Faculty Opinions recommendation of Usefulness of aortic root dimension in persons > or = 65 years of age in predicting heart failure, stroke, cardiovascular mortality, all-cause mortality and acute myocardial infarction (from the Cardiovascular Health Study).

2006 ◽  
Author(s):  
Wilbert Aronow
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Cardiovascular Mortality ◽  
Aortic Root ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
All Cause Mortality

scholarly journals Blood Pressure Variability and the Risk of All-Cause Mortality, Incident Myocardial Infarction, and Incident Stroke in the Cardiovascular Health Study

2013 ◽  
Vol 26 (10) ◽  
pp. 1210-1217 ◽  
Author(s):  
Astrid M. Suchy-Dicey ◽  
Erin R. Wallace ◽  
Mitchell S. Elkind ◽  
Maria Aguilar ◽  
Rebecca F. Gottesman ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
All Cause Mortality

Abstract MP11: Association of Sick Sinus Syndrome with Incident Cardiovascular Disease and Mortality: the Atherosclerosis Risk in Communities Study and Cardiovascular Health Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Alvaro Alonso ◽  
Paul N Jensen ◽  
Faye L Lopez ◽  
Lin Y Chen ◽  
Bruce M Psaty ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Cardiovascular Health ◽  
Sick Sinus Syndrome ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Incident Cases ◽  
The Impact

Background: Sick sinus syndrome (SSS) is a disorder characterized by symptomatic dysfunction of the sinoatrial node. Despite being relatively frequent and a major indication for pacemaker implantation (PMI), the impact of SSS on the risk of other cardiovascular diseases (CVD) and mortality is unclear. Thus, we assessed whether SSS incidence was associated with mortality and CVD in two community-based studies. Methods: We included 19,893 men and women age 45 and older enrolled in the Atherosclerosis Risk in Communities (ARIC) study and the Cardiovascular Health Study (CHS), without pacemaker and free of atrial fibrillation (AF) at baseline. Incident cases of SSS were adjudicated after review of medical charts from hospitalizations with a 427.81 ICD-9 code. Ascertainment of incident CVD (heart failure, myocardial infarction, stroke, AF, PMI) and mortality was done according to standard validated protocols. The association between SSS and the selected outcomes was assessed using age, sex, and race-standardized rates and multivariable Cox models adjusted for potential confounders. Results: During a mean follow-up of 17 years, 213 incident SSS events were identified and validated (incidence = 6 events per 10,000 person-years). Age, sex, and race-standardized rates for each of the outcomes in those with and without SSS are presented in the Table. Overall, individuals with SSS had higher rates of mortality and CVD. These differences were still present, though weakened, after adjustment for baseline cardiovascular risk factors (Table, Model 2). After additional adjustment for incident CVD (Model 3), SSS was no longer associated with higher mortality, myocardial infarction or stroke, but an association with heart failure, AF and PMI remained. Conclusion: Individuals who develop SSS are at increased risk of death and incident CVD. Their management should incorporate comprehensive cardiovascular prevention in addition to symptom relief. The mechanisms underlying these associations warrant further investigation.

Abstract 5011: Role of Autonomic Nervous System Dysregulation and Inflammation in the Increased Risk of Depression for Cardiovascular Mortality: The Cardiovascular Health Study

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Willem J Kop ◽  
Phyllis K Stein ◽  
Joshua I Barzilay ◽  
Russell P Tracy ◽  
John S Gottdiener
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Cardiovascular Mortality ◽  
Inflammatory Markers ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Scaling Exponent ◽  
Autonomic Nervous

