CORONARY ARTERY LESIONS IN PATIENTS OVER 50 YEAR OLD WITH VALVULAR HEART DISEASES INDICATED FOR VALVE SURGERY

2016 ◽  
pp. 20-24
Author(s):  
Bang Giap Vo ◽  
Anh Binh Ho ◽  
Van Minh Huynh
Keyword(s):  
Coronary Artery ◽  
Mitral Valve ◽  
Heart Valve ◽  
Right Coronary Artery ◽  
Heart Diseases ◽  
Heart Valve Diseases ◽  
Coronary Artery Lesions ◽  
Circumflex Coronary Artery ◽  
Valvular Heart Diseases ◽  
Valve Diseases

Objectives: To investigate the features of coronary artery lesions in patients over 50 with heart valve diseases and to find out the relationship between the levels of coronary artery lesions and heart valve diseases. Results: In patients over 50 year old with heart valve diseases, the rate of significant coronary artery lesions is 55.5%. In which, significant lesions in the group of both mitral and aorta valve diseases is 44.19%, only mitral valve diseases is of 70%, only aortic valve diseases is of 51.85%. There is a relationship between the severity of mitral valve diseases and right coronary artery lesions (OR 3.74: 1.64 to 8.5, p = 0.0017) and circumflex coronary artery lesions (OR 2.59: 1.16 to 5.75, p = 0.0192). The severity of heart valve lesions in significant coronary artery lesions group is higher than insignificant coronary artery lesions group or normal group. Conclusion: Coronary artery lesions is common in patients > 50 years old with heart valve diseases, there is a relationship between the severity of mitral valve diseases and and right coronary artery lesions and circumflex coronary artery lesions. Key words: coronary artery lesions, mitral valvediseases

Abstract 319: Tnf-α and Il-1β Decrease Myofibroblast Differentiation in 3d-cultured Mitral Valve Interstitial Cells

2020 ◽  
Vol 127 (Suppl_1) ◽  
Author(s):  
Amadeus Zhu ◽  
Jane Grande-Allen
Keyword(s):  
Smooth Muscle ◽  
Mitral Valve ◽  
Heart Valve ◽  
Interstitial Cells ◽  
Valve Disease ◽  
Tissue Type ◽  
Heart Valve Diseases ◽  
Valve Interstitial Cells ◽  
Tnf Α ◽  
Valve Diseases

Background: Fibrosis contributes to many heart valve diseases such as calcific aortic valve disease, rheumatic heart disease, and secondary mitral regurgitation. Heart valve leaflets are populated by quiescent, fibroblast-like valve interstitial cells (VICs). During fibrosis, VICs differentiate into activated, myofibroblast-like cells that adversely remodel the extracellular matrix. Activated VICs overexpress α-smooth muscle actin (ACTA2/αSMA) and smooth muscle 22-α (TAGLN/SM22α) and display increased contractility. Tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) have been reported to either promote or inhibit fibrosis, depending on tissue type. Understanding how TNF-α and IL-1β affect VIC activation in the mitral valve of the heart could enable development of pharmaceutical treatments for heart valve diseases, which are currently managed surgically. Methods: To avoid artifactual activation on tissue culture plastic, VICs were encapsulated in biomimetic scaffolds consisting of polyethylene glycol (4% w/v) functionalized with protease-degradable (GGGPQGIWGQGK) and integrin-binding (RGDS) peptides. These 3D cultures were treated with 10 ng/ml TNF-α, 10 ng/ml IL-1β, or vehicle for 2 days in low-serum (1%) media. RNA and protein were measured via qRT-PCR, western blotting, and immunostaining. To measure contractility, VICs were encapsulated in collagen I (2.5 mg/ml) gels and allowed to contract freely for 2 days. Results: TNF-α and IL-1β significantly decreased RNA expression of ACTA2 (TNF-α: -91±6%, IL-1β: -99±1% change vs. vehicle) and TAGLN (TNF-α: -77±9%, IL-1β: -93±1% change). TNF-α and IL-1β also significantly decreased αSMA protein expression (TNF-α: -76±11%, IL-1β: -91±5% change) and the percentage of αSMA-positive cells (vehicle: 21±3%, TNF-α: 13±2%, IL-1β: 13±5% positive). Finally, TNF-α and IL-1β attenuated VIC-mediated collagen gel contraction (vehicle: 81±7%, TNF-α: 71±3%, IL-1β: 61±4% contraction). Conclusions: TNF-α and IL-1β decrease VIC activation in a 3D culture model of the mitral valve. These results reveal novel pathway targets for reducing fibrosis during mitral valve disease. Future work will use this model to study the downstream signaling events that drive VIC de-activation.

