scholarly journals Current Knowledge on Snake Dry Bites

Toxins ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 668 ◽  
Author(s):  
Manuela B. Pucca ◽  
Cecilie Knudsen ◽  
Isadora S. Oliveira ◽  
Charlotte Rimbault ◽  
Felipe A. Cerni ◽  
...  
Keyword(s):  
Medical Care ◽  
Clinical Diagnosis ◽  
Patient Outcomes ◽  
Current Knowledge ◽  
Clinical Knowledge ◽  
Snake Species ◽  
Therapeutic Protocol ◽  
History Of ◽  
Improve Patient

Snake ‘dry bites’ are characterized by the absence of venom being injected into the victim during a snakebite incident. The dry bite mechanism and diagnosis are quite complex, and the lack of envenoming symptoms in these cases may be misinterpreted as a miraculous treatment or as proof that the bite from the perpetrating snake species is rather harmless. The circumstances of dry bites and their clinical diagnosis are not well-explored in the literature, which may lead to ambiguity amongst treating personnel about whether antivenom is indicated or not. Here, the epidemiology and recorded history of dry bites are reviewed, and the clinical knowledge on the dry bite phenomenon is presented and discussed. Finally, this review proposes a diagnostic and therapeutic protocol to assist medical care after snake dry bites, aiming to improve patient outcomes.

scholarly journals von Hippel-Lindau Disease: an Update

2019 ◽  
Vol 7 (4) ◽  
pp. 227-235 ◽  
Author(s):  
Eamonn R Maher ◽  
Richard N Sandford
Keyword(s):  
Natural History ◽  
Patient Outcomes ◽  
Molecular Characterisation ◽  
Von Hippel Lindau ◽  
Functional Characterisation ◽  
History Of ◽  
Vhl Protein ◽  
Von Hippel Lindau Disease ◽  
Vhl Disease ◽  
Improve Patient

Abstract Purpose of Review In this review, we discuss the key molecular and clinical developments in VHL disease that have the potential to impact on the natural history of the disease and improve patient outcomes. Recent Findings Identifiable mutations in VHL underlie most cases of VHL and define clear genotype-phenotype correlations. Detailed clinical and molecular characterisation has allowed the implementation of lifelong screening programmes that have improved clinical outcomes. Functional characterisation of the VHL protein complex has revealed its role in oxygen sensing and the mechanisms of tumourigenesis that are now being exploited to develop novel therapies for VHL and renal cancer. Summary The molecular and cellular landscape of VHL-associated tumours is revealing new opportunities to modify the natural history of the disease and develop therapies. Drugs are now entering clinical trials and combined with improved clinical and molecular diagnosis, and lifelong surveillance programmes, further progress towards reducing the morbidity and mortality associated with VHL disease is anticipated.

scholarly journals Morel-Lavallée lesion of the anterior leg: a rare anatomical presentation

2020 ◽  
Vol 13 (2) ◽  
pp. e233295 ◽  
Author(s):  
Karthik Ramaseshan ◽  
Laura D Bauler ◽  
Joshua Mastenbrook
Keyword(s):  
Patient Outcomes ◽  
Surgical Intervention ◽  
Subcutaneous Tissue ◽  
Lower Leg ◽  
Deep Fascia ◽  
Oral Antibiotics ◽  
Rare Injury ◽  
Blunt Force Trauma ◽  
History Of ◽  
Improve Patient

A Morel-Lavallée lesion (MLL) is a rare injury caused by blunt force trauma causing separation of subcutaneous tissue from the deep fascia. It is frequently seen in orthopaedic cases involving fractures of the hip or pelvis but is rare in the lower leg. The rarity of this condition often leads to misdiagnosis. A 66-year-old man presented to the emergency department after a 300-pound safe sheered across his left anterolateral leg causing skin avulsion, tenderness, swelling, ecchymosis, and erythema. The patient was treated for suspected cellulitis with oral antibiotics, but the lesion evolved into a necrotic eschar necessitating surgical intervention. In hindsight, MLL is a more appropriate diagnosis based on injury mechanism, disease progression and intraoperative findings. A history of shearing trauma with diffuse ecchymosis and erythema should prompt consideration of MLL. Due to rampant misdiagnosis, this case aims to increase awareness, as early diagnosis of MLL will improve patient outcomes.

