Faculty Opinions recommendation of Quantifying the dominance of local control and the sources of regional control in the assembly of a metacommunity.

2017 ◽  
Author(s):  
Frédéric Guichard
Keyword(s):  
Local Control ◽  
Regional Control

scholarly journals Analysis of Radiation Therapy for the Control of Merkel Cell Carcinoma of the Head and Neck Based on 36 Cases and a Literature Review

2008 ◽  
Vol 87 (11) ◽  
pp. 634-643 ◽  
Author(s):  
Brian D. Lawenda ◽  
Michelle G. Arnold ◽  
Valerie A. Tokarz ◽  
Joshua R. Silverstein ◽  
Paul M. Busse ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck ◽  
Local Control ◽  
Clinical Stage ◽  
Local Control Rate ◽  
Stage I ◽  
Stage Iii ◽  
Regional Control ◽  
Kaplan Meier ◽  
Significant Difference

Merkel cell carcinoma (MCC) is a rare and aggressive epidermal cancer. We conducted a retrospective study and literature review to investigate the impact that radiation therapy has on local, regional, and distant control as part of the oncologic management of MCC of the head and neck and to further elucidate the role of radiation therapy with regard to regional control for the clinically uninvolved neck. We reviewed all registered cases of head and neck MCC that had occurred at four institutions from January 1988 through December 2005. Treatment and outcomes data were collected on patients with American Joint Committee on Cancer stage I, II, and III tumors. Local, regional, and distant control rates were calculated by comparing variables with the Fisher exact test; Kaplan-Meier analysis was used to report actuarial control data. Stage I to III head and neck MCC was identified in 36 patients— 22 men and 14 women, aged 43 to 97 years (mean: 71.6) at diagnosis. Patients with stage I and II tumors were combined into one group, and their data were compared with those of patients with stage III tumors. Twenty-sixpatients(72%) had clinical stage I/II disease and 10 patients (28%) had clinical stage III disease. Median follow-up was 41 months for the stage I/II group and 19 months for the stage III group. Based on examination at final follow-up visits, local recurrence was seen in 7 of the 36 patients (19%), for a local control rate of 81 %. The 2-year actuarial local control rate for all stages of MCC was 83%; by treatment subgroup, the rates were 95% for those who had undergone radiation therapy to the primary site and 69%) for those who had not— a statistically significant difference(p = 0.020). Based on information obtained at final follow-ups, 10 of the 36 patients (28%) experienced a regional recurrence, for a regional control rate of 72%. The 2-year actuarial regional control rate among all patients was 70%; by subgroup, rates were 82%) for patients who had undergone regional node radiation therapy and 60% for those who had not— not a statistically significant difference (p = 0.225). Nine patients (25%) overall developed a distant metastasis, for a distant control rate of 75%. Salvage therapies included chemotherapy and/or radiation therapy to the metastatic site, but neither had any significant effect on survival. Regardless of treatment, the Kaplan-Meier survival curves leveled off at 30 months with 82% survival for the stage I/II group and at 19 months with 60% survival for the stage III group. We conclude that radiation therapy to the primary tumor site (either following resection or definitively) results in a local control rate of more than 90% in patients with head and neck MCC. We also found a trend toward improved regional control of the clinically negative neck with the addition of radiation therapy.

Retrospective review of patients treated with intensity modulated radiation therapy (IMRT) with or without concurrent chemotherapy for locally advanced thyroid cancer: The Dana-Farber experience.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e16060-e16060
Author(s):  
Swati Kodali ◽  
Sewanti Atul Limaye ◽  
Aditya V. Shreenivas ◽  
Dave Zhao ◽  
Jochen H. Lorch ◽  
...  
Keyword(s):  
Overall Survival ◽  
Thyroid Cancer ◽  
Local Control ◽  
Locally Advanced ◽  
Medullary Carcinoma ◽  
Concurrent Chemotherapy ◽  
Anaplastic Carcinoma ◽  
Regional Control ◽  
Locally Recurrent ◽  
Advanced Thyroid Cancer