scholarly journals Automatic Detection of Mitral Regurgitation from Heart Sounds using SODP of Imperical Mode Decomposition

2021 ◽  
Vol 9 (VI) ◽  
pp. 1874-1877
Author(s):  
Gabbar Jadhav
Keyword(s):  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Heart Valve ◽  
Valve Disease ◽  
Heart Valve Disease ◽  
Heart Valve Diseases ◽  
Mode Decomposition ◽  
The World ◽  
Valve Diseases ◽  
Pcg Signals

In this paper we discussed the heart valve disease. This heart valve disease occur throughout the world due to the more ethical estimation and grow curator of heart valve diseases use the diagnosis for this type of valve disease . Actually Phonocardiogram (PCG) signals are used because it having less price and acquire the signals. In this we learn five different kind of heart areas, Also typical are aortic stenosis, mitral valve prolapse, mitral stenosis and mitral regurgitation.

Heart Valve Diseases in the Elderly

2013 ◽  
pp. 240-260
Author(s):  
Yos Morsi ◽  
Zhang Li ◽  
Sheng Wang
Keyword(s):  
Valve Replacement ◽  
Heart Valve ◽  
Heart Valves ◽  
Heart Diseases ◽  
Heart Valve Replacement ◽  
Heart Valve Diseases ◽  
Full Account ◽  
Prosthetic Valves ◽  
Aortic Sclerosis ◽  
Valve Diseases

This chapter gives an overview of heart valve diseases, their diagnostics techniques, and current and future treatments with particular emphasis on the elder generation. It starts with a brief presentation of anatomy of the heart and its valves and the effect of aging on the function of the heart. Subsequently the projection of the global older population is given, and the most common and frequently occurring valvular heart diseases including aortic regurgitation, aortic stenosis, and aortic sclerosis are presented and discussed. Moreover, the current heart valve replacement techniques using mechanical or bio-prosthetic valves and the complications associated with the use of these artificial heart valves are presented and discussed. The chapter ends with a full account of the risk of mortality associated with the operation of heart valve replacement for older patients and the future directions for heart valve implementation using the tissue engineering concept.

scholarly journals The Inter-Relationship of Periostin, TGFβ, and BMP in Heart Valve Development and Valvular Heart Diseases

2011 ◽  
Vol 11 ◽  
pp. 1509-1524 ◽  
Author(s):  
Simon J. Conway ◽  
Thomas Doetschman ◽  
Mohamad Azhar
Keyword(s):  
Heart Valve ◽  
Transforming Growth Factor ◽  
Heart Diseases ◽  
Cardiovascular Development ◽  
Valve Development ◽  
Morphogenetic Protein ◽  
Valvular Heart Diseases ◽  
Valve Diseases ◽  
Relationship Of

Recent studies have suggested an important role for periostin and transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) ligands in heart valve formation and valvular heart diseases. The function of these molecules in cardiovascular development has previously been individually reviewed, but their association has not been thoroughly examined. Here, we summarize the current understanding of the association between periostin and TGFβ and BMP ligands, and discuss the implications of this association in the context of the role of these molecules in heart valve development and valvular homeostasis. Information about hierarchal connections between periostin and TGFβ and BMP ligands in valvulogenesis will increase our understanding of the pathogenesis, progression, and medical treatment of human valve diseases.