Implementing Interprofessional Collaboration to Improve Patient Outcomes: A Caring and Social Approach to Integrated Nurse-Led Community Based-Care

2020 ◽  
Vol 24 (1) ◽  
pp. 39-49
Author(s):  
Eugenia Millender ◽  
Kathleen Valentine ◽  
Terry Eggenberger ◽  
Cristina Lucier ◽  
Heather Sandala ◽  
...  
Keyword(s):  
Patient Outcomes ◽  
Interprofessional Collaboration ◽  
Treatment Plan ◽  
Models Of Care ◽  
Theory And Practice ◽  
Model Of Care ◽  
Community Based ◽  
Social Approach ◽  
History Of ◽  
Improve Patient

Nurses have a history of providing compassionate care while caring for patients living with co-occurring medical and mental conditions. Therefore, it is reasonable to develop and implement nurse-led interprofessional (IP) models of care to address chronic illness. A nurse-led IP model of care was evaluated utilizing three selected patient outcomes. Results revealed an increase in mental health stability and access to care and successful completion of a treatment plan. Integrating caring theory and practice with social determinants of health and nurse-led IP models of care is a valuable approach to improving patient outcomes and addressing health disparity.

scholarly journals Roles for Autophagy in Esophageal Carcinogenesis: Implications for Improving Patient Outcomes

Cancers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1697 ◽  
Author(s):  
Saxena ◽  
Klochkova ◽  
Murray ◽  
Kabir ◽  
Samad ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Patient Outcomes ◽  
Current Knowledge ◽  
Survival Rates ◽  
Response To Therapy ◽  
Evolutionarily Conserved ◽  
Human Malignancy ◽  
Esophageal Carcinogenesis ◽  
Improve Patient ◽  
Potential Use

Esophageal cancer is among the most aggressive forms of human malignancy with five-year survival rates of <20%. Autophagy is an evolutionarily conserved catabolic process that degrades and recycles damaged organelles and misfolded proteins to maintain cellular homeostasis. While alterations in autophagy have been associated with carcinogenesis across tissues, cell type- and context-dependent roles for autophagy have been reported. Herein, we review the current knowledge related to autophagy in esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), the two most common subtypes of esophageal malignancy. We explore roles for autophagy in the development and progression of ESCC and EAC. We then continue to discuss molecular markers of autophagy as they relate to esophageal patient outcomes. Finally, we summarize current literature examining roles for autophagy in ESCC and EAC response to therapy and discuss considerations for the potential use of autophagy inhibitors as experimental therapeutics that may improve patient outcomes in esophageal cancer.

Abstract P858: The Impact of a Dedicated Stroke Program Quality Coordinator Registered Nurse on the Volume of Performance Improvement Projects

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Denise Gaffney ◽  
Lorina Punsalang ◽  
Alvina Mkrtumyan ◽  
Raeesa Dhanji ◽  
David L McCartney ◽  
...  
Keyword(s):  
Los Angeles ◽  
Performance Improvement ◽  
Patient Outcomes ◽  
Neurosurgical Procedures ◽  
Clinical Knowledge ◽  
Regulatory Requirements ◽  
Survey Results ◽  
The Impact ◽  
Improve Patient

Background: Performance Improvement (PI) enhances processes, services, and outcomes. The Joint Commission (TJC) standards require a comprehensive approach to PI. This can be challenging due to variability of staffing within a stroke program. The stroke coordinator is often left to manage PI projects, which can be arduous due to the multiple demands of their role. A dedicated Stroke Quality Coordinator RN (SQCRN) manages quality improvement activities solely for the stroke program. It is a unique position that requires clinical knowledge of stroke, neuro-interventional and neurosurgical procedures, as well as, comprehension of regulatory requirements, PI and data analysis. Purpose: To determine if having an SQCRN dedicated to a stroke program results in an increased number of PI Projects implemented. Methods: The SQCRN initiative was implemented in 2020 with the objective of determining the impact of having a dedicated SQCRN on the number of projects completed. A survey was created consisting of 5 questions and sent to 328 individuals via email utilizing an anonymous Microsoft Forms Link. The survey was emailed to the Los Angeles Stroke Coordinator Network and National Stroke Coordinator group. Fifty-eight (17.6%) responded. Survey results were compared for stroke programs with a Dedicated SQCRN to those without. Data were analyzed using T-Test. Results: In stroke programs with a dedicated SQCRN, there were more respondents who reported 6 or greater PI projects than stroke programs who did not have a dedicated SQCRN. This was statistically significant when compared to both 2 or less (p=0.001) or 4 or less projects p=0.035. Conclusion: A dedicated SQCRN improves the number of PI projects that a stroke program can implement. PI initiatives help to improve the safety, treatments, services and quality of care in order to improve patient outcomes.

