The role of ALK5 in the profile of early reproductive losses in the use of assisted reproductive technologies

2021 ◽  
pp. 70-76
Author(s):  
Abuduwaili Ruziguli ◽  
Nikolai Nikolaevich Rukhliada ◽  
Anna Nikolaevna Taits ◽  
Tatyana Ivanovna Prohorovich ◽  
Tatyana Aleksandrovna Libova
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Embryo Transfer ◽  
Spontaneous Abortion ◽  
Assisted Reproductive Technologies ◽  
Immunohistochemical Study ◽  
Reproductive Technologies ◽  
Decidual Tissue ◽  
Reproductive Losses

This article is devoted to the assessment of the role of ALK5 in the profile of early reproductive losses in the use of assisted reproductive technologies, in particular, by using immunohistochemical study in the group of patients with early spontaneous abortion after the procedure of embryo transfer, a lower level of ALK5 expression in the decidual tissue was revealed (in comparison with control), which may be related to the occurrence of early reproductive losses caused by the imbalance in Th1 / Th2 and its effect on the increase in the concentration of natural killer cells.

The role of peripheral and endometrial natural killer cells in recurrent reproductive losses

2021 ◽  
Vol 7_2021 ◽  
pp. 19-27
Author(s):  
Zagainova V.A. Zagainova ◽  
Kogan I.Yu. Kogan ◽  
Bespalova O.N. Bespalova ◽  
Selkov S.A. Selkov ◽  
Sokolov D.I. Sokolov ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Killer Cells ◽  
Reproductive Losses

scholarly journals Pannexins and Connexins: Their Relevance for Oocyte Developmental Competence

2021 ◽  
Vol 22 (11) ◽  
pp. 5918
Author(s):  
Paweł Kordowitzki ◽  
Gabriela Sokołowska ◽  
Marta Wasielak-Politowska ◽  
Agnieszka Skowronska ◽  
Mariusz T. Skowronski
Keyword(s):  
Assisted Reproductive Technologies ◽  
Mammalian Species ◽  
Atp Release ◽  
Reproductive Technologies ◽  
High Energy ◽  
Developmental Competence ◽  
Physiological Processes ◽  
Protein Group ◽  
Multicellular Organisms

The oocyte is the major determinant of embryo developmental competence in all mammalian species. Although fundamental advances have been generated in the field of reproductive medicine and assisted reproductive technologies in the past three decades, researchers and clinicians are still trying to elucidate molecular factors and pathways, which could be pivotal for the oocyte’s developmental competence. The cell-to-cell and cell-to-matrix communications are crucial not only for oocytes but also for multicellular organisms in general. This latter mentioned communication is among others possibly due to the Connexin and Pannexin families of large-pore forming channels. Pannexins belong to a protein group of ATP-release channels, therefore of high importance for the oocyte due to its requirements of high energy supply. An increasing body of studies on Pannexins provided evidence that these channels not only play a role during physiological processes of an oocyte but also during pathological circumstances which could lead to the development of diseases or infertility. Connexins are proteins that form membrane channels and gap-junctions, and more precisely, these proteins enable the exchange of some ions and molecules, and therefore they do play a fundamental role in the communication between the oocyte and accompanying cells. Herein, the role of Pannexins and Connexins for the processes of oogenesis, folliculogenesis, oocyte maturation and fertilization will be discussed and, at the end of this review, Pannexin and Connexin related pathologies and their impact on the developmental competence of oocytes will be provided.

scholarly journals The Role of Natural Killer Cells in the Immune Response in Kidney Transplantation

2020 ◽  
Vol 11 ◽  
Author(s):  
Paola Pontrelli ◽  
Federica Rascio ◽  
Giuseppe Castellano ◽  
Giuseppe Grandaliano ◽  
Loreto Gesualdo ◽  
...  
Keyword(s):  
Immune Response ◽  
Kidney Transplantation ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Killer Cells

The role of maternal age in the assisted reproductive technologies

1999 ◽  
Vol 7 (1) ◽  
pp. 41-60 ◽  
Author(s):  
Mark A Damario ◽  
Owen K Davis ◽  
Zev Rosenwaks
Keyword(s):  
Older Women ◽  
Assisted Reproductive Technologies ◽  
Clinical Importance ◽  
Ovarian Response ◽  
Reproductive Technologies ◽  
Abortion Rate ◽  
Western World ◽  
Delayed Childbearing ◽  
Art Outcome

Age is perhaps the most important single variable influencing outcome in the assisted reproductive technologies (ART). The effect of advancing age on clinical ART outcome is manifested not only in the pattern of ovarian response to stimulation regimens, but also in reduced implantation efficiency and an increased spontaneous abortion rate. The clinical importance of these factors is compounded by the fact that increasing numbers of older women are presenting for ART treatment. Delayed childbearing is becoming increasingly common in the western world. The availability of methods of birth control, educational and career priorities for women, and the increased rates of divorce and remarriage are some of the factors contributing to this phenomenon.

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