scholarly journals Primary Retrobulbar Leiomyosarcoma in a Dog: A Case Report

2020 ◽  
Vol 7 (4) ◽  
pp. 145
Author(s):  
Joong-Hyun Song ◽  
Do-Hyeon Yu ◽  
Dong-In Jung
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Needle Aspiration ◽  
Tissue Mass ◽  
Undifferentiated Sarcoma ◽  
Malignant Mesenchymal Tumor ◽  
Atypical Cells ◽  
Mongrel Dog ◽  
Affected Tissue ◽  
Needle Aspiration Cytology

A 2-year-old female Mongrel dog weighing 3.12 kg presented with a 2-month history of progressive exophthalmos of the left eye and periorbital swelling. Fine-needle aspiration cytology of the affected tissue revealed atypical cells of suspected malignant mesenchymal tumor origin. Computed tomography and magnetic resonance imaging revealed an ill-demarcated soft tissue mass in the left retrobulbar space extending into the nasal cavity and into the frontal lobes of the brain with destruction of the adjacent cribriform plate and the basisphenoid bone. Histopathological features of the tumor were consistent with the diagnosis of undifferentiated sarcoma. The tumor cells were immunoreactive for vimentin, smooth muscle actin, and desmin and negative for S100. These findings were mostly consistent with leiomyosarcoma arising from the smooth muscle on the retrobulbar tissues. Primary retrobulbar leiomyosarcoma is an extremely rare tumor in dogs. To expand our knowledge of retrobulbar leiomyosarcoma in dogs, we have described its clinical, diagnostic imaging, histopathological, and immunohistochemical characteristics in a dog.

scholarly journals Cutaneous leiomyosarcoma with visceral metastases in a White Carneau pigeon and literature review

2021 ◽  
pp. 104063872199206
Author(s):  
Niora J. Fabian ◽  
Michael Y. Esmail ◽  
Lauren Richey ◽  
Sureshkumar Muthupalani ◽  
Jennifer L. Haupt ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Surgical Excision ◽  
Columba Livia ◽  
Avian Species ◽  
Doppler Imaging ◽  
Mesenchymal Tumors ◽  
Tissue Mass ◽  
Color Flow ◽  
Visceral Metastases

Cutaneous leiomyosarcomas are malignant mesenchymal tumors of smooth muscle origin and are reported occasionally in avian species. A 14-y-old male laboratory White Carneau pigeon ( Columba livia) was presented for surgical excision of a cervical soft tissue mass. Ultrasonography with color flow Doppler imaging revealed multiple cavitations of mixed echogenicity within the mass and vascularization. Histologically, the dermis and subcutis were expanded by a densely cellular multinodular mass comprised of fusiform cells forming haphazardly arranged broad streams and short interwoven bundles, often surrounding blood vessels and variably sized cavitations. Neoplastic cells were strongly immunopositive for desmin and α–smooth muscle actin, and negative for pancytokeratin, S100, and von Willebrand factor. Based on histopathology and IHC findings, the cutaneous mass was diagnosed as leiomyosarcoma (LMS). The pigeon died 312 d post-operatively. Postmortem examination revealed masses infiltrating the left and right pulmonary airways and one hepatic nodule, but no regrowth at the surgical site. Histologic and IHC evaluation of the pulmonary and hepatic masses were consistent with LMS, representing metastatic foci from the primary cutaneous LMS. Our case highlights the malignant behavior and histomorphologic features of cutaneous LMS in an avian species.

Fibroadenoma Mimicking Papillary Carcinoma on ThinPrep of Fine-Needle Aspiration of the Breast

