Faculty Opinions recommendation of Two time-series analyses of the impact of antibiotic consumption and alcohol-based hand disinfection on the incidences of nosocomial methicillin-resistant Staphylococcus aureus infection and Clostridium difficile infection.

2009 ◽  
Author(s):  
Stephen Weber
Keyword(s):  
Staphylococcus Aureus ◽  
Time Series ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Antibiotic Consumption ◽  
Hand Disinfection ◽  
Aureus Infection ◽  
Time Series Analyses ◽  
The Impact

Two Time-Series Analyses of the Impact of Antibiotic Consumption and Alcohol-Based Hand Disinfection on the Incidences of Nosocomial Methicillin-ResistantStaphylococcus aureusInfection andClostridium difficileInfection

2009 ◽  
Vol 30 (4) ◽  
pp. 346-353 ◽  
Author(s):  
Klaus Kaier ◽  
Christian Hagist ◽  
Uwe Frank ◽  
Andreas Conrad ◽  
Elisabeth Meyer
Keyword(s):  
Time Series ◽  
Multivariate Analysis ◽  
Multivariate Time Series ◽  
Antibiotic Consumption ◽  
Third Generation ◽  
Hand Disinfection ◽  
Mrsa Infection ◽  
Time Series Analyses ◽  
The Impact ◽  
Third Generation Cephalosporins

Objective.To determine the impact of antibiotic consumption and alcohol-based hand disinfection on the incidences of nosocomial methicillin-resistantStaphylococcus aureus(MRSA) infection andClostridium difficileinfection (CDI).Methods.Two multivariate time-series analyses were performed that used as dependent variables the monthly incidences of nosocomial MRSA infection and CDI at the Freiburg University Medical Center during the period January 2003 through October 2007. The volume of alcohol-based hand rub solution used per month was quantified in liters per 1,000 patient-days. Antibiotic consumption was calculated in terms of the number of defined daily doses per 1,000 patient-days per month.Results.The use of alcohol-based hand rub was found to have a significant impact on the incidence of nosocomial MRSA infection (P<.001). The multivariate analysis (R2= 0.66) showed that a higher volume of use of alcohol-based hand rub was associated with a lower incidence of nosocomial MRSA infection. Conversely, a higher level of consumption of selected antimicrobial agents was associated with a higher incidence of nosocomial MRSA infection. This analysis showed this relationship was the same for the use of second-generation cephalosporins (P= .023), third-generation cephalosporins (P= .05), fluoroquinolones (P= .01), and lincosamides (P= .05). The multivariate analysis (R2= 0.55) showed that a higher level of consumption of third-generation cephalosporins (P= .008), fluoroquinolones (P= .084), and/or macrolides (P= .007) was associated with a higher incidence of CDI. A correlation with use of alcohol-based hand rub was not detected.Conclusion.In 2 multivariate time-series analyses, we were able to show the impact of hand hygiene and antibiotic use on the incidence of nosocomial MRSA infection, but we found no association between hand hygiene and incidence of CDI.

scholarly journals Impact of an antimicrobial stewardship program in the antimicrobial-resistant and prevalence of clostridium difficile infection and amount of antimicrobial consumed in cancer patients

2019 ◽  
Author(s):  
Masoud Mardani ◽  
Sara Abolghasemi ◽  
Shiva Shabani
Keyword(s):  
Clostridium Difficile ◽  
Cancer Patients ◽  
Clostridium Difficile Infection ◽  
Antimicrobial Stewardship ◽  
Antibiotic Consumption ◽  
Epidemiological Studies ◽  
Blood Cultures ◽  
University Hospital ◽  
Stewardship Program ◽  
The Impact

Abstract Objective: The objective of this study was to determine the impact of a hospital antimicrobial stewardship on antimicrobial resistant, clostridium difficile rates and amount of antimicrobial consumed in cancer patients. The intervention effects of ASP plans in 2017–2018 and 2018–2019 were respectively evaluated among hematology/oncology and bone morrow transplant patients in Ayatollah Taleghani University Hospital, Tehran, Iran. In this interventional quasi-experimental study, the ASP repository was utilized to capture four survey questions encompassed in these immunocompromised patients: amount of antibiotics (MPM and VMN) consumption gr-year, number of positive clostridium difficile infection and multidrug resistant positive cases in blood cultures. Results: The number of MDR cases in the time periods of 2017–2018 and 2018–2019 were 145 and 75, respectively (p = 0.011). A significant reduction in positive blood cultures from 2017–2018 to 2018–2019 was found (p = 0.001).The amount of MPM prescriptions in 2018–2019 was significantly decreased from 22464 to 17262 g (p = 0.043). The significant reduction in antibiotic consumption, MDR organisms and CDI can highly promote patients’ health and decreasing medical costs and long-term defects for patients. Finally, future stewardship studies should made efforts for joining clinical and epidemiological studies.

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