e16060 Background: Chemotherapy has been used concurrently with radiation for local control as adjuvant treatment or for locally recurrent thyroid cancer. We present our experience using IMRT with or without sensitizing concurrent chemotherapy in this setting. Methods: All patients with thyroid carcinoma with or without minimal metastatic disease treated since 2005 at DFCI were reviewed. We collected data and analyzed the outcomes of patients treated with IMRT with or without concurrent chemotherapy for local control. Results: Twenty-two patients were identified: 13 Males, 9 Female, Median age 60 years There were 11 papillary, 6 medullary, 4 anaplastic, and1 follicular. Thirteen patients were treated adjuvantly, seven for locally recurrent disease and two definitively for unresectable disease. All patients with papillary and follicular thyroid cancer had prior surgery and radioactive iodine therapy. Patients with medullary carcinoma had surgery alone. Two patients with anaplastic carcinoma had surgery and two were found to be unresectable.. Seventeen patients received concurrent weekly carboplatin AUC1.5 and paclitaxel 30mg/m2 with radiation. Five patients did not receive any concurrent chemotherapy and were treated with radiotherapy alone. Radiation fields encompassed the thyroid bed, bilateral neck and in some cases the mediastinum. The radiation dose ranged from 5600cGy to 6600cGy. Mean follow up was 42 months. The overall survival at 36 months was 89.5% (95% CI, 76.7-100). Two patients with unresectable anaplastic thyroid cancer died from progressive disease. Loco-regional control rate at 36 months was 78.9% (95% CI, 62.6-99.6). No grade 3 or 4 toxicities were reported during treatment. Conclusions: IMRT with or without concurrent chemotherapy provided excellent loco regional control and might have contributed to improved overall survival in patients with locally advanced thyroid cancer.

Is Radiation Therapy a Preferred Alternative to Surgery for Squamous Cell Carcinoma of the Base of Tongue?

2000 ◽  
Vol 18 (1) ◽  
pp. 35-35 ◽  
Author(s):  
William M. Mendenhall ◽  
Scott P. Stringer ◽  
Robert J. Amdur ◽  
Russell W. Hinerman ◽  
Giselle J. Moore-Higgs ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Multivariate Analysis ◽  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Local Control ◽  
Treatment Time ◽  
Overall Treatment Time ◽  
Regional Control ◽  
Base Of Tongue ◽  
Local Regional Control

PURPOSE: To evaluate irradiation alone for treatment of base-of-tongue cancer. PATIENTS AND METHODS: Two hundred seventeen patients with squamous cell carcinoma of the base of tongue were treated with radiation alone and had follow-up for ≥ 2 years. RESULTS: Local control rates at 5 years were as follows: T1, 96%; T2, 91%; T3, 81%; and T4, 38%. Multivariate analysis revealed that T stage (P = .0001) and overall treatment time (P = .0006) significantly influenced local control. The 5-year rates of local-regional control were as follows: I, 100%; II, 100%; III, 83%; IVA, 64%; and IVB, 65%. Multivariate analysis revealed that the following parameters significantly affect the probability of this end point: T stage (P = .0001), overall treatment time (P = .0001), overall stage (P = .0131), and addition of a neck dissection (P = .0021). The rates of absolute and cause-specific survival at 5 years were as follows: I, 50% and 100%; II, 81% and 100%; III, 65% and 76%; IVA, 42% and 56%; and IVB, 44% and 52%. Severe radiation complications developed in eight patients (4%). CONCLUSION: The likelihood of cure after external-beam irradiation was related to stage, overall treatment time, and addition of a planned neck dissection. The local-regional control rates and survival rates after radiation therapy were comparable to those after surgery, and the morbidity associated with irradiation was less.

