Faculty Opinions recommendation of Direct infant UV light exposure is associated with eczema and immune development.

AbstractPolymeric nanoparticles have been investigated as potential delivery systems for therapeutic compounds to address many ailments including eye disease. The stability and spatiotemporal distribution of polymeric nanoparticles in the eye are important regarding the practical applicability and efficacy of the delivery system in treating eye disease. We selected poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with lutein, a carotenoid antioxidant associated with eye health, as our model ophthalmic nanodelivery system and evaluated its stability when suspended in various conditions involving temperature and light exposure. We also assessed the ocular biodistribution of the fluorescently labeled nanoparticle vehicle when administered topically. Lutein-loaded nanoparticles were stable in suspension when stored at 4 °C with only 26% lutein release and no significant lutein decay or changes in nanoparticle morphology. When stored at 25 °C and 37 °C, these NPs showed signs of bulk degradation, had significant lutein decay compared to 4 °C, and released over 40% lutein after 5 weeks in suspension. Lutein-loaded nanoparticles were also more resistant to photodegradation compared to free lutein when exposed to ultraviolet (UV) light, decaying approximately 5 times slower. When applied topically in vivo, Cy5-labled nanoparticles showed high uptake in exterior eye tissues including the cornea, episcleral tissue, and sclera. The choroid was the only inner eye tissue that was significantly higher than the control group. Decreased fluorescence in all exterior eye tissues and the choroid at 1 h compared to 30 min indicated rapid elimination of nanoparticles from the eye.

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795 A multicenter phase II trial (SWOG S1609, cohort 51) of ipilimumab and nivolumab in metastatic or unresectable angiosarcoma: a substudy of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART)

Journal for ImmunoTherapy of Cancer ◽

10.1136/jitc-2020-sitc2020.0795 ◽

2020 ◽

Vol 8 (Suppl 3) ◽

pp. A843-A843

Author(s):

Michael Wagner ◽

Megan Othus ◽

Sandip Patel ◽

Christopher Ryan ◽

Ashish Sangal ◽

...

Keyword(s):

Phase Ii ◽

Immune Checkpoint ◽

Uv Light ◽

Light Exposure ◽

Case Reports ◽

Objective Response ◽

Open Label ◽

Primary Tumors ◽

Multicenter Phase ◽

Grade 3

BackgroundAngiosarcoma is a rare cancer of endothelial cells that can be aggressive and carries a high mortality. A subset of angiosarcomas are characterized by high tumor mutational burden (TMB) and UV light exposure DNA mutational signature. Isolated case reports have suggested clinical efficacy of immune checkpoint blockade in angiosarcoma; no prospective studies of immune checkpoint inhibition in angiosarcoma have been reported. We report efficacy analysis results for patients with advanced or unresectable angiosarcoma treated with ipilimumab and nivolumab as a cohort of an ongoing phase II study for rare cancers (NCT02834013).MethodsThis is a prospective, open-label, multicenter phase II clinical trial of ipilimumab (1mg/kg IV q6weeks) plus nivolumab (240mg IV q2weeks) for patients with metastatic or unresectable angiosarcoma. Primary endpoint is objective response rate as assessed by RECIST v1.1, including measurable cutaneous disease that can be followed by photography. Secondary endpoints include PFS, OS, stable disease at six months, and toxicity. A two-stage design is used with six patients in the first stage and an additional ten patients in the second stage.ResultsAt data cutoff, 16 patients with angiosarcoma were enrolled. Median age was 68 years (25-81 years). Median number of prior lines of therapy was 2 (0-5). 9 patients had cutaneous primary tumors of any cutaneous site, 7 had non-cutaneous primary tumors. ORR for all patients was 25% (4/16, table 1, figure 1). Subgroup analysis revealed that 60% (3/5) of patients with primary cutaneous tumors of the scalp or face had a confirmed objective response. 6-month PFS was 38%. 75% of patients experienced an adverse event (AE), and 25% experienced a grade 3-4 AE. 68.8% experienced an immune related AE (irAE), and 2 (12.5%) developed grade 3 or 4 irAEs. Grade 3-4 irAEs were ALT and AST increase and diarrhea. There were no grade 5 toxicities.ConclusionsThe combination of ipilimumab and nivolumab was well tolerated and had an ORR of 25% in angiosarcoma regardless of primary site, with 3 of 5 patients with cutaneous tumors of the scalp or face responding. Ipilimumab and nivolumab warrant further investigation in angiosarcoma.AcknowledgementsFunding: National Institutes of Health/National Cancer Institute grant awards CA180888, CA180819, CA180868; and in part by Bristol-Myers Squibb CompanyTrial RegistrationNCT02834013Ethics ApprovalThis study was approved by the NCI CIRB.

