scholarly journals Metabolic Reprogramming and Renal Fibrosis

2021 ◽  
Vol 8 ◽  
Author(s):  
Xiaoyu Zhu ◽  
Lili Jiang ◽  
Mengtuan Long ◽  
Xuejiao Wei ◽  
Yue Hou ◽  
...  
Keyword(s):  
Renal Fibrosis ◽  
Potential Role ◽  
Acid Metabolism ◽  
Metabolic Reprogramming ◽  
Novel Drugs ◽  
Future Challenges ◽  
And Function ◽  
Relationship Of ◽  
The Relationship

There are several causes of chronic kidney disease, but all of these patients have renal fibrosis. Although many studies have examined the pathogenesis of renal fibrosis, there are still no effective treatments. A healthy and balanced metabolism is necessary for normal cell growth, proliferation, and function, but metabolic abnormalities can lead to pathological changes. Normal energy metabolism is particularly important for maintaining the structure and function of the kidneys because they consume large amounts of energy. We describe the metabolic reprogramming that occurs during renal fibrosis, which includes changes in fatty acid metabolism and glucose metabolism, and the relationship of these changes with renal fibrosis. We also describe the potential role of novel drugs that disrupt this metabolic reprogramming and the development of fibrosis, and current and future challenges in the treatment of fibrosis.

1. Everything has structure

2014 ◽  
Author(s):  
David Blockley
Keyword(s):  
Decision Making ◽  
Structural Engineering ◽  
Fitness For Purpose ◽  
Form And Function ◽  
Environmental Criteria ◽  
Flow Through ◽  
And Function ◽  
Relationship Of ◽  
The Relationship

‘Everything has structure’ considers the fundamental nature and role of structure and the relationship of structural engineering with other engineering disciplines and with architecture. Decision making is driven by the purpose of a man-made structure and how ‘fitness for purpose’ is realised. There is a need to understand how forces flow through a structure in order to ensure it meets its primary purpose of being strong and safe whilst at the same time meeting many other needs such as affordability, aesthetic, and regulatory and environmental criteria. The best structures are a harmony of architecture and engineering—where form and function are one and the flow of forces is logical.

scholarly journals Potential Role of Laccases in the Relationship of the Maize Late Wilt Causal Agent, Magnaporthiopsis maydis, and Its Host

2020 ◽  
Vol 6 (2) ◽  
pp. 63
Author(s):  
Ofir Degani ◽  
Yuval Goldblat
Keyword(s):  
Potential Role ◽  
Dry Weight ◽  
Maize Cultivars ◽  
Maize Plants ◽  
Relationship Of ◽  
The Relationship ◽  
Host Tissues ◽  
Adult Plants

Late wilt is a vascular disease of maize (Zea mays L.) caused by the soil-borne and seed-borne fungus Magnaporthiopsis maydis. The pathogen penetrates the roots of maize plants at the seedling stage, grows into the xylem vessels, and gradually spreads upwards. From the flowering stage to the kernel ripening, the fungal hyphae and secreted materials block the water supply in susceptible maize cultivars, leading to rapid dehydration and death. Laccase is an enzyme secreted by fungus for diverse purposes. The M. maydis laccase gene was identified in our laboratory, but under what conditions it is expressed and to what functions remain unknown. In the current study, we tested the influence of plant age and tissue source (roots or leaves) on M. maydis laccase secretion. The results show increasing laccase secretion as corn parts (as ground tissue) were added to the minimal medium (MM). Furthermore, roots stimulated laccase secretion more than leaves, and adult plants enhanced laccase secretion more than young plants. This implies the possibility that the richer lignin tissue of adult plants may cause increased secretion of the enzyme. In vitro pathogenicity assay proved the ability of M. maydis to develop inside detached roots of maize, barley, watermelon, and cotton but not peanut. Testing root powder from those plants in MM revealed a negative correlation between M. maydis growth (expressed as biomass) and laccase secretion. For example, while the addition of maize, barley, or cotton root powder led to increasing fungal dry weight, it also resulted in relatively lower laccase activity. Watermelon and peanut root powder led to opposite responses. These findings suggest a pivotal role of laccase in the ability of M. maydis to exploit and grow on different host tissues. The results encourage further examination and a deeper understanding of the laccase role in these interesting host–pathogen interactions.

The potential role of bacteria in pancreatic cancer: a systematic review

2020 ◽  
Vol 41 (4) ◽  
pp. 397-404 ◽  
Author(s):  
Ping Li ◽  
Yongqian Shu ◽  
Yanhong Gu
Keyword(s):  
Pancreatic Cancer ◽  
Type Ii Diabetes ◽  
Potential Role ◽  
Blood Type ◽  
Type Ii ◽  
Future Studies ◽  
Abo Blood Type ◽  
Relationship Of ◽  
The Relationship

Abstract Pancreatic cancer is a lethal and devastating disease in the worldwide. Recognized risk factors for pancreatic cancer include cigarette smoking, obesity, type II diabetes and chronic pancreatitis. Other factors such as variant ABO blood type and Helicobacter pylori may also play an important role in pancreatic carcinogenesis. Recently, growing evidence suggests that the association between bacteria and pancreatic cancer is positive and related immune/inflammation activation and increased nitrosamine exposure may be its potential mechanism. Interestingly, it is debatable whether the relationship of bacteria and pancreatic cancer is causative, reactive or parallel and future studies are in progress. Here we review recent progress in pancreatic cancer and its related bacteria.

