Vitamin D levels and predictors in Swiss elite athletes – recommandation for supplementation

2018 ◽  
Vol 66 (2) ◽  
Keyword(s):  
Vitamin D ◽  
Bone Health ◽  
Athletic Performance ◽  
Muscle Function ◽  
Elite Athletes ◽  
The Sun ◽  
Predicted Probability ◽  
Vitamin D Levels ◽  
Z Scores ◽  
To Come

Background: Vitamin D concentrations corresponding to 75 nmol/L of 25(OH)D or more have been related to maintained muscle function, growth and regeneration, to optimal bone health and immunology in athletes. The objective of this study was to investigate prevalence and predictors of insufficient 25(OH)D concentrations in athletes and to come up with recommendations for our Swiss athletes. Methods: 603 competitive Swiss athletes were assessed during their annual pre-participation examination. A standardized questionnaire was used to gather information about potential predictors for 25(OH)D concentrations. Results: One in 2 athletes showed insufficient 25(OH)D concentrations. Differences in predicted probability of insufficient 25(OH)D were found for those that were not substituted (56%) vs. those substituted (42%) versus unsubstituted (52%), for those performing indoor (58%) vs. outdoor (43%) sports and during the sun deprived seasons fall (49%), winter (70%) and spring (57%) as compared to summer (17%). An increase in BMI z-scores and age was associated with higher 25(OH)D. Implication: One in two Swiss athletes shows insufficient 25(OH)D concentrations. To prevent potential harmful consequences on athletic performance, muscular, skeletal and immunological health, we recommend a regular substitution in daily, weekly or monthly intervals with a daily equivalent dose of 600–2000 IE Vit D except perhaps in summer. Routine assessments of 25(OH)D concentrations are not necessary.

scholarly journals Predictive Factors for Vitamin D Concentrations in Swiss Athletes: A Cross-sectional Study

2018 ◽  
Vol 02 (05) ◽  
pp. E148-E156 ◽  
Author(s):  
Simeon Zürcher ◽  
Andrea Quadri ◽  
Andreas Huber ◽  
Lothar Thomas ◽  
Graeme Close ◽  
...  
Keyword(s):  
Vitamin D ◽  
High Performance ◽  
Cross Sectional Study ◽  
The Sun ◽  
Cross Sectional ◽  
Outdoor Sports ◽  
Predicted Probability ◽  
Optimal Health ◽  
Z Scores ◽  
And Performance

AbstractVitamin D concentrations corresponding to 75 nmol/L 25(OH)D have been associated with maintained muscle function, growth and regeneration, optimal bone health and immunology in athletes. The objective of this study was to investigate the prevalence and predictors of insufficient 25(OH)D concentrations in athletes. Six hundred three Swiss athletes were assessed. 25(OH)D was analysed by high-performance liquid chromatography (HPLC). A standardized questionnaire was used to gather information about potential predictors for 25(OH)D concentrations; 50.5% showed insufficient 25(OH)D concentrations. Differences in predicted probability of insufficient 25(OH)D were found for those vitamin D supplemented (42%) versus not supplemented (52%), in those performing indoor (58%) versus outdoor sports (43%), and during the sun-deprived seasons of fall (49%), winter (70%) and spring (57%) compared with summer (17%). Higher BMI z-scores and age were associated with higher 25(OH)D concentrations. In conclusion, insufficient 25(OH)D concentrations were common among athletes especially at a younger age, among those not supplemented, in athletes who trained indoors, and during the sun-deprived seasons. Because the prevalence of insufficient 25(OH)D concentrations in this study was high, regular supplementation in athletes may be indicated, except perhaps during the summer season. Further research is needed to determine which 25(OH)D concentrations lead to optimal health and performance in athletes.

scholarly journals Impact of Chrysin on Vitamin D and Bone Health - Preclinical Studies

2020 ◽  
Author(s):  
Siva Swapna Kasarla ◽  
Sujatha Dodoala ◽  
Sunitha Sampathi ◽  
Narendra Kumar Talluri
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Health ◽  
Low Dose ◽  
Active Vitamin ◽  
Deficient Diet ◽  
Bone Parameters ◽  
Active Vitamin D ◽  
Vitamin D Levels ◽  
The Impact