2000 ◽  
Vol 124 (11) ◽  
pp. 1667-1669
Author(s):  
Timothy Myers ◽  
Helen H. Wang
Keyword(s):  
Fine Needle Aspiration ◽  
Stromal Cells ◽  
Fine Needle Aspiration Cytology ◽  
Smooth Muscle Actin ◽  
Single Cells ◽  
False Negative ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Abstract Objective.—To compare and contrast benign and malignant lesions of the breast that have similar appearances on fine-needle aspiration cytology and that constitute diagnostic pitfalls. Design.—The cytology files (dated November 1995 through May 1998) of the Beth Israel Deaconess Medical Center were searched to identify cases of breast fine-needle aspiration biopsies that were highly cellular and composed of bland-appearing spindle/columnar cells and that could represent either epithelial or stromal cells; these cases were reported as indeterminate (atypical/suspicious) and had subsequent excisional biopsies taken. Results.—Four such cases were found. Two were fibroadenomas and 2 were papillary carcinomas. Their appearances were strikingly similar on aspiration cytology. All cases were prepared with the ThinPrep method. On microscopic examination, all 4 cases were hypercellular and had many single cells and clusters of columnar/elongate cells. Immunocytochemistry proved these cells to be of epithelial origin. At least occasional bipolar stromal cells were seen in the background. The only appreciable difference between the benign and malignant cases was more significant nuclear atypia, which was barely discernible, in the malignant cases. Immunocytochemistry for smooth muscle actin was helpful in 2 cases that had sufficient material. Conclusions.—Some cases of fibroadenomas and papillary carcinomas can be very difficult, if not impossible, to distinguish on fine-needle aspiration cytology. Immunocytochemistry may be helpful if sufficient material is available. To avoid false-negative or false-positive diagnosis on cytology, it is best to report such cases as atypical or suspicious with final diagnosis pending excisional biopsy.

scholarly journals CT-Guided Percutaneous Fine Needle Aspiration Cytology of Pulmonary Mass.

2013 ◽  
Vol 11 (1) ◽  
pp. 37-41
Author(s):  
Rajive Raj Shahi ◽  
Mukunda Singh Shrestha ◽  
Sujata Pant ◽  
Sunil Singh ◽  
Dinesh Maharjan
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Lung Lesion ◽  
Aspiration Cytology ◽  
Ct Guided ◽  
Lung Lesions ◽  
Fine Needle ◽  
Atypical Cells ◽  
Needle Aspiration Cytology

Introduction: Following the first study of Computed tomography guided trans thoracic biopsy of lung lesion by Haaga and Alfidi in 1976, CT guided transthoracic biopsy has been widely used for confirming the diagnosis of suspicious lung lesions. This study is aimed to assess the effectiveness of Transthoracic percutaneous fi ne needle aspiration cytology and frequency of associated complications. Methods: A retrospective, hospital based study was performed between 11/06/2008 and 1/12/2009 at Department of Radiology, Shree Birendra Hospital, Kathmandu, Nepal. Thirty nine consecutive cases of lung lesions who underwent Trans Thoracic Percutaneous Fine Needle Aspiration Cytology (TTFNAC) under CT guidance were analysed. Smears of the aspirated material were evaluated by the pathology consultant (cytopathological evaluation) for adequacy. Results: There was adequate material for a cytopathological diagnosis in thirty four (87.18 %) cases. Two cases were hemorrhagic while three cases revealed only reactive cells thus inadequate and non representative case constituted (12.8 %). Eight cases were reported as benign (23.53 %). Twenty three samples (67.65%) were reported as definite malignant cases and three cases (8.82%) showed atypical cells, suggestive of malignancy. Squamous cell carcinoma was the single most frequent histological diagnosis (12 cases). Conclusions: The FNAC of lung is useful, safe and economical technique providing 87% diagnostic accuracy for lung mass without significant increase in complications. Medical Journal of Shree Birendra Hospital; Jan-June 2012/vol.11/Issue1/37-41 DOI: http://dx.doi.org/10.3126/mjsbh.v11i1.7766

scholarly journals Major Clues and Pitfalls in the Differential Diagnosis of Parathyroid and Thyroid Lesions Using Fine Needle Aspiration Cytology

Medicina ◽  
2020 ◽  
Vol 56 (11) ◽  
pp. 558
Author(s):  
Hwa Jeong Ha ◽  
Eun Ju Kim ◽  
Jung-Soon Kim ◽  
Myung-Soon Shin ◽  
Insup Noh ◽  
...  
Keyword(s):  
Parathyroid Adenoma ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Parathyroid Lesions ◽  
Atypical Cells ◽  
Needle Aspiration Cytology ◽  
Thyroid Lesions