Bark Anatomy of Four Tropical Vitaceae from Veracruz, Mexico

IAWA Journal ◽  
1997 ◽  
Vol 18 (3) ◽  
pp. 215-228 ◽  
Author(s):  
Guillermo Angeles ◽  
Calixto León-Gómez
Keyword(s):  
Potential Role ◽  
Stem Anatomy ◽  
Field Station ◽  
Tropical Biology ◽  
Microscopic Features ◽  
Bark Anatomy ◽  
Relationship Of ◽  
The Relationship ◽  
Water Holding

Bark anatomy of four species of Vitaceae growing at the tropical rain forest of Veracruz, Mexico, is described. Young and mature individuals were collected at the tropical biology field station 'Los Tuxtlas' . External, gross characteristics of the bark and microscopic features of young and adult individuals are given. Sectorization of the vascular tissues into minor and major areas was found in the three Cissus species, but not in Vitis tiliifolia, where it was apparent only at early stages of development. All the species studied have storied secondary phloem and very tall rays. The potential role of mucilage in water-holding capacity and the relationship of stem anatomy and aerial root formation are discussed.

Part V Fairness and Expeditiousness of ICC Proceedings, 38 The Role of the Appeals Chamber

2015 ◽  
Author(s):  
Nerlich Volker
Keyword(s):  
Trial Chamber ◽  
System P ◽  
The Law ◽  
The Right ◽  
And Function ◽  
Relationship Of ◽  
The Relationship ◽  
Role And Function ◽  
Meaningful Role

This chapter analyses the role and function of the Appeals Chamber of the ICC. The right to appeal under the Statute goes beyond what is mandated by human rights law. This contribution analyses the specificities of appeals in the ICC system, including the relationship of the Appeals Chamber to other Chambers, its jurisdiction over different types of appeal under Articles 81 and 82 (e.g. interlocutory appeal, and appeal against final decisions of the Trial Chamber), review and revision of sentences, and the relevant standards of review. The chapter contrasts approaches of the ICC with the practice of the Appeals Chambers of the ICTY and ICTR, which have used their first cases to clarify and develop the law. It shows that the ICC has taken an approach of judicial restraint. It argues that development of the law in small steps may be the most effective approach to building a lasting and meaningful role of the Appeals Chamber in the ICC system.

Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation

2000 ◽  
Vol 279 (6) ◽  
pp. H2587-H2592 ◽  
Author(s):  
Hilmar Dörge ◽  
Till Neumann ◽  
Matthias Behrends ◽  
Andreas Skyschally ◽  
Rainer Schulz ◽  
...  
Keyword(s):  
Microvascular Obstruction ◽  
Regional Myocardial Blood Flow ◽  
Wall Thickening ◽  
Area At Risk ◽  
Close Relationship ◽  
Anesthetized Dogs ◽  
And Function ◽  
Relationship Of ◽  
The Relationship

A close relationship exists between regional myocardial blood flow (RMBF) and function during acute coronary inflow restriction (perfusion-contraction matching). However, the relationship of flow and function during coronary microvascular obstruction is unknown. In 12 anesthetized dogs, the left circumflex coronary artery was perfused from an extracorporeal circuit. After control measurements, 3,000 microspheres (42 μm diameter) per milliliter per minute inflow were injected to cause a microembolism (ME, n = 6). With unchanged systemic hemodynamics and RMBF, posterior systolic wall thickening (PWT) decreased from 19.8 ± 1.9% SD at control to 13.3 ± 4.0, 10.3 ± 3.8, and 6.9 ± 4.7% ( P < 0.05 vs. control) at 1, 4, and 8 h, respectively. For comparison, inflow was progressively reduced to match PWT to that of the ME group at 1, 4, and 8 h (stenosis, STE, n = 6). RMBF in the STE group was reduced in proportion to PWT. Infarct size was not different among groups (6.5 ± 4.5 vs. 3.4 ± 3.2%). However, the number of leukocytes infiltrating the area at risk was significantly greater in the ME group than in the STE group. Coronary microembolization results in perfusion-contraction mismatch and is associated with an inflammatory response.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

Management of Economics and State "Bottom"

2020 ◽  
Vol 17 (6) ◽  
pp. 76-91
Author(s):  
E. D. Solozhentsev
Keyword(s):  
Quality Of Life ◽  
Artificial Intelligence ◽  
Probabilistic Models ◽  
Human Life ◽  
Special Software ◽  
Human Quality ◽  
Relationship Of ◽  
The Relationship

The scientific problem of economics “Managing the quality of human life” is formulated on the basis of artificial intelligence, algebra of logic and logical-probabilistic calculus. Managing the quality of human life is represented by managing the processes of his treatment, training and decision making. Events in these processes and the corresponding logical variables relate to the behavior of a person, other persons and infrastructure. The processes of the quality of human life are modeled, analyzed and managed with the participation of the person himself. Scenarios and structural, logical and probabilistic models of managing the quality of human life are given. Special software for quality management is described. The relationship of human quality of life and the digital economy is examined. We consider the role of public opinion in the management of the “bottom” based on the synthesis of many studies on the management of the economics and the state. The bottom management is also feedback from the top management.

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