Identification of Heart Valve Disease using Bijective Soft Sets Theory

2014 ◽  
Vol 1 (2) ◽  
pp. 1-14 ◽  
Author(s):  
S. Udhaya Kumar ◽  
H. Hannah Inbarani ◽  
Ahmad Taher Azar ◽  
Aboul Ella Hassanien
Keyword(s):  
Heart Valve ◽  
Classification Accuracy ◽  
Heart Diseases ◽  
Soft Set ◽  
Heart Valve Disease ◽  
Heart Valve Diseases ◽  
Human Beings ◽  
Soft Sets ◽  
Feature Selection Technique ◽  
Valve Diseases

Major complication of heart valve diseases is congestive heart valve failure. The heart is of essential significance to human beings. Auscultation with a stethoscope is considered as one of the techniques used in the analysis of heart diseases. Heart auscultation is a difficult task to determine the heart condition and requires some superior training of medical doctors. Therefore, the use of computerized techniques in the diagnosis of heart sounds may help the doctors in a clinical environment. Hence, in this study computer-aided heart sound diagnosis is performed to give support to doctors in decision making. In this study, a novel hybrid Rough-Bijective soft set is developed for the classification of heart valve diseases. A rough set (Quick Reduct) based feature selection technique is applied before classification for increasing the classification accuracy. The experimental results demonstrate that the overall classification accuracy offered by the employed Improved Bijective soft set approach (IBISOCLASS) provides higher accuracy compared with other classification techniques including hybrid Rough-Bijective soft set (RBISOCLASS), Bijective soft set (BISOCLASS), Decision table (DT), Naïve Bayes (NB) and J48.

Right Coronary Artery Fistula Draining into the Right Atrium and Associated with Mitral Valve Stenosis: A Case Report

2007 ◽  
Vol 10 (4) ◽  
pp. E325-E328 ◽  
Author(s):  
Ali Gürbüz ◽  
Ufuk Yetkin ◽  
Ömer Tetik ◽  
Mert Kestelli ◽  
Murat Yesil
Keyword(s):  
Case Report ◽  
Coronary Artery ◽  
Mitral Valve ◽  
Right Coronary Artery ◽  
Right Atrium ◽  
Coronary Artery Fistula ◽  
Mitral Valve Stenosis ◽  
The Right

Dialdehyde pectin-crosslinked and hirudin-loaded decellularized porcine pericardium with improved matrix stability, enhanced anti-calcification and anticoagulant for bioprosthetic heart valves

2021 ◽  
Author(s):  
Mengyue Hu ◽  
Xu Peng ◽  
Yang Zhao ◽  
Xiaoshuang Yu ◽  
Can Cheng ◽  
...  
Keyword(s):  
Heart Valve ◽  
Heart Valves ◽  
Heart Valve Diseases ◽  
Bioprosthetic Heart Valves ◽  
Matrix Stability ◽  
Transcatheter Valve ◽  
Valve Diseases ◽  
Porcine Pericardium

To conveniently and effectively cure heart valve diseases or defects, combining with transcatheter valve technology, bioprosthetic heart valves (BHVs) originated from the decellularized porcine pericardium (D-PP) have been broadly used...

Congenital Absence of Left Circumflex Coronary Artery: Circumflex Artery Extended from Right Coronary Artery

1999 ◽  
Vol 29 (1) ◽  
pp. 67
Author(s):  
Jeong Woon Park ◽  
Kwang Soo Cha ◽  
Seong Wook Park ◽  
Soo Hoon Lee ◽  
In Ah Seo ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Right Coronary Artery ◽  
Congenital Absence ◽  
Circumflex Coronary Artery ◽  
Circumflex Artery ◽  
Left Circumflex Coronary Artery
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