EFFICACY OF TREATMENT OF H.PYLORI EARDICATION WITH STANDARD TRIPLE THERAPY IN PEPTIC ULCER PATIENTS

2011 ◽  
pp. 122-129
Author(s):  
Quang Di Bui ◽  
Phuoc Lam Nguyen
Keyword(s):  
Peptic Ulcer ◽  
Adverse Effects ◽  
Triple Therapy ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Duodenal Ulcers ◽  
Ulcer Disease ◽  
Intention To Treat ◽  
Standard Triple Therapy

Objectives: The aim of study is to evaluate the efficacy, tolerability and adverse effects of a standard triple therapy including Rabeprazole, Clarithromycin and Amoxicilline at Sai gon Hoan My hospital in order to consider treatment H.pylori for patients who have not yet eradicated before or need to be undertaked by alternative regimens. Methods: By descriptive cross-sectional study, the authors have examined 116 patients sufferring from peptic ulcer received 10-day therapy including Rabe (20mg b.d) plus Clari(500mg b.d) plus Amoxi(1g b.d). Eradication is confirmed with endoscopy after 4 weeks from completing of treatment. Results and Discussion: 100% of patients were initially included and noboby was dropped out of the follow-up satges. The mean age was 49 in which 62% was male, 73(62,9%) presented duodenal ulcer, 28(24,1%) gastric ulcer and 15(13%) simultaneous gastric and duodenal ulcers. All patients took medications correctly. Per-protocol and intention to treat eradication rates were both 75%(95% CI=73,4-78,3). Additionally, 62(53,4%) patients had at least one risky factor for peptic ulcer disease, smoking being the most common one 44(37,9%).The adverse effects were reported overall in 67% of the patients, mainly including changed taste, very bitter, tired 49%, trouble sleeping 12% and diarrhea 5%. Conclusion: this ten-day standard triple therapy used in this study is ineffective with high adverse effects.The first line eradication with new regimens should be alternative.

EFFICACY OF H.PYLORI ERADICATION TREATMENT WITH LEVOFLOXACIN – BASED TRIPLE THERAPY IN GASTRODUODENITISS PATIENTS

2011 ◽  
pp. 35-41
Author(s):  
Quang Di Bui ◽  
Trong Thang Hoang
Keyword(s):  
Adverse Effects ◽  
Triple Therapy ◽  
Cross Sectional Study ◽  
First Line ◽  
Second Line Therapy ◽  
Cross Sectional ◽  
Intention To Treat ◽  
Line Therapy ◽  
Standard Triple Therapy

Objective: This study is to evaluate the efficacy, tolerability and adverse effects of a triple second line therapy including of Rabeprazole, Amoxicilin và Levofloxacin in patients who have failed first-line Helicobacter pylory (H.Pylori) therapy. Methods: By descriptive cross-sectional study, the authors have examined 101 gastro-duodenitis patients, who had failed first treatment with standard triple therapy, received 10-days therapy including Rabeprazole (20mg b.d), Levofloxacin (500mg b.d) and Amoxycillin (1g b.d). Eradication is confirmed with by the C13-urea breat h test after 4 weeks from completing of treatment. Results: 100% of patients are initially included and noboby is lost for follow-up. Mean age was 44 yr, 38% were male, 68,3% had duodenitis, 20,7% gastritis, 11% gastro-duodenitis. All patients took medications correctly. Per-protocol and intention to treat eradication rates were both 83,3% (95% CI=75,4-91,3). Mild adverse effects were reported overall in 8% of the patients, mainly including rash 2%, myalgias 2% and diarrhea 5%, none of them were severe. Conclusion: This ten-days levofloxacin-base therapy represents an alternative to standard quadruple therapy in patents with previous PPI-Clarithromycin-Amoxicillin failure, being effective, safe and simple.

scholarly journals The number of household members as a risk factor for peptic ulcer disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mi Hong Yim ◽  
Keun Ho Kim ◽  
Bum Ju Lee
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Living Alone ◽  
Cross Sectional ◽  
Ulcer Disease ◽  
Logistic Regression Models ◽  
Household Members ◽  
H Pylori

