrointestinal Tract ◽  
Bowel Disease ◽  
Pathological Changes ◽  
Inflammatory Bowel

Cilj ovog rada bio je istražiti korisnost upotrebe imunohistokemijske metode (IHK) zajedno s histopatološkom pretragom u dijagnosticiranju i razlikovanju alimentarnog limfoma (AL) od upalne bolesti crijeva (UBC). U istraživanju su korišteni arhivski histopatološki nalazi i preparati tkiva, parafinski blokovi i stakalca. Prema pripadnosti pasmina podijelili u tri skupine malu, srednju ili veliku skupinu pasa. Cilj istraživanja bio je utvrditi povezanost pojedinih patoloških promjena ovisno o skupini pasa, dobi i spolu. Obavljenim istraživanjem zabilježili smo da je srednja vrijednost dobi u skupini malih pasmina pasa iznosila 7,58±3,59 godina, u skupini srednjih pasmina 7,45±3,04 godina te u skupini velikih pasmina 6,58±3,47 godina. Prosječna dob pasa oboljelih od alimentarnog limfoma iznosila je 8,8 godina, za razliku od upalne bolesti crijeva gdje je iznosila 7,0 godina. Unutar sve tri skupine pasa zabilježen je veći broj jedinki muškog spola. Najveći udio biopsiranih uzoraka (70,73 %) analiziran je iz tkiva tankog crijeva; po 8 uzoraka (27,59 %) iz male skupine pasa, 11 uzoraka iz srednje skupine (37,93 %) te po 10 uzoraka iz velike skupine pasa (34,48 %). Udio biopsiranog tkiva želudca bio je nešto niži (24,39 %) dok je tkivo debelog crijeva uzorkovano u samo dva psa (4,88 %). Histopatološkom analizom utvrđeno je 16 slučajeva upalne bolesti crijeva (45,71 %), 7 slučajeva limfoma (20,00 %), 9 slučajeva suspektne upale (25,71 %) te 3 slučaja suspektne upale/limfoma (8,58 %). Nakon provedene IHK metode ustanovljeno je da je u 6 slučajeva dijagnoza donesena histopatološkom evaluacijom potvrđena, u 5 slučajeva je opovrgnuta dok je u 5 slučajeva IHK metoda bila korisna kako bi razlučili AL od UBC. Utvrđene su značajne razlike (P&lt;0,05) između dijagnoze upalne bolesti crijeva te limfoma ustanovljene patohistološkom pretragom te imunohistokemijskom metodom. Ustanovljena je češća pojavnost T staničnog limfoma u tankom crijevu dok je pojavnost B staničnog limfoma učestalija u želudcu. Povezanost s tendencijom učinka zabilježena je između patohistološke dijagnoze i CD3 biljega (r=-0.34; P=0,08) odnosno između patohistološke dijagnoze i CD79 biljega (r=0.36; P=0,09) s nešto nižom razinom povezanosti između patohistološke dijagnoze i dijagnoze IHK (r=0.21; P=0,34). Na temelju rezultata našeg istraživanja može se zaključiti da je imunohistokemijska metoda korisna za potvrdu dijagnoze i razlikovanje alimentarnog limfoma i upalne bolesti crijeva.

Profiling of histone 3 lysine 27 acetylation reveals its role in a chronic DSS-induced colitis mouse model

2019 ◽  
Vol 15 (4) ◽  
pp. 296-307
Author(s):  
Meng Chen ◽  
Qinglan Li ◽  
Nan Cao ◽  
Yanan Deng ◽  
Lianyun Li ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gastrointestinal Tract ◽  
Mouse Model ◽  
Bowel Disease ◽  
Inflammatory Condition ◽  
Histone 3 ◽  
Chronic Inflammatory Condition ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract.

scholarly journals Ileocecal Burkitt’s Lymphoma Presenting as Acute Abdominal Pain

