Faculty Opinions recommendation of Maternal Obesity and the Risk of Early-Onset and Late-Onset Hypertensive Disorders of Pregnancy.

Abstract High serum immunoglobulin E (IgE) levels are associated with cardiovascular events. We aimed to evaluate the association between total IgE levels during the first trimester of pregnancy and hypertensive disorders of pregnancy (HDP) development in a large Japanese cohort. We analysed data pertaining to singleton primipara pregnancies recorded in the Japan Environment and Children’s Study involving births in 2011–2014. First trimester’s serum IgE levels were determined using the immunonephelometric technique. High serum IgE was defined as IgE levels ≥170 IU/ml. A multiple logistic regression model was used to estimate the risk of high serum IgE levels on HDP, comprising early-onset and late-onset hypertension. A total of 32,518 participants were enrolled. The prevalence of total, early-onset, and late-onset HDP was 3.2%, 0.6%, and 2.3%, respectively. Patients with high serum IgE levels had an increased risk of late-onset hypertension (adjusted odds ratio [aOR]: 1.19, 95% confidence interval: 1.01–1.40). No correlation was found with either HDP (total) or early-onset hypertension (aOR: 1.15 and 0.85, 95% confidence interval: 0.99–1.32 and 0.60–1.21, respectively). High serum IgE levels during the first trimester are associated with late-onset hypertension. Our results could influence and shape further research regarding the pathogenesis of late-onset hypertension.

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One-year infant outcome in women with early-onset hypertensive disorders of pregnancy

BJOG An International Journal of Obstetrics & Gynaecology ◽

10.1111/j.1471-0528.2007.01544.x ◽

2007 ◽

Vol 115 (2) ◽

pp. 290-298 ◽

Cited By ~ 11

Author(s):

A Rep ◽

W Ganzevoort ◽

AG Van Wassenaer ◽

GJ Bonsel ◽

H Wolf ◽

...

Keyword(s):

Early Onset ◽

Hypertensive Disorders Of Pregnancy ◽

Hypertensive Disorders ◽

Infant Outcome ◽

One Year

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General movements in infants born from mothers with early-onset hypertensive disorders of pregnancy in relation to one year's neurodevelopmental outcome

Early Human Development ◽

10.1016/j.earlhumdev.2008.03.002 ◽

2008 ◽

Vol 84 (9) ◽

pp. 605-611 ◽

Cited By ~ 6

Author(s):

P.E.M. van Schie ◽

A. Rep ◽

W. Ganzevoort ◽

L. de Groot ◽

H. Wolf ◽

...

Keyword(s):

Early Onset ◽

Neurodevelopmental Outcome ◽

Hypertensive Disorders Of Pregnancy ◽

Hypertensive Disorders ◽

General Movements

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Outcome at 4.5 years of children born after expectant management of early-onset hypertensive disorders of pregnancy

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2011.02.032 ◽

2011 ◽

Vol 204 (6) ◽

pp. 510.e1-510.e9 ◽

Cited By ~ 24

Author(s):

Aleid G. van Wassenaer ◽

Jolanda Westera ◽

Petra E.M. van Schie ◽

Bregje A. Houtzager ◽

Anneke Cranendonk ◽

...

Keyword(s):

Early Onset ◽

Expectant Management ◽

Hypertensive Disorders Of Pregnancy ◽

Hypertensive Disorders

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Association between maternal serum beta human chorionic gonadotropin levels and hypertensive disorders of pregnancy

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20203052 ◽

2020 ◽

Vol 9 (8) ◽

pp. 3157

Author(s):

Archana Kumari ◽

Vahini M.

Keyword(s):

Pregnant Women ◽

Late Onset ◽

Maternal Serum ◽

Severe Preeclampsia ◽

Control Group ◽

Study Group ◽

Hypertensive Disorders Of Pregnancy ◽

Hypertensive Disorders ◽

Significant Difference ◽

Β Hcg

Background: A major challenge in obstetrics is early identification of hypertensive disorders of pregnancy (HDP). This study was performed to determine the association between elevated maternal serum β-hCG levels and HDP, the correlation between serum β-hCG level and severity of preeclampsia and to determine the value of serum β-hCG level as a diagnostic marker for early diagnosis of HDP.Methods: This was a hospital based observational study conducted in the department of obstetrics and gynecology, Rajendra Institute of Medical Sciences, Ranchi on 375 pregnant women with period of gestation more than 20 weeks, including 250 pregnant women with HDP as study group and 125 normotensive pregnant women as controls. Serum β-hCG concentration was measured and its level was compared between two groups.Results: The maternal mean serum β-hCG levels (51161.08±30038.21 IU/L) of study group of HDP were higher than the normotensive control group (17603.23±16748.21 IU/L). In non-severe preeclampsia, the mean serum levels were 36417.32±23876.74 IU/L while in severe preeclampsia, 60030.34±28771.31 IU/L. There was statistically significant difference (p<0.001) with higher levels in early onset preeclamptic mothers than late onset preeclampsia. The cut-off point of β-hCG for predicting HDP was 32077 IU/L with sensitivity of 65% and specificity of 86%.Conclusions: Serum β-hCG level is higher in HDP when compared to normotensive women. Higher levels of β-hCG are associated with increasing severity of hypertensive disorders of pregnancy. The utility of serum β-hCG as a diagnostic test is limited because of low sensitivity and difficulty in deciding the cut-off value.

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Hypertensive Disorders of Pregnancy Appear Not to Be Associated with Alzheimer's Disease Later in Life

Dementia and Geriatric Cognitive Disorders Extra ◽

10.1159/000439043 ◽

2015 ◽

Vol 5 (3) ◽

pp. 375-385 ◽

Cited By ~ 10

Author(s):

Carolien N.H. Abheiden ◽

Rebecca van Doornik ◽

Annet M. Aukes ◽

Wiesje M. van der Flier ◽

Philip Scheltens ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Late Onset ◽

Medical Center ◽

White Matter Lesions ◽

Hypertensive Disorders Of Pregnancy ◽

Telephone Surveys ◽

Hypertensive Disorders ◽

Increased Risk ◽

History Of

Background: After hypertensive disorders of pregnancy, more subjective cognitive complaints and white matter lesions are reported compared to women after normal pregnancies. Both have a causal relationship with Alzheimer's disease (AD). Aim: To investigate if women whose pregnancy was complicated by hypertensive disorders have an increased risk of AD. Methods: A case-control study in women with AD from the Alzheimer Center of the VU University Medical Center Amsterdam and women without AD. Paper and telephone surveys were performed. Results: The response rate was 85.2%. No relation between women with (n = 104) and without AD (n = 129) reporting pregnancies complicated by hypertensive disorders (p = 0.11) was found. Women with early-onset AD reported hypertensive disorders of pregnancy more often (p = 0.02) compared to women with late-onset AD. Conclusion: A reported history of hypertensive disorders of pregnancy appears not to be associated with AD later in life.

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