Prognostic factors for local control, regional control and survival in oropharyngeal squamous cell carcinoma

1994 ◽  
Vol 30 (14) ◽  
pp. 2060-2067 ◽  
Author(s):  
C.A. Regueiro ◽  
G. Aragón ◽  
L Millán ◽  
F.J. Valcárcel ◽  
A. de la Torre ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Local Control ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Regional Control

scholarly journals Mixed Photon and Carbon-Ion Beam Radiotherapy in the Management of Non-Metastatic Nasopharyngeal Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Jiyi Hu ◽  
Qingting Huang ◽  
Jing Gao ◽  
Weixu Hu ◽  
Jing Yang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Local Control ◽  
Ion Beam ◽  
Cervical Lymphadenopathy ◽  
Heavy Ion ◽  
Toxicity Profile ◽  
Carbon Ion ◽  
Regional Control ◽  
Mixed Treatment

BackgroundCarbon-ion radiotherapy (CIRT) may further increase the therapeutic ratio for patients with newly diagnosed nasopharyngeal carcinoma (NPC). The purpose of the current study is to examine the effectiveness and toxicity profile of photon-based intensity-modulated radiotherapy (IMRT) plus CIRT boost in a relatively large cohort of NPC patients.MethodsIn the current study, non-metastatic NPC patients treated with IMRT plus CIRT boost at Shanghai Proton and Heavy Ion Center between June, 2015 and June, 2018 were included. Overall survival (OS), progression-free survival (PFS), local control, regional control, and distant control were calculated with Kaplan–Meier method. Acute and late toxicities were graded using CTCAE 4.03.ResultsA total of 69 patients were included in the analysis. Among those, 74% of the patients had locoregionally advanced (stage III/IV) disease, and 92.8% had cervical lymphadenopathy. With a median follow-up of 31.9 months, the 3-year OS, PFS, local control, regional control, and distant control rates were 94.9, 85.2, 96.9, 98.4, and 89.7%, respectively. Mixed treatment of IMRT with CIRT boost was well tolerated. Severe acute toxicities induced by radiation therapy were observed in only two patients (dermatitis). No severe radiation-induced late toxicity was observed at the time of analysis. Univariable analysis showed N2/3 disease was correlated with an inferior distant control (p = 0.040).ConclusionMixed treatment of IMRT plus CIRT boost provides an excellent disease control and a favorable toxicity profile for patients with non-metastatic NPC. Further follow-up is necessary to evaluate the long-term survivals and toxicities more accurately.

Linear Accelerator Radiosurgery in the Treatment of Brain Metastases

Neurosurgery ◽  
2004 ◽  
Vol 55 (5) ◽  
pp. 1076-1085 ◽  
Author(s):  
Arthur J. Ulm ◽  
William A. Friedman ◽  
Frank J. Bova ◽  
Patrick Bradshaw ◽  
Robert J. Amdur ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Brain Metastases ◽  
Local Control ◽  
Linear Accelerator ◽  
Whole Brain Radiation Therapy ◽  
Tumor Type ◽  
Whole Brain ◽  
Regional Control ◽  
Whole Brain Radiation ◽  
Brain Radiation

Abstract OBJECTIVE: To review a 12-year experience treating metastatic brain disease with linear accelerator-based stereotactic radiosurgery (SRS). METHODS: We performed a retrospective analysis of all patients treated between 1989 and 2001 with linear accelerator radiosurgery for brain metastases. Patients were followed up both clinically and with imaging studies to document local control, regional control, and survival. Demographic data, dosing parameters, number of lesions, histology, history of whole-brain radiation therapy, and other factors were obtained prospectively. Cox proportional-hazards regression with multivariate and univariate analysis was performed with Stata 8.0 software. RESULTS: A total of 383 patients received SRS for brain metastases during the study interval. Median survival was 9 months. Patients with tumor-type melanoma or multiple metastatic lesions had decreased survival. Actuarial 1-year local control was 75%. Differences in regional control rates were not statistically significant between patients treated with SRS and whole-brain radiation therapy versus SRS alone. CONCLUSION: Radiosurgery is an effective and safe method for treating selected patients with brain metastases.