2020 ◽  
Vol 13 (2) ◽  
pp. 968-972
Author(s):  
Mostafa Mosbeh Abdelmaksoud ◽  
Maram Kheder Alshareef ◽  
Alaa Osama Jamjoom ◽  
Mohamed Tarek Hafez
Keyword(s):  
Inflammatory Bowel Disease ◽  
Abdominal Pain ◽  
Renal Transplantation ◽  
Gastrointestinal Tract ◽  
Bowel Disease ◽  
Acute Abdominal Pain ◽  
Emergency Laparotomy ◽  
Ileocecal Region ◽  
Inflammatory Bowel ◽  
Hodgkin's Lymphomas

Primary gastrointestinal non-Hodgkin’s lymphomas are rare tumors which account for about 0.9% of all gastrointestinal tract tumors. They are usually associated with inflammatory bowel disease, previous radiotherapy, and renal transplantation. We report a case of non-Hodgkin’s lymphoma involving the ileocecal region in a 46-year-old gentleman who presented with acute abdominal pain that mandated emergency laparotomy.

scholarly journals The Influence of Probiotics on the Firmicutes/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease

2020 ◽  
Vol 8 (11) ◽  
pp. 1715
Author(s):  
Spase Stojanov ◽  
Aleš Berlec ◽  
Borut Štrukelj
Keyword(s):  
Inflammatory Bowel Disease ◽  
Weight Loss ◽  
Gastrointestinal Tract ◽  
Bowel Disease ◽  
Important Influence ◽  
Considerable Evidence ◽  
Bacterial Phyla ◽  
Genus Lactobacillus ◽  
Inflammatory Bowel ◽  
Treatment Of Obesity

The two most important bacterial phyla in the gastrointestinal tract, Firmicutes and Bacteroidetes, have gained much attention in recent years. The Firmicutes/Bacteroidetes (F/B) ratio is widely accepted to have an important influence in maintaining normal intestinal homeostasis. Increased or decreased F/B ratio is regarded as dysbiosis, whereby the former is usually observed with obesity, and the latter with inflammatory bowel disease (IBD). Probiotics as live microorganisms can confer health benefits to the host when administered in adequate amounts. There is considerable evidence of their nutritional and immunosuppressive properties including reports that elucidate the association of probiotics with the F/B ratio, obesity, and IBD. Orally administered probiotics can contribute to the restoration of dysbiotic microbiota and to the prevention of obesity or IBD. However, as the effects of different probiotics on the F/B ratio differ, selecting the appropriate species or mixture is crucial. The most commonly tested probiotics for modifying the F/B ratio and treating obesity and IBD are from the genus Lactobacillus. In this paper, we review the effects of probiotics on the F/B ratio that lead to weight loss or immunosuppression.

Faecal markers of gastrointestinal inflammation

2012 ◽  
Vol 65 (11) ◽  
pp. 981-985 ◽  
Author(s):  
Roy A Sherwood
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Waiting Times ◽  
Indeterminate Colitis ◽  
Faecal Calprotectin ◽  
Infectious Colitis ◽  
Inflammatory Conditions ◽  
Gi Symptoms ◽  
Rome Iii ◽  
Inflammatory Bowel

Gastrointestinal (GI) symptoms including abdominal pain, bloating and diarrhoea are a relatively common reason for consulting a physician. They may be due to inflammatory bowel disease (inflammatory bowel disease; Crohn's disease, ulcerative colitis and indeterminate colitis), malignancy (colorectal cancer), infectious colitis or irritable bowel syndrome (IBS). Differentiation between these involves the use of clinical, radiological, endoscopic and serological techniques, which are invasive or involve exposure to radiation. Serological markers include C-reactive protein, erythrocyte sedimentation rate and antibodies (perinuclear antineutrophil cytoplasm antibody and anti-Saccharomyces cerevisiae antibody). Faecal markers that can aid in distinguishing inflammatory disorders from non-inflammatory conditions are non-invasive and generally acceptable to the patient. As IBS accounts for up to 50% of cases presenting to the GI clinic and is a diagnosis of exclusion (Rome III criteria), any test that can reliably distinguish IBS from organic disease could speed diagnosis and reduce endoscopy waiting times. Faecal calprotectin, lactoferrin, M2-PK and S100A12 will be reviewed.

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