scholarly journals Field-Effect Transistor Biosensors for Biomedical Applications: Recent Advances and Future Prospects

Sensors ◽  
2019 ◽  
Vol 19 (19) ◽  
pp. 4214 ◽  
Author(s):  
Vu ◽  
Chen
Keyword(s):  
Clinical Trials ◽  
Field Effect ◽  
Biomedical Applications ◽  
Field Effect Transistor ◽  
Disease Diagnosis ◽  
Antibody Fragments ◽  
Future Perspective ◽  
Future Prospects ◽  
Effect Transistor ◽  
Points Of View

During recent years, field-effect transistor biosensors (Bio-FET) for biomedical applications have experienced a robust development with evolutions in FET characteristics as well as modification of bio-receptor structures. This review initially provides contemplation on this progress by briefly summarizing remarkable studies on two aforementioned aspects. The former includes fabricating unprecedented nanostructures and employing novel materials for FET transducers whereas the latter primarily synthesizes compact molecules as bio-probes (antibody fragments and aptamers). Afterwards, a future perspective on research of FET-biosensors is also predicted depending on current situations as well as its great demand in clinical trials of disease diagnosis. From these points of view, FET-biosensors with infinite advantages are expected to continuously advance as one of the most promising tools for biomedical applications.

scholarly journals Detection of Immunoglobulin E with a Graphene-Based Field-Effect Transistor Aptasensor

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Yi Lan ◽  
Sidra Farid ◽  
Xenia Meshik ◽  
Ke Xu ◽  
Min Choi ◽  
...  
Keyword(s):  
Field Effect ◽  
Biomedical Applications ◽  
Field Effect Transistor ◽  
High Selectivity ◽  
Immunoglobulin E ◽  
Dna Aptamer ◽  
Conductive Substrate ◽  
Wide Range ◽  
Target Molecules ◽  
Effect Transistor

DNA aptamers have the ability to bind to target molecules with high selectivity and therefore have a wide range of clinical applications. Herein, a graphene substrate functionalized with a DNA aptamer is used to sense immunoglobulin E. The graphene serves as the conductive substrate in this field-effect-transistor-like (FET-like) structure. A voltage probe in an electrolyte is used to sense the presence of IgE as a result of the changes in the charge distribution that occur when an IgE molecule binds to the IgE DNA-based aptamer. Because IgE is an antibody associated with allergic reactions and immune deficiency-related diseases, its detection is of utmost importance for biomedical applications.

scholarly journals Silicon Nanowire Field-effect-transistor-based Biosensor for Biomedical Applications

2018 ◽  
Vol 30 (8) ◽  
pp. 1619 ◽  
Author(s):  
Anran Gao ◽  
Shixing Chen ◽  
Yuelin Wang ◽  
Tie Li
Keyword(s):  
Field Effect ◽  
Biomedical Applications ◽  
Field Effect Transistor ◽  
Silicon Nanowire ◽  
Effect Transistor

scholarly journals Design and Analysis of Heavily Doped n+ Pocket Asymmetrical Junction-Less Double Gate MOSFET for Biomedical Applications

2020 ◽  
Vol 10 (7) ◽  
pp. 2499 ◽  
Author(s):  
Namrata Mendiratta ◽  
Suman Lata Tripathi ◽  
Sanjeevikumar Padmanaban ◽  
Eklas Hossain
Keyword(s):  
Metal Oxide ◽  
Field Effect ◽  
Biomedical Applications ◽  
Field Effect Transistor ◽  
Gate Oxide ◽  
Metal Oxide Semiconductor ◽  
Oxide Semiconductor ◽  
Oxide Interface ◽  
Heavily Doped ◽  
Effect Transistor