AbstractPeptic ulcer disease (PUD) is caused by many sociodemographic and economic risk factors other than H. pylori infection. However, no studies reported an association between PUD and the number of household members. We showed the number of family members affected by PUD based on sex in a Korean population. This cross-sectional study used 1998–2009 data from the Korea National Health and Nutrition Examination Survey of the Korea Centers for Disease Control and Prevention. Multiple binary logistic regression models adjusted for confounders were constructed to analyze the association of PUD with the number of household members. The number of household members was associated with PUD, age, body mass index (BMI), waist circumference, systolic blood pressure, hemoglobin, glucose, location (urban/rural), income, education level, stress, current drinking, and smoking in both sexes. Men with other household members had a higher PUD risk compared to men or women living alone (reference), and the opposite was observed for women. Men with 4 household members had a higher PUD risk than men living alone in the model adjusted for age, BMI, income, location, education, and stress (OR = 2.04 [95% CI 1.28–3.27], p value = .003). Women with more than 6 household members had a lower PUD risk than women living alone in the adjusted model (OR = 0.50 [0.33–0.75], p value = .001). Women with more household members had a lower PUD risk. However, more men had PUD than women regardless of the number of household members.

scholarly journals Frequency of osteoporosis in patients with peptic ulcer disease

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Amber Amin ◽  
Qaisar Farooq ◽  
Rizwan Jameel
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Ulcer Disease ◽  
Short And Long Term ◽  
The Common ◽  
The Mean ◽  
Age Range

BACKGROUND & OBJECTIVE: Peptic ulcer disease (PUD) is one of the common presentations in the medical as well as Gastroenterology clinics and it can end up in various short- and long-term complications among which osteoporosis is highly under rated. Therefore, the present study was designed to determine the frequency of osteoporosis in cases having PUD. METHODOLOGY: A cross-sectional study was conducted at the Department of Medicine during 1st January 2020 to 30th June 2020 in Sheikh Zayed Hospital, Lahore. The diagnosed cases of PUD on the basis of history and endoscopic findings with the age range of 20 to 60 years were included. Osteoporosis was labelled as yes, where a T-score of ≤ -2.5 on DEXA scan was noted. RESULTS: In this study, there were a total of 139 cases, out of which 75 (53.95%) were males and 64 (46.05%) females. The mean age of the participants was 48.11±9.43 years. Osteoporosis was observed in 14 (10.07%) out of 139 cases. Osteoporosis was seen in 05 (6.67%) males vs 09 (14.06%) females in their respective groups with p= 0.148. Osteoporosis was observed in 4 (5.80%) cases with a duration of PUD up to 2 years and 10 (14.28%) cases with duration more than this with p= 0.096 CONCLUSION: Osteoporosis is not uncommon in cases with Peptic ulcer disease, and there is no significant association with any of the confounders of this study.

scholarly journals Helicobacter Pylori as a Risk Factor for Post Infectious Irritable Bowel Syndrome

2022 ◽  
pp. 1-3
Author(s):  
Essamaddin Ahmed Abdelhamid Ibrahim ◽  
Keyword(s):  
Helicobacter Pylori ◽  
Irritable Bowel Syndrome ◽  
Peptic Ulcer ◽  
Triple Therapy ◽  
Analytical Study ◽  
Ulcer Disease ◽  
Standard Triple Therapy ◽  
Irritable Bowel ◽  
Post Infectious ◽  
Structured Questionnaire

Backgrounds: Helicobacter Pylori is a common pathogen leading cause of peptic ulcer disease. Several studies linked Helicobacter Pylori infection and the development of irritable bowel syndrome. Aims: We investigated the effectiveness of standard triple therapy and the association between H.Pylori infection and the development of post infectious irritable bowel syndrome. Materials and methods: Prospective analytical study was conducted and we appointed 200 H.Pylori positive patients, they consented and subjected to structured questionnaire and received standard triple therapy (14 days course of proton pump inhibitor (PPI), clarithromycin and either amoxicillin or metronidazole). After three months all patients re-evaluated regarding their symptoms and tested for eradication. Additionally we evaluated the association between H.Pylori infection and irritable bowel syndrome

Reasons why patients with tuberculosis in South Korea stop anti-TB treatment: a cross-sectional study

2020 ◽  
Vol 24 (10) ◽  
pp. 1016-1023
Author(s):  
H. W. Kim ◽  
J. Min ◽  
A. Y. Shin ◽  
H-K. Koo ◽  
S. Y. Lim ◽  
...  
Keyword(s):  
Adverse Effects ◽  
South Korea ◽  
Previous History ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
Specialist Nurses ◽  
Lost To Follow Up

BACKGROUND: As there had been no reduction in the TB burden in South Korea since 2000, a public-private mix (PPM) strategy was launched in 2011. The purpose of this study was to investigate the reasons for lost to follow-up (LTFU) among TB patients and their clinical characteristics.METHOD: A multicentre, cross-sectional study based on in-depth interviews with patients and their families by TB specialist nurses was conducted. Patients who were reported with a final outcome of LTFU in 2015–2017 at all PPM hospitals across the country were enrolled. Enrolled patients were classified into six subgroups by age and three major reasons for LTFU (adverse effects, refusal of treatment, marginalisation) and their clinical features were compared.RESULTS: Among 780 patients, those who were lost to follow-up due to adverse effects accounted for the largest proportion (n = 387). LTFU in those aged <65 years who refused treatment (n = 189) and those aged <65 years who were marginalised (n = 108) were related to having smear-positive TB and a previous history of unfavourable outcomes.CONCLUSION: To reduce LTFU in South Korea, comprehensive strategies, including management of adverse effects, systematic counselling and education, should be implemented.