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UV-light-assisted green preparation of Bi/BiOBr/RGO composites with oxygen vacancies toward enhanced photocatalytic removal of organic dye

New Journal of Chemistry ◽

10.1039/d0nj01296c ◽

2020 ◽

Vol 44 (19) ◽

pp. 7749-7757 ◽

Cited By ~ 1

Author(s):

Wen Jia ◽

Dong Peng ◽

Zijuan Feng ◽

Xue Wu ◽

Yi Liu ◽

...

Keyword(s):

Oxygen Vacancies ◽

Uv Light ◽

Light Exposure ◽

Organic Dye ◽

Photocatalytic Removal ◽

Bi Nanoparticles

Concomitant formation of metallic Bi nanoparticles and oxygen vacancies was successfully achieved within Bi/BiOBr/RGO composites by green UV-light exposure.

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Hydrophylicity Enhancement of Modified Cellulose Acetate Membrane to Improve the Membrane Performance in Produced Water Treatment

MATEC Web of Conferences ◽

10.1051/matecconf/201815608003 ◽

2018 ◽

Vol 156 ◽

pp. 08003 ◽

Cited By ~ 1

Author(s):

Tutuk Djoko Kusworo ◽

Danny Soetrisnanto ◽

Cynthia Santoso ◽

Tyas Dwi Payanti ◽

Dani Puji Utomo

Keyword(s):

Water Treatment ◽

Produced Water ◽

Uv Light ◽

Light Exposure ◽

Membrane Surface ◽

Asymmetric Structure ◽

Dense Layer ◽

Cellulose Acetate Membrane ◽

Permeate Flux ◽

Produced Water Treatment

Produced water is a wastewater generated from petroleum industry with high concentration of pollutants such as Total Dissolved Solid, Organic content, and Oil and grease. Membrane technology has been currently applied for produced water treatment due to its efficiency, compact, mild and clean process. The main problem of produced water using membrane is fouling on the membrane surface which causes on low permeate productivity. This paper is majority focused on the improvement of anti-fouling performance through several modifications to increase CA membrane hydrophilicity. The membrane was prepared by formulating the dope solution consists of 18 wt-% CA polymer, acetone, and PEG additive (3 wt-%, 5 wt-%, and 7 wt-%). The membranes are casted using NIPS method and being irradiated under UV light exposure. The SEM images show that parepared membrane has asymmetric structure consist of dense layer, intermediete layer, and finger-like support layer. The filtration test shows that PEG addition increase the membrane hydrophilicity and the permeate flux increases. UV light exposure on the membrane improves the membrane stability and hydrophilicity. The imrpovement of membrane anti-fouling performance is essential to achieve the higher productivity without lowering its pollutants rejection.

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A Left-Sided Prevalence of Lentigo Maligna: A UK Based Observational Study and Review of the Evidence

Dermatology Research and Practice ◽

10.1155/2015/310270 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Mark Gorman ◽

Andrew Hart ◽

Bipin Mathew

Keyword(s):

Risk Factor ◽

Uv Light ◽

Light Exposure ◽

Significant Risk ◽

Significant Risk Factor ◽

Evidence Base ◽

The Body ◽

Cumulative Exposure ◽

Lentigo Maligna ◽

Recent Trends

Skin cancer has been shown to present asymmetrically, prevalent on the left side of the body, more so in subtypes of cutaneous melanoma such as lentigo maligna. Biases have been linked to cumulative UV light exposure and automobile driving patterns. Though left-right ratios have previously correlated with the side men or women tend to position themselves or countries drive on, more recent trends indicate a consistent left-sided bias. To clarify reasons for changing trends, a review of the evidence base and LM’s laterality in a UK cohort (99 cases 2000–2011) was conducted for the first time. The strong correlation of left-sided excess, found in both genders (ratios 1.381–1.5,P<0.05 X20.841), is congruent with more recent findings. Though evidence indicates that driving position is no longer a risk factor for LM, due most likely to improved car window UV protection, it remains the most commonly attributed cause. Understanding phenomena such as UV lights “scatter effect” or that cumulative exposure may not be a significant risk factor helps rationalize older conclusions that would otherwise appear contradictory. The reasons for left-sided excess remain unclear but may be due to factors requiring further research such as the body’s anatomical/embryological asymmetry.

