Faculty Opinions recommendation of Resveratrol inhibits renal fibrosis in the obstructed kidney: potential role in deacetylation of Smad3.

2010 ◽  
Author(s):  
Frank Strutz
Keyword(s):  
Renal Fibrosis ◽  
Potential Role

MicroRNA21 promotes interstitial fibrosis via targeting DDAH1: a potential role in renal fibrosis

2015 ◽  
Vol 411 (1-2) ◽  
pp. 181-189 ◽  
Author(s):  
Xiu-Juan Liu ◽  
Quan Hong ◽  
Zhen Wang ◽  
Yan-yan Yu ◽  
Xin Zou ◽  
...  
Keyword(s):  
Renal Fibrosis ◽  
Potential Role ◽  
Interstitial Fibrosis

Different regulation of miR-29a-3p in glomeruli and tubules in an experimental model of angiotensin II-dependent hypertension: potential role in renal fibrosis

2016 ◽  
Vol 43 (3) ◽  
pp. 335-342 ◽  
Author(s):  
Giovanna Castoldi ◽  
Cira di Gioia ◽  
Fabrizio Giollo ◽  
Raffaella Carletti ◽  
Camila Bombardi ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Experimental Model ◽  
Renal Fibrosis ◽  
Potential Role

scholarly journals Metabolic Reprogramming and Renal Fibrosis

2021 ◽  
Vol 8 ◽  
Author(s):  
Xiaoyu Zhu ◽  
Lili Jiang ◽  
Mengtuan Long ◽  
Xuejiao Wei ◽  
Yue Hou ◽  
...  
Keyword(s):  
Renal Fibrosis ◽  
Potential Role ◽  
Acid Metabolism ◽  
Metabolic Reprogramming ◽  
Novel Drugs ◽  
Future Challenges ◽  
And Function ◽  
Relationship Of ◽  
The Relationship

There are several causes of chronic kidney disease, but all of these patients have renal fibrosis. Although many studies have examined the pathogenesis of renal fibrosis, there are still no effective treatments. A healthy and balanced metabolism is necessary for normal cell growth, proliferation, and function, but metabolic abnormalities can lead to pathological changes. Normal energy metabolism is particularly important for maintaining the structure and function of the kidneys because they consume large amounts of energy. We describe the metabolic reprogramming that occurs during renal fibrosis, which includes changes in fatty acid metabolism and glucose metabolism, and the relationship of these changes with renal fibrosis. We also describe the potential role of novel drugs that disrupt this metabolic reprogramming and the development of fibrosis, and current and future challenges in the treatment of fibrosis.

scholarly journals Gremlin Regulates Tubular Epithelial to Mesenchymal Transition via VEGFR2: Potential Role in Renal Fibrosis

2018 ◽  
Vol 9 ◽  
Author(s):  
Laura Marquez-Exposito ◽  
Carolina Lavoz ◽  
Raul R. Rodrigues-Diez ◽  
Sandra Rayego-Mateos ◽  
Macarena Orejudo ◽  
...  
Keyword(s):  
Renal Fibrosis ◽  
Epithelial To Mesenchymal Transition ◽  
Potential Role ◽  
Mesenchymal Transition

scholarly journals Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosis

2004 ◽  
Vol 19 (12) ◽  
pp. 2987-2996 ◽  
Author(s):  
F. Y. Chow ◽  
D. J. Nikolic-Paterson ◽  
R. C. Atkins ◽  
G. H. Tesch
Keyword(s):  
Diabetic Nephropathy ◽  
Renal Fibrosis ◽  
Potential Role

scholarly journals Potential role of upregulated microRNA-146b and −21 in renal fibrosis

2017 ◽  
Vol 16 (3) ◽  
pp. 2863-2867 ◽  
Author(s):  
Guangda Xin ◽  
Guangyu Zhou ◽  
Xiaofei Zhang ◽  
Wanning Wang
Keyword(s):  
Renal Fibrosis ◽  
Potential Role

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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