Faculty Opinions recommendation of Mucinous breast carcinoma and mixed mucinous-infiltrating ductal carcinoma: a comparative cytologic study.

2016 ◽  
Author(s):  
Jan Jakobsson
Keyword(s):  
Breast Carcinoma ◽  
Ductal Carcinoma ◽  
Infiltrating Ductal Carcinoma ◽  
Mucinous Breast Carcinoma ◽  
Cytologic Study

scholarly journals The clinical features and prognosis of patients with mucinous breast carcinoma compared with those with infiltrating ductal carcinoma: a population-based study

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xingtong Zhou ◽  
Zhibo Zheng ◽  
Yan Li ◽  
Weiwei Zhao ◽  
Yan Lin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Prognostic Factors ◽  
Breast Carcinoma ◽  
Clinical Features ◽  
Ductal Carcinoma ◽  
Cox Proportional Hazards ◽  
Rank Test ◽  
Cancer Specific Survival ◽  
Infiltrating Ductal Carcinoma ◽  
Mucinous Breast Carcinoma

Abstract Background At present, the characteristics of mucinous breast carcinoma (MBC) and the factors affecting its prognosis are controversial. We compared the clinical features of MBC with those of infiltrating ductal carcinoma (IDC) and summarized the relevant prognostic factors. Methods The Surveillance, Epidemiology, and End Results (SEER) database includes information on 10,593 patients diagnosed with MBC between 2004 and 2016. Chi-square tests and analyses were used to analyze differences in variables between the MBC and IDC groups. Univariate and multivariate Cox proportional hazards models were used to assess the relative impacts of risk factors on cancer-specific survival (CSS) in patients. Kaplan-Meier survival curves were constructed to assess cancer-specific mortality and were compared using the log-rank test. Results From 2004 to 2016, 10,593 people were diagnosed with MBC, and 402,797 were diagnosed with IDC. Patients with MBC had significantly higher 5−/10-year CSS rates (96.4%/93.4%) than those with IDC (89%/83.8%). Compared with IDC patients, MBC patients had less lymph node metastasis, an earlier stage, a higher rate of hormone receptor positivity and a lower expression rate of HER2. Univariate and multivariate analyses showed that age ≥ 60 years old (HR = 1.574, 95%CI: 1.238–2.001, P < 0.001), singled status (HR = 1.676, 95%CI: 1.330–2.112, P < 0.001) and advanced TNM/SEER stage were independent prognostic risk factors for MBC. In addition, positive estrogen receptor (HR = 0.577, 95%CI: 0.334–0.997, P = 0.049), positive progesterone receptor (HR = 0.740, 95%CI: 0.552–0.992, P = 0.044), surgical treatment (HR = 0.395, 95%CI: 0.288–0.542, P < 0.001) and radiotherapy (HR = 0.589, 95%CI: 0.459–0.756, P < 0.001) were identified as protective factors. Conclusion Compared with IDC, MBC has a better prognosis. For patients with MBC, we identified prognostic factors that can help clinicians better assess patient outcomes and guide individualized treatment.

scholarly journals Expression of PDL-1 and Its Correlation with TIL in Triple Negative Cases of Breast Carcinoma

2021 ◽  
Vol 8 (6) ◽  
pp. A136-141
Author(s):  
Neha Sharma ◽  
Akashdeep Singh ◽  
Arshdeep Kaur ◽  
Mridu Manjari
Keyword(s):  
Breast Carcinoma ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Histological Grade ◽  
Breast Carcinomas ◽  
Not Otherwise Specified ◽  
Infiltrating Ductal Carcinoma ◽  
Grade Ii ◽  
Patient Prognosis ◽  
Grade Iii