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Suspected Pulmonary Metastasis of Actinic Cutaneous Squamous Cell Carcinoma

Case Reports in Surgery ◽

10.1155/2017/4176071 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Monet E. Meter ◽

David J. Nye ◽

Christian R. Galvez

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Actinic Keratosis ◽

Uv Light ◽

Light Exposure ◽

Thoracoscopic Surgery ◽

Wedge Resection ◽

Lung Lesion ◽

The Right

Introduction. It is rare for actinic or squamous cell carcinoma (SCC) in situ to metastasize. Case Presentation. A 67-year-old male had a significant medical history including severe psoriatic arthritis treated with UVB, methotrexate, and rapamycin. He had twenty-five different skin excisions of actinic keratosis four of which were invasive SCC. Our patient developed shortness of breath necessitating a visit to the emergency department. A CT scan of his chest revealed a mass in the right lower lung. A subsequent biopsy of the mass revealed well-differentiated SCC. He underwent thoracoscopic surgery with wedge resection of the lung lesion. Discussion. Actinic keratosis (AK) is considered precancerous and associated with UV exposure. It exists as a continuum of progression with low potential for malignancy. The majority of invasive SCCs are associated with malignant progression of AK, but only 5–10% of AKs will progress to malignant potential. Conclusion. In this case, a new finding of lung SCC in the setting of multiple invasive actinic cutaneous SCC associated with a history of extensive UV light exposure and immunosuppression supports a metastatic explanation for lung cancer.

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The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research

10.1101/741744 ◽

2019 ◽

Cited By ~ 1

Author(s):

Corrie A. Painter ◽

Esha Jain ◽

Brett N. Tomson ◽

Michael Dunphy ◽

Rachel E. Stoddard ◽

...

Keyword(s):

Immune Checkpoint ◽

Uv Light ◽

Light Exposure ◽

Scientific Discovery ◽

Clinical Information ◽

Causative Factor ◽

Research Approach ◽

Rare Cancers ◽

Geographically Dispersed ◽

Dismal Prognosis

ABSTRACTDespite collectively accounting for 25% of tumors in U.S. adults, rare cancers have significant unmet clinical needs as they are difficult to study due to low incidence and geographically dispersed patient populations. We sought to assess whether a patient-partnered research approach using online engagement can overcome these challenges and accelerate scientific discovery in rare cancers, focusing on angiosarcoma (AS), an exceedingly rare sarcoma with a dismal prognosis and an annual U.S. incidence of 300 cases. Here, we describe the development of the Angiosarcoma Project (ASCproject), an initiative enabling patients across the U.S. and Canada to remotely share their clinical information and biospecimens for research. The project generates and publicly releases clinically annotated genomic data on tumor and germline specimens on an ongoing basis. Over 18 months, 338 AS patients registered for the ASCproject, comprising a significant fraction of all patients. Whole exome sequencing of 47 AS tumors revealed several recurrently mutated genes, including KDR, TP53, and PIK3CA. Activating mutations in PIK3CA were observed nearly exclusively in primary breast AS, suggesting a therapeutic rationale in these patients. AS of the head, neck, face, and scalp (HNFS) was associated with high tumor mutation burden and a dominant mutational signature of UV light exposure, suggesting that UV damage may be a causative factor in HNFS AS and that this AS subset might be amenable to immune checkpoint inhibitor therapy. Medical record review revealed two patients with HNFS AS received off-label treatment with anti-PD-1 therapy and experienced exceptional responses, highlighting immune checkpoint inhibition as a therapeutic avenue for HNFS AS. This patient-partnered approach has catalyzed an opportunity to discover the etiology and potential therapies for AS patients. Collectively, this proof of concept study demonstrates that empowering patients to directly participate in research can overcome barriers in rare diseases and enable biological and clinical discoveries.

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