Background: It is difficult to distinguish parathyroid lesions (PLs) from thyroid lesions using fine needle aspiration cytology (FNAC) because of their proximity and their similar cytomorphological features. Methods: FNAC smears of 46 patients with pathologically proven PLs that were histologically diagnosed as parathyroid adenoma (PA, n = 35), parathyroid hyperplasia (PH, n = 3), atypical parathyroid adenoma (APA, n = 1), and parathyroid carcinoma (PC, n = 7) were retrospectively reviewed and analyzed. Results: Our initial cytological diagnoses indicated correct diagnoses in 31 of 46 PL patients (67%). The 15 erroneous diagnoses were 5 patients with non-specific benign disease (11%), 4 with nodular hyperplasia of the thyroid (9%), 5 with atypical cells (11%), and 1 with a metastatic papillary thyroid carcinoma (2%). Follicular pattern, papillary structures, colloid-like material, and macrophages, which often suggest thyroid lesions, were also present in some PLs. We found that branching capillaries along the papillary structures, stippled nuclear chromatin, and frequent occurrence of naked nuclei were useful for determining a parathyroid origin. Conclusions: It is important to be aware that PLs are frequently mistaken for thyroid lesions based on FNAC. The specific and unique characteristics of PLs identified here may be helpful in diagnosis.

scholarly journals Paraspinal Extraosseous Ewing's Sarcoma With Disseminated Metastases Masquerading As Pott's Spine

2013 ◽  
Vol 12 (3) ◽  
pp. 334-338
Author(s):  
Ansari Sajid ◽  
Ahmad Kaleem ◽  
Amanullah Md. Farid ◽  
Dhungel Kanchan ◽  
Gupta Mukesh Kumar ◽  
...  
Keyword(s):  
Medical Science ◽  
Plain Radiograph ◽  
Lung Parenchyma ◽  
Needle Aspiration ◽  
Lower Limbs ◽  
Lytic Lesion ◽  
Tissue Mass ◽  
Antitubercular Drugs ◽  
Needle Aspiration Cytology ◽  
Extraosseous Ewing’S Sarcoma

A 16 years old girl presented with low back pain, fever and weakness in both lower limbs for 3 months. Plain radiograph shows lytic lesion in first sacral vertebra and multiple lung nodules. In suspicion of tuberculosis, antitubercular drugs were advised. But magnetic resonance imaging revealed right paraspinal soft tissue mass with multiple lesions in several vertebrae causing spinal canal compression alongwith lesions in iliac bones, sacrum, lung parenchyma and scalp tissue. Fine needle aspiration cytology and biopsy revealed Ewing’s sarcoma. Patient was referred to higher centre for chemotherapy/radiotherapy. Herein we report this rare case of extraosseous Ewing’s sarcoma with disseminated metastases masquerading as Pott’s spine. Bangladesh Journal of Medical Science Vol. 12 No. 03 July ’13 Page 334-338 DOI: http://dx.doi.org/10.3329/bjms.v12i3.15447

Gastric Adenomyoma: Salient Imitator

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S67-S67
Author(s):  
A J Kobalka ◽  
S Singh
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Fine Needle Aspiration ◽  
Smooth Muscle Actin ◽  
Gastric Wall ◽  
Needle Aspiration ◽  
Smooth Muscle Tissue ◽  
Fine Needle ◽  
Gastrointestinal Lesions ◽  
Gastric Type

Abstract Introduction/Objective Gastric adenomyoma is a lesion characterized by proliferation of epithelium and smooth muscle in the stomach or small bowel. By ultrasound, gastric adenomyoma usually appears as a submucosal nodule with a cystic center. They can mimic many benign and malignant conditions and are an important differential diagnosis to consider in fine needle aspiration of submucosal upper gastrointestinal lesions. Methods/Case Report We present a 30-year-old male who presented with abdominal pain, dyspepsia, and heartburn. Esophagogastroduodenoscopy demonstrated a 10 mm well-circumscribed hypoechoic mass in the antral submucosa along the greater curvature of the stomach. Two years later, the lesion was 18.6 mm in greatest dimension and fine needle aspiration was performed. Cell block showed foci of benign gastric glands and bland smooth muscle tissue, positive for smooth muscle actin and desmin, and negative for CD34 and c-kit (CD117). Gastrointestinal stromal tumor was the main differential diagnosis and adenomyosis was not considered, thus, the biopsy was thought to represent normal gastric wall, and the glands were dismissed as contaminant from the aspiration. A subsequent ultrasound two years later again demonstrated the lesion, now 21.5 mm in greatest dimension, and definitive resection was performed. Histologic examination showed a segment of stomach with gastric antral-type mucosa and an underlying mass forming lesion consisting of scattered gastric type glands admixed with smooth muscle bundles, consistent with gastric adenomyoma. The glands were completely surrounded by smooth muscle and lamina propria. Our patient has been asyptomatic one year since resection of the gastric adenomyoma. Results (if a Case Study enter NA) NA Conclusion Gastric adenomyoma is an important differential of intramural spindle cell neoplasms of the gastrointestinal tract alongside many benign and malignant conditions. Consideration of gastric adenomyoma at the time of the original biopsy would have spared the patient uncertainty regarding their prognosis and allowed for definitive resection two years earlier.