AbstractVitamin D deficiency is an endemic problem existing worldwide. Although several strategies were established to enhance vitamin D3 levels, studies specifically focussing inhibition of vitamin D metabolism which may prolong the availability of active vitamin D in pathological conditions are less explored. Studies also suggest that higher doses of vitamin D3 fail to achieve optimum vitamin D levels. In this context, we focussed on the enzyme CYP3A4 which promotes inactivation of active vitamin D. The current study was aimed to decipher the impact of chrysin, a proven CYP3A4 inhibitor as an intervention and its effects in combination with low dose vitamin D3 (40 IU) and bone health in vitamin D deficiency condition. The in-vivo activity of chrysin was evaluated on female Wistar albino rats fed with a vitamin D deficient diet to attain vitamin D deficiency for 28 days. Chrysin was given alone and in combination with calcium carbonate (CaCO3) and/or vitamin D3. All the therapeutic interventions were assessed for serum 25-OH-D3 by LC-MS, biochemical, urinary, and bone parameters. Animals treated with chrysin alone and in combination with low dose vitamin D3 and/or CaCO3 showed an eminent rise in serum 25-OH-D3 levels along with increased serum biochemical parameters. On contrary, a significant decrease in the urinary parameters followed by beneficial effects on bone parameters was noticed in contrast with the vitamin D deficient diet group. Our findings revealed that although chrysin alone showed a notable effect on 25-OH-D3 and osseous tissue, comparatively it showed intensified therapeutic effect in combination with vitamin D3 and CaCO3 which can be employed as a cost-effective option to improve bone health.Graphical Abstract

scholarly journals Characterizing the Assessment and Management of Vitamin D Levels in Patients with Osteoporosis in Clinical Practice: A Chart Review Initiative

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Jonathan D. Adachi ◽  
Jacques P. Brown ◽  
George Ioannidis
Keyword(s):  
Vitamin D ◽  
Clinical Practice ◽  
Bone Health ◽  
Chart Review ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Vitamin D Supplements

Though vitamin D is important for bone health, little is known about the monitoring and management of vitamin D levels in patients with osteoporosis in clinical practice—a deficit this chart review initiative aimed to remedy. A total of 52 physicians completed profiles for 983 patients being treated for osteoporosis between November 2008 and April 2009. Information collected included demographics; fracture risk factors; availability and level of serum vitamin D measurements; and information on osteoporosis medications and calcium and vitamin D supplementation. Physicians also evaluated patients’ current regimens and detailed proposed changes, if applicable. Nearly 85% of patients were prescribed calcium and vitamin D supplements. Serum 25-hydroxy vitamin D levels were available for 73% of patients. Of these patients, approximately 50% had levels less than 80 nmol/L, which contrasts with the 37% thought to have “unsatisfactory” vitamin D levels based on physician perceptions. Physicians felt 26% of patients would benefit from additional vitamin D supplementation. However, no changes to the osteoporosis regimen were suggested for 48% of patients perceived to have “unsatisfactory” vitamin D levels. The results underscore the importance of considering vitamin D status when looking to optimize bone health.

scholarly journals Vitamin D Review: The Low Hanging Fruit for Human Health

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Lucy N. W. Mungai ◽  
Zanuba Mohammed ◽  
Michuki Maina ◽  
Omar Anjumanara
Keyword(s):  
Vitamin D ◽  
Cell Death ◽  
Immune Regulation ◽  
The Body ◽  
The Sun ◽  
Biological Processes ◽  
Phosphate Metabolism ◽  
Vitamin D Levels ◽  
Bone Mineralisation ◽  
Calcium And Phosphate Metabolism

Vitamin D is an important hormone that is known for the regulation of calcium and phosphate metabolism. Vitamin D deficiency leads to rickets in children and osteoporosis in adults leading to poor bone mineralisation and can also lead to serious dental complications in the same population. Recent studies have shown vitamin D to work as a hormone needed not only in bone and teeth but also in other body organs from intrauterine life up to old age. It has been demonstrated that Vitamin D has various effects on biological processes that deal with cell growth, differentiation, cell death, immune regulation, DNA stability, and neuronal growth. Despite being readily formed in the body through the intervention of the sun, patients are still found to have low vitamin D levels. We review studies done to show how vitamin D works.

scholarly journals MON-387 Association Between Vitamin D Level and Bone Mineral Density in Korean Adolescents

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Kyungchul Song ◽  
Han saem CHOI ◽  
Junghwan Suh ◽  
Ah Reum Kwon ◽  
Hyun-wook Chae ◽  
...  
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
Lean Mass ◽  
Calcium Intake ◽  
Whole Body ◽  
Vitamin D Status ◽  
Mineral Density ◽  
Femur Neck ◽  
Vitamin D Levels ◽  
Z Scores