scholarly journals A study on healing of peptic ulcer disease after eradication of helicobacter pylori infection

2014 ◽  
Vol 43 (2) ◽  
pp. 84-89 ◽  
Author(s):  
Md Razibul Alam ◽  
Ershad Uddin Ahmed ◽  
Md Zahidur Rahman ◽  
ASM Nazmul Islam ◽  
Md Masudur Rahman Khan ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Triple Therapy ◽  
Ulcer Healing ◽  
Eradication Rate ◽  
Helicobacter Pylori Infection ◽  
Ulcer Disease ◽  
Standard Triple Therapy ◽  
H Pylori

There is intimate connection between peptic ulcer & Helicobacter pylori infection. But some uncertainties still surround the relationship between status of H. pylori infection and extent & time required for ulcer healing. This prospective observational study was carried out in the department of Gastroenterology, BSMMU, Dhaka from January 2007 to January 2008 to determine whether the successful eradication of H. pylori leads to adequate ulcer healing. To see the pattern of endoscopic findings in patients still having H. pylori infection after standard triple therapy for H. pylori were also a objective. Eighty nine consecutive patients, aged 15-60 years and of both genders, coming to the gastroenterology outpatient department with the symptoms suggestive of peptic ulcer disease and dyspepsia were included and H. pylori status was defined as positive if both rapid urease test & histopathology were positive. As found in this study, H. pylori was associated with 90% of duodenal ulcers and 80% of gastric ulcers. H. pylori eradication rate was 69%. Healing rate of duodenal ulcer and gastric ulcer after standard triple therapy for 14 days were 80% and 78% respectively. Adequate ulcer healing was achieved in this study despite relatively low eradication rate. Follow-up for additional period is required for recurrence of ulcer in 84 patients whose peptic ulcer disease had resolved but could not attain H. pylori eradication and H. pylori eradicated patients who are still having ulcer at endoscopy DOI: http://dx.doi.org/10.3329/bmj.v43i2.21388 Bangladesh Med J. 2014 May; 43 (2): 84-89

scholarly journals Testing for Helicobacter pylori in dyspeptic patients suspected of peptic ulcer disease in primary care: cross sectional study

BMJ ◽  
2001 ◽  
Vol 323 (7304) ◽  
pp. 71-75 ◽  
Author(s):  
C. F Weijnen ◽  
M. E Numans ◽  
N. J de Wit ◽  
A. J P M Smout ◽  
K. G M Moons ◽  
...  
Keyword(s):  
Primary Care ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ulcer Disease

scholarly journals Correlation Between Candidiasis And Mortality In Gastric Ulcer Perforation Patients

2021 ◽  
Vol 5 (11) ◽  
pp. 1037-1041
Author(s):  
Faradina Sulistiyani ◽  
Vicky Sumarki Budipramana ◽  
Pepy Dwi Endraswari
Keyword(s):  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
General Hospital ◽  
Gastrointestinal Disease ◽  
Perforated Peptic Ulcer ◽  
Cross Sectional Study ◽  
Peptic Ulcer Perforation ◽  
Cross Sectional ◽  
Ulcer Disease ◽  
Ulcer Perforation

Background: Gastric ulcer disease remains the most common gastrointestinal disease. This affects about 4 million people every year worldwide with an incidence of 1.5%-3% and 2-14% of these will progress to perforation. Mortality is reported in 30% of cases and caused morbidity in 50% of patients. Some studies have suggested that mortality in patients with peritonitis accompanied by candidiasis ranges from 20%-75%, whereas others have argued that the presence of fungal isolates in patients with perforated peptic ulcer does not affect the outcome. A recent study reported an incidence of 45% of patients peptic ulcer perforation cases accompanied by candidiasis in Dr. Soetomo General Hospital Surabaya in 2019.Methods: This was a cross sectional study based on medical record data of patients with gastric ulcer perforation accompanied by candidiasis who underwent laparotomy and gastric repair surgery at Dr. Soetomo General Hospital Surabaya from January 2019 to December 2020.Results: There was no significant correlation between candidiasis and mortality in gastric ulcer perforation patients (p=0.989).Conclusion: Candidiasis does not increase mortality in patients with gastric ulcer perforation.

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