scholarly journals Uterine Smooth Muscle Tumors in Potbellied Pigs (Sus scrofa) Resemble Human Fibroids: A Potential Animal Model

2004 ◽  
Vol 32 (4) ◽  
pp. 402-407 ◽  
Author(s):  
Kristie Mozzachio ◽  
Keith Linder ◽  
Darlene Dixon
Keyword(s):  
Animal Model ◽  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Clinical Signs ◽  
The United States ◽  
Uterine Leiomyomas ◽  
Reproductive Age ◽  
Variable Degree ◽  
Undifferentiated Sarcoma ◽  
Uterine Tumors

Uterine leiomyomas, commonly termed fibroids, clinically affect approximately 25% of women of reproductive age in the United States, with a subclinical incidence as high as 77%. The pathogenesis of fibroid formation remains poorly understood, due in large part to the lack of a suitable animal model. This retrospective study characterizes the clinical, gross, and histopathologic features of similar, spontaneously occurring uterine tumors in potbellied pigs. Medical records available through a local Potbellied Pig Spay/Neuter Program, pig sanctuaries, and the Duchess Fund database were reviewed for evidence of reproductive disease or surgery. One-hundred and six female potbellied pigs were evaluated and uterine neoplasia was identified in 17 animals; tissues were available for 13 of these. Uterine leiomyoma was diagnosed in 11 of 13 cases, leiomyosarcoma in 1 of 13 cases, and undifferentiated sarcoma in 1 case. Pigs presented with clinical signs including abdominal distension or vaginal bleeding or were subclinical and identified during ovariohysterectomy. Tumors ranged from microscopic to 45 kg, were often multiple, and primarily involved the uterine horns. Hematoxylin and eosin and trichrome-stained sections were evaluated for morphological features of human and animal leiomyomas; immunohistochemistry to detect smooth muscle actin was also performed. The cellular pattern/morphology and variable degree of fibroplasia of the leiomyomas were similar to that reported for human fibroids. These results support further investigation of uterine leiomyomas in potbellied pigs as a potentially valuable animal model for studying human fibroids.

scholarly journals Primary Hepatoid Adenocarcinoma of the Lung

2016 ◽  
Vol 50 (2) ◽  
pp. 103-106 ◽  
Author(s):  
Uma Devaraj ◽  
Gnanapriya Vellaisamy ◽  
Julian Crasta
Keyword(s):  
Needle Aspiration ◽  
Hepatoid Adenocarcinoma ◽  
Male Smoker ◽  
Rare Type ◽  
Adenocarcinoma Of The Lung ◽  
Thyroid Transcription Factor ◽  
Atypical Cells ◽  
Serum Alpha Fetoprotein ◽  
Clear Cytoplasm ◽  
Needle Aspiration Cytology

ABSTRACT Hepatoid adenocarcinoma lung (HAL) is an extremely rare type of extrahepatic adenocarcinoma with morphological similarity to hepatocellular carcinoma. We report a case of 59 years male smoker who presented with anorexia, weight loss and cough. Chest X-ray revealed a homogenous opacity in the left upper and mid zone. Computed tomography (CT) chest showed a left upper lobe mass with enlarged hilar lymph nodes. Serum alpha fetoprotein (AFP) was normal. Guided fine needle aspiration cytology (FNAC) of the mass revealed a few atypical cells. Endobronchial biopsy showed sheets of polygonal cells with coarsely clumped chromatin, eosinophilic nucleoli and abundant eosinophilic to clear cytoplasm. The neoplastic cells were positive for hepatocyte-1, Carcinogenic embryonic antigen (CEA), Cytokeratin 7 (CK-7) and cytoplasmic positivity for thyroid transcription factor (TTF-1). After 3 months, the tumor had grown significantly. Due to its aggressive behavior, early and accurate diagnosis is necessary. How to cite this article Vellaisamy G, Rout P, Crasta J, Devaraj U. Primary Hepatoid Adenocarcinoma of the Lung. J Postgrad Med Edu Res 2016;50(2):103-106.

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