Background:  In the present study, we aimed to determine the expression of PDL1 and its correlation with TIL in Triple Negative (ER, PR and Her 2neu negative) cases of breast carcinoma (immune-histochemical study)  Methods: Expression of PD-L1 was seen on 40 proven triple negative cases of breast carcinomas (TNBC) and to correlate it with other parameters affecting prognosis of the disease. All the cases were infiltrating ductal carcinoma NOS (not otherwise specified) Result: Maximum cases were Grade III (67.5%) followed by Grade II (32.5%). PD-L1 positivity was seen in 32.5% cases whereas TIL was positive for PD-L1 in 27.5 %. 5 cases were positive for both epithelial cell and TIL. Out of 13 PD-L1 positive tumors, 38.5% cases showed TIL positivity whereas out of 27 PD-L1 negative tumors, only 22.2% were TIL positive. PD-L1 expression in TIL was seen in 38.5% of cases however there was no statistically significant correlation between PD-L1 positivity and TIL positivity. PDL-1 positivity was more in Grade III (33.3%) as compared to Grade II (23%) lesions. Thus, it was observed that PD-L1 positivity increased from grade II to grade III lesions. Conclusion: Intra-tumoral expression of PD-L1 is directly proportional to histological grade, aggressive subtypes in TNBC cases however there was no statistically significant correlation between PD-L1 positivity in tumor cells and TIL positivity. We thus postulate that measurement of PD-L1 expression in TNBC cases could enhance the accuracy of predicting patient prognosis and allow for optimal treatment selection.

scholarly journals Metaplastic carcinoma breast (IDC and chondrosarcoma): a rare entity

2018 ◽  
Vol 5 (7) ◽  
pp. 2646
Author(s):  
Deepesh Kalra ◽  
Bhanu Kaushik ◽  
Shalu Gupta ◽  
Pradeep Tanwar ◽  
Sami Anwar Khan
Keyword(s):  
Breast Carcinoma ◽  
Ductal Carcinoma ◽  
Radical Mastectomy ◽  
Metaplastic Carcinoma ◽  
Ki 67 ◽  
Mucinous Component ◽  
Infiltrating Ductal Carcinoma ◽  
Characteristic Features ◽  
The Right ◽  
Metaplastic Breast Carcinoma

Metaplastic breast carcinoma is very rare neoplasm. Authors report a case of metaplastic breast carcinoma containing characteristic features of infiltrating ductal carcinoma and chondrosarcoma. A 62-year-old female presented with complaint of a lump in the right breast for the last 2 years. FNAC was suggestive of mucinous tumour. Tru-cut biopsy had been performed outside the institution, which was suggestive of a Ductal carcinoma with mucinous component. Modified radical mastectomy of the right breast was performed and histopathology was suggestive of infiltrating ductal carcinoma and chondrosarcoma of the right breast. All resected lymph nodes were free of metastasis. Immunohistochemistry was suggestive of a metaplastic carcinoma with components of ductal carcinoma and chondrosarcoma with moderately positive ER, negative PR, positive Pancytokeratin in ductal carcinoma component, positive S-100 and KI-67.

scholarly journals Mucinous Breast Carcinoma: Clinicopathological Comparison With Invasive Ductal Carcinoma

Cureus ◽  
2021 ◽  
Author(s):  
Atif A Hashmi ◽  
Shamail Zia ◽  
Syed Rafay Yaqeen ◽  
Omer Ahmed ◽  
Ishaq Azeem Asghar ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Mucinous Breast Carcinoma

Breast Carcinoma with Osteoclast-Like Giant Cells: Immunohistochemical and Ultrastructural Study of a Case and Review of the Literature

1995 ◽  
Vol 81 (2) ◽  
pp. 135-141 ◽  
Author(s):  
Paolo Viacava ◽  
Antonio Giuseppe Naccarato ◽  
Vincenzo Nardini ◽  
Generoso Bevilacqua
Keyword(s):  
Electron Microscopy ◽  
Breast Carcinoma ◽  
Tumor Cells ◽  
Unusual Case ◽  
Ductal Carcinoma ◽  
Benign Lesion ◽  
Giant Cells ◽  
Review Of The Literature ◽  
Not Otherwise Specified ◽  
Infiltrating Ductal Carcinoma

We describe an unusual case of infiltrating ductal carcinoma, not otherwise specified, containing numerous benign stromal osteoclast giant cells (OGCs). Macroscopically, the tumor appeared as a well-outlined dark brown mass and was initially interpreted as a benign lesion on the mammograms. OGCs were uniformly distributed in the tumor and were found in vascularized, hemorrhagic stroma often abutted on the nests of tumor cells. Electron microscopy supported a histiocytic origin of the OGCs, but immunohistochemistry failed to confirm the observation. The patient was alive and well 30 months following the operation. A review of the literature concerning breast carcinoma with OGCs is also presented.

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