The Complementary Metal-Oxide Semiconductor (CMOS) technology has evolved to a great extent and is being used for different applications like environmental, biomedical, radiofrequency and switching, etc. Metal-Oxide-Semiconductor Field-Effect Transistor (MOSFET) based biosensors are used for detecting various enzymes, molecules, pathogens and antigens efficiently with a less time-consuming process involved in comparison to other options. Early-stage detection of disease is easily possible using Field-Effect Transistor (FET) based biosensors. In this paper, a steep subthreshold heavily doped n+ pocket asymmetrical junctionless MOSFET is designed for biomedical applications by introducing a nanogap cavity region at the gate-oxide interface. The nanogap cavity region is introduced in such a manner that it is sensitive to variation in biomolecules present in the cavity region. The analysis is based on dielectric modulation or changes due to variation in the bio-molecules present in the environment or the human body. The analysis of proposed asymmetrical junctionless MOSFET with nanogap cavity region is carried out with different dielectric materials and variations in cavity length and height inside the gate–oxide interface. Further, this device also showed significant variation for changes in different introduced charged particles or region materials, as simulated through a 2D visual Technology Computer-Aided Design (TCAD) device simulator.

Development of a miniaturepH glass electrode with field-effect-transistor amplifier for biomedical applications

1975 ◽  
Vol 13 (3) ◽  
pp. 450-456 ◽  
Author(s):  
B. K. Ahn ◽  
C. C. Liu ◽  
A. O. Wist ◽  
W. H. Ko
Keyword(s):  
Field Effect ◽  
Biomedical Applications ◽  
Field Effect Transistor ◽  
Glass Electrode ◽  
Transistor Amplifier ◽  
Effect Transistor

scholarly journals Engineering functional protein interfaces for immunologically modified field effect transistor (ImmunoFET) by molecular genetic means

2007 ◽  
Vol 5 (18) ◽  
pp. 123-127 ◽  
Author(s):  
Edward Eteshola ◽  
Matthew T Keener ◽  
Mark Elias ◽  
John Shapiro ◽  
Leonard J Brillson ◽  
...  
Keyword(s):  
Protein Engineering ◽  
Field Effect ◽  
Field Effect Transistor ◽  
Molecular Genetic ◽  
Antibody Fragments ◽  
Single Chain ◽  
Functional Protein ◽  
Receptor Proteins ◽  
Assembled Monolayers ◽  
Effect Transistor

The attachment and interactions of analyte receptor biomolecules at solid–liquid interfaces are critical to development of hybrid biological–synthetic sensor devices across all size regimes. We use protein engineering approaches to engineer the sensing interface of biochemically modified field effect transistor sensors (BioFET). To date, we have deposited analyte receptor proteins on FET sensing channels by direct adsorption, used self-assembled monolayers to tether receptor proteins to planar FET SiO 2 sensing gates and demonstrated interface biochemical function and electrical function of the corresponding sensors. We have also used phage display to identify short peptides that recognize thermally grown SiO 2 . Our interest in these peptides is as affinity domains that can be inserted as translational fusions into receptor proteins (antibody fragments or other molecules) to drive oriented interaction with FET sensing surfaces. We have also identified single-chain fragment variables (scFvs, antibody fragments) that recognize an analyte of interest as potential sensor receptors. In addition, we have developed a protein engineering technology (scanning circular permutagenesis) that allows us to alter protein topography to manipulate the position of functional domains of the protein relative to the BioFET sensing surface.

Performance Analysis of Ion-Sensitive Field Effect Transistor with Various Oxide Materials for Biomedical Applications

Silicon ◽  
2021 ◽  
Author(s):  
M. Durga Prakash ◽  
Beulah Grace Nelam ◽  
Shaik Ahmadsaidulu ◽  
Alluri Navaneetha ◽  
Asisa Kumar Panigrahy
Keyword(s):  
Performance Analysis ◽  
Field Effect ◽  
Biomedical Applications ◽  
Field Effect Transistor ◽  
Oxide Materials ◽  
Effect Transistor

Simulation of Gate-All-Around Tunnel Field-Effect Transistor with an n-Doped Layer

2010 ◽  
Vol E93-C (5) ◽  
pp. 540-545 ◽  
Author(s):  
Dong Seup LEE ◽  
Hong-Seon YANG ◽  
Kwon-Chil KANG ◽  
Joung-Eob LEE ◽  
Jung Han LEE ◽  
...  
Keyword(s):  
Field Effect ◽  
Field Effect Transistor ◽  
Effect Transistor ◽  
Tunnel Field Effect Transistor
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