Faculty Opinions recommendation of Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice.

2021 ◽  
Author(s):  
Shinya Kuroda ◽  
Keigo Morita
Keyword(s):  
Restricted Diet

0137 The endometrial microbiome in transition cows fed an energy-restricted diet

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 64-65
Author(s):  
G. Esposito ◽  
J. J. Lim ◽  
T. Tasara ◽  
P. C. Irons ◽  
E. C. Webb ◽  
...  
Keyword(s):  
Restricted Diet ◽  
Transition Cows

Nutrients Mediate Bioavailability and Turnover of Proteins in Mammals

2019 ◽  
Vol 20 (7) ◽  
pp. 661-665
Author(s):  
Cunxi Nie ◽  
Fei Xie ◽  
Ning Ma ◽  
Yueyu Bai ◽  
Wenju Zhang ◽  
...  
Keyword(s):  
The Body ◽  
Biologically Active ◽  
Nitrogen Excretion ◽  
Dietary Proteins ◽  
Restricted Diet ◽  
Nutritional Interventions ◽  
Body Tissues ◽  
Utilization Of Protein ◽  
High Level ◽  
Protein Restricted Diet

As a major component of biologically active compounds in the body, proteins contribute to the synthesis of body tissues for the renewal and growth of the body. The high level of dietary protein and the imbalance of amino acid (AA) composition in mammals result in metabolic disorders, inefficient utilization of protein resources and increased nitrogen excretion. Fortunately, nutritional interventions can be an effective way of attenuating the nitrogen excretion and increasing protein utilization, which include, but are not limited to, formulating the AA balance and protein-restricted diet supplementing with essential AAs, and adding probiotics in the diet. This review highlights recent advances in the turnover of dietary proteins and mammal’s metabolism for health, in order to improve protein bioavailability through nutritional approach.

scholarly journals Current and Future Treatments for Classic Galactosemia

2021 ◽  
Vol 11 (2) ◽  
pp. 75 ◽  
Author(s):  
Britt Delnoy ◽  
Ana I. Coelho ◽  
Maria Estela Rubio-Gozalbo
Keyword(s):  
Standard Of Care ◽  
Type I ◽  
Therapeutic Approaches ◽  
Restricted Diet ◽  
Galactose Metabolism ◽  
Galt Activity ◽  
Classic Galactosemia ◽  
Pathogenic Factors ◽  
Future Treatments ◽  
Novel Therapeutic

Type I (classic) galactosemia, galactose 1-phosphate uridylyltransferase (GALT)-deficiency is a hereditary disorder of galactose metabolism. The current therapeutic standard of care, a galactose-restricted diet, is effective in treating neonatal complications but is inadequate in preventing burdensome complications. The development of several animal models of classic galactosemia that (partly) mimic the biochemical and clinical phenotypes and the resolution of the crystal structure of GALT have provided important insights; however, precise pathophysiology remains to be elucidated. Novel therapeutic approaches currently being explored focus on several of the pathogenic factors that have been described, aiming to (i) restore GALT activity, (ii) influence the cascade of events and (iii) address the clinical picture. This review attempts to provide an overview on the latest advancements in therapy approaches.

Health Status of French Young Patients with Inborn Errors of Metabolism with Lifelong Restricted Diet

2020 ◽  
Vol 220 ◽  
pp. 184-192.e6
Author(s):  
Aline Cano ◽  
Noemie Resseguier ◽  
Abdoulaye Ouattara ◽  
Pascale De Lonlay ◽  
Jean-Baptiste Arnoux ◽  
...  
Keyword(s):  
Health Status ◽  
Inborn Errors Of Metabolism ◽  
Young Patients ◽  
Restricted Diet ◽  
Inborn Errors

scholarly journals A Novel Dietary Intervention Reduces Circulatory Branched-Chain Amino Acids by 50%: A Pilot Study of Relevance for Obesity and Diabetes

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 95
Author(s):  
Imran Ramzan ◽  
Moira Taylor ◽  
Beth Phillips ◽  
Daniel Wilkinson ◽  
Kenneth Smith ◽  
...  
Keyword(s):  
Amino Acids ◽  
Pilot Study ◽  
Dietary Intervention ◽  
Control Diet ◽  
Branched Chain Amino Acids ◽  
Model Assessment ◽  
Dietary Intakes ◽  
Restricted Diet ◽  
Obesity And Diabetes ◽  
Branched Chain