Abstract Introduction Fractures are common in pediatric population, and lower bone density increases the risk of fracture. Most bone acquisition happens during youth, so juvenile bone mineral density (BMD) assessment is important. There are many factors associated with low BMD, including vitamin D status, calcium intake, low body weight, and physical activity. Among these, our investigation focused on the association of BMD with vitamin D in adolescents. Methods This study investigated data of 1,063 adolescents aged 12-18 years from the fifth and sixth Korea National Health and Nutritional Examination Survey (2009-2011). The association of various factors (vitamin D level, calcium intake, body mass index (BMI), lean mass, fat mass, and physical activity) with BMD Z-scores in whole body, lumbar spine, total femur, and femur neck were analyzed. We defined vitamin D deficiency (≤ 12 ng/mL), vitamin D insufficiency (12-20 ng/mL), and sufficiency (> 20ng/mL) according to the 25-hydroxyvitamin D (25-OHD) level. We analyzed association between BMD and vitamin D levels after adjusting for other factors. Results The mean 25-OHD level of subjects was low (16.28 ng/ml). Of all subjects, 21.9% were vitamin D deficient, and 58.5% were vitamin D insufficient. Among the vitamin D groups, the vitamin D sufficient group had significantly higher BMD Z-scores than the vitamin D deficient group in whole body, lumbar spine, and femur neck. The sufficient vitamin D group had higher BMD Z-score than the vitamin D insufficient group in femur neck, and the vitamin D insufficient group had higher BMD Z-score than the vitamin D deficient group in whole body. Among various factors, vitamin D status, calcium intake, BMI, lean mass, fat mass, and physical activity were positively associated with BMD Z-scores. In particular, lean mass was the strongest independent factor. Vitamin D levels were positively associated with the BMD Z-scores even after adjusting for other factors. Conclusions Vitamin D deficiency and insufficiency were common among adolescents. This study suggested that vitamin D level was positively associated with BMD, and that sufficient vitamin D level was needed to prevent low BMD. Vitamin D status is an important factor of BMD in adolescents.

scholarly journals Vitamin D monitoring and management in the inpatient services – reaudit

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S86-S87
Author(s):  
Vasudevan Krishnan ◽  
Ciara Doyle ◽  
Maciej Rusilowicz
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Health ◽  
Clinical Guideline ◽  
Scientific Advisory Committee ◽  
Inpatient Ward ◽  
Number Of Patients ◽  
Vitamin D Levels ◽  
Laboratory Results ◽  
Sufficient Vitamin

AimsTo survey the prevalence of monitoring of vitamin D on an inpatient ward.To audit the treatment if there is identified vitamin D deficiency or insufficiencyTo compare differences between findings in auditsMethodAll inpatients admitted to Milford centre between August 2019 and August 2020 were selected as part of the sample size.Data were collected by FY1 and FY2Patients’ laboratory results were accessed to determine vitamin D levels.E-notes were used to conclude who were vitamin D sufficient or deficient for treatmentThe standard for the audit were as per:Management of vitamin D deficiency or insufficiency in adults – CKS (2018)The above was based on National Osteoporosis Society (NOS) guideline Vitamin D and bone health: a practical clinical guideline for patient management [National Osteoporosis Society, 2013] and Scientific Advisory Committee on Nutrition (SACN) guidelineResult201748/188 patients had vitamin D levels measured36/48 patients had sufficient vitamin D levels12/48 patients were either deficient or insufficient12/12 patients were treated where found deficient or insufficient202090/115 patients had vitamin D levels measured47/90 patients had sufficient vitamin D Levels43/90 patients had either insufficient or deficient vitamin D levels22/43 patients had treatment documented in noted where found deficient or insufficientConclusionDifficult to make comparisons with previous audit due to difference in number of patients testedVitamin D is routinely tested on Milford ward on admission hence the large number compared to the last audit52% had noted to have sufficient levels of vitamin DConcerning were results that only 51% of those deemed to have insufficient or deficient were treated based on notesPotential reasons could be:Prescribed in medication card and not documented in notes.Vitamin D results checked in another ward, no supplementation given, and then transferred to Milford house.Patients refused treatment but not documented adequately.Patient discharged before results were received due to quick aroundResults were deemed insufficient in terms of the range but very close to normal hence decision made not to start supplementationResults to be disseminated with medical and nursing colleaguesRe-audit in September 2021

Vitamin D in relation to bone health and muscle function in young female soccer players

2016 ◽  
Vol 17 (2) ◽  
pp. 249-256 ◽  
Author(s):  
André Brännström ◽  
Ji-Guo Yu ◽  
Per Jonsson ◽  
Torbjörn Åkerfeldt ◽  
Mats Stridsberg ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Health ◽  
Muscle Function ◽  
Young Female ◽  
Soccer Players
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