scholarly journals Fulminant Emphysematous Hepatitis – A Rare Cause of Septic Shock

2020 ◽  
Author(s):  
Gonçalo Miranda ◽  
Ana Catarina Dionísio ◽  
Constança Azevedo ◽  
Eduardo Carvalho ◽  
Miguel Semião ◽  
...  
Keyword(s):  
Patient Outcomes ◽  
Hepatitis A ◽  
Early Recognition ◽  
Case Reports ◽  
Fatal Outcome ◽  
Hepatic Parenchyma ◽  
Aggressive Management ◽  
Patients With Diabetes ◽  
History Of ◽  
Improve Patient

Emphysematous hepatitis is a rare entity characterized by the replacement of hepatic parenchyma by gas, leading to acute liver failure. Often it occurs in patients with diabetes mellitus, liver disease or a recent history of abdominal surgery. We present a case of emphysematous hepatitis in a 74-year-old man with no recognizable risk factors. Despite the early broad-spectrum antimicrobial therapy and supportive care, the condition progressed to a fatal outcome, as seen in other case reports. Early recognition of this condition and rapid and aggressive management may improve patient outcomes.

scholarly journals Anticancer Activity of "Ziziphus jujuba" - A Review

2021 ◽  
pp. 261-269
Author(s):  
U. Vidhya Rekha ◽  
S. Bhuminathan ◽  
P. Ravi Shankar
Keyword(s):  
Drug Resistance ◽  
Patient Outcomes ◽  
Therapeutic Interventions ◽  
Anticancer Efficacy ◽  
Wide Range ◽  
History Of ◽  
Ziziphus Jujuba ◽  
Review Study ◽  
Improve Patient ◽  
Anti Inflammation

Ziziphus jujuba Mill. (Z. jujube) is a conventional plant that has a long history of usage in nutrients and the therapeutic interventions of a wide range of ailments. It grows mainly in South and East Asia, and also in Australia and Europe. Mounting data supports the health advantages of Z. jujuba, including anticancer, anti-inflammation, anti-obesity, antioxidant, and hepato- and gastrointestinal protective characteristics. Chemotherapy, particularly with cis-diamminedichloroplatinium (CDDP, cisplatin) and its derivatives, is commonly used to treat cancer. Although it is an effective therapy for human tumors, drug resistance impedes successful treatment. A better knowledge of the processes and develop strategies to address chemoresistance can improve patient outcomes dramatically. Numerous researchers have recently focused their attention on the increasing occurrence of numerous types of malignancies worldwide. The anticancer efficacy of Z. jujuba was discussed in this review study.

Combined Approaches to the Skull Base for Intracranial Extension of Tumors via Perineural Spread can Improve Patient Outcomes

2016 ◽  
Vol 77 (S 01) ◽  
Author(s):  
Sheri Palejwala ◽  
Jonnae Barry ◽  
Crystal Rodriguez ◽  
Chandni Parikh ◽  
Stephen Goldstein ◽  
...  
Keyword(s):  
Skull Base ◽  
Patient Outcomes ◽  
Intracranial Extension ◽  
Perineural Spread ◽  
Improve Patient

Microporous Polysaccharide Hemosphere Absorbable Hemostat (AristaAH®) in Re-Operative Cardiac Surgical Procedures

2012 ◽  
Vol 9 (2) ◽  
pp. 96-98
Author(s):  
Brian A Bruckner ◽  
Matthias Loebe
Keyword(s):  
Patient Outcomes ◽  
Surgical Procedures ◽  
Systematic Approach ◽  
Surgical Intervention ◽  
Transfusion Requirement ◽  
Cardiac Surgical Procedures ◽  
Platelet Inhibitors ◽  
Hemostatic Agents ◽  
Surgical Field ◽  
Improve Patient

Patients undergoing re-operative cardiac surgical procedures present a great challenge with regard to obtaining hemostasis in the surgical field. Adhesions are ever-present and these patients are often on oral anti-coagulants and platelet inhibitors. As part of a well-planned surgical intervention, a systematic approach to hemostasis should be employed to decrease blood transfusion requirement and improve patient outcomes. Topical hemostatic agents can be a great help to the surgeon in achieving surgical field hemostasis and are increasingly being employed. Our approach, to these difficult patients, includes the systematic and planned use of AristaAH, which is a novel hemostatic agent whose use has proven safe and efficacious in our patient population.

Sign in / Sign up

Export Citation Format

Share Document