Definitive radiotherapy for T3 squamous cell carcinoma of the glottic larynx.

1997 ◽  
Vol 15 (6) ◽  
pp. 2394-2402 ◽  
Author(s):  
W M Mendenhall ◽  
J T Parsons ◽  
A A Mancuso ◽  
F J Pameijer ◽  
S P Stringer ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Local Control ◽  
Squamous Cell ◽  
Survival Rates ◽  
Regional Control ◽  
Radiotherapy Alone ◽  
Local Regional Control ◽  
Cause Specific Survival

PURPOSE To report the results of radiotherapy alone for stage T3 squamous cell carcinoma of the true vocal cord and compare these data with those obtained with other treatment modalities. METHODS AND MATERIALS Seventy-five patients with previously untreated T3 squamous cell carcinoma of the glottic larynx were treated with curative intent with radiotherapy alone (73 patients) or followed by a planned neck dissection (two patients) at the University of Florida between September 1966 and August 1994. No patient received adjuvant chemotherapy. All patients were monitored for at least 2 years and 85% had a minimum follow-up duration of 5 years. No patient was lost to follow-up evaluation. RESULTS The 5-year local control and ultimate local control rates were 63% and 86%, respectively. The volume of the primary tumor (which was calculated on pretreatment computed tomographic [CT] scans in 38 patients) was inversely related to local control with larynx preservation: < or = 3.5 cm3, 20 of 23 (87%) versus greater than 3.5 cm3, four of 14 (29%) (P = .0005). There was no apparent relationship between local control after radiotherapy as a function of whether the vocal cord regained mobility or remained fixed during or shortly after completion of treatment. The 5-year absolute and cause-specific survival rates were 54% and 78%, respectively. Multivariate analysis showed that pretreatment tracheostomy was significantly related to diminished cause-specific survival (P = .0345). CONCLUSION Radiotherapy alone results in long-term local-regional control and survival rates that are comparable to those obtained with surgery. It is unclear whether induction or concomitant chemotherapy is associated with improved local-regional control and survival compared with radiotherapy alone.

scholarly journals A COMPREHENSIVE ASSESSMENT OF CANDIDATES TO SYNTHETIC VARIETY-POPULATIONS IN THE SCOTS PINE VARIETY TESTS IN GUTYANSKE FOREST ENTERPRISE

2018 ◽  
pp. 57-65
Author(s):  
V. A. Dyshko ◽  
L. O. Torosova
Keyword(s):  
Scots Pine ◽  
Local Control ◽  
Root Rot ◽  
Growth Characteristics ◽  
Synthetic Variety ◽  
Regional Control ◽  
Central Regions ◽  
Seed Stand ◽  
Scots Pine Stands ◽  
Better Than

The article presents the results of the examination of Scots pine progenies from nine clonal seed orchards (CSO) and one permanent forest seed stand (PFSS), which were potential synthetic variety-populations, as well as of their regional control variants (Kharkiv, Kyiv, Rivne and Volyn regions). All the progenies were tested in the Gutyanske Forest Enterprise in Kharkiv region. Mensuration and breeding indicators and state and level of resin productivity were estimated. At the age of 20, three out of ten potential variety-populations exceeded local control by the heights and diameters. The variants from the eastern and central regions were better than western ones by the breeding structure and state category. Only one candidate to the variety-population exceeded local control by the level of resin productivity, the rest ones were somewhat lower. In seven variants, the proportion of trees with higher resistance to phytopathology, in particular, to the annosum root rot, were higher (Pst = 45…50 %) than in the control (Pst = 40 %). The correlation between the resin productivity and the growth characteristics were weak (for diameter, r = 0,32 ± 0,055; for height, r = 0,17 ± 0,057). The results of integrated point assessment of candidates to variety-populations indicated the feasibility of using seeds from CSO and PFSS to create Scots pine stands to be potentially resistant to phytopathogenic diseases.

Sign in / Sign up

Export Citation Format

Share Document