Elevated circulating branched-chain amino acids (BCAAs; isoleucine, leucine, and valine) are associated with obesity and type 2 diabetes (T2D). Reducing circulatory BCAAs by dietary restriction was suggested to mitigate these risks in rodent models, but this is a challenging paradigm to deliver in humans. We aimed to design and assess the feasibility of a diet aimed at reducing circulating BCAA concentrations in humans, while maintaining energy balance and overall energy/protein intake. Twelve healthy individuals were assigned to either a 7-day BCAA-restricted diet or a 7-day control diet. Diets were iso-nitrogenous and iso-caloric, with only BCAA levels differing between the two. The BCAA-restricted diet significantly reduced circulating BCAA concentrations by ~50% i.e., baseline 437 ± 60 to 217 ± 40 µmol/L (p < 0.005). Individually, both valine (245 ± 33 to 105 ± 23 µmol/L; p < 0.0001), and leucine (130 ± 20 to 75 ± 13 µmol/L; p < 0.05), decreased significantly in response to the BCAA-restricted diet. The BCAA-restricted diet marginally lowered Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) levels: baseline 1.5 ± 0.2 to 1.0 ± 0.1; (p = 0.096). We successfully lowered circulating BCAAs by 50% while maintaining iso-nitrogenous, iso-caloric dietary intakes, and while meeting the recommended daily allowances (RDA) for protein requirements. The present pilot study represents a novel dietary means by which to reduce BCAA, and as such, provides a blueprint for a potential dietary therapeutic in obesity/diabetes.

scholarly journals Sex-Specific Effects of Dietary Methionine Restriction on the Intestinal Microbiome

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 781 ◽  
Author(s):  
Katherine F. Wallis ◽  
Stepan B. Melnyk ◽  
Isabelle R. Miousse
Keyword(s):  
Body Weight ◽  
Animal Models ◽  
Intestinal Microbiota ◽  
Methylation Status ◽  
Intestinal Microbiome ◽  
Protein Methylation ◽  
Restricted Diet ◽  
Male And Female ◽  
Specific Effects ◽  
Methionine Restriction

Dietary methionine restriction is associated with improved health outcomes and an increase in lifespan in animal models. We have previously shown that an increase in dietary methionine induces alteration in the intestinal microbiome. The composition of the intestinal microbiota is a determinant of health and we, therefore, hypothesized that dietary methionine restriction would also induce changes in the murine microbiome. After one month on a methionine-restricted diet, five-month-old male and female C57BL/6 mice had decreased levels of serum methionine, without changes in body weight. We identified a decrease in the hepatic methylation status of animals fed a methionine-restricted diet compared to controls. This decrease was not associated with changes in DNA or protein methylation in the liver. In males, we saw an increase in families Bacteroidaceae and Verrucoccaceae (mostly A. mucinophila) and a decrease in Rumminococcaceae in animals fed a methionine-restricted diet compared to controls. In females, Bacteroidales family S24-7 was increased two-fold, while families Bacteroidaceae, Verrucoccaceae, Rumminococcaceae, and Rikenellaceae were decreased compared to controls. In summary, feeding a methionine-restricted diet for one month was associated with significant and sex-specific changes in the intestinal microbiome.

Faecal Lipid Excretion Levels in Normal Japanese Females on an Unrestricted Diet and a Fat-Restricted Diet Measured by Simultaneous Analysis of Faecal Lipids

1992 ◽  
Vol 20 (6) ◽  
pp. 461-466 ◽  
Author(s):  
T Nakamura ◽  
H Kikuchi ◽  
K Takebe ◽  
K Kudoh ◽  
A Terada ◽  
...  
Keyword(s):  
Bile Acids ◽  
Dietary Fat ◽  
Chromatographic Method ◽  
Simultaneous Analysis ◽  
Restricted Diet ◽  
Neutral Sterol ◽  
Neutral Sterols ◽  
Unrestricted Diet ◽  
Lipid Excretion ◽  
Normal Japanese

Faecal lipid excretion was determined in 16 females on an unrestricted diet and on a fat-restricted diet using a chromatographic method for the simultaneous analysis of faecal lipids. The fat-restricted diet reduced the total quantity of faeces and the amounts of fatty acids, neutral sterols and bile acids excreted were almost halved compared with when on an unrestricted diet. This indicates that dietary fat, fibre and cholesterol affect the amount of faecal bile acid, neutral sterol and fatty acid excretion. The amount of cholesterol/animal sterols excreted and the percentage of primary bile acids were, however, similar for both the fat-restricted and unrestricted diets.

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