The increased cardiovascular (CV) risk associated with depression is hypothesized to be explained by autonomic nervous system (ANS) dysregulation and inflammatory processes. This study determines the role of ANS dysregulation and inflammation in the predictive value of depression for CV mortality. 908 participants of the Cardiovascular Health Study (age 71±5 yrs) free of CV disease were evaluated for depression (CES-D scale), ANS dysregulation by abnormal non-linear heart rate variability (decreased short-term fractal scaling exponent), and inflammation (IL-6, CRP, fibrinogen and WBC). Predictors of CV mortality were examined using Cox regression analysis, adjusting for age, sex, race, systolic blood pressure, diabetes, subclinical disease, use of beta-blockers, smoking status, BMI, and physical activity (median follow-up=13.3 yrs). Risks were calculated for subgroups based on the presence or absence of depression, and ANS or inflammatory CV risk factors (Figure ). Depression was predictive of CV mortality (RR=1.88, CI=1.23–2.86), ANS dysregulation (p=0.014) and inflammatory markers (IL-6 p=0.072; WBC p=0.033; and fibrinogen p=0.050) were correlated with depression. The association of depression with CV mortality occurred primarily in the presence of ANS dysregulation and/or inflammation (Figure ). Addition of ANS and inflammatory markers to the multivariate model did not substantially reduce the CV mortality risk of depression (adjusted RR=1.65, CI=1.03–2.65). Depression is predictive of cardiovascular mortality, and the elevated risk is additive to autonomic nervous system dysregulation and inflammation

Abstract MP03: Plasma Sphingolipids and Risks of Heart Failure and Atrial Fibrillation in Older Adults: The Cardiovascular Health Study

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Rozenn N Lemaitre ◽  
Paul N Jensen ◽  
Barbara McKnight ◽  
Andrew Hoofnagle ◽  
Irena B King ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Fatty Acid ◽  
Lower Risk ◽  
Cardiovascular Health ◽  
Biological Activities ◽  
Experimental Studies ◽  
Health Study ◽  
Cardiovascular Health Study

Introduction: Ceramides and sphingomyelins (sphingolipids) are circulating lipids involved in multiple physiological pathways relevant to heart failure (HF) and atrial fibrillation (AF), including apoptosis, oxidative stress, and inflammation. Experimental studies suggest that sphingolipids with different saturated fatty acids exhibit different biological activities, but their relationships with HF and AF are unknown. Hypothesis: Higher levels of plasma ceramide and sphingomyelin that contain the fatty acid 16:0 are associated with higher risks of HF and AF; and higher levels of ceramides and sphingomyelins that contain the fatty acid 20:0, 22:0 or 24:0 are associated with lower risks. Methods: We measured sphingolipids in the Cardiovascular Health Study (CHS) in plasma samples from 1994-95 (N=4026) or from 1992-93 (N=586). We assessed the separate associations of the levels of 8 sphingolipids with risks of incident HF and incident AF using Cox regression. A p-value threshold of 0.006 was used to account for multiple testing. Results: Among 4,612 participants, 1179 incident HF and 1198 incident AF occurred during >40,000 person-years of follow-up. In adjusted analyses, higher levels of Cer-16 (ceramide with 16:0) and SM-16 (sphingomyelin with 16:0) were associated with higher risk of incident HF, but not with risk of incident AF (Table). In contrast, higher levels of Cer-20, Cer-22 and Cer-24 were each associated with lower risk of AF, but not with risk of HF. Higher levels of SM-20, SM-22, and SM-24 tended to be associated with lower risks of AF and HF, with only the association of SM-20 with AF significant. Conclusions: Plasma levels of ceramide and sphingomyelin with 16:0 show different associations with HF and AF than species with 20:0, 22:0 or 24:0. Associations of Cer-16 and SM-16 specifically with higher risk of HF may be due to a role of apoptosis in HF. The novel findings that Cer-20, Cer-22, and Cer-24 are associated with lower risk of AF warrant further examination of the role of these sphingolipids in protecting from AF.

scholarly journals Race, Gender, and Mortality in Adults ≥65 Years of Age With Incident Heart Failure (from the Cardiovascular Health Study)

2009 ◽  
Vol 103 (8) ◽  
pp. 1120-1127 ◽  
Author(s):  
Susmita Parashar ◽  
Ronit Katz ◽  
Nicholas L. Smith ◽  
Alice M. Arnold ◽  
Viola Vaccarino ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